psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	G.HN.30	G.HN.33	2.96087	No	No	0	7	4
2	G.HN.36	b.b5x2	6.27881	No	Yes	0	4	7
3	G.HN.40	G.HN.44	4.47595	No	No	3	7	6
4	G.HN.40	b.b5x2	8.60143	No	Yes	0	7	7
5	G.HN.40	b.b5x3	4.0131	No	Yes	3	7	9
6	G.HN.43	b.b5x3	5.41175	No	Yes	0	9	9
7	G.HN.44	b.b5x3	8.77389	No	Yes	3	6	9
8	G.HN.47	b.b4x2	3.8719	No	Yes	0	6	8
9	G.HN.50	b.b4x2	6.49635	No	Yes	0	5	8
10	G.HN.51	b.l1x4	5.71214	No	No	0	5	6
11	G.S1.01	G.S3.04	5.81238	No	Yes	0	7	7
12	G.S1.02	G.S3.03	5.88325	No	Yes	0	6	8
13	G.S1.02	G.h2s4.05	3.8827	No	No	0	6	8
14	G.S1.03	G.S3.06	4.89643	No	Yes	0	9	7
15	G.S1.04	G.S3.03	4.03	No	Yes	0	7	8
16	G.S1.04	G.S4.03	3.67992	No	No	0	7	7
17	G.S1.05	G.S1.07	5.82127	No	No	0	9	8
18	G.S1.05	G.h2s4.01	15.1167	No	Yes	0	9	9
19	G.S1.05	G.S4.02	6.96619	No	No	0	9	8
20	G.H1.01	G.S1.06	4.87905	Yes	No	15	9	8
21	G.S1.06	G.S3.05	7.37095	No	No	0	8	8
22	G.S1.06	G.S3.07	6.505	No	No	15	8	9
23	G.H3.01	G.s1h1.04	5.18444	Yes	No	0	9	9
24	G.S4.05	G.s1h1.05	3.45008	No	No	0	7	9
25	G.H1.01	G.S3.07	8.36206	Yes	No	15	9	9
26	G.H1.04	G.S4.05	4.38818	No	No	0	7	7
27	G.H1.04	G.S5.07	4.19183	No	Yes	0	7	9
28	G.hfs2.07	b.l7x4	4.28119	No	No	0	8	9
29	G.S2.01	b.l5x5	4.00675	No	Yes	0	9	9
30	G.S2.03	G.S2.05	4.14643	Yes	No	10	9	4
31	G.S2.03	G.S3.04	7.53222	Yes	Yes	10	9	7
32	G.S2.03	G.S3.06	9.95825	Yes	Yes	10	9	7
33	G.S2.05	G.S3.04	12.5386	No	Yes	10	4	7
34	G.S2.06	G.S3.03	12.5371	Yes	Yes	0	9	8
35	G.S2.07	G.S3.02	7.20762	No	No	0	3	4
36	G.H5.08	G.S2.08	6.63643	Yes	No	0	8	6
37	G.H5.05	G.s2s3.01	7.95008	No	No	0	5	5
38	G.H5.08	G.s2s3.01	6.8896	Yes	No	0	8	5
39	G.S3.01	G.S3.03	4.78468	No	Yes	7	5	8
40	G.H5.08	G.S3.01	3.17159	Yes	No	7	8	5
41	G.S3.01	I2x51	4.20675	No	Yes	7	5	6
42	G.H5.08	G.S3.03	3.40159	Yes	Yes	7	8	8
43	G.H5.11	G.S3.03	3.58944	No	Yes	0	8	8
44	G.S3.04	G.S3.06	7.04754	Yes	Yes	10	7	7
45	G.S3.06	b.l5x5	16.9261	Yes	Yes	0	7	9
46	G.H2.07	G.S3.08	11.5872	Yes	No	1	9	9
47	G.H2.03	b.l13x6	3.75357	No	Yes	1	9	9
48	G.H2.04	G.H2.07	7.77778	No	Yes	0	9	9
49	G.H2.04	G.H3.08	8.81397	No	Yes	0	9	8
50	G.H2.06	b.l9x6	3.64667	Yes	Yes	1	9	8
51	G.H2.06	b.b14x1	9.52	Yes	No	1	9	8
52	G.H2.06	b.l15x1	4.40111	Yes	Yes	1	9	7
53	G.H2.06	b.l17x6	6.71667	Yes	Yes	1	9	9
54	G.H2.06	b.b18x1	4.17722	Yes	No	0	9	9
55	G.H2.07	G.h2s4.01	3.40317	Yes	Yes	0	9	9
56	G.H2.07	b.l9x6	3.50643	Yes	Yes	1	9	8
57	G.H2.08	G.H3.18	3.96389	No	No	0	9	9
58	G.H2.09	G.H3.17	8.05063	No	Yes	1	8	5
59	G.H2.09	b.l25x6	4.63397	No	Yes	1	8	8
60	G.H2.10	b.b2x1	3.82937	No	Yes	1	8	8
61	G.H2.10	b.l3x1	3.8027	No	Yes	1	8	9
62	G.H2.10	b.b6x1	3.88286	No	Yes	1	8	9
63	G.h2s4.01	G.h2s4.04	3.29579	Yes	No	0	9	9
64	G.h2s4.01	b.l5x5	12.4565	Yes	Yes	0	9	9
65	G.h2s4.02	G.h2s4.03	6.11198	No	No	1	8	6
66	G.h2s4.02	b.l1x6	6.48421	No	Yes	1	8	9
67	G.h2s4.02	b.l28x1	5.48857	No	Yes	1	8	9
68	G.h2s4.03	b.l1x6	6.58492	No	Yes	1	6	9
69	G.S4.01	G.S5.03	3.06889	No	No	0	8	9
70	G.S4.02	G.h3s5.03	3.35175	No	No	0	8	7
71	G.S4.03	G.S5.05	3.38786	No	Yes	8	7	9
72	G.H5.07	G.S4.03	3.44222	No	No	8	9	7
73	G.S4.04	G.S4.06	3.15024	Yes	No	0	9	7
74	G.H3.08	G.S4.04	6.21349	Yes	Yes	0	8	9
75	G.H3.09	G.S4.04	3.51198	Yes	Yes	0	9	9
76	G.S4.04	G.S5.04	3.14064	Yes	No	0	9	9
77	G.H4.15	G.S4.06	4.68071	Yes	No	0	8	7
78	G.S4.07	G.s4h3.02	3.58754	No	No	0	8	9
79	G.S4.07	G.s5hg.01	8.075	No	No	0	8	9
80	G.HG.04	G.s4h3.01	4.05032	No	No	0	8	6
81	G.HG.03	G.s4h3.02	4.95698	Yes	No	0	6	9
82	G.H3.01	G.s4h3.03	6.46635	Yes	No	0	9	8
83	G.HG.07	G.s4h3.04	8.10365	Yes	No	0	9	8
84	G.HG.15	G.s4h3.04	10.6006	No	No	0	7	8
85	G.hgh4.01	G.s4h3.04	6.78381	Yes	No	0	6	8
86	G.H3.01	G.H3.04	6.42524	Yes	No	0	9	9
87	G.H3.02	G.hgh4.02	4.75817	No	No	0	8	8
88	G.H3.03	G.H3.06	3.05167	No	No	0	4	6
89	G.H3.03	G.H3.07	6.3831	No	No	0	4	5
90	G.H3.06	G.H4.14	3.42103	No	No	0	6	5
91	G.H3.06	G.H4.15	8.73738	No	Yes	0	6	8
92	G.H3.08	G.H3.12	4.19127	Yes	No	0	8	8
93	G.H3.09	G.H3.13	4.67635	Yes	Yes	16	9	6
94	G.H3.09	G.S5.02	4.61619	Yes	No	16	9	6
95	G.H3.09	G.H4.15	6.57476	Yes	Yes	0	9	8
96	G.H3.09	G.h4s6.01	4.43452	Yes	No	0	9	4
97	G.H3.09	G.S6.01	3.19167	Yes	No	0	9	5
98	G.H3.10	G.H3.14	4.14857	No	No	0	5	8
99	G.H3.10	G.h4s6.01	5.66833	No	No	0	5	4
100	G.H3.13	G.H3.14	3.44381	Yes	No	0	6	8
101	G.H3.13	G.S5.02	4.28032	Yes	No	16	6	6
102	G.H3.13	G.h4s6.02	8.03103	Yes	No	0	6	7
103	G.H3.13	G.h4s6.13	24.786	Yes	No	0	6	7
104	G.H3.14	G.h4s6.08	3.79595	No	No	0	8	5
105	G.H3.15	G.H3.18	9.38111	No	No	0	8	9
106	G.H3.16	G.H3.17	11.5898	No	Yes	0	5	5
107	G.H3.17	b.l23x1	7.86159	Yes	Yes	1	5	6
108	G.H3.17	b.l25x6	14.0801	Yes	Yes	1	5	8
109	G.H3.17	b.l28x1	3.45706	Yes	Yes	1	5	9
110	G.H5.14	G.S5.01	8.05984	No	No	0	6	8
111	G.S5.03	G.S5.05	4.05714	No	Yes	0	9	9
112	G.H5.10	G.S5.03	7.77706	No	No	0	7	9
113	G.S5.04	G.S5.06	3.52675	No	No	0	9	8
114	G.H4.15	G.S5.04	8.29349	Yes	No	0	8	9
115	G.S5.05	G.S6.04	4.57079	Yes	No	0	9	9
116	G.S5.05	G.s6h5.01	5.01278	Yes	Yes	8	9	9
117	G.H5.03	G.S5.05	6.82659	Yes	Yes	8	9	9
118	G.H5.07	G.S5.05	3.80421	No	Yes	8	9	9
119	G.S5.06	G.S6.05	6.23357	No	Yes	0	8	5
120	G.S5.07	G.s5hg.01	6.28405	Yes	No	0	9	9
121	G.S5.07	G.s6h5.01	4.38659	Yes	Yes	0	9	9
122	G.HG.03	G.s5hg.01	3.995	Yes	No	0	6	9
123	G.H4.07	G.HG.01	5.55286	No	No	17	5	6
124	G.HG.01	G.S6.05	4.5081	No	Yes	17	6	5
125	G.HG.02	G.HG.03	3.21103	No	Yes	0	9	6
126	G.HG.02	G.s6h5.02	3.97643	No	No	0	9	8
127	G.H4.03	G.HG.05	3.21865	No	No	0	4	4
128	G.HG.07	G.HG.13	5.13643	Yes	No	0	9	7
129	G.HG.09	G.hgh4.21	4.60921	No	No	0	2	4
130	G.HG.14	G.HG.16	3.69643	No	No	0	6	4
131	G.HG.14	G.HG.17	6.18992	No	No	0	6	3
132	G.HG.15	G.hgh4.05	10.3874	No	Yes	0	7	6
133	G.HG.16	G.hgh4.05	6.66262	No	Yes	0	4	6
134	G.HG.16	G.hgh4.06	3.3904	No	No	0	4	2
135	G.HG.17	G.hgh4.01	4.69857	No	Yes	0	3	6
136	G.H4.10	G.hgh4.02	5.3331	Yes	No	0	7	8
137	G.hgh4.03	G.hgh4.04	3.90484	No	No	0	6	6
138	G.H4.05	G.hgh4.05	12.1744	No	Yes	0	5	6
139	G.H4.10	G.hgh4.05	12.5182	Yes	Yes	0	7	6
140	G.hgh4.08	G.hgh4.11	4.19206	No	Yes	0	6	5
141	G.H4.10	G.hgh4.08	9.75135	Yes	No	0	7	6
142	G.H4.13	G.hgh4.08	7.03087	No	No	0	3	6
143	G.hgh4.10	G.hgh4.11	4.26389	No	Yes	0	1	5
144	G.H4.05	G.hgh4.10	3.06873	No	No	0	5	1
145	G.H4.08	G.hgh4.11	4.43476	No	Yes	0	3	5
146	G.H4.08	G.hgh4.14	5.31563	No	No	0	3	3
147	G.H4.04	G.hgh4.16	5.32992	No	No	0	4	1
148	G.H4.03	G.hgh4.20	3.20349	No	Yes	0	4	3
149	G.H4.04	G.hgh4.20	5.62214	No	Yes	0	4	3
150	G.H4.07	G.hgh4.20	5.13214	No	Yes	0	5	3
151	G.H4.01	G.hgh4.21	7.14278	No	No	0	1	4
152	G.H4.02	G.hgh4.21	9.87056	No	No	0	5	4
153	G.H4.07	G.S6.05	13.2358	No	Yes	17	5	5
154	G.H4.08	G.H4.12	7.16841	No	Yes	0	3	4
155	G.H4.10	G.H4.14	9.99413	Yes	No	0	7	5
156	G.H4.12	G.H4.16	3.43103	Yes	No	0	4	4
157	G.H4.12	G.S6.03	5.22468	Yes	No	0	4	5
158	G.H4.12	G.S6.05	5.16817	Yes	Yes	0	4	5
159	G.S6.01	G.h4s6.02	4.53389	No	No	0	5	7
160	G.h4s6.10	G.h4s6.12	5.08508	No	Yes	0	3	2
161	G.S6.02	G.h4s6.20	6.7169	Yes	No	0	8	4
162	G.H5.17	G.h4s6.20	5.455	Yes	No	0	5	4
163	G.H5.10	G.S6.02	13.0058	No	Yes	0	7	8
164	G.H5.13	G.S6.02	10.1437	No	Yes	0	8	8
165	G.H5.14	G.S6.02	6.8777	No	Yes	0	6	8
166	G.H5.06	G.S6.04	9.51119	Yes	No	0	4	9
167	G.H5.10	G.S6.04	10.3249	No	No	0	7	9
168	G.s6h5.01	G.s6h5.05	3.53413	Yes	Yes	8	9	9
169	G.H5.03	G.s6h5.01	7.5554	Yes	Yes	8	9	9
170	G.H5.03	G.s6h5.05	3.20675	Yes	Yes	8	9	9
171	G.H5.06	G.s6h5.05	4.04603	Yes	Yes	8	4	9
172	G.H5.03	G.H5.06	3.8273	Yes	Yes	8	9	4
173	G.H5.08	I2x51	7.32183	Yes	Yes	7	8	6
174	G.H5.12	I2x50	4.84833	No	No	0	7	9
175	G.H5.12	I2x51	4.37944	No	Yes	0	7	6
176	G.H5.13	G.H5.17	6.4704	No	Yes	0	8	5
177	G.H5.15	G.H5.19	3.76913	No	Yes	7	8	8
178	G.H5.15	I2x51	3.34683	No	Yes	7	8	6
179	G.H5.15	I2x54	3.94643	No	No	7	8	5
180	G.H5.16	I2x50	3.77492	No	No	0	6	9
181	3x53	G.H5.19	3.26921	No	Yes	7	8	8
182	G.H5.19	I2x53	7.83333	Yes	Yes	7	8	6
183	G.H5.19	I2x54	3.07833	Yes	No	7	8	5
184	2x37	G.H5.22	5.5754	No	No	0	7	4
185	G.H5.22	I2x57	3.10167	No	No	0	4	8
186	2x39	G.H5.23	8.36516	No	Yes	0	7	4
187	3x49	G.H5.23	6.13214	No	Yes	0	8	4
188	3x50	G.H5.23	7.95937	Yes	Yes	0	9	4
189	b.1x5	b.1x9	3.27127	No	Yes	0	3	4
190	b.1x13	b.1x9	3.36675	No	Yes	0	1	4
191	b.1x11	g.h1x11	4.2504	Yes	No	0	8	9
192	b.1x13	b.1x16	6.57222	No	No	0	1	4
193	b.1x15	b.1x19	3.48817	No	No	0	7	6
194	b.1x19	b.b21x1	8.07357	No	Yes	0	6	7
195	b.lh12x2	g.l1x6	7.24373	No	No	0	8	4
196	b.lh12x2	g.h2x2	5.09286	No	No	0	8	9
197	b.h2x2	b.lh12x4	2.98413	No	No	0	1	3
198	b.h2x3	b.lh12x4	7.14437	No	No	0	1	3
199	b.b21x4	b.h2x1	4.31698	No	No	0	5	5
200	b.b21x5	b.h2x1	6.1581	Yes	No	0	4	5
201	b.h2x5	b.lhb1x3	3.01587	No	Yes	0	5	2
202	b.h2x5	b.l24x2	3.84833	No	No	0	5	6
203	b.l22x5	b.lhb1x3	4.17595	Yes	Yes	0	9	2
204	b.l24x3	b.lhb1x3	4.13167	Yes	Yes	0	5	2
205	b.l22x5	b.lhb1x6	5.03587	Yes	Yes	18	9	3
206	b.b24x7	b.lhb1x6	7.27754	No	Yes	18	9	3
207	b.lhb1x10	b.lhb1x8	5.71976	No	No	0	4	2
208	b.b23x1	b.lhb1x9	3.68032	No	No	0	5	3
209	b.b25x7	b.lhb1x11	5.13659	No	No	0	7	4
210	b.lhb1x11	g.ctx5	4.17222	No	No	0	4	9
211	b.b1x1	b.b1x3	5.59389	No	Yes	0	5	7
212	b.b1x2	b.b28x4	6.42373	No	Yes	6	3	6
213	b.b1x2	b.b28x6	9.2519	No	Yes	6	3	9
214	b.b1x3	b.b28x7	9.19199	Yes	No	0	7	9
215	b.b1x3	g.ctx17	3.68992	Yes	No	0	7	7
216	b.b1x4	b.b5x1	4.67	No	No	0	7	5
217	b.b1x4	b.b28x5	4.35468	No	No	3	7	5
218	b.b1x4	g.ctx16	3.44484	No	Yes	3	7	8
219	b.b1x5	b.l1x1	10.216	No	No	0	3	7
220	b.b1x5	b.b28x4	6.90032	No	Yes	0	3	6
221	b.b1x6	b.b4x6	16.7205	No	Yes	3	9	9
222	b.b1x6	b.b28x3	6.79952	No	Yes	3	9	7
223	b.b28x2	b.l1x1	9.56889	No	No	0	4	7
224	b.l1x3	b.l1x7	10.301	Yes	No	0	9	9
225	b.b3x4	b.l1x3	7.21595	No	Yes	3	9	9
226	b.b3x6	b.l1x3	11.289	No	Yes	0	9	9
227	b.b4x4	b.l1x3	11.7334	No	Yes	3	8	9
228	b.b4x6	b.l1x3	5.11341	Yes	Yes	3	9	9
229	b.l1x4	b.l3x2	7.75492	No	Yes	0	6	9
230	b.b2x1	b.l1x6	6.31214	Yes	Yes	1	8	9
231	b.l1x6	b.l3x1	9.35135	Yes	Yes	1	9	9
232	b.l1x6	b.l28x1	15.8461	Yes	Yes	1	9	9
233	b.b28x3	b.l1x7	3.11373	Yes	No	0	7	9
234	b.b2x1	b.l3x1	11.0408	Yes	Yes	1	8	9
235	b.b2x1	b.b6x1	3.96206	Yes	Yes	1	8	9
236	b.b2x1	b.l28x1	7.60984	Yes	Yes	1	8	9
237	b.b2x2	b.b6x3	3.31	No	No	0	7	8
238	b.b2x3	b.b2x5	3.65738	Yes	Yes	3	6	7
239	b.b2x3	b.b3x2	3.4873	Yes	No	3	6	5
240	b.b26x2	b.b2x3	5.88857	No	Yes	0	7	6
241	b.b10x4	b.b2x4	11.8308	No	No	0	6	6
242	b.b2x5	b.b3x2	10.1779	Yes	No	3	7	5
243	b.b2x5	b.l4x1	5.35222	Yes	No	3	7	5
244	b.b2x5	b.l27x1	10.9073	Yes	No	3	7	7
245	b.b27x2	b.b2x5	4.31302	No	Yes	0	5	7
246	b.b6x5	b.l2x1	3.83032	Yes	No	0	6	5
247	b.l2x3	b.l2x5	3.30683	No	No	0	8	5
248	b.b3x1	b.l2x3	6.92579	No	No	0	5	8
249	b.l27x1	b.l2x4	5.62246	No	No	3	7	5
250	b.l27x3	b.l2x4	9.04381	No	No	3	7	5
251	b.b4x7	b.l2x5	14.2844	No	No	0	8	5
252	b.l2x5	b.l4x2	21.6884	No	Yes	0	5	4
253	b.b3x1	b.b6x5	3.8419	No	Yes	0	5	6
254	b.b3x2	b.b4x6	3.95841	No	Yes	3	5	9
255	b.b3x3	b.b4x5	3.42413	No	No	0	8	7
256	b.b3x3	b.b6x5	5.59944	No	Yes	0	8	6
257	b.b3x4	b.b4x6	6.84341	No	Yes	3	9	9
258	b.b28x3	b.b3x4	3.74008	Yes	No	3	7	9
259	b.b3x5	b.l5x6	3.79476	No	No	0	9	9
260	b.b3x5	b.b6x3	3.41	No	No	0	9	8
261	b.b3x6	b.l3x2	7.78254	No	Yes	0	9	9
262	b.l3x1	b.l5x5	5.5896	Yes	Yes	0	9	9
263	b.b4x2	b.l3x2	5.89413	Yes	Yes	0	8	9
264	b.b4x2	b.b5x8	4.84587	Yes	No	0	8	5
265	b.b4x3	b.b5x7	5.09627	No	Yes	0	7	7
266	b.b4x3	b.l5x1	5.54762	No	Yes	11	7	8
267	b.b4x3	b.b7x4	3.47508	No	No	11	7	8
268	b.b4x4	b.b4x6	15.4745	No	Yes	3	8	9
269	b.b4x4	b.b5x3	4.50048	No	Yes	3	8	9
270	b.b4x5	b.b5x5	6.08183	No	No	0	7	5
271	b.b4x5	b.l8x1	3.28341	No	No	0	7	5
272	b.b4x6	b.b5x3	10.9463	Yes	Yes	3	9	9
273	b.b28x3	b.b4x6	3.26619	Yes	Yes	3	7	9
274	b.b4x7	b.l4x3	8.29373	No	No	0	8	6
275	b.l4x1	b.l4x2	3.03659	No	Yes	3	5	4
276	b.l4x1	g.ctx16	3.37405	No	Yes	3	5	8
277	b.l4x2	g.ctx15	8.4019	Yes	Yes	3	4	9
278	b.l4x2	g.ctx16	5.16603	Yes	Yes	3	4	8
279	b.b5x2	b.l4x3	9.18032	Yes	No	0	7	6
280	b.b5x4	b.b5x5	6.04381	No	No	0	5	5
281	b.b5x5	b.l8x8	3.00881	No	No	0	5	4
282	b.b5x7	b.b5x8	3.39	Yes	No	0	7	5
283	b.b5x7	b.b8x4	5.9304	Yes	Yes	0	7	6
284	b.b5x7	b.l8x8	8.32468	Yes	No	0	7	4
285	b.l5x1	b.l5x6	4.36357	Yes	No	0	8	9
286	b.b7x4	b.l5x1	4.79786	No	Yes	11	8	8
287	b.b8x4	b.l5x1	5.26571	Yes	Yes	11	6	8
288	b.b9x3	b.l5x2	5.23444	Yes	No	0	6	6
289	b.l5x3	b.l7x3	8.15587	No	No	0	8	9
290	b.l5x5	b.l7x2	5.91929	Yes	No	0	9	9
291	b.b6x1	b.l7x1	4.0046	Yes	No	0	9	9
292	b.b6x1	b.l9x6	5.49167	Yes	Yes	1	9	8
293	b.b10x3	b.b6x2	4.76151	No	No	0	8	8
294	b.b6x5	b.l6x4	3.56405	Yes	No	0	6	5
295	b.b6x5	b.b7x2	3.65492	Yes	No	19	6	8
296	b.b6x5	b.l8x1	3.1469	Yes	No	19	6	5
297	b.b10x5	b.l6x1	7.01056	Yes	No	0	9	6
298	b.l6x3	b.l6x5	7.62738	No	Yes	12	6	4
299	b.l10x3	b.l6x3	6.95024	No	No	12	6	6
300	b.b7x1	b.l6x5	4.30183	Yes	Yes	12	4	4
301	b.l6x5	b.l8x2	9.48127	Yes	No	0	4	4
302	b.l10x3	b.l6x5	3.31286	No	Yes	12	6	4
303	b.b7x1	b.b8x3	3.47635	Yes	No	0	4	6
304	b.b7x1	b.b8x5	12.2669	Yes	No	0	4	4
305	b.b7x1	b.l10x3	6.02325	Yes	No	12	4	6
306	b.b7x2	b.l8x1	5.96	No	No	19	8	5
307	b.b10x5	b.b7x3	3.14508	Yes	No	0	9	9
308	b.b7x4	b.b8x4	4.04341	No	Yes	11	8	6
309	b.l7x3	b.l7x5	5.82222	No	No	0	9	6
310	b.l7x4	b.l9x5	3.87754	No	No	0	9	8
311	b.b9x3	b.l7x5	4.00087	Yes	No	0	6	6
312	b.l7x5	b.l9x1	3.11849	No	No	0	6	5
313	b.b8x1	b.b9x4	3.53794	No	No	0	8	9
314	b.b8x2	b.b8x4	5.68468	No	Yes	0	8	6
315	b.b8x2	b.b9x3	3.63913	No	Yes	0	8	6
316	b.b8x3	b.l12x1	3.49452	No	No	0	6	6
317	b.b8x4	b.l8x10	5.68944	Yes	No	0	6	4
318	b.b8x5	b.l8x3	5.66389	No	Yes	0	4	3
319	b.l8x3	b.l8x5	3.20103	Yes	No	0	3	3
320	b.l8x3	b.l8x9	2.98675	Yes	No	0	3	3
321	b.b9x3	b.l8x10	3.46437	Yes	No	0	6	4
322	b.b12x6	b.b9x4	15.7633	Yes	No	0	8	9
323	b.l9x3	b.l9x7	3.63381	Yes	No	1	9	7
324	b.b11x4	b.l9x3	5.31635	Yes	Yes	1	9	9
325	b.b11x6	b.l9x3	13.9146	No	Yes	1	9	9
326	b.l11x2	b.l9x3	7.54111	Yes	Yes	1	9	9
327	b.b12x6	b.l9x3	6.54881	Yes	Yes	1	8	9
328	b.l11x2	b.l9x4	6.75651	Yes	No	0	9	5
329	b.l11x1	b.l9x6	6.97659	No	Yes	1	9	8
330	b.l13x6	b.l9x6	8.23984	Yes	Yes	1	9	8
331	b.b11x4	b.l9x7	3.33484	Yes	No	1	9	7
332	b.b10x1	b.b11x5	3.55754	No	No	0	9	6
333	b.b10x2	b.b10x4	4.54349	No	No	0	6	6
334	b.b10x2	b.b14x3	4.81087	No	Yes	0	6	5
335	b.b10x3	b.b11x4	3.36659	No	Yes	0	8	9
336	b.b10x4	b.b14x5	3.37365	No	No	0	6	5
337	b.b10x5	b.b11x2	8.03349	Yes	No	0	9	7
338	b.b11x1	b.l10x1	4.30921	No	No	0	5	3
339	b.b14x5	b.l10x1	4.36048	No	No	0	5	3
340	b.l10x1	b.l14x4	3.09944	No	No	0	3	1
341	b.b11x1	b.l10x2	8.24683	No	No	0	5	5
342	b.b12x7	b.l10x4	9.95833	Yes	No	20	9	3
343	b.l10x4	b.l12x2	6.68516	No	No	20	3	6
344	b.b11x1	b.b12x5	4.71087	No	No	0	5	6
345	b.b11x2	b.l12x1	3.34048	No	No	0	7	6
346	b.b11x3	b.b14x3	3.6304	No	Yes	5	5	5
347	b.b11x3	b.b15x1	4.00405	No	Yes	5	5	9
348	b.b11x4	b.b12x6	8.97087	Yes	Yes	1	9	8
349	b.b11x5	b.l13x7	5.28333	No	Yes	0	6	9
350	b.b11x5	b.b14x3	6.0673	No	Yes	0	6	5
351	b.b11x6	b.l11x1	3.40167	No	No	1	9	9
352	b.b11x6	b.l11x2	9.44175	No	Yes	1	9	9
353	b.l11x1	b.l13x6	4.40556	No	Yes	1	9	9
354	b.b12x2	b.l11x2	9.8423	No	Yes	0	7	9
355	b.b12x3	b.l13x7	3.87635	No	Yes	0	8	9
356	b.b12x4	b.b12x6	3.9946	No	Yes	1	4	8
357	b.b12x4	b.b13x3	5.17222	No	No	1	4	4
358	b.b12x5	b.b13x5	4.38643	No	No	0	6	4
359	b.b12x6	b.b13x3	13.5249	Yes	No	1	8	4
360	b.b12x7	b.l12x3	7.28524	Yes	No	0	9	5
361	b.b13x2	b.l12x3	5.42063	No	No	0	4	5
362	b.b13x4	b.b13x5	3.60103	No	No	0	4	4
363	b.b13x5	b.b13x7	5.31286	No	Yes	0	4	7
364	b.b13x7	b.b15x1	10.301	Yes	Yes	5	7	9
365	b.b13x7	b.b16x6	13.1651	Yes	Yes	5	7	8
366	b.b13x7	b.b17x1	3.37008	Yes	No	0	7	4
367	b.l13x3	b.l13x7	5.22976	Yes	Yes	5	9	9
368	b.b15x3	b.l13x3	6.01024	No	Yes	5	9	9
369	b.b15x5	b.l13x3	7.69968	No	Yes	5	8	9
370	b.l13x3	b.l15x2	5.52	Yes	Yes	5	9	9
371	b.b16x4	b.l13x3	15.8864	Yes	Yes	5	6	9
372	b.b16x6	b.l13x3	5.34873	Yes	Yes	5	8	9
373	b.l13x4	b.l15x2	7.49079	No	Yes	0	3	9
374	b.l13x6	b.l15x1	3.84222	Yes	Yes	1	9	7
375	b.b15x3	b.l13x7	3.61643	No	Yes	5	9	9
376	b.b14x1	b.l15x1	3.15	No	Yes	1	8	7
377	b.b14x2	b.b18x3	3.74722	No	Yes	0	7	8
378	b.b14x3	b.b15x1	3.25841	Yes	Yes	5	5	9
379	b.b14x4	b.b18x5	5.18016	No	Yes	0	8	5
380	b.b18x5	b.l14x1	4.21532	Yes	No	0	5	4
381	b.l14x2	b.l18x4	4.06	No	No	0	4	7
382	b.l14x3	b.l14x5	7.02397	No	No	0	5	5
383	b.b16x5	b.l14x6	4.20841	Yes	No	0	5	3
384	b.b16x7	b.l14x6	4.40571	No	No	0	9	3
385	b.b15x1	b.b16x6	10.8184	Yes	Yes	5	9	8
386	b.b15x2	b.b18x3	6.33794	No	Yes	4	6	8
387	b.b15x2	b.b18x5	7.61778	No	Yes	0	6	5
388	b.b15x2	b.b19x2	7.88659	No	Yes	4	6	6
389	b.b15x3	b.b16x6	6.24397	No	Yes	5	9	8
390	b.b15x5	b.l15x2	3.73651	No	Yes	5	8	9
391	b.l15x1	b.l17x6	8.0773	Yes	Yes	1	7	9
392	b.b16x2	b.l15x2	8.17976	No	Yes	0	5	9
393	b.b16x4	b.b16x6	8.72762	Yes	Yes	5	6	8
394	b.b16x4	b.b17x3	5.26175	Yes	No	5	6	5
395	b.b16x4	b.b17x6	10.9279	Yes	No	0	6	7
396	b.b16x5	b.b17x4	3.0254	Yes	No	0	5	5
397	b.b16x5	b.b17x5	4.40222	Yes	No	0	5	7
398	b.b16x5	b.l20x1	5.51413	Yes	No	0	5	6
399	b.b16x6	b.b17x3	6.07421	Yes	No	5	8	5
400	b.b16x7	b.l16x3	9.02143	No	No	21	9	3
401	b.b16x7	b.b17x4	8.32786	No	No	21	9	5
402	b.b17x2	b.l16x3	3.71587	No	No	0	3	3
403	b.b17x4	b.l16x3	3.19381	No	No	21	5	3
404	b.b17x5	b.b17x7	7.40198	No	Yes	4	7	8
405	b.b17x5	b.b21x1	12.4424	No	Yes	4	7	7
406	b.b17x7	b.b19x2	9.08317	Yes	Yes	4	8	6
407	b.b17x7	b.b20x6	10.3945	Yes	Yes	4	8	6
408	b.b17x7	b.b21x1	5.07056	Yes	Yes	4	8	7
409	b.l17x3	b.l17x7	8.49048	Yes	No	4	9	7
410	b.b19x4	b.l17x3	8.51667	Yes	Yes	4	8	9
411	b.b19x6	b.l17x3	13.8148	No	Yes	4	9	9
412	b.l17x3	b.l19x2	3.38	Yes	Yes	4	9	9
413	b.b20x4	b.l17x3	16.7013	Yes	Yes	4	8	9
414	b.b20x6	b.l17x3	3.04381	Yes	Yes	4	6	9
415	b.l17x4	b.l19x2	7.76484	No	Yes	0	3	9
416	b.l17x5	b.l19x1	3.25754	No	No	0	6	9
417	b.l17x5	b.l19x2	4.04254	No	Yes	0	6	9
418	b.l17x6	b.l19x1	4.94127	Yes	No	0	9	9
419	b.b19x4	b.l17x7	4.97016	Yes	No	4	8	7
420	b.b18x1	b.l19x1	7.12722	No	No	0	9	9
421	b.b18x2	b.b22x3	3.16357	No	No	0	5	6
422	b.b18x3	b.b19x2	4.68381	Yes	Yes	4	8	6
423	b.b18x3	b.b19x4	4.58413	Yes	Yes	4	8	8
424	b.l18x1	b.l18x2	10.0884	Yes	Yes	13	6	7
425	b.l18x1	b.l18x3	9.93436	Yes	No	0	6	5
426	b.b22x5	b.l18x1	8.76143	Yes	Yes	13	7	6
427	b.l18x1	b.l22x4	3.7519	Yes	No	13	6	9
428	b.l18x1	g.h2x8	5.01778	Yes	No	0	6	7
429	b.b22x5	b.l18x2	3.63317	Yes	Yes	13	7	7
430	b.l18x2	b.l22x4	3.045	Yes	No	13	7	9
431	b.l18x2	g.h2x11	4.78778	Yes	No	0	7	6
432	b.l18x3	b.l18x5	10.4867	No	No	0	5	2
433	b.l18x3	g.h2x11	9.34921	No	No	0	5	6
434	b.l18x5	b.l20x2	10.5421	No	No	0	2	9
435	b.b19x2	b.b20x6	10.209	Yes	Yes	4	6	6
436	b.b19x2	b.l20x1	3.8473	Yes	No	0	6	6
437	b.b19x4	b.b20x6	6.65936	Yes	Yes	4	8	6
438	b.b19x5	b.l21x9	4.12952	No	No	0	5	6
439	b.b19x6	b.l19x2	5.42159	No	Yes	4	9	9
440	b.b20x2	b.l19x2	5.26627	No	Yes	0	6	9
441	b.b20x2	b.b20x4	5.63556	No	Yes	0	6	8
442	b.b20x2	b.l21x1	4.50722	No	No	0	6	2
443	b.b20x3	b.b21x7	4.09524	No	Yes	0	8	5
444	b.b20x3	b.l21x9	4.78198	No	No	0	8	6
445	b.b20x4	b.b20x6	4.66524	Yes	Yes	4	8	6
446	b.b20x4	b.b21x3	9.91262	Yes	No	4	8	6
447	b.b20x4	b.b21x6	9.18968	Yes	No	4	8	1
448	b.b20x5	b.b21x7	5.1623	No	Yes	0	7	5
449	b.b20x6	b.b21x3	5.23754	Yes	No	4	6	6
450	b.b20x7	b.l20x3	4.47206	No	No	0	9	7
451	b.b20x7	b.b21x4	5.14905	No	No	0	9	5
452	b.b20x7	g.h2x4	3.33333	No	No	0	9	7
453	b.l20x2	g.l1x5	7.10817	No	No	0	9	4
454	b.l20x2	g.h2x7	7.2904	No	No	0	9	5
455	b.b21x2	g.h2x1	3.60532	No	No	0	6	8
456	b.b21x3	b.b21x6	4.48016	No	No	4	6	1
457	b.b21x5	b.b21x7	9.1423	Yes	Yes	0	4	5
458	b.b21x5	b.b25x1	4.15278	Yes	No	0	4	2
459	b.b21x7	b.b23x2	4.3827	Yes	No	0	5	6
460	b.b21x7	b.b24x6	6.5146	Yes	Yes	0	5	8
461	b.l21x2	b.l21x4	8.58325	Yes	No	0	4	4
462	b.l21x2	b.l21x5	4.10381	Yes	No	0	4	4
463	b.b25x3	b.l21x2	2.96484	Yes	Yes	0	5	4
464	b.b23x6	b.l21x5	5.55571	Yes	No	0	7	4
465	b.l21x7	b.l23x1	3.11127	No	Yes	0	5	6
466	b.l21x7	b.l23x2	6.54333	No	No	0	5	8
467	b.b23x6	b.l21x9	11.0235	Yes	No	0	7	6
468	b.b22x1	b.l23x1	4.0969	No	Yes	1	8	6
469	b.b22x1	b.l25x6	8.70746	No	Yes	1	8	8
470	b.b22x2	b.b26x3	5.4946	No	No	0	8	6
471	b.b22x4	b.b26x5	4.14413	No	No	0	5	7
472	b.b22x5	b.b23x2	8.4677	Yes	No	0	7	6
473	b.b23x1	b.l22x1	3.38151	No	No	0	5	9
474	b.l22x1	g.ctx3	6.98611	No	Yes	0	9	9
475	b.l22x3	g.ctx3	8.69492	No	Yes	0	9	9
476	b.b24x7	b.l22x5	12.9304	No	Yes	18	9	9
477	b.l22x5	b.l24x2	8.37754	Yes	No	0	9	6
478	b.l22x5	g.ctx6	4.2304	Yes	Yes	0	9	6
479	b.b23x1	b.b24x5	5.47516	No	No	0	5	5
480	b.b23x3	b.b24x5	3.55944	No	No	0	7	5
481	b.b23x3	b.b27x1	4.47	No	No	0	7	6
482	b.b23x4	b.b23x6	4.24587	No	Yes	0	6	7
483	b.b23x5	b.b24x3	3.48444	No	No	0	7	5
484	b.b23x5	b.l25x7	3.00825	No	No	0	7	7
485	b.b23x6	b.b24x4	10.8819	Yes	Yes	9	7	6
486	b.b23x6	b.b24x6	6.6827	Yes	Yes	9	7	8
487	b.l23x1	b.l25x6	11.8548	Yes	Yes	1	6	8
488	b.b24x2	b.l23x2	4.28762	No	No	0	5	8
489	b.b24x2	b.l25x1	3.57405	No	No	0	5	3
490	b.b24x3	b.b25x7	5.27865	No	No	0	5	7
491	b.b24x4	b.b24x6	5.58722	Yes	Yes	9	6	8
492	b.b24x4	b.b25x3	9.36492	Yes	Yes	9	6	5
493	b.b24x4	b.b25x6	3.41389	Yes	No	9	6	3
494	b.b24x6	b.b25x3	5.92063	Yes	Yes	9	8	5
495	b.b24x7	b.l24x3	8.37286	No	Yes	0	9	5
496	b.l24x2	g.h2x12	5.20365	No	No	0	6	7
497	b.b25x2	b.l24x3	3.89667	No	Yes	0	2	5
498	b.b25x3	b.b25x6	3.23778	Yes	No	9	5	3
499	b.b25x7	b.b28x6	16.8933	No	Yes	0	7	9
500	b.l25x3	b.l25x7	4.20587	Yes	No	0	9	7
501	b.b27x3	b.l25x3	7.46595	No	Yes	0	8	9
502	b.b27x5	b.l25x3	12.1204	No	Yes	6	9	9
503	b.l25x3	b.l28x2	5.16	Yes	Yes	6	9	9
504	b.b28x4	b.l25x3	7.58968	Yes	Yes	6	6	9
505	b.l25x4	b.l28x2	5.22627	No	Yes	6	5	9
506	b.l25x5	b.l28x1	6.55579	No	Yes	0	7	9
507	b.l25x6	b.l28x1	18.508	Yes	Yes	1	8	9
508	b.b26x1	b.l28x1	4.92103	No	Yes	0	9	9
509	b.b26x3	b.b27x3	3.69794	No	No	0	6	8
510	b.b26x5	b.b27x1	4.77317	No	No	0	7	6
511	b.l27x1	b.l27x3	5.43849	No	No	3	7	7
512	b.l27x3	b.l27x5	7.61357	No	No	0	7	5
513	b.l27x5	g.ctx4	6.03	No	No	0	5	7
514	b.l27x5	g.ctx15	3.07468	No	Yes	0	5	9
515	b.l27x6	g.ctx16	3.77532	No	Yes	0	7	8
516	b.b27x3	b.b28x6	8.41333	No	Yes	0	8	9
517	b.b27x5	b.l28x2	7.12754	No	Yes	6	9	9
518	b.b28x2	b.l28x2	8.42682	No	Yes	0	4	9
519	b.b28x4	b.b28x6	6.15905	Yes	Yes	6	6	9
520	b.b28x5	g.ctx16	3.78667	No	Yes	3	5	8
521	b.b28x7	g.ctx14	7.04841	No	Yes	0	9	9
522	g.h1x1	g.h1x5	4.36437	No	Yes	0	2	6
523	g.h2x3	g.l1x5	3.00095	No	No	0	5	4
524	g.h2x3	g.h2x7	5.57603	No	No	0	5	5
525	g.h2x11	g.h2x15	18.192	No	No	0	6	6
526	g.ctx2	g.h2x15	3.75095	No	No	0	3	6
527	g.ctx1	g.ctx2	4.33929	No	No	0	1	3
528	g.ctx3	g.ctx4	4.30611	Yes	No	0	9	7
529	g.ctx3	g.ctx5	3.04937	Yes	No	0	9	9
530	g.ctx3	g.ctx6	7.5069	Yes	Yes	0	9	6
531	g.ctx10	g.ctx9	3.50444	No	No	0	5	6
532	g.ctx14	g.ctx15	4.41135	Yes	Yes	0	9	9
533	g.ctx14	g.ctx17	3.8754	Yes	No	0	9	7
534	g.ctx15	g.ctx16	3.5527	Yes	Yes	3	9	8
535	1x36	2x65	5.23436	Yes	No	0	6	4
536	1x38	7x39	7.36119	No	No	0	5	6
537	1x43	1x47	3.91246	No	No	0	6	5
538	1x43	2x57	5.90135	No	No	0	6	9
539	1x47	2x51	3.11603	No	Yes	0	5	7
540	1x50	2x50	5.84532	Yes	Yes	0	9	9
541	1x50	2x51	6.25968	Yes	Yes	0	9	7
542	1x50	7x50	5.70444	Yes	No	0	9	9
543	1x57	2x44	3.71825	No	No	0	6	6
544	2x38	4x42	3.76151	No	No	0	7	8
545	2x41	4x43	3.81159	No	No	0	7	4
546	2x42	3x46	4.26024	No	No	0	7	8
547	2x45	3x42	3.54937	No	No	0	9	6
548	2x45	4x46	5.08937	No	No	0	9	7
549	2x49	4x50	3.40659	No	Yes	14	8	9
550	2x50	7x46	5.93635	Yes	No	0	9	7
551	2x53	3x35	7.97818	No	No	0	7	8
552	2x59	3x28	4.78833	No	No	0	6	5
553	2x63	E1x50	3.94754	No	Yes	0	7	9
554	E1x50	E1x52	3.08532	Yes	Yes	0	9	7
555	3x25	E1x50	3.20286	No	Yes	2	9	9
556	E1x50	E2	5.42373	Yes	Yes	2	9	3
557	E1x50	E2x50	2.94421	Yes	No	2	9	9
558	3x25	E2x50	6.67333	No	No	2	9	9
559	3x26	4x61	3.05841	No	No	0	7	4
560	3x26	E2	3.8581	No	Yes	2	7	3
561	3x33	Lig	4.51722	No	Yes	0	6	0
562	3x34	3x35	5.36341	Yes	No	0	5	8
563	3x34	3x38	3.07333	Yes	No	14	5	6
564	3x34	4x50	3.31968	Yes	Yes	14	5	9
565	3x34	4x53	3.82532	Yes	No	0	5	7
566	3x34	4x54	3.77794	Yes	No	0	5	3
567	3x43	7x49	3.8731	No	Yes	22	8	9
568	3x43	7x53	2.93198	No	Yes	22	8	7
569	3x46	3x50	3.01016	No	Yes	0	8	9
570	3x47	5x54	2.95794	No	No	0	9	8
571	3x51	3x55	4.53246	Yes	No	23	7	8
572	3x51	5x57	2.93262	Yes	No	0	7	7
573	3x53	I2x53	5.36952	No	Yes	7	8	6
574	3x55	3x56	3.21921	No	No	23	8	6
575	I2x52	I2x56	5.66754	No	No	0	4	4
576	I2x53	I2x57	8.88349	Yes	No	0	6	8
577	I2x55	I2x56	5.77032	No	No	0	3	4
578	4x38	4x41	4.23563	No	No	0	5	3
579	4x46	4x50	4.63833	No	Yes	0	7	9
580	4x52	4x56	3.29532	No	No	0	5	5
581	4x60	5x39	5.15905	Yes	No	0	5	4
582	4x61	Lig	3.30056	No	Yes	0	4	0
583	4x64	E2	5.21667	No	Yes	2	4	3
584	E2	E2	71.6352	Yes	Yes	2	3	3
585	E2	E2x51	7.93191	Yes	No	2	3	5
586	E2	E2x52	4.51341	Yes	Yes	2	3	6
587	5x35	E2	3.41905	No	Yes	0	1	3
588	5x36	E2	8.69111	No	Yes	2	4	3
589	5x40	7x34	3.61278	No	Yes	0	6	7
590	5x40	Lig	3.96444	No	Yes	0	6	0
591	5x41	6x59	6.19103	No	No	0	4	5
592	5x47	6x52	7.88532	No	No	0	9	9
593	6x40	7x53	5.89516	No	Yes	0	5	7
594	6x47	7x45	5.30524	No	No	0	8	9
595	6x48	7x45	6.80643	No	No	0	8	9
596	6x49	6x50	3.09778	No	No	0	4	9
597	6x50	7x40	5.10333	No	No	0	9	5
598	6x51	6x55	3.37246	No	No	0	8	7
599	6x54	6x58	3.75349	Yes	No	0	5	6
600	6x54	7x33	4.50929	Yes	No	0	5	5
601	6x54	7x34	3.52357	Yes	Yes	0	5	7
602	E3	E3	18.426	Yes	Yes	2	3	3
603	7x33	E3	8.52817	No	Yes	2	5	3
604	7x45	7x49	5.57175	No	Yes	0	9	9
605	7x52	7x53	3.17294	No	Yes	0	7	7
606	G.S2.07	G.s2s3.02	3.59429	No	No	0	3	4
607	G.H2.07	G.s3h2.03	6.56349	Yes	Yes	1	9	0
608	G.H2.03	G.H2.05	8.75921	No	No	1	9	8
609	G.h3s5.02	G.h4s6.12	4.03611	No	Yes	0	4	2
610	G.hgh4.17	G.hgh4.18	3.01778	No	No	0	0	0
611	G.H4.13	G.H4.17	4.75079	No	No	0	3	4
612	G.H5.21	G.h4s6.12	5.19619	No	Yes	0	4	2
613	G.s6h5.02	G.s6h5.05	3.37214	No	Yes	0	8	9
614	G.H5.22	G.H5.23	4.99103	No	Yes	0	4	4
615	b.b21x2	b.lh12x1	3.41857	No	No	0	6	3
616	b.b12x3	b.b13x7	3.4031	No	Yes	0	8	7
617	b.b12x7	b.l12x2	3.53817	Yes	No	20	9	6
618	b.b13x3	b.b13x6	4.31905	No	No	0	4	4
619	b.l14x5	b.l16x2	8.18984	No	No	0	5	9
620	b.b20x4	b.l17x4	3.64579	Yes	No	0	8	3
621	g.ctx14	g.ctx9	3.67143	Yes	No	0	9	6
622	g.ctx10	g.ctx13	3.28127	No	No	0	5	5
623	1x42	7x43	4.16476	No	No	0	7	4
624	1x46	7x47	3.76238	No	No	0	8	6
625	2x40	I1	3.14794	No	Yes	6	7	5
626	2x46	3x42	5.08048	No	No	0	9	6
627	2x46	7x49	4.57802	No	Yes	0	9	9
628	2x49	3x38	3.81278	No	No	14	8	6
629	2x56	3x31	3.26349	No	No	0	7	5
630	2x60	3x28	5.7254	No	No	0	7	5
631	3x41	4x49	4.09564	No	No	0	5	6
632	3x46	7x53	4.44897	No	Yes	0	8	7
633	3x50	6x37	2.94429	Yes	No	0	9	7
634	E2	Lig	7.76579	Yes	Yes	2	3	0
635	5x61	5x65	3.78627	No	No	0	7	8
636	6x60	6x61	3.76794	No	No	0	4	2
637	7x49	7x53	3.65976	Yes	Yes	22	9	7
638	G.HN.46	G.HN.50	4.39333	No	No	0	4	5
639	G.S1.03	G.hns1.01	9.35817	No	No	0	9	3
640	G.S4.07	G.s1h1.04	3.41968	No	No	0	8	9
641	G.S2.02	G.s3h2.01	2.97571	No	No	0	5	9
642	G.S3.08	G.s3h2.03	3.9	No	Yes	1	9	0
643	G.s3h2.03	b.l7x4	3.18476	Yes	No	0	0	9
644	G.s3h2.03	b.l9x6	3.94429	Yes	Yes	1	0	8
645	G.H2.01	G.H2.03	5.25214	No	No	1	0	9
646	G.H2.01	b.b12x1	3.61214	No	No	0	0	6
647	G.H2.01	b.l13x6	7.35429	No	Yes	1	0	9
648	G.H2.05	b.l15x1	3.18476	No	Yes	1	8	7
649	G.H2.05	b.l17x6	9.28222	No	Yes	1	8	9
650	G.hgh4.01	G.s4h3.15	6.84913	Yes	No	0	6	0
651	3x53	G.H5.23	3.03905	No	Yes	0	8	4
652	b.1x4	g.h1x4	3.00246	Yes	No	0	8	5
653	b.b17x3	g.h1x10	3.86254	No	No	0	5	9
654	b.b17x6	g.h1x14	5.37778	No	No	0	7	9
655	b.b21x1	g.l1x4	7.34595	Yes	Yes	0	7	8
656	g.h1x10	g.h1x14	5.2281	No	No	0	9	9
657	g.l1x2	g.l1x4	3.85722	No	Yes	0	2	8
658	NT	NT	3.93167	Yes	Yes	2	7	7
659	I1	I1	6.785	Yes	Yes	6	5	5
660	2x46	2x50	4.4169	No	Yes	0	9	9
661	2x50	3x39	4.33651	Yes	No	0	9	9
662	3x32	Lig	5.17937	No	Yes	0	6	0
663	3x38	4x50	3.73857	No	Yes	14	6	9
664	3x40	6x48	7.93214	No	No	0	8	8
665	3x47	5x58	3.35103	No	Yes	0	9	8
666	4x60	E2	5.43778	Yes	Yes	2	5	3
667	7x51	7x55	8.96182	No	No	0	6	7
668	b.1x1	b.1x5	4.28079	No	No	0	0	3
669	3x51	3x56	4.35056	Yes	No	23	7	6
670	G.H5.02	G.H5.06	3.46135	No	Yes	0	4	4
671	b.l22x2	g.ctx2	3.62143	No	No	0	1	3
672	I1	b.l25x4	6.09413	Yes	No	6	5	5
673	1x57	2x43	3.04444	No	No	0	6	7
674	2x38	3x49	3.75278	No	No	0	7	8
675	2x39	2x43	3.18389	No	No	0	7	7
676	3x49	I2x53	6.3223	No	Yes	0	8	6
677	E2	E3	11.1795	Yes	Yes	2	3	3
678	7x34	E3	3.01071	Yes	Yes	2	7	3
679	G.H4.14	G.H4.17	3.22913	No	No	0	5	4
680	3x27	3x31	3.18087	No	No	0	5	5
681	G.HN.36	b.b4x7	3.88548	No	No	0	4	8
682	6x30	G.H5.17	3.22548	No	Yes	0	5	5
683	6x33	G.H5.20	3.95214	No	No	0	7	8
684	6x32	G.H5.24	4.28151	Yes	Yes	0	4	6
685	1x36	2x64	3.13183	Yes	No	0	6	6
686	1x39	Lig	4.86571	No	Yes	0	9	0
687	2x54	Lig	6.58778	No	Yes	0	6	0
688	2x57	Lig	5.33516	No	Yes	0	9	0
689	2x60	Lig	3.62278	No	Yes	0	7	0
690	2x64	E2	3.21032	No	Yes	2	6	3
691	3x29	E2	5.64683	No	Yes	2	6	3
692	3x33	E2x52	3.47714	No	Yes	0	6	6
693	7x34	E2	4.65754	Yes	Yes	2	7	3
694	7x35	E2	3.3981	Yes	Yes	2	3	3
695	7x38	E2	4.89436	No	Yes	2	5	3
696	E2x51	E2x52	5.03508	No	Yes	2	5	6
697	6x58	E2	3.46762	No	Yes	2	6	3
698	6x36	8x47	5.59802	No	No	0	5	0
699	7x35	7x39	6.83508	Yes	No	2	3	6
700	7x35	Lig	3.39659	Yes	Yes	2	3	0
701	7x39	Lig	4.32524	No	Yes	2	6	0
702	7x42	Lig	8.28452	No	Yes	0	6	0
703	7x46	Lig	4.0896	No	Yes	0	7	0
704	6x29	G.H5.24	3.17929	No	Yes	0	3	6
705	1x65	b.b28x2	3.28357	No	No	0	0	4
706	2x67	E1	2.99071	No	No	0	4	6
707	3x37	5x41	3.07	Yes	No	0	8	4
708	4x60	5x37	3.57571	Yes	No	0	5	3
709	5x34	E2	5.38929	No	Yes	0	1	3
710	5x56	6x41	2.97786	No	No	0	4	8
711	5x67	6x30	6.45714	No	No	0	4	5
712	6x32	8x48	3.505	Yes	No	0	4	0
713	8x52	8x55	4.18857	No	Yes	24	0	0
714	2x56	3x32	2.91627	No	No	0	7	6
715	b.h2x5	g.h2x9	2.91627	No	No	0	5	4
716	3x22	E2	2.915	No	Yes	2	3	3
717	G.hns1.01	b.l1x4	2.91151	No	No	0	3	6
718	G.H1.01	G.s1h1.05	2.90214	Yes	No	0	9	9
719	b.b2x4	b.b6x5	2.88071	No	Yes	0	6	6
720	6x54	7x37	2.87619	Yes	No	0	5	6
721	1x35	2x64	2.87357	No	No	0	3	6
722	1x43	2x58	2.87079	No	No	0	6	9
723	2x63	E1	2.86333	No	No	0	7	6
724	5x41	5x45	2.85889	No	No	0	4	4
725	1x57	7x54	2.85643	No	No	0	6	4
726	6x61	E3	2.85635	No	Yes	2	2	3
727	G.H1.05	G.S2.06	2.85095	No	Yes	0	7	9
728	b.b7x5	b.l9x7	2.85	No	No	0	9	7
729	b.b15x4	b.l17x7	2.84143	No	No	0	6	7
730	G.HN.29	G.HN.33	2.84087	No	No	0	2	4
731	7x43	7x47	2.83349	No	No	0	4	6
732	1x66	b.l25x5	2.82857	No	No	0	0	7
733	6x51	7x41	2.82778	No	No	0	8	8
734	b.l16x1	b.l16x2	2.82373	No	No	0	4	9
735	G.HN.52	G.hns1.02	2.82238	No	No	0	4	4
736	3x36	Lig	2.81579	No	Yes	0	7	0
737	G.H4.11	G.s4h3.01	2.81508	No	No	0	8	6
738	G.HG.07	G.s4h3.02	2.805	Yes	No	0	9	9
739	G.S1.01	G.S3.02	2.79508	No	No	0	7	4
740	b.b23x6	b.l23x2	2.78373	Yes	No	0	7	8
741	b.h2x4	g.h2x5	2.78262	No	No	0	3	6
742	G.H1.01	G.s1h1.01	2.78079	Yes	No	0	9	9
743	G.HN.34	G.HN.37	2.78	No	Yes	0	3	3
744	b.b24x1	b.l25x5	2.77151	No	No	0	4	7
745	b.b19x3	b.b22x5	2.77	No	Yes	0	4	7
746	G.H5.01	G.H5.02	2.76516	No	No	0	9	4
747	G.H3.02	G.H4.11	2.76413	No	No	0	8	8
748	G.hgh4.17	G.hgh4.20	2.75905	No	Yes	0	0	3
749	b.b26x4	b.b2x3	2.7581	No	Yes	0	5	6
750	G.H4.10	G.hgh4.04	2.75714	Yes	No	0	7	6
751	G.H5.05	G.H5.09	2.75675	No	No	0	5	4
752	g.ctx12	g.ctx13	2.74865	No	No	0	6	5
753	G.HN.43	b.b5x6	2.74476	No	No	0	9	6
754	b.l1x5	b.l3x2	2.74286	No	Yes	0	7	9
755	5x33	5x36	2.72921	No	No	0	1	4
756	b.b8x3	b.b9x4	2.72786	No	No	0	6	9
757	b.b21x5	b.h2x2	2.72564	Yes	No	0	4	1
758	3x37	5x43	2.71056	Yes	No	0	8	6
759	G.H4.02	G.HG.08	2.71008	No	No	0	5	7
760	3x56	I2x52	2.70405	No	No	0	6	4
761	1x42	Lig	2.70032	No	Yes	0	7	0
762	b.b16x3	b.b19x2	2.69333	No	Yes	0	6	6
763	1x49	7x51	2.67992	No	No	0	7	6
764	b.b9x2	b.l12x1	2.66802	No	No	0	5	6
765	G.HN.51	G.hns1.02	2.64317	No	No	0	5	4
766	b.1x3	b.ntx3	2.64	No	No	0	1	0
767	7x32	7x33	2.63794	No	No	0	1	5
768	3x50	G.H5.25	2.63222	Yes	No	0	9	8
769	2x41	4x42	2.63175	No	No	0	7	8
770	3x37	4x53	2.60984	Yes	No	0	8	7
771	G.S2.04	G.S3.05	2.60706	No	No	0	7	8
772	3x51	5x60	2.60548	Yes	No	0	7	4
773	b.l5x4	b.l5x5	2.58817	No	Yes	0	8	9
774	4x39	I1	2.58714	No	Yes	0	4	5
775	G.H3.05	G.S4.06	2.58524	No	No	0	9	7
776	G.H3.15	G.H3.17	2.58286	No	Yes	0	8	5
777	1x54	2x47	2.5827	No	No	0	7	8
778	3x33	4x57	2.57381	No	No	0	6	6
779	3x30	4x57	2.57032	No	No	0	6	6
780	g.ctx7	g.ctx8	2.56944	No	No	0	4	8
781	G.H5.04	G.S2.08	2.56857	No	No	0	8	6
782	b.1x19	b.b21x2	2.55889	No	No	0	6	6
783	b.b19x1	b.l18x1	2.55206	No	Yes	0	6	6
784	b.1x12	b.1x9	2.55	No	Yes	0	6	4
785	g.h1x12	g.h1x9	2.55	No	No	0	6	6
786	b.b18x4	b.b22x5	2.52754	No	Yes	0	3	7
787	6x33	G.H5.24	2.5273	No	Yes	0	7	6
788	b.b22x3	b.b23x2	2.51881	No	No	0	6	6
789	b.b10x5	b.b6x4	2.5181	Yes	No	0	9	7
790	1x56	8x50	2.51016	No	No	0	7	0
791	g.h1x10	g.h1x13	2.49333	No	No	0	9	1
792	6x51	7x38	2.4896	No	No	0	8	5
793	7x51	7x56	2.48135	No	No	0	6	5
794	G.H3.01	G.s1h1.03	2.47968	Yes	No	0	9	8
795	G.H4.03	G.HG.08	2.47056	No	No	0	4	7
796	5x44	6x52	2.46222	No	No	0	5	9
797	g.h1x5	g.h1x9	2.44595	Yes	No	0	6	6
798	5x46	6x52	2.43714	No	No	0	5	9
799	5x52	6x44	2.435	No	No	0	2	6
800	b.l27x4	g.ctx4	2.43278	No	No	0	9	7
801	b.h2x1	g.h2x5	2.42929	No	No	0	5	6
802	5x32	5x33	2.42913	No	No	0	6	1
803	b.l8x5	b.l8x7	2.42897	No	No	0	3	3
804	6x33	G.H5.23	2.42611	No	Yes	0	7	4
805	G.h4s6.12	G.h4s6.13	2.40976	Yes	No	0	2	7
806	b.b12x2	b.l13x1	2.40484	No	No	0	7	2
807	5x75	G.S6.02	2.40056	No	Yes	0	0	8
808	4x59	4x60	2.3969	No	Yes	0	7	5
809	b.b7x1	b.b9x1	2.38254	Yes	No	0	4	4
810	b.b15x1	b.l16x1	2.38087	Yes	No	0	9	4
811	8x49	G.H5.24	2.36857	No	Yes	0	0	6
812	G.S1.02	I2x55	2.35135	No	No	0	6	3
813	b.b4x1	b.l5x1	2.34786	No	Yes	0	8	8
814	1x53	2x47	2.34548	No	No	0	9	8
815	G.HN.37	b.b5x2	2.33675	Yes	Yes	0	3	7
816	5x38	E2x52	2.33	No	Yes	0	4	6
817	b.b5x3	b.l1x2	2.31183	Yes	No	0	9	9
818	6x31	6x35	2.30714	No	No	0	6	5
819	b.lhb1x1	b.lhb1x2	2.30254	No	No	0	1	1
820	b.1x11	b.1x7	2.29373	Yes	No	0	8	8
821	b.b13x1	b.l12x3	2.28222	No	No	0	4	5
822	b.1x2	b.1x5	2.26833	No	No	0	1	3
823	b.1x18	g.l1x4	2.26254	No	Yes	0	4	8
824	G.S2.02	G.S3.07	2.24619	No	No	0	5	9
825	3x54	G.H5.20	2.23563	No	No	0	8	8
826	3x41	5x50	2.23484	No	No	0	5	9
827	b.b10x5	b.l6x2	2.23405	Yes	No	0	9	6
828	G.HN.33	G.HN.37	2.22802	No	Yes	0	4	3
829	3x37	5x461	2.22556	Yes	No	0	8	6
830	b.1x4	g.h1x5	2.20786	Yes	Yes	0	8	6
831	b.b1x1	b.lhb1x10	2.20659	No	No	0	5	4
832	b.1x15	g.h1x15	2.20508	No	No	0	7	8
833	8x53	8x57	2.2046	No	No	0	0	0
834	3x42	4x49	2.20111	No	No	0	6	6
835	5x58	6x41	2.20095	Yes	No	0	8	8
836	G.h3s5.01	G.h4s6.12	2.2004	No	Yes	0	3	2
837	g.h1x11	g.h1x7	2.18643	No	No	0	9	2
838	5x69	6x31	2.18611	Yes	No	0	0	6
839	g.h1x3	g.h1x7	2.18024	No	No	0	3	2
840	G.HG.10	G.HG.12	2.17992	No	No	0	5	3
841	2x52	3x35	2.1773	No	No	0	7	8
842	3x50	5x58	2.17683	Yes	Yes	0	9	8
843	G.HN.46	G.HN.49	2.16706	No	No	0	4	4
844	1x45	7x47	2.16619	No	No	0	6	6
845	G.HN.31	G.HN.32	2.16	No	No	0	1	5
846	5x51	6x45	2.14579	No	No	0	6	9
847	b.b12x7	b.b13x4	2.1381	Yes	No	0	9	4
848	b.b18x5	b.l14x2	2.13183	Yes	No	0	5	4
849	b.1x7	g.h1x8	2.12873	No	No	0	8	7
850	b.b16x2	b.l17x1	2.12064	No	No	0	5	2
851	b.l13x1	b.l13x2	2.10889	No	No	0	2	6
852	b.b27x4	b.b28x3	2.09	No	Yes	0	5	7
853	g.h1x12	g.l1x1	2.08722	No	No	0	6	1
854	b.lhb1x3	g.h2x13	2.08254	Yes	No	0	2	1
855	2x51	2x55	2.0823	Yes	No	0	7	4
856	5x58	5x62	2.07778	Yes	No	0	8	5
857	b.b20x6	b.l17x2	2.06675	Yes	No	0	6	6
858	b.1x11	g.h1x12	2.05905	Yes	No	0	8	6
859	1x50	2x47	2.05563	Yes	No	0	9	8
860	4x56	5x39	2.05492	No	No	0	5	4
861	b.b12x1	b.l13x5	2.05111	No	No	0	6	5
862	5x49	5x50	2.04587	No	No	0	4	9
863	3x30	4x58	2.04222	No	No	0	6	4
864	b.l21x8	b.l23x1	2.03548	No	Yes	0	4	6
865	1x27	NT	2.03111	No	Yes	0	0	7
866	3x51	5x55	2.02786	Yes	No	0	7	4
867	7x43	7x48	2.01183	No	No	0	4	6
868	1x61	2x41	2.01	No	No	0	5	7
869	3x54	5x59	2.00786	No	No	0	8	3
870	b.b28x1	b.l1x3	2.00071	No	Yes	0	4	9
871	1x36	1x40	2.0004	Yes	No	0	6	6
872	1x39	2x61	1.99571	No	No	0	9	7
873	G.hgh4.01	G.s4h3.05	1.98444	Yes	No	0	6	9
874	5x47	5x51	1.98286	No	No	0	9	6
875	3x52	I2x52	1.97556	No	No	0	7	4
876	5x47	5x48	1.97333	No	No	0	9	4
877	6x57	6x61	1.97333	No	No	0	5	2
878	b.h2x3	b.lh12x3	1.95151	No	No	0	1	4
879	3x24	E1x52	1.94746	No	Yes	0	5	7
880	5x67	6x27	1.945	No	No	0	4	0
881	5x64	5x68	1.93571	No	No	0	5	0
882	g.h2x14	g.h2x15	1.91627	No	No	0	4	6
883	b.1x22	g.l1x4	1.9123	No	Yes	0	3	8
884	G.hgh4.11	G.hgh4.13	1.90389	Yes	No	0	5	4
885	5x65	6x34	1.89841	No	Yes	0	8	8
886	6x36	6x40	1.88873	No	No	0	5	5
887	5x49	6x44	1.88143	No	No	0	4	6
888	b.1x10	b.1x11	1.87944	No	Yes	0	1	8
889	5x42	6x56	1.87714	No	No	0	5	5
890	5x69	6x30	1.84667	Yes	No	0	0	5
891	4x40	G.HN.52	1.84	No	No	0	4	4
892	5x58	6x42	1.83889	Yes	No	0	8	8
893	b.b28x6	b.l25x2	1.83	Yes	No	0	9	5
894	G.HN.45	G.HN.49	1.81833	No	No	0	4	4
895	1x51	2x51	1.80381	No	Yes	0	3	7
896	3x54	5x61	1.80373	No	No	0	8	7
897	b.lhb1x4	b.lhb1x5	1.78889	No	No	0	1	1
898	b.lhb1x3	b.lhb1x4	1.78889	Yes	No	0	2	1
899	5x54	6x45	1.775	No	No	0	8	9
900	g.h1x1	g.ntx2	1.77333	No	No	0	2	0
901	7x31	NT	1.765	No	Yes	0	5	7
902	G.s6h5.02	G.s6h5.04	1.76357	No	No	0	8	9
903	5x31	5x33	1.76357	No	No	0	0	1
904	b.ntx1	b.ntx2	1.74651	No	No	0	0	0
905	1x36	1x37	1.73698	Yes	No	0	6	5
906	1x52	7x55	1.73452	No	No	0	5	7
907	3x44	5x51	1.73	No	No	0	7	6
908	G.hgh4.15	G.hgh4.16	1.72222	No	No	0	2	1
909	4x56	5x42	1.71944	No	No	0	5	5
910	1x62	b.l25x4	1.71722	No	No	0	5	5
911	b.1x10	b.1x14	1.70667	No	No	0	1	4
912	6x42	6x46	1.7031	No	No	0	8	5
913	4x38	G.hns1.02	1.67611	No	No	0	5	4
914	G.H5.17	I3	1.67548	Yes	No	0	5	3
915	3x45	4x45	1.66683	No	No	0	6	5
916	G.h4s6.09	G.h4s6.13	1.66571	No	No	0	4	7
917	G.H5.21	G.H5.26	1.66111	No	No	0	4	8
918	b.l2x2	b.l6x2	1.65278	No	No	0	1	6
919	7x54	7x55	1.6519	No	No	0	4	7
920	5x64	6x34	1.64929	No	Yes	0	5	8
921	4x45	4x49	1.62611	No	No	0	5	6
922	1x31	1x34	1.61611	No	No	0	6	7
923	5x49	5x53	1.60825	No	No	0	4	6
924	b.b25x4	b.lhb1x6	1.60556	No	Yes	0	4	3
925	4x40	4x44	1.58889	No	No	0	4	1
926	7x35	7x36	1.58278	Yes	No	0	3	3
927	b.1x4	b.1x8	1.57857	Yes	No	0	8	5
928	2x48	2x52	1.56905	No	No	0	4	7
929	G.S5.07	G.s6h5.03	1.56563	Yes	No	0	9	9
930	G.H1.07	G.S2.06	1.56167	No	Yes	0	9	9
931	b.l8x3	b.l8x6	1.56	Yes	No	0	3	4
932	E2	NT	1.55444	Yes	Yes	2	3	7
933	1x60	2x40	1.54905	No	No	0	4	7
934	b.l27x2	b.l2x2	1.54849	No	No	0	1	1
935	G.H1.08	G.S2.06	1.54008	No	Yes	0	9	9
936	b.1x17	b.1x20	1.53667	No	No	0	2	2
937	G.HN.37	G.HN.41	1.53103	Yes	No	0	3	4
938	b.1x6	b.1x9	1.5269	No	Yes	0	3	4
939	b.b25x5	b.lhb1x8	1.52381	No	No	0	4	2
940	2x66	E1x51	1.51333	No	No	0	3	4
941	b.ntx1	g.ntx1	1.50857	No	No	0	0	0
942	b.1x3	b.1x7	1.50683	No	No	0	1	8
943	b.lh12x2	g.h2x1	1.50635	No	No	0	8	8
944	b.b21x7	b.l24x1	1.50016	Yes	No	0	5	5
945	8x53	8x56	1.49643	No	No	0	0	0
946	6x47	7x40	1.49238	No	No	0	8	5
947	3x29	4x65	1.48833	No	No	0	6	3
948	G.hgh4.04	G.hgh4.07	1.48667	No	No	0	6	2
949	b.l9x1	b.l9x2	1.48571	No	No	0	5	5
950	6x32	8x51	1.45357	Yes	No	0	4	0
951	6x32	8x52	1.44643	Yes	No	24	4	0
952	6x32	8x55	1.44643	Yes	Yes	24	4	0
953	1x56	7x54	1.44056	No	No	0	7	4
954	5x63	6x34	1.42929	No	Yes	0	4	8
955	1x54	1x58	1.4281	No	No	0	7	1
956	3x21	E1x52	1.41849	No	Yes	0	8	7
957	b.1x1	g.ntx4	1.41667	No	No	0	0	0
958	b.b20x1	b.l21x5	1.41651	No	No	0	5	4
959	G.S2.02	G.hfs2.06	1.40381	No	No	0	5	7
960	6x24	G.h4s6.20	1.39643	No	No	0	0	4
961	G.S5.07	G.s1h1.06	1.38968	Yes	No	0	9	9
962	5x69	5x73	1.38611	Yes	No	0	0	0
963	5x72	5x76	1.36944	No	No	0	0	0
964	1x28	E1	1.35667	No	No	0	0	6
965	4x46	4x47	1.34786	No	No	0	7	4
966	b.l8x4	b.l8x5	1.33802	No	No	0	3	3
967	1x41	1x45	1.3277	No	No	0	4	6
968	2x551	3x31	1.32476	No	No	0	0	5
969	G.HG.03	G.HG.06	1.31675	Yes	No	0	6	6
970	G.s1h1.02	G.s1h1.05	1.30286	No	No	0	8	9
971	G.H1.03	G.s1h1.06	1.3	No	No	0	9	9
972	6x28	6x31	1.29548	No	No	0	0	6
973	g.l1x1	g.l1x4	1.27222	No	Yes	0	1	8
974	g.ctx11	g.ctx17	1.25079	No	No	0	4	7
975	b.lhb1x6	b.lhb1x7	1.24127	Yes	No	0	3	1
976	g.ctx6	g.ctx7	1.23833	Yes	No	0	6	4
977	6x43	7x48	1.23444	No	No	0	5	6
978	G.HN.39	G.HN.43	1.22294	No	No	0	5	9
979	E1x50	E1x51	1.22198	Yes	No	0	9	4
980	1x59	I1	1.20889	No	Yes	6	3	5
981	3x22	3x23	1.20413	No	No	0	3	1
982	6x34	6x38	1.19413	Yes	No	0	8	7
983	1x30	1x31	1.18722	No	No	0	0	6
984	b.1x16	b.1x17	1.18111	No	No	0	4	2
985	G.H4.06	G.hgh4.05	1.17754	No	Yes	0	8	6
986	5x67	5x71	1.14643	No	No	0	4	0
987	G.HN.38	G.HN.41	1.13571	No	No	0	3	4
988	5x70	I3	1.135	No	No	0	0	3
989	8x55	8x58	1.12786	Yes	No	0	0	0
990	5x58	6x39	1.12611	Yes	No	0	8	4
991	1x48	1x49	1.12595	No	No	0	5	7
992	b.l21x2	b.l21x3	1.12	Yes	No	0	4	3
993	5x66	5x69	1.11183	No	Yes	0	2	0
994	G.hns1.03	I2x56	1.09722	No	No	0	5	4
995	b.1x12	g.h1x11	1.09667	No	No	0	6	9
996	4x63	4x64	1.09389	No	No	0	3	4
997	g.ctx6	g.h2x16	1.09095	Yes	No	0	6	4
998	b.b16x1	b.l17x3	1.08921	No	Yes	0	4	9
999	6x20	6x23	1.08444	No	No	0	0	0
1000	E1x49	E1x52	1.08	No	Yes	0	4	7
1001	6x53	6x54	1.05992	No	Yes	0	5	5
1002	3x48	5x55	1.04143	No	No	0	6	4
1003	G.hfs2.07	G.s3h2.02	1.03032	No	No	0	8	9
1004	G.h4s6.02	G.h4s6.03	1.02857	No	No	0	7	4
1005	1x56	8x54	1.01857	No	No	0	7	0
1006	5x72	I3	1.01222	No	No	0	0	3
1007	G.H5.18	G.H5.21	0.993968	No	No	0	3	4
1008	b.1x3	b.ntx2	0.984048	No	No	0	1	0
1009	G.HG.07	G.HG.12	0.981191	Yes	No	0	9	3
1010	G.h4s6.10	G.h4s6.11	0.972064	No	No	0	3	2
1011	G.H1.02	G.H1.03	0.965079	No	No	0	9	9
1012	G.HN.30	G.HN.32	0.958571	No	No	0	7	5
1013	7x30	7x32	0.947619	No	No	0	0	1
1014	1x34	1x35	0.946508	No	No	0	7	3
1015	g.h1x3	g.h1x6	0.940476	No	No	0	3	4
1016	G.HG.10	G.HG.11	0.928571	No	No	0	5	5
1017	G.HN.45	G.HN.48	0.920397	No	No	0	4	3
1018	G.H3.08	G.H3.11	0.912857	Yes	No	0	8	8
1019	b.b1x3	g.ctx18	0.904444	Yes	No	0	7	6
1020	3x30	4x62	0.895556	No	No	0	6	3
1021	1x44	1x48	0.895238	No	No	0	5	5
1022	g.h1x2	g.h1x5	0.87746	No	Yes	0	2	6
1023	8x56	8x60	0.872143	No	No	0	0	0
1024	6x23	G.H4.16	0.845556	No	No	0	0	4
1025	5x71	5x74	0.843889	No	No	0	0	0
1026	G.H1.03	G.H1.06	0.833333	No	No	0	9	9
1027	G.S2.03	G.hfs2.05	0.795079	Yes	No	0	9	9
1028	1x64	2x40	0.782143	No	No	0	4	7
1029	G.H1.07	G.H1.09	0.778889	No	No	0	9	0
1030	4x55	4x59	0.777302	No	No	0	4	7
1031	1x63	1x64	0.763571	No	No	0	4	4
1032	G.HN.49	G.HN.53	0.75	No	No	0	4	1
1033	1x55	1x59	0.731667	No	No	0	2	3
1034	1x32	2x65	0.720556	No	No	0	7	4
1035	b.l24x3	b.lhb1x1	0.711111	Yes	No	0	5	1
1036	G.HN.26	G.HN.29	0.708333	No	No	0	0	2
1037	8x52	8x56	0.695873	No	No	0	0	0
1038	G.hgh4.12	G.hgh4.13	0.69127	No	No	0	1	4
1039	G.hgh4.18	G.hgh4.19	0.628333	No	No	0	0	0
1040	G.HN.26	G.HN.27	0.627222	No	No	0	0	0
1041	G.HN.38	G.HN.42	0.589841	No	No	0	3	4
1042	b.1x4	g.ntx8	0.583889	Yes	No	0	8	4
1043	8x55	8x59	0.571429	Yes	No	0	0	0
1044	G.H2.02	G.H2.04	0.529444	No	No	0	8	9
1045	b.1x22	g.l1x3	0.518889	No	No	0	3	1
1046	b.1x21	g.l1x4	0.497143	No	Yes	0	3	8
1047	1x29	1x32	0.490556	No	No	0	0	7
1048	G.hgh4.09	G.hgh4.10	0.461032	No	No	0	5	1
1049	6x20	6x22	0.452778	No	No	0	0	0
1050	b.l21x6	b.l21x7	0.44254	No	No	0	3	5
1051	6x26	G.h4s6.03	0.431111	No	No	0	0	4
1052	6x20	6x21	0.399444	No	No	0	0	0
1053	4x47	4x48	0.398571	No	No	0	4	3
1054	2x62	E1x51	0.398333	No	No	0	4	4
1055	g.h2x6	g.h2x7	0.391111	No	No	0	2	5
1056	G.H1.12	b.l5x3	0.387222	No	No	0	8	8
1057	g.ctx18	g.ctx19	0.385714	No	No	0	6	0
1058	G.HN.28	G.HN.31	0.374444	No	No	0	0	1
1059	2x68	E1x49	0.371429	No	No	0	0	4
1060	4x48	4x51	0.366429	No	No	0	3	4
1061	G.H1.10	G.H5.04	0.347143	No	No	0	0	8
1062	6x461	6x47	0.345556	No	No	0	5	8
1063	G.H1.11	G.H5.04	0.296667	No	No	0	0	8
1064	g.h1x1	g.ntx6	0.253333	No	No	0	2	3
1065	g.h1x3	g.ntx3	0.253333	No	No	0	3	0
1066	G.hfs2.04	G.hfs2.05	0.25	No	No	0	0	9
1067	1x28	1x33	0.197778	No	No	0	0	4
1068	g.h2x10	g.h2x13	0.167778	No	No	0	3	1
1069	8x61	8x62	0.13	No	No	0	0	0
1070	G.h4s6.04	G.h4s6.08	0.095	No	No	0	4	5
1071	g.ntx5	g.ntx7	0.0866667	No	No	0	4	4
1072	G.hfs2.03	G.hfs2.04	0.0844444	No	No	0	0	0
1073	g.ntx5	g.ntx6	0.0811111	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg. Int. Strength	Num. Of Links	Community	ConSurf
1	G.HN.37	2.21895	4	0	3
2	G.H1.01	4.73101	4	15	9
3	G.S2.03	5.608	4	10	9
4	G.S2.06	4.62246	4	0	9
5	G.S3.03	5.70435	6	7	8
6	G.S3.04	8.23268	4	10	7
7	G.S3.06	9.70708	4	10	7
8	G.H2.06	5.69233	5	1	9
9	G.H2.07	6.56762	5	1	9
10	G.h2s4.01	8.56806	4	0	9
11	G.S4.04	4.00409	4	0	9
12	G.H3.01	5.13893	4	0	9
13	G.H3.08	5.0329	4	0	8
14	G.H3.09	4.50091	6	16	9
15	G.H3.13	9.04349	5	16	6
16	G.H3.17	7.937	6	1	5
17	G.S5.05	4.60989	6	8	9
18	G.S5.07	3.56356	5	0	9
19	G.HG.03	3.36994	4	0	6
20	G.HG.07	4.25657	4	0	9
21	G.hgh4.01	5.07899	4	0	6
22	G.hgh4.05	8.58403	5	0	6
23	G.hgh4.11	3.69865	4	0	5
24	G.hgh4.20	4.17921	4	0	3
25	G.H4.10	8.07078	5	0	7
26	G.H4.12	5.24808	4	0	4
27	G.H4.15	7.07159	4	0	8
28	G.h4s6.12	3.78551	5	0	2
29	G.S6.02	7.82894	5	0	8
30	G.S6.05	7.28641	4	17	5
31	G.s6h5.01	5.12222	4	8	9
32	G.s6h5.05	3.53976	4	8	9
33	G.H5.03	5.35401	4	8	9
34	G.H5.06	5.21147	4	8	4
35	G.H5.08	5.48421	5	7	8
36	G.H5.17	4.20659	4	0	5
37	G.H5.19	4.4875	4	7	8
38	G.H5.23	5.48548	6	0	4
39	G.H5.24	3.08917	4	0	6
40	b.1x4	1.84319	4	0	8
41	b.1x9	2.67873	4	0	4
42	b.1x11	2.62065	4	0	8
43	b.lhb1x3	3.03898	5	0	2
44	b.lhb1x6	3.79006	4	18	3
45	b.b1x3	4.84506	4	0	7
46	b.l1x3	7.94226	6	3	9
47	b.l1x6	8.91575	5	1	9
48	b.b2x1	6.55084	5	1	8
49	b.b2x3	3.94784	4	3	6
50	b.b2x5	6.88156	5	3	7
51	b.l3x1	7.44611	4	1	9
52	b.l3x2	6.04361	4	0	9
53	b.b4x2	5.27706	4	0	8
54	b.b4x6	8.90325	7	3	9
55	b.l4x2	9.57323	4	3	4
56	b.b5x2	6.59933	4	0	7
57	b.b5x3	5.9929	6	3	9
58	b.b5x7	5.68534	4	0	7
59	b.l5x1	4.46452	5	11	8
60	b.l5x5	7.9144	6	0	9
61	b.b6x1	4.3353	4	1	9
62	b.b6x5	3.78832	7	19	6
63	b.l6x5	6.18083	4	12	4
64	b.b7x1	5.69017	5	12	4
65	b.b8x4	5.32273	5	11	6
66	b.l8x3	3.35292	4	0	3
67	b.b9x3	4.0847	4	0	6
68	b.l9x3	7.39094	5	1	9
69	b.l9x6	5.30091	6	1	8
70	b.b10x5	4.58825	5	0	9
71	b.b11x4	5.24716	4	1	9
72	b.l11x2	8.39542	4	1	9
73	b.b12x6	9.76049	5	1	8
74	b.b12x7	5.72996	4	20	9
75	b.b13x7	7.11043	5	5	7
76	b.l13x3	7.61579	6	5	9
77	b.l13x6	5.5191	5	1	9
78	b.l13x7	4.50147	4	5	9
79	b.b14x3	4.44175	4	5	5
80	b.b15x1	6.15256	5	5	9
81	b.l15x1	4.53108	5	1	7
82	b.l15x2	6.23177	4	5	9
83	b.b16x4	10.2009	4	5	6
84	b.b16x5	4.28754	4	0	5
85	b.b16x6	8.39634	6	5	8
86	b.b17x7	7.98756	4	4	8
87	b.l17x3	7.86231	7	4	9
88	b.l17x6	7.25436	4	1	9
89	b.b18x3	4.83827	4	4	8
90	b.b18x5	4.78627	4	0	5
91	b.l18x1	6.68432	6	13	6
92	b.l18x2	5.38859	4	13	7
93	b.b19x2	6.40054	6	4	6
94	b.b19x4	6.18258	4	4	8
95	b.l19x2	5.17505	5	4	9
96	b.b20x4	8.29169	6	4	8
97	b.b20x6	6.03947	7	4	6
98	b.b21x1	8.23312	4	4	7
99	b.b21x5	5.5447	4	0	4
100	b.b21x7	5.13288	6	0	5
101	b.l21x2	4.19298	4	0	4
102	b.b22x5	5.23197	5	13	7
103	b.l22x5	6.95003	5	18	9
104	b.b23x6	6.86224	6	9	7
105	b.l23x1	5.792	5	1	6
106	b.b24x4	7.31198	4	9	6
107	b.b24x6	6.17629	4	9	8
108	b.l24x3	4.27808	4	0	5
109	b.b25x3	5.37204	4	9	5
110	b.l25x3	7.30838	5	6	9
111	b.l25x6	11.5569	5	1	8
112	b.l28x1	8.91235	7	1	9
113	b.l28x2	6.48516	4	6	9
114	b.b28x3	3.80191	5	3	7
115	b.b28x4	6.7682	4	6	6
116	b.b28x6	8.50951	5	6	9
117	g.h1x5	2.47391	4	0	6
118	g.l1x4	2.8579	6	0	8
119	g.ctx3	6.10868	5	0	9
120	g.ctx6	3.51665	4	0	6
121	g.ctx14	4.75165	4	0	9
122	g.ctx15	4.86016	4	3	9
123	g.ctx16	3.84993	6	3	8
124	NT	2.64278	5	2	7
125	1x36	3.02589	4	0	6
126	1x50	4.96627	4	0	9
127	I1	4.43468	6	6	5
128	2x50	5.13377	4	0	9
129	2x51	3.31546	4	0	7
130	E1x50	3.30427	6	2	9
131	E1x52	1.88282	4	0	7
132	3x34	3.87194	5	14	5
133	3x37	2.65399	4	0	8
134	3x50	3.74457	5	0	9
135	3x51	3.28979	5	23	7
136	I2x51	4.81371	4	7	6
137	I2x53	7.10216	4	7	6
138	4x50	3.77579	4	14	9
139	4x60	4.14236	4	2	5
140	E2	11.5162	21	2	3
141	E2x52	3.83891	4	2	6
142	5x58	2.1286	6	0	8
143	6x32	2.42659	5	24	4
144	6x34	1.54278	4	0	8
145	6x54	3.14449	5	0	5
146	E3	10.4044	6	2	3
147	7x34	3.70115	4	2	7
148	7x35	3.80314	4	2	3
149	7x49	4.42065	4	22	9
150	7x53	4.02176	5	22	7
151	Lig	4.71672	15	2	0
152	G.s3h2.03	4.39813	4	1	0
153	5x69	1.63268	4	0	0
154	8x55	1.83357	4	24	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	b.b3x6	b.l1x3	27.5225	11.289	No	Yes	0	9	9
2	b.b3x6	b.l3x2	27.6514	7.78254	No	Yes	0	9	9
3	b.b4x2	b.l3x2	23.6746	5.89413	Yes	Yes	0	8	9
4	b.b4x6	b.l1x3	23.152	5.11341	Yes	Yes	3	9	9
5	b.l1x4	b.l3x2	51.1508	7.75492	No	Yes	0	6	9
6	G.hns1.01	b.l1x4	52.0934	2.91151	No	No	0	3	6
7	G.S1.03	G.hns1.01	52.2124	9.35817	No	No	0	9	3
8	G.S1.03	G.S3.06	52.3313	4.89643	No	Yes	0	9	7
9	G.S3.06	b.l5x5	53.6893	16.9261	Yes	Yes	0	7	9
10	G.h2s4.01	b.l5x5	51.387	12.4565	Yes	Yes	0	9	9
11	G.H2.07	G.h2s4.01	52.0026	3.40317	Yes	Yes	0	9	9
12	G.H2.04	G.H2.07	98.5627	7.77778	No	Yes	0	9	9
13	G.H2.04	G.H3.08	98.7221	8.81397	No	Yes	0	9	8
14	G.H3.08	G.S4.04	98.9948	6.21349	Yes	Yes	0	8	9
15	G.S4.04	G.S4.06	32.6183	3.15024	Yes	No	0	9	7
16	G.H4.15	G.S4.06	32.6469	4.68071	Yes	No	0	8	7
17	G.H3.06	G.H4.15	98.7425	8.73738	No	Yes	0	6	8
18	G.H3.06	G.H4.14	98.6419	3.42103	No	No	0	6	5
19	G.H4.10	G.H4.14	98.5043	9.99413	Yes	No	0	7	5
20	G.H4.10	G.hgh4.05	99.2255	12.5182	Yes	Yes	0	7	6
21	G.HG.15	G.hgh4.05	100	10.3874	No	Yes	0	7	6
22	G.HG.15	G.s4h3.04	99.9642	10.6006	No	No	0	7	8
23	G.HG.07	G.s4h3.04	99.8913	8.10365	Yes	No	0	9	8
24	G.HG.07	G.s4h3.02	99.7101	2.805	Yes	No	0	9	9
25	G.S4.07	G.s4h3.02	48.2443	3.58754	No	No	0	8	9
26	G.S4.07	G.s5hg.01	47.9132	8.075	No	No	0	8	9
27	G.S5.07	G.s5hg.01	95.6263	6.28405	Yes	No	0	9	9
28	G.S5.07	G.s6h5.01	93.1805	4.38659	Yes	Yes	0	9	9
29	G.S5.05	G.s6h5.01	92.9578	5.01278	Yes	Yes	8	9	9
30	G.S4.03	G.S5.05	82.1798	3.38786	No	Yes	8	7	9
31	G.S1.04	G.S4.03	82.06	3.67992	No	No	0	7	7
32	G.S1.04	G.S3.03	81.9256	4.03	No	Yes	0	7	8
33	G.H3.09	G.S4.04	33.1635	3.51198	Yes	Yes	0	9	9
34	G.H3.09	G.H4.15	33.5038	6.57476	Yes	Yes	0	9	8
35	G.S4.04	G.S5.04	33.3445	3.14064	Yes	No	0	9	9
36	G.H4.15	G.S5.04	32.6666	8.29349	Yes	No	0	8	9
37	G.HG.03	G.s4h3.02	51.4309	4.95698	Yes	No	0	6	9
38	G.HG.03	G.s5hg.01	47.8429	3.995	Yes	No	0	6	9
39	G.H5.08	G.S3.03	40.062	3.40159	Yes	Yes	7	8	8
40	G.S3.01	G.S3.03	39.0367	4.78468	No	Yes	7	5	8
41	G.S3.01	I2x51	38.894	4.20675	No	Yes	7	5	6
42	G.H5.08	I2x51	38.94	7.32183	Yes	Yes	7	8	6
43	G.H2.07	b.l9x6	52.295	3.50643	Yes	Yes	1	9	8
44	G.H2.06	b.l9x6	29.8794	3.64667	Yes	Yes	1	9	8
45	G.H2.06	b.l17x6	14.7619	6.71667	Yes	Yes	1	9	9
46	G.H2.06	b.b18x1	14.633	4.17722	Yes	No	0	9	9
47	G.H3.17	b.l28x1	10.1028	3.45706	Yes	Yes	1	5	9
48	b.b2x1	b.l28x1	18.9503	7.60984	Yes	Yes	1	8	9
49	b.b2x1	b.b6x1	17.8503	3.96206	Yes	Yes	1	8	9
50	G.H5.10	G.S6.02	14.8832	13.0058	No	Yes	0	7	8
51	G.H5.15	I2x51	76.6634	3.34683	No	Yes	7	8	6
52	G.H5.15	G.H5.19	76.0711	3.76913	No	Yes	7	8	8
53	3x53	G.H5.19	72.8091	3.26921	No	Yes	7	8	8
54	3x53	G.H5.23	72.5225	3.03905	No	Yes	0	8	4
55	3x50	G.H5.23	60.129	7.95937	Yes	Yes	0	9	4
56	b.l17x6	b.l19x1	14.6908	4.94127	Yes	No	0	9	9
57	b.l17x5	b.l19x1	28.9594	3.25754	No	No	0	6	9
58	b.l17x5	b.l19x2	28.7001	4.04254	No	Yes	0	6	9
59	b.l17x3	b.l19x2	25.8186	3.38	Yes	Yes	4	9	9
60	b.b20x6	b.l17x3	21.6324	3.04381	Yes	Yes	4	6	9
61	b.b17x7	b.b20x6	16.6675	10.3945	Yes	Yes	4	8	6
62	b.b17x7	b.b21x1	14.3207	5.07056	Yes	Yes	4	8	7
63	b.b21x1	g.l1x4	11.7133	7.34595	Yes	Yes	0	7	8
64	g.l1x1	g.l1x4	10.1384	1.27222	No	Yes	0	1	8
65	b.b18x1	b.l19x1	14.528	7.12722	No	No	0	9	9
66	b.l21x7	b.l23x1	17.9145	3.11127	No	Yes	0	5	6
67	b.l21x7	b.l23x2	17.3398	6.54333	No	No	0	5	8
68	b.b23x6	b.l23x2	16.4773	2.78373	Yes	No	0	7	8
69	b.b23x6	b.b24x6	12.724	6.6827	Yes	Yes	9	7	8
70	b.b21x7	b.b24x6	12.1546	6.5146	Yes	Yes	0	5	8
71	b.l27x5	g.ctx4	11.6404	6.03	No	No	0	5	7
72	g.ctx3	g.ctx4	11.3701	4.30611	Yes	No	0	9	7
73	b.b4x2	b.b5x8	22.6269	4.84587	Yes	No	0	8	5
74	b.b5x7	b.b5x8	22.4959	3.39	Yes	No	0	7	5
75	b.b3x2	b.b4x6	19.4864	3.95841	No	Yes	3	5	9
76	b.b2x5	b.b3x2	18.9641	10.1779	Yes	No	3	7	5
77	b.b2x4	b.b6x5	16.3153	2.88071	No	Yes	0	6	6
78	b.b10x4	b.b2x4	16.0494	11.8308	No	No	0	6	6
79	b.b2x5	b.l27x1	11.6855	10.9073	Yes	No	3	7	7
80	b.l27x3	b.l27x5	11.2987	7.61357	No	No	0	7	5
81	b.l27x1	b.l27x3	11.4198	5.43849	No	No	3	7	7
82	b.b4x5	b.b5x5	17.8241	6.08183	No	No	0	7	5
83	b.b5x5	b.l8x8	18.0639	3.00881	No	No	0	5	4
84	b.b5x7	b.l8x8	18.1851	8.32468	Yes	No	0	7	4
85	b.b10x2	b.b10x4	12.04	4.54349	No	No	0	6	6
86	b.b10x2	b.b14x3	11.7735	4.81087	No	Yes	0	6	5
87	E2	Lig	22.2925	7.76579	Yes	Yes	2	3	0
88	7x46	Lig	35.1548	4.0896	No	Yes	0	7	0
89	2x50	7x46	35.4555	5.93635	Yes	No	0	9	7
90	2x46	2x50	39.6612	4.4169	No	Yes	0	9	9
91	2x46	7x49	49.193	4.57802	No	Yes	0	9	9
92	7x49	7x53	51.8239	3.65976	Yes	Yes	22	9	7
93	3x46	7x53	53.6106	4.44897	No	Yes	0	8	7
94	3x46	3x50	54.2043	3.01016	No	Yes	0	8	9
95	b.b6x1	b.l9x6	18.1922	5.49167	Yes	Yes	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
1x38	7x39	7.36119	0	No	No	5	6	2	1
1x43	2x57	5.90135	0	No	No	6	9	2	1
2x50	7x46	5.93635	0	Yes	No	9	7	2	1
E1x50	E2	5.42373	2	Yes	Yes	9	3	2	1
3x26	4x61	3.05841	2	No	No	7	4	2	1
3x26	E2	3.8581	2	No	Yes	7	3	2	1
3x33	Lig	4.51722	0	No	Yes	6	0	1	0
4x61	Lig	3.30056	0	No	Yes	4	0	1	0
4x64	E2	5.21667	2	No	Yes	4	3	2	1
E2	E2	71.6352	2	Yes	Yes	3	3	1	1
E2	E2x51	7.93191	2	Yes	No	3	5	1	2
E2	E2x52	4.51341	2	Yes	Yes	3	6	1	2
5x35	E2	3.41905	0	No	Yes	1	3	2	1
5x36	E2	8.69111	2	No	Yes	4	3	2	1
5x40	7x34	3.61278	0	No	Yes	6	7	1	2
5x40	Lig	3.96444	0	No	Yes	6	0	1	0
E3	E3	18.426	2	Yes	Yes	3	3	2	2
1x42	7x43	4.16476	0	No	No	7	4	1	2
2x60	3x28	5.7254	0	No	No	7	5	1	2
E2	Lig	7.76579	2	Yes	Yes	3	0	1	0
NT	NT	3.93167	2	Yes	Yes	7	7	2	2
3x32	Lig	5.17937	0	No	Yes	6	0	1	0
4x60	E2	5.43778	2	Yes	Yes	5	3	2	1
E2	E3	11.1795	2	Yes	Yes	3	3	1	2
7x34	E3	3.01071	2	Yes	Yes	7	3	2	2
1x39	Lig	4.86571	0	No	Yes	9	0	1	0
2x54	Lig	6.58778	0	No	Yes	6	0	1	0
2x57	Lig	5.33516	0	No	Yes	9	0	1	0
2x60	Lig	3.62278	0	No	Yes	7	0	1	0
2x64	E2	3.21032	2	No	Yes	6	3	2	1
3x29	E2	5.64683	2	No	Yes	6	3	2	1
3x33	E2x52	3.47714	0	No	Yes	6	6	1	2
7x34	E2	4.65754	2	Yes	Yes	7	3	2	1
7x35	E2	3.3981	2	Yes	Yes	3	3	1	1
7x38	E2	4.89436	2	No	Yes	5	3	2	1
E2x51	E2x52	5.03508	2	No	Yes	5	6	2	2
6x58	E2	3.46762	2	No	Yes	6	3	2	1
7x35	7x39	6.83508	2	Yes	No	3	6	1	1
7x35	Lig	3.39659	2	Yes	Yes	3	0	1	0
7x39	Lig	4.32524	2	No	Yes	6	0	1	0
7x42	Lig	8.28452	0	No	Yes	6	0	1	0
7x46	Lig	4.0896	0	No	Yes	7	0	1	0
5x34	E2	5.38929	0	No	Yes	1	3	2	1
2x56	3x32	2.91627	0	No	No	7	6	2	1
3x22	E2	2.915	2	No	Yes	3	3	2	1
3x36	Lig	2.81579	0	No	Yes	7	0	1	0
1x42	Lig	2.70032	0	No	Yes	7	0	1	0
3x33	4x57	2.57381	0	No	No	6	6	1	2
1x39	2x61	1.99571	0	No	No	9	7	1	2
7x35	7x36	1.58278	2	Yes	No	3	3	1	2
E2	NT	1.55444	2	Yes	Yes	3	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
70.59	Consensus	ep_on	Orthosteric Ligand	ep4_on ep2_on ep3_on
66.67	Consensus	gs_prostanoid	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
61.11	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1
61.11	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2
61.11	Consensus	gi_prostanoid	Orthosteric Ligand	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2 8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
61.11	Consensus	prostanoid_on	Orthosteric Ligand	ep_on fpa_on
58.82	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
58.82	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2
58.82	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/&β;1/&γ;2
57.89	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2
57.89	Consensus	ep2_on	Orthosteric Ligand	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
57.89	Consensus	ep4_on	Orthosteric Ligand	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2
55.56	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
55.56	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
55.00	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
52.63	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
52.38	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
50.00	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/&β;1/&γ;2
50.00	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
50.00	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00	Consensus	ep3_on	Orthosteric Ligand	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
50.00	Consensus	fpa_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
47.62	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
45.00	Single	6IIU	Ramatroban	6IIU-TP-Ramatroban
44.44	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
42.11	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
42.11	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
42.11	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
42.11	Consensus	ep_off	Orthosteric Ligand	ep4_off
40.91	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
40.00	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
39.13	Single	7QA8	Peptide	7QA8-STE2-Peptide
39.13	Single	7QA8	Peptide	7QA8-STE2-Peptide
39.13	Consensus	class-d_off	Orthosteric Ligand	ste2_off
38.89	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
38.46	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
37.04	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
36.84	Single	6IIV	Daltroban	6IIV-TP-Daltroban
36.84	Single	7T2G	Mitragynine pseudoindoxyl	7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
36.84	Consensus	prostanoid_off	Orthosteric Ligand	ep_off tp_off dp_off
36.84	Consensus	tp_off	Orthosteric Ligand	6IIV-TP-Daltroban 6IIU-TP-Ramatroban
36.36	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/&β;1/&γ;2
36.36	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.36	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2
35.29	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/&β;1/&γ;2
35.00	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
35.00	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
35.00	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
34.78	Consensus	class-d_off	Orthosteric Ligand	ste2_off
34.78	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
33.33	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
33.33	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2
33.33	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/&β;1/&γ;2
33.33	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/&β;1/&γ;2
33.33	Consensus	gs_ffa	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2 8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
32.14	Consensus	class-d_on	Orthosteric Ligand	ste2_on
32.00	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
31.82	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/&β;1/&γ;2
31.82	Consensus	opioid_off	Orthosteric Ligand	kop_off mop_off nop_off dop_off
31.58	Single	7F61	PF-03654746	7F61-H₃-PF-03654746-Cholesterol
31.58	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
31.58	Single	8GCM	L902688	8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
31.58	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2
31.58	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
31.58	Consensus	at1_off	Orthosteric Ligand	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
31.58	Consensus	h3_on_allo	Orthosteric Ligand	7F61-H₃-PF-03654746-Cholesterol
31.58	Consensus	hca_on	Orthosteric Ligand	hca2_on hca3_on
31.58	Consensus	hcar_on	Orthosteric Ligand	hca_on
31.03	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
31.03	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
31.03	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
31.03	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
31.03	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
30.77	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
30.43	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
30.43	Single	8GAG	YVF	8GAG-CB₁-YVF-Gi1/&β;1/&γ;2
30.43	Single	8WRZ	8D0	8WRZ-CB₁-8D0-Arrestin1
30.00	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
30.00	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
30.00	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2
30.00	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
30.00	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
30.00	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/&β;1/&γ;2
30.00	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
30.00	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
30.00	Consensus	blt_on	Orthosteric Ligand	blt1_on
30.00	Consensus	cb1_on_allo	Orthosteric Ligand	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
30.00	Consensus	gi_hca	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
30.00	Consensus	gi_hcar	Orthosteric Ligand	gi_hca
30.00	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
30.00	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
30.00	Consensus	hca2_on	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
30.00	Consensus	hca3_on	Orthosteric Ligand	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
30.00	Consensus	leuko_on	Orthosteric Ligand	blt_on
30.00	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
30.00	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
29.63	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
29.63	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2
29.63	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/&β;1/&γ;2
29.63	Consensus	class-d_on	Orthosteric Ligand	ste2_on
29.63	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
29.63	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
29.41	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
29.41	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
29.17	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
29.17	Single	7XY6	PubChem 11717831	7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
29.17	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/&β;1/&γ;2
29.17	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
28.57	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
28.57	Single	6GPX	MK0812	6GPX-CCR2-MK0812
28.57	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
28.57	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
28.57	Single	7KH0	Acyclovir triphosphate	7KH0-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.57	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
28.57	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/&β;1/&γ;2
28.57	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
28.57	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
28.57	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
28.57	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
28.57	Consensus	a1_on_allo	Orthosteric Ligand	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
28.57	Consensus	bk1_on	Orthosteric Ligand	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57	Consensus	cb2_on	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
28.57	Consensus	ccr2_off_allo	Other Ligand	5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
28.57	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
28.00	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
28.00	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
28.00	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
28.00	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
28.00	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
28.00	Consensus	mop_off	Orthosteric Ligand	7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
27.78	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2
27.78	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/&β;1/&γ;2
27.78	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/&β;1/&γ;2
27.78	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
27.78	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
27.78	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
27.27	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
27.27	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
27.27	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
27.27	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
27.27	Single	7WV9	PubMed 104895	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
27.27	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/&β;1/&γ;2
27.27	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2
27.27	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2
27.27	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/&β;1/&γ;2
27.27	Consensus	angiotensin_off	Orthosteric Ligand	at1_off at2_off
26.92	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
26.92	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
26.92	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
26.92	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
26.92	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
26.67	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
26.32	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
26.32	Single	5U09	Taranabant	5U09-CB₁-Taranabant
26.32	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
26.32	Single	6AKX	A4R	6AKX-CCR5-A4R
26.32	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
26.32	Single	6B73	PubChem 131955138	6B73-κ-PubChem 131955138
26.32	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/&β;1/&γ;2
26.32	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
26.32	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/&β;1/&γ;2
26.32	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
26.32	Single	8IW4	Spermidine	8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
26.32	Single	8IWE	Spermidine	8IWE-TAAR9-Spermidine
26.32	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
26.32	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
26.32	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
26.32	Consensus	gi_nucleotide	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
26.09	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
26.09	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
26.09	Single	6H7N	(S)-Xamoterol	6H7N-β₁-(S)-Xamoterol
26.09	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
26.09	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
26.09	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2
26.09	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
26.09	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
26.09	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
26.09	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
26.09	Single	8WU1	KCA	8WU1-CB₁-KCA-Arrestin1
26.09	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
26.09	Consensus	at2_off	Orthosteric Ligand	7JNI-AT₂-Olodanrigan
26.09	Consensus	beta1_on	Orthosteric Ligand	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
26.09	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
26.09	Consensus	cannabinoid_on	Orthosteric Ligand	cb1_on cb2_on
26.09	Consensus	cb1_on	Orthosteric Ligand	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
26.09	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
26.09	Consensus	gs_bileacid	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
26.09	Consensus	gs_steroid	Orthosteric Ligand	gs_bileacid
26.09	Consensus	leuko_off	Orthosteric Ligand	blt_off cyslt_off
26.09	Consensus	peptide_off	Orthosteric Ligand	opioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
25.93	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
25.93	Single	7F4D	Alpha-MSH	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
25.93	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
25.93	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
25.81	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
25.00	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
25.00	Single	4DKL	Beta-funaltrexamine	4DKL-μ-Beta-funaltrexamine
25.00	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
25.00	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
25.00	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
25.00	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
25.00	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
25.00	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
25.00	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
25.00	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
25.00	Single	6ZFZ	77-LH-28-1	6ZFZ-M₁-77-LH-28-1
25.00	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
25.00	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2
25.00	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
25.00	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
25.00	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
25.00	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
25.00	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
25.00	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
25.00	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
25.00	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
25.00	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
25.00	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/&β;1/&γ;2
25.00	Single	8GUR	PubChem 104895	8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2
25.00	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
25.00	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
25.00	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/&β;1/&γ;2
25.00	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/&β;1/&γ;2
25.00	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2
25.00	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
25.00	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
25.00	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/&β;1/&γ;2
25.00	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2
25.00	Consensus	bileacid_on	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
25.00	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
25.00	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
25.00	Consensus	d1_on_allo	Orthosteric Ligand	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
25.00	Consensus	dop_off_allo	Orthosteric Ligand	4N6H-δ-Naltrindole-Na
25.00	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
25.00	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
25.00	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
25.00	Consensus	gs_tar	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
25.00	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
25.00	Consensus	ox1_off	Orthosteric Ligand	6TOT-OX₁-Lemborexant 6TP4-OX₁-ACT-462206 6TP6-OX₁-Filorexant 6V9S-OX₁-GTPL11403 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ7-OX₁-SB-334867 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant
25.00	Consensus	ox2_off	Orthosteric Ligand	6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant
25.00	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
25.00	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
25.00	Consensus	steroid_on	Orthosteric Ligand	bileacid_on
24.24	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
24.14	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
24.14	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
24.14	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
24.14	Consensus	gs_bradykinin	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14	Consensus	gs_melanocortin	Orthosteric Ligand	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2
24.00	Single	3NY9	PubChem 913103	3NY9-β₂-PubChem 913103
24.00	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
24.00	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
24.00	Single	6PT3	DPI-287	6PT3-δ-DPI-287
24.00	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
24.00	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
24.00	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
24.00	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
24.00	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
24.00	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/&β;1/&γ;2
24.00	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
24.00	Consensus	go_vasopressin	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
24.00	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
23.81	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
23.81	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
23.81	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
23.81	Single	5DHG	PubChem 25001412	5DHG-NOP-PubChem 25001412
23.81	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
23.81	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
23.81	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
23.81	Single	5ZKP	Foropafant (SR27417)	5ZKP-PAF-Foropafant (SR27417)
23.81	Single	6GPS	MK0812	6GPS-CCR2-MK0812
23.81	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
23.81	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
23.81	Single	7CFM	P395	7CFM-GPBA-P395-Gs/&β;1/&γ;2
23.81	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/&β;1/&γ;2
23.81	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
23.81	Single	7LJC	PubChem 86764103	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
23.81	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/&β;1/&γ;2
23.81	Single	7V3Z	PubMed 104895	7V3Z-CB₁-PubMed 104895
23.81	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
23.81	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
23.81	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
23.81	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
23.81	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
23.81	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
23.81	Single	8X17	Namodenoson	8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
23.81	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on
23.81	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
23.81	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on
23.81	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
23.81	Consensus	tar_on	Orthosteric Ligand	ta1_on
23.53	Single	6TQ9	SB-408124	6TQ9-OX₁-SB-408124
23.53	Single	8DPH	Lorcaserin	8DPH-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53	Single	8IWM	2-Phenylethylamine	8IWM-TAAR9-2-Phenylethylamine
23.53	Consensus	hca2_on_allo	Orthosteric Ligand	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
23.33	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
23.33	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
23.33	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
23.08	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
23.08	Single	8GHV	PubChem 145964903	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
23.08	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/&β;1/&γ;2
23.08	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
23.08	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
23.08	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
23.08	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
22.86	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
22.73	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
22.73	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
22.73	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
22.73	Single	5C1M	BU72	5C1M-μ-BU72
22.73	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
22.73	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
22.73	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
22.73	Single	5WQC	EMPA	5WQC-OX₂-EMPA
22.73	Single	5X7D	(S)-Carazolol	5X7D-β₂-(S)-Carazolol-PubChem 129318963
22.73	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
22.73	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
22.73	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
22.73	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
22.73	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
22.73	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2
22.73	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
22.73	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
22.73	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
22.73	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
22.73	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/&β;1/&γ;2
22.73	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
22.73	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
22.73	Single	8J19	PubChem 127045422	8J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
22.73	Consensus	adrenergic_off	Orthosteric Ligand	beta_off alpha_off
22.73	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
22.73	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
22.73	Consensus	d4_off	Orthosteric Ligand	5WIU-D₄-Nemonapride
22.73	Consensus	d4_off_allo	Orthosteric Ligand	5WIV-D₄-Nemonapride-Na
22.73	Consensus	go_opioid	Orthosteric Ligand	8DZQ-κ-momSalB-Go/&β;1/&γ;2
22.73	Consensus	gs_adrenergic	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJI-β₃-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
22.73	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
22.58	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
22.22	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
22.22	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
22.22	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
22.22	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
22.22	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
22.22	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
22.22	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/&β;1/&γ;2
22.22	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
22.22	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
22.22	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
22.22	Single	8IW7	2-Phenylethylamine	8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
22.22	Single	8J6Q	Beta-hydroxybutyrate	8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
22.22	Single	8WC9	ZH8651	8WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22	Consensus	cx3cr_on	Orthosteric Ligand	cx3cr1_on
22.22	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
21.88	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
21.88	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
21.88	Single	7VGX	Neuropeptide Y	7VGX-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
21.74	Single	2YDV	NECA	2YDV-A_2A-NECA
21.74	Single	4DJH	JDTic	4DJH-κ-JDTic
21.74	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
21.74	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
21.74	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
21.74	Single	5G53	NECA	5G53-A_2A-NECA-Gs
21.74	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
21.74	Single	5V56	TC114	5V56-SMO-TC114
21.74	Single	5V57	TC114	5V57-SMO-TC114
21.74	Single	5XR8	AM841	5XR8-CB₁-AM841
21.74	Single	6E59	L-760735	6E59-NK₁-L-760735
21.74	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
21.74	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
21.74	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
21.74	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
21.74	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
21.74	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/&β;1/&γ;2
21.74	Single	7EW7	PubChem 4077460	7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
21.74	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
21.74	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/&β;1/&γ;2
21.74	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/&β;1/&γ;2
21.74	Single	8E0G	BU72	8E0G-μ-BU72
21.74	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
21.74	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/&β;1/&γ;2
21.74	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
21.74	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
21.74	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2
21.74	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
21.74	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/&β;1/&γ;2
21.74	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/&β;1/&γ;2
21.74	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/&β;1/&γ;2
21.74	Single	8X16	Piclidenoson	8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
21.74	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
21.74	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
21.74	Consensus	5ht1b_on	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
21.74	Consensus	a2_on	Orthosteric Ligand	a2a_on a2b_on
21.74	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
21.74	Consensus	dopamine_off	Orthosteric Ligand	d3_off d2_off d4_off
21.74	Consensus	ffa4_on	Orthosteric Ligand	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
21.74	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2
21.74	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
21.74	Consensus	nk1_off	Orthosteric Ligand	6J20-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
21.74	Consensus	npy_off	Orthosteric Ligand	npy2_off npy1_off
21.43	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
21.43	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
21.43	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
21.43	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
21.43	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1
21.43	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
21.43	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
21.43	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
21.43	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
21.43	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
21.43	Consensus	cx3cr1_on	Orthosteric Ligand	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
21.43	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
21.21	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
21.21	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
21.21	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
21.05	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
21.05	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
21.05	Single	6HLL	CP99994	6HLL-NK₁-CP99994
21.05	Single	6QNO	All-trans-retinal	6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
21.05	Single	7DFL	Histamine	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
21.05	Single	7EJK	Oxymetazoline	7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2
21.05	Single	7XP6	Strychnine	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
21.05	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/&β;1/&γ;2
21.05	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2
21.05	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05	Single	8GEI	Epinephrine	8GEI-β₂-Epinephrine-Gs/&β;1/&γ;2
21.05	Single	8GGC	Epinephrine	8GGC-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05	Single	8GGE	Epinephrine	8GGE-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2
21.05	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
21.05	Single	8W8B	SEP-363856	8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2
21.05	Single	8WC3	SEP-363856	8WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
21.05	Consensus	class-t_on	Orthosteric Ligand	taste2_on
21.05	Consensus	gq_histamine	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
21.05	Consensus	gs_class-t	Orthosteric Ligand	gs_taste
21.05	Consensus	gs_taste	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
21.05	Consensus	h1_on	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
21.05	Consensus	taste2_on	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
20.83	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
20.83	Single	4LDE	BI167107	4LDE-β₂-BI167107
20.83	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
20.83	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
20.83	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
20.83	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
20.83	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.83	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
20.83	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
20.83	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2
20.83	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2
20.83	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
20.83	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
20.83	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
20.83	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
20.83	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
20.83	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/&β;1/&γ;2
20.83	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
20.83	Single	8JWY	PubChem 168451710	8JWY-A_2A-PubChem 168451710
20.83	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
20.83	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg3_on
20.83	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on
20.83	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
20.83	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
20.83	Consensus	dp_off	Orthosteric Ligand	dp2_off
20.83	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
20.83	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
20.69	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
20.69	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
20.69	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
20.69	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.69	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
20.69	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
20.69	Consensus	gi_somatostatin	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
20.69	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.59	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
20.59	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
20.00	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
20.00	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
20.00	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
20.00	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
20.00	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
20.00	Single	5WS3	EMPA	5WS3-OX₂-EMPA
20.00	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
20.00	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
20.00	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
20.00	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
20.00	Single	6KUY	PubChem 145704643	6KUY-α_2a-PubChem 145704643
20.00	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
20.00	Single	6TOD	EMPA	6TOD-OX₁-EMPA-Na
20.00	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
20.00	Single	7EJ0	L-Norepinephrine	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2
20.00	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
20.00	Single	7EZC	UKA	7EZC-A_2A-UKA
20.00	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2
20.00	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
20.00	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
20.00	Single	7F24	Dopamine	7F24-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
20.00	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
20.00	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
20.00	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
20.00	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00	Single	7T8X	Acetylcholine	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
20.00	Single	7T90	Acetylcholine	7T90-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
20.00	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
20.00	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
20.00	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
20.00	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
20.00	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
20.00	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
20.00	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2
20.00	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.00	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
20.00	Single	7YM8	Oxymetazoline	7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
20.00	Single	7YMH	Norepinephrine	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
20.00	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
20.00	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
20.00	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
20.00	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
20.00	Single	8E9Y	PubChem 446603	8E9Y-M₃-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
20.00	Single	8GEC	Epinephrine	8GEC-β₂-Epinephrine-Gs/&β;1/&γ;2
20.00	Single	8GEF	Epinephrine	8GEF-β₂-Epinephrine-Gs/&β;1/&γ;2
20.00	Single	8GGA	Epinephrine	8GGA-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00	Single	8GGV	Epinephrine	8GGV-β₂-Epinephrine
20.00	Single	8GGW	Epinephrine	8GGW-β₂-Epinephrine
20.00	Single	8GGX	Epinephrine	8GGX-β₂-Epinephrine
20.00	Single	8GH0	Epinephrine	8GH0-β₂-Epinephrine
20.00	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2
20.00	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2
20.00	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
20.00	Single	8ID8	TUG-891	8ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
20.00	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
20.00	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
20.00	Single	8UO0	Epinephrine	8UO0-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00	Single	8UO3	Epinephrine	8UO3-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
20.00	Consensus	5ht2_on	Orthosteric Ligand	5ht2a_on 5ht2c_on
20.00	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
20.00	Consensus	alpha1_on	Orthosteric Ligand	alpha1a_on
20.00	Consensus	alpha1a_on	Orthosteric Ligand	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00	Consensus	beta1_off_allo	Orthosteric Ligand	4BVN-β₁-Cyanopindolol-Na
20.00	Consensus	class-f_off	Orthosteric Ligand	smo_off
20.00	Consensus	endothelin_off	Orthosteric Ligand	etb_off
20.00	Consensus	etb_off	Orthosteric Ligand	5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500 5X93-ET_B-K-8794
20.00	Consensus	gi_histamine	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2 8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
20.00	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
20.00	Consensus	gs_histamine	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00	Consensus	h4_on	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00	Consensus	m2_on	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
20.00	Consensus	mglu_on	Other Ligand	mglu2_on mglu4_on
20.00	Consensus	orexin_off	Orthosteric Ligand	ox2_off ox1_off
20.00	Consensus	ot_on	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.00	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
19.51	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
19.44	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
19.44	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
19.44	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
19.35	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
19.35	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/&β;1/&γ;2
19.35	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
19.35	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
19.35	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
19.35	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
19.35	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.35	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
19.35	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
19.35	Consensus	gi_neuromedin	Orthosteric Ligand	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
19.35	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
19.35	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
19.35	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
19.23	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
19.23	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
19.23	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
19.23	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
19.23	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
19.23	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
19.23	Single	8INR	Alpha-MSH	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
19.23	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
19.23	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2 8I95-C3a_B-EP54-Go/&β;1/&γ;2
19.23	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
19.23	Consensus	gs_adgr	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
19.23	Consensus	gs_class-b2	Orthosteric Ligand	gs_adgr
19.23	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
19.23	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
19.23	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.23	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
19.05	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
19.05	Single	4LDO	L-Epinephrine	4LDO-β₂-L-Epinephrine
19.05	Single	6DS0	Ly266097	6DS0-5-HT_2B-Ly266097
19.05	Single	6IQL	L745870	6IQL-D₄-L745870
19.05	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
19.05	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
19.05	Single	6PS4	ICI 118-551	6PS4-β₂-ICI 118-551
19.05	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
19.05	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
19.05	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
19.05	Single	6TPG	EMPA	6TPG-OX₂-EMPA
19.05	Single	6TPK	Retosiban	6TPK-OT-Retosiban
19.05	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
19.05	Single	6V9S	GTPL11403	6V9S-OX₁-GTPL11403
19.05	Single	6VI4	JDTic	6VI4-κ-JDTic
19.05	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
19.05	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
19.05	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/&β;1/&γ;2
19.05	Single	7CMU	Pramipexole	7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
19.05	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/&β;1/&γ;2
19.05	Single	7DHI	Salbutamol	7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2
19.05	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
19.05	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/&β;1/&γ;2
19.05	Single	7RAN	PubChem 164575847	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05	Single	7SR8	TAK-925	7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.05	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
19.05	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2
19.05	Single	7UM7	Methylergometrine	7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
19.05	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
19.05	Single	8DPG	Psilocin	8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05	Single	8GE1	Epinephrine	8GE1-β₂-Epinephrine-Gs/&β;1/&γ;2
19.05	Single	8GE4	Epinephrine	8GE4-β₂-Epinephrine-Gs/&β;1/&γ;2
19.05	Single	8GE6	Epinephrine	8GE6-β₂-Epinephrine-Gs/&β;1/&γ;2
19.05	Single	8GE7	Epinephrine	8GE7-β₂-Epinephrine-Gs/&β;1/&γ;2
19.05	Single	8GE8	Epinephrine	8GE8-β₂-Epinephrine-Gs/&β;1/&γ;2
19.05	Single	8GE9	Epinephrine	8GE9-β₂-Epinephrine-Gs/&β;1/&γ;2
19.05	Single	8GEG	Epinephrine	8GEG-β₂-Epinephrine-Gs/&β;1/&γ;2
19.05	Single	8GFV	Epinephrine	8GFV-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05	Single	8GG4	Epinephrine	8GG4-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05	Single	8GGI	Epinephrine	8GGI-β₂-Epinephrine
19.05	Single	8GGQ	Epinephrine	8GGQ-β₂-Epinephrine
19.05	Single	8GGT	Epinephrine	8GGT-β₂-Epinephrine
19.05	Single	8HQN	9(S)-HODE	8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
19.05	Single	8JLN	T1AM	8JLN-TA1-T1AM-Gs/&β;1/&γ;2
19.05	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
19.05	Single	8THK	A61603	8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05	Single	8THL	Epinephrine	8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05	Single	8UNQ	Epinephrine	8UNQ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05	Single	8UNZ	Epinephrine	8UNZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05	Single	8UO2	Epinephrine	8UO2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
19.05	Consensus	5ht2a_on	Orthosteric Ligand	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05	Consensus	alpha2b_on	Orthosteric Ligand	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
19.05	Consensus	d3_on	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
19.05	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
19.05	Consensus	sensory_off	Orthosteric Ligand	opsin_off
19.05	Consensus	vasopressin-ot_off	Orthosteric Ligand	ot_off
18.75	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
18.75	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
18.75	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
18.75	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
18.75	Single	8WCC	Cyclohexylammonium ion	8WCC-TA1-Cyclohexylammonium ion
18.52	Single	4AMJ	(S)-Carvedilol	4AMJ-β₁-(S)-Carvedilol
18.52	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
18.52	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
18.52	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
18.52	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
18.52	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
18.52	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
18.52	Single	8G59	TUG-891	8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
18.52	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
18.52	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
18.52	Consensus	sst2_on	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
18.52	Consensus	sst_on	Orthosteric Ligand	sst2_on sst4_on
18.18	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
18.18	Single	3NY8	ICI 118-551	3NY8-β₂-ICI 118-551
18.18	Single	3NYA	(S)-Alprenolol	3NYA-β₂-(S)-Alprenolol
18.18	Single	4GBR	(S)-Carazolol	4GBR-β₂-(S)-Carazolol
18.18	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
18.18	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
18.18	Single	4QKX	PubChem 76210628	4QKX-β₂-PubChem 76210628
18.18	Single	4U16	N-Methyl Scopolamine	4U16-M₃-N-Methyl Scopolamine
18.18	Single	4X1H	Nonyl Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
18.18	Single	5JQH	(S)-Carazolol	5JQH-β₂-(S)-Carazolol
18.18	Single	5NDD	AZ8838; Na	5NDD-PAR2-AZ8838; Na
18.18	Single	5UEN	DU172	5UEN-A₁-DU172
18.18	Single	5YC8	N-Methyl Scopolamine	5YC8-M₂-N-Methyl Scopolamine
18.18	Single	5ZK8	N-Methyl Scopolamine	5ZK8-M₂-N-Methyl Scopolamine
18.18	Single	5ZKC	N-Methyl Scopolamine	5ZKC-M₂-N-Methyl Scopolamine
18.18	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
18.18	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
18.18	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol
18.18	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
18.18	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
18.18	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
18.18	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
18.18	Single	6PS0	(S)-Carazolol	6PS0-β₂-(S)-Carazolol
18.18	Single	6PS1	Timolol	6PS1-β₂-Timolol
18.18	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
18.18	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18	Single	6Z10	PubChem 154585554	6Z10-Succinate-PubChem 154585554
18.18	Single	7BTS	L-Epinephrine	7BTS-β₁-L-Epinephrine
18.18	Single	7BU6	L-Norepinephrine	7BU6-β₁-L-Norepinephrine
18.18	Single	7BU7	BI167107	7BU7-β₁-BI167107
18.18	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
18.18	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
18.18	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
18.18	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
18.18	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
18.18	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/&β;1/&γ;2
18.18	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
18.18	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
18.18	Single	7UM5	5-CT	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
18.18	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/&β;1/&γ;2
18.18	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
18.18	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
18.18	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
18.18	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
18.18	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
18.18	Single	8EJC	TAK-875	8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.18	Single	8EJK	TAK-875	8EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.18	Single	8FEG	PRD_002517	8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
18.18	Single	8GE3	Epinephrine	8GE3-β₂-Epinephrine-Gs/&β;1/&γ;2
18.18	Single	8GEB	Epinephrine	8GEB-β₂-Epinephrine-Gs/&β;1/&γ;2
18.18	Single	8GEE	Epinephrine	8GEE-β₂-Epinephrine-Gs/&β;1/&γ;2
18.18	Single	8GEH	Epinephrine	8GEH-β₂-Epinephrine-Gs/&β;1/&γ;2
18.18	Single	8GFW	Epinephrine	8GFW-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18	Single	8GFX	Epinephrine	8GFX-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18	Single	8GFY	Epinephrine	8GFY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18	Single	8GFZ	Epinephrine	8GFZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18	Single	8GG0	Epinephrine	8GG0-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18	Single	8GG1	Epinephrine	8GG1-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18	Single	8GG2	Epinephrine	8GG2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18	Single	8GG6	Epinephrine	8GG6-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18	Single	8GGJ	Epinephrine	8GGJ-β₂-Epinephrine
18.18	Single	8GGN	Epinephrine	8GGN-β₂-Epinephrine
18.18	Single	8GGO	Epinephrine	8GGO-β₂-Epinephrine
18.18	Single	8GGU	Epinephrine	8GGU-β₂-Epinephrine
18.18	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/&β;1/&γ;2
18.18	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2
18.18	Single	8J18	(3R)-3-hydroxydodecanoic acid	8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
18.18	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
18.18	Single	8JLJ	T1AM	8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
18.18	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
18.18	Single	8UNN	Epinephrine	8UNN-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18	Single	8UNP	Epinephrine	8UNP-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18	Single	8UO4	Epinephrine	8UO4-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
18.18	Single	8WC7	ZH8667	8WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
18.18	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
18.18	Consensus	5ht1a_on	Orthosteric Ligand	8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2
18.18	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
18.18	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
18.18	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
18.18	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
18.18	Consensus	adrenergic_on	Orthosteric Ligand	beta_on alpha_on
18.18	Consensus	alpha2_on	Orthosteric Ligand	alpha2a_on alpha2b_on
18.18	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
18.18	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
18.18	Consensus	amine_on	Orthosteric Ligand	adrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
18.18	Consensus	crf1_on	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
18.18	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
18.18	Consensus	dopamine_on	Orthosteric Ligand	d3_on d2_on d5_on d1_on
18.18	Consensus	ffa_on	Orthosteric Ligand	ffa4_on ffa1_on ffa2_on ffa3_on
18.18	Consensus	gi_5ht	Orthosteric Ligand	7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2
18.18	Consensus	go_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
18.18	Consensus	gq_amine	Orthosteric Ligand	gq_muscarinic gq_histamine
18.18	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
18.18	Consensus	hcar_off	Orthosteric Ligand	succinate_off
18.18	Consensus	histamine_on	Orthosteric Ligand	h1_on h4_on
18.18	Consensus	m2_on_allo	Orthosteric Ligand	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
18.18	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
18.18	Consensus	succinate_off	Orthosteric Ligand	6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
17.86	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
17.86	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
17.86	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
17.86	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
17.86	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
17.86	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
17.86	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
17.86	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
17.86	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
17.86	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
17.65	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
17.65	Single	7XKE	Betahydroxyandrosterone	7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
17.65	Single	8GEJ	Epinephrine	8GEJ-β₂-Epinephrine-Gs/&β;1/&γ;2
17.65	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
17.65	Consensus	gs_crf	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
17.39	Single	2RH1	(S)-Carazolol	2RH1-β₂-(S)-Carazolol
17.39	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
17.39	Single	2YCW	(S)-Carazolol	2YCW-β₁-(S)-Carazolol
17.39	Single	4PHU	Fasiglifam	4PHU-FFA1 (GPR40)-Fasiglifam
17.39	Single	4WW3	All-trans-retinal	4WW3-Rhodopsin-All-trans-retinal
17.39	Single	5CGC	HTL14242	5CGC-mGlu₅-HTL14242
17.39	Single	5D6L	(S)-Carazolol	5D6L-β₂-(S)-Carazolol
17.39	Single	5NM2	ZM241385	5NM2-A_2A-ZM241385-Na
17.39	Single	5ZK3	Quinuclidinyl benzilate hydrobromide	5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
17.39	Single	6E67	BI167107	6E67-β₂-BI167107-Gs (fused)
17.39	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
17.39	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
17.39	Single	6PS3	(S)-Carvedilol	6PS3-β₂-(S)-Carvedilol
17.39	Single	6PS6	Timolol	6PS6-β₂-Timolol
17.39	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
17.39	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
17.39	Single	7BVQ	(S)-Carazolol	7BVQ-β₁-(S)-Carazolol
17.39	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
17.39	Single	7C4S	S1P	7C4S-S1P₃-S1P
17.39	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/&β;1/&γ;2
17.39	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
17.39	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2
17.39	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
17.39	Single	7XKA	Epinephrine	7XKA-β₂-Epinephrine
17.39	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
17.39	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
17.39	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
17.39	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
17.39	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
17.39	Single	8QOT	Nanobody E	8QOT-μ-Nanobody E
17.39	Single	8UNY	Epinephrine	8UNY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
17.39	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
17.39	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
17.39	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide 6DRX-5-HT_2B-Lisuride
17.39	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
17.39	Consensus	a2a_on	Orthosteric Ligand	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
17.39	Consensus	alpha2a_on	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
17.39	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
17.39	Consensus	amine_off	Orthosteric Ligand	adrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
17.39	Consensus	beta2_off	Orthosteric Ligand	6PS2-β₂-(S)-Alprenolol 6PS3-β₂-(S)-Carvedilol 6PS5-β₂-(S)-Propranolol 6PS6-β₂-Timolol 2RH1-β₂-(S)-Carazolol 6PS4-β₂-ICI 118-551 3NY9-β₂-PubChem 913103
17.39	Consensus	beta2_on	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2
17.39	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
17.39	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
17.39	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
17.39	Consensus	gi_adrenergic	Orthosteric Ligand	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
17.39	Consensus	go_amine	Orthosteric Ligand	go_adrenergic go_muscarinic go_5ht
17.39	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
17.39	Consensus	gs_muscarinic	Orthosteric Ligand	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
17.39	Consensus	m2_off	Orthosteric Ligand	5ZKB-M₂-AF-DX 384 5ZKC-M₂-N-Methyl Scopolamine 5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
17.39	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
17.24	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
17.24	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
17.24	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
17.24	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
17.24	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
17.24	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
17.24	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
17.24	Consensus	gi_chemerin	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
17.24	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.24	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.14	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
17.14	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
17.14	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
16.67	Single	2HPY	All-trans-retinal	2HPY-Rhodopsin-All-trans-retinal
16.67	Single	3P0G	BI167107	3P0G-β₂-BI167107
16.67	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
16.67	Single	3UON	Quinuclidinyl benzilate hydrobromide	3UON-M₂-Quinuclidinyl benzilate hydrobromide
16.67	Single	4OO9	Mavoglurant	4OO9-mGlu₅-Mavoglurant
16.67	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
16.67	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
16.67	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
16.67	Single	5D5A	(S)-Carazolol	5D5A-β₂-(S)-Carazolol
16.67	Single	5D5B	(S)-Carazolol	5D5B-β₂-(S)-Carazolol
16.67	Single	5TZR	-	5TZR-FFA1 (GPR40)-MK8666
16.67	Single	5X93	K-8794	5X93-ET_B-K-8794
16.67	Single	5XRA	AM11542	5XRA-CB₁-AM11542
16.67	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
16.67	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
16.67	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
16.67	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
16.67	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
16.67	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
16.67	Single	6OS1	TRV026	6OS1-AT₁-TRV026
16.67	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2
16.67	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
16.67	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
16.67	Single	7FEE	PubMed 104895	7FEE-CB₁-PubMed 104895-ZCZ011
16.67	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
16.67	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2
16.67	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/&β;1/&γ;2
16.67	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/&β;1/&γ;2
16.67	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
16.67	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
16.67	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
16.67	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
16.67	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
16.67	Single	7W6P	W96	7W6P-α_2a-W96-Go/&β;1/&γ;2
16.67	Single	7W7E	W58	7W7E-α_2a-W58-Go/&β;1/&γ;2
16.67	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
16.67	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
16.67	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2
16.67	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
16.67	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
16.67	Single	8JD0	J9R	8JD0-mGlu2; mGlu3-Glutamate-J9R
16.67	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
16.67	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
16.67	Single	8WC5	Tetramethylammonium ion	8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
16.67	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
16.67	Consensus	5ht5_off	Orthosteric Ligand	5ht5a_off
16.67	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht5_off 5ht1_off
16.67	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
16.67	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
16.67	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCZ-β₁-Iodocyanopindolol
16.67	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
16.67	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
16.67	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
16.67	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
16.67	Consensus	gi_dopamine	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
16.67	Consensus	gi_ffa	Orthosteric Ligand	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
16.67	Consensus	go_adrenergic	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
16.67	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A_2A-NECA-Gs/&β;1/&γ;1 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
16.67	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
16.67	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
16.67	Consensus	h1_off	Orthosteric Ligand	3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole 8X63-H₁-Mepyramine 8X64-H₁-Desloratadine
16.67	Consensus	histamine_off	Orthosteric Ligand	h1_off
16.67	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
16.67	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
16.67	Consensus	nmur2_on	Orthosteric Ligand	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
16.67	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
16.67	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
16.67	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
16.67	Consensus	s1p2_on	Orthosteric Ligand	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
16.67	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
16.67	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
16.67	Consensus	sst4_on	Orthosteric Ligand	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
16.67	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
16.22	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
16.22	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
16.22	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
16.22	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
16.22	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
16.22	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
16.13	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.13	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
16.13	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
16.13	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
16.13	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
16.13	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.13	Consensus	bombesin_on	Orthosteric Ligand	bb2_on bb1_on
16.13	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
16.13	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
16.00	Single	3D4S	Timolol Maleate	3D4S-β₂-Timolol Maleate
16.00	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
16.00	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
16.00	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
16.00	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
16.00	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
16.00	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
16.00	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
16.00	Single	6KQI	PubMed 104895	6KQI-CB₁-PubMed 104895-ORG27569
16.00	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
16.00	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
16.00	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
16.00	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
16.00	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
16.00	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
16.00	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
16.00	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
16.00	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
16.00	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
16.00	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/&β;1/&γ;2
16.00	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.00	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
16.00	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/&β;1/&γ;2
16.00	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2
16.00	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2
16.00	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2
16.00	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
16.00	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
16.00	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
16.00	Consensus	blt1_off	Orthosteric Ligand	7K15-BLT₁-MKD046-Na
16.00	Consensus	blt_off	Orthosteric Ligand	blt1_off
16.00	Consensus	cb1_off_allo	Orthosteric Ligand	6KQI-CB₁-PubMed 104895-ORG27569
16.00	Consensus	gi_class-f	Other Ligand	gi_frizzled
16.00	Consensus	gi_frizzled	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
16.00	Consensus	go_5ht	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
16.00	Consensus	gs_trh	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.00	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
16.00	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
16.00	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
16.00	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.79	Single	3C9M	11-cis-Retinal	3C9M-Rhodopsin-11-cis-Retinal
15.79	Single	3OE6	IT1t	3OE6-CXCR4-IT1t
15.79	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
15.79	Single	6FUF	All-trans-retinal	6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
15.79	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
15.79	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
15.79	Single	6ME9	Ramelteon	6ME9-MT₂-Ramelteon
15.79	Single	7F61	Cholesterol	7F61-H₃-PF-03654746-Cholesterol
15.79	Single	7MT8	All-trans-retinal	7MT8-Rhodopsin-All-trans-retinal-GRK1
15.79	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
15.79	Single	8DPI	Lorcaserin	8DPI-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79	Single	8EIT	Doconexent	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.79	Single	8GGR	Epinephrine	8GGR-β₂-Epinephrine
15.79	Single	8GGZ	Epinephrine	8GGZ-β₂-Epinephrine
15.79	Single	8IU2	Retinal	8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
15.79	Single	8JXT	Histamine	8JXT-H₄-Histamine-PO4-Gi1/&β;1/&γ;2
15.79	Single	8POK	Histamine	8POK-H₂-Histamine-Gs/&β;1/&γ;2
15.79	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
15.79	Consensus	h3_on_allo	Other Ligand	7F61-H₃-PF-03654746-Cholesterol
15.79	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
15.62	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
15.62	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.62	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
15.62	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
15.62	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
15.62	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
15.62	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
15.62	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.62	Consensus	bb1_on	Orthosteric Ligand	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.62	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
15.62	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
15.62	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
15.62	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
15.38	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
15.38	Single	5CGD	HTL14242	5CGD-mGlu₅-HTL14242
15.38	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
15.38	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
15.38	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/&β;1/&γ;2
15.38	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
15.38	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
15.38	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
15.38	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2
15.38	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
15.38	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
15.38	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
15.38	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38	Consensus	5ht5a_off	Orthosteric Ligand	7UM4-5-HT_5A-AS2674723
15.38	Consensus	cckb_on	Orthosteric Ligand	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
15.38	Consensus	ffa4_on_allo	Orthosteric Ligand	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38	Consensus	gs_orexin	Orthosteric Ligand	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.38	Consensus	orexin_on	Orthosteric Ligand	ox2_on
15.15	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
15.15	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
15.15	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
15.15	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
15.15	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
15.15	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
15.15	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
15.15	Consensus	etb_on	Orthosteric Ligand	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
15.15	Consensus	go_class-b1	Orthosteric Ligand	go_crf
15.15	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
15.15	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.00	Single	1L9H	11-cis-Retinal	1L9H-Rhodopsin-11-cis-Retinal
15.00	Single	1U19	11-cis-Retinal	1U19-Rhodopsin-11-cis-Retinal
15.00	Single	2G87	All-trans-retinal	2G87-Rhodopsin-All-trans-retinal
15.00	Single	2I35	11-cis-Retinal	2I35-Rhodopsin-11-cis-Retinal
15.00	Single	3OE9	IT1t	3OE9-CXCR4-IT1t
15.00	Single	3PBL	Eticlopride	3PBL-D₃-Eticlopride
15.00	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
15.00	Single	6TQ4	PubChem 16046844	6TQ4-OX₁-PubChem 16046844-Na
15.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
15.00	Single	7E2Y	Serotonin	7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2
15.00	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
15.00	Single	7SRQ	LSD	7SRQ-5-HT_2B-LSD
15.00	Single	7V68	Iperoxo	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
15.00	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
15.00	Single	7XKF	Betahydroxyandrosterone	7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
15.00	Single	7XTB	Serotonin	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2
15.00	Single	7YFC	Histamine	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00	Single	7YS6	Serotonin	7YS6-5-HT₆-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
15.00	Single	8DPF	Lorcaserin	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/&β;1/&γ;2
15.00	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
15.00	Single	8GGS	Epinephrine	8GGS-β₂-Epinephrine
15.00	Single	8GGY	Epinephrine	8GGY-β₂-Epinephrine
15.00	Single	8GH1	Epinephrine	8GH1-β₂-Epinephrine
15.00	Single	8ITF	DMCHA	8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
15.00	Single	8UNV	Epinephrine	8UNV-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00	Single	8UNX	Epinephrine	8UNX-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00	Consensus	5ht4_on	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
15.00	Consensus	d3_off	Orthosteric Ligand	3PBL-D₃-Eticlopride
15.00	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
15.00	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.00	Consensus	ox1_off_allo	Orthosteric Ligand	6TOD-OX₁-EMPA-Na 6TOS-OX₁-GSK1059865-Na 6TQ4-OX₁-PubChem 16046844-Na 6TO7-OX₁-Suvorexant-Na
14.81	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
14.81	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
14.81	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
14.81	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
14.81	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
14.81	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
14.81	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
14.81	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
14.81	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
14.81	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
14.81	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.71	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.71	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
14.71	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
14.71	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
14.71	Consensus	gs_endothelin	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.71	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
14.63	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
14.29	Single	1GZM	11-cis-Retinal	1GZM-Rhodopsin-11-cis-Retinal
14.29	Single	2PED	9-cis-Retinal	2PED-Rhodopsin-9-cis-Retinal
14.29	Single	2X72	All-trans-retinal	2X72-Rhodopsin-All-trans-retinal-Gt(CT)
14.29	Single	3C9L	11-cis-Retinal	3C9L-Rhodopsin-11-cis-Retinal
14.29	Single	3ODU	IT1t	3ODU-CXCR4-IT1t
14.29	Single	3PWH	ZM241385	3PWH-A_2A-ZM241385
14.29	Single	3VGA	ZM241385	3VGA-A_2A-ZM241385-Antibody
14.29	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
14.29	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
14.29	Single	6KUX	RS-79948	6KUX-α_2a-RS-79948
14.29	Single	6OBA	(S)-Alprenolol	6OBA-β₂-(S)-Alprenolol-GTPL11074
14.29	Single	6OYA	All-trans-retinal	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
14.29	Single	6RNK	NF-56-EJ40	6RNK-Succinate-NF-56-EJ40
14.29	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
14.29	Single	6TQ6	PubChem 145714283	6TQ6-OX₁-PubChem 145714283
14.29	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
14.29	Single	7DHR	Isoprenaline	7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2
14.29	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
14.29	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
14.29	Single	7LJD	Dopamine	7LJD-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;1
14.29	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
14.29	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
14.29	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
14.29	Single	7SRR	LSD	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29	Single	7T94	PubChem 57664406	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
14.29	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
14.29	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
14.29	Single	7TUZ	7alpha,25-dihydroxycholesterol	7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
14.29	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
14.29	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
14.29	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
14.29	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29	Single	7X2F	Dopamine	7X2F-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
14.29	Single	7X5H	5-CT	7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2
14.29	Single	7XRR	Lemborexant	7XRR-OX₂-Lemborexant
14.29	Single	8A6C	All-trans-retinal	8A6C-Rhodopsin-All-trans-retinal
14.29	Single	8A6D	All-trans-retinal	8A6D-Rhodopsin-All-trans-retinal
14.29	Single	8A6E	All-trans-retinal	8A6E-Rhodopsin-All-trans-retinal
14.29	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
14.29	Single	8GEA	Epinephrine	8GEA-β₂-Epinephrine-Gs/&β;1/&γ;2
14.29	Single	8GG7	Epinephrine	8GG7-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29	Single	8GG9	Epinephrine	8GG9-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29	Single	8GGF	Epinephrine	8GGF-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
14.29	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29	Single	8U4P	AMD3100	8U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
14.29	Single	8UNO	Epinephrine	8UNO-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29	Single	8UNW	Epinephrine	8UNW-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29	Consensus	5ht2c_on	Orthosteric Ligand	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29	Consensus	5ht_on	Orthosteric Ligand	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
14.29	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
14.29	Consensus	alpha2_off	Orthosteric Ligand	alpha2a_off alpha2c_off
14.29	Consensus	alpha2a_off	Orthosteric Ligand	6KUX-α_2a-RS-79948
14.29	Consensus	beta2_off_allo	Orthosteric Ligand	6OBA-β₂-(S)-Alprenolol-GTPL11074
14.29	Consensus	fpr-alx_on	Orthosteric Ligand	fpr1-alx_on fpr2-alx_on
14.29	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
14.29	Consensus	gs_5ht	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29	Consensus	gt_class-a	Orthosteric Ligand	gt_opsin
14.29	Consensus	gt_opsin	Orthosteric Ligand	gt_sensory
14.29	Consensus	gt_sensory	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
14.29	Consensus	melatonin_on	Orthosteric Ligand	mt1_on mt2_on
14.29	Consensus	nmur1_on	Orthosteric Ligand	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
14.29	Consensus	opsin_off	Orthosteric Ligand	1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
14.29	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
14.29	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
13.89	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
13.89	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
13.89	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
13.89	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
13.79	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
13.79	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
13.79	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.79	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off alpha1b_off
13.64	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
13.64	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
13.64	Single	3UZC	PubChem 135566609	3UZC-A_2A-PubChem 135566609
13.64	Single	4MQT	Iperoxo	4MQT-M₂-Iperoxo-LY2119620
13.64	Single	5IU4	ZM241385	5IU4-A_2A-ZM241385-Na
13.64	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
13.64	Single	5K2C	ZM241385	5K2C-A_2A-ZM241385-Na
13.64	Single	5NM4	ZM241385	5NM4-A_2A-ZM241385-Na
13.64	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
13.64	Single	6AQF	ZM241385	6AQF-A_2A-ZM241385
13.64	Single	6FFI	MMPEP	6FFI-mGlu₅-MMPEP
13.64	Single	6PS5	(S)-Propranolol	6PS5-β₂-(S)-Propranolol
13.64	Single	6WJC	Atropine	6WJC-M₁-Atropine-Muscarinic toxin 7
13.64	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
13.64	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.64	Single	7S8P	MS47134	7S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64	Single	7T32	ZM241385	7T32-A_2A-ZM241385
13.64	Single	7TRQ	VU0467154	7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
13.64	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
13.64	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
13.64	Single	8DWG	ML382	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64	Single	8FCZ	11-cis-Retinal	8FCZ-Rhodopsin-11-cis-Retinal
13.64	Single	8GDZ	Epinephrine	8GDZ-β₂-Epinephrine-Gs/&β;1/&γ;2
13.64	Single	8GG3	Epinephrine	8GG3-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
13.64	Single	8GG5	Epinephrine	8GG5-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
13.64	Single	8GG8	Epinephrine	8GG8-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
13.64	Single	8GGK	Epinephrine	8GGK-β₂-Epinephrine
13.64	Single	8GGL	Epinephrine	8GGL-β₂-Epinephrine
13.64	Single	8GGM	Epinephrine	8GGM-β₂-Epinephrine
13.64	Single	8GGP	Epinephrine	8GGP-β₂-Epinephrine
13.64	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64	Single	8JSP	Ulotaront	8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2
13.64	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/&β;1/&γ;2
13.64	Single	8T3V	DHA	8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64	Single	8UNR	Epinephrine	8UNR-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
13.64	Single	8UNS	Epinephrine	8UNS-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
13.64	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6WH4-5-HT_2A-Methiothepin 7VOE-5-HT_2A-Aripiprazole 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 6A93-5-HT_2A-Risperidone
13.64	Consensus	5ht5_on	Orthosteric Ligand	5ht5a_on
13.64	Consensus	5ht5a_on	Orthosteric Ligand	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
13.64	Consensus	ffa2_on	Orthosteric Ligand	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
13.64	Consensus	gi_melatonin	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
13.64	Consensus	m1_off_allo	Orthosteric Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
13.64	Consensus	m1_off_allo	Other Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
13.51	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
13.51	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.33	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
13.33	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;2
13.33	Consensus	gi_formylpeptide	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
13.33	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.33	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
13.04	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
13.04	Single	2VT4	Cyanopindolol	2VT4-β₁-Cyanopindolol
13.04	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
13.04	Single	3ZPQ	4-(piperazin-1- yl)-1H-indole	3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na
13.04	Single	3ZPR	4-methyl-2-(piperazin-1-yl)	3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
13.04	Single	4DAJ	Tiotropium	4DAJ-M₃-Tiotropium
13.04	Single	4EIY	ZM241385	4EIY-A_2A-ZM241385-Na
13.04	Single	4MQS	Iperoxo	4MQS-M₂-Iperoxo
13.04	Single	4U14	Tiotropium	4U14-M₃-Tiotropium
13.04	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
13.04	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
13.04	Single	5OLG	ZM241385	5OLG-A_2A-ZM241385-Na
13.04	Single	5UIG	J3.651.884G	5UIG-A_2A-J3.651.884G
13.04	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
13.04	Single	6FFH	Fenobam	6FFH-mGlu₅-Fenobam
13.04	Single	6LPJ	ZM241385	6LPJ-A_2A-ZM241385-Na
13.04	Single	6LPK	ZM241385	6LPK-A_2A-ZM241385-Na
13.04	Single	6ORV	TT-OAD2	6ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
13.04	Single	6PRZ	(S)-Alprenolol	6PRZ-β₂-(S)-Alprenolol
13.04	Single	6PS2	(S)-Alprenolol	6PS2-β₂-(S)-Alprenolol
13.04	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
13.04	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
13.04	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
13.04	Single	7TRP	Iperoxo	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
13.04	Single	7UM6	Lisuride	7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
13.04	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
13.04	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
13.04	Single	7WC7	Lisuride	7WC7-5-HT_2A-Lisuride
13.04	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
13.04	Single	7XJH	Isoproterenol	7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
13.04	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
13.04	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
13.04	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
13.04	Single	8GGB	Epinephrine	8GGB-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
13.04	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
13.04	Single	8UNM	Epinephrine	8UNM-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
13.04	Consensus	a2_off	Orthosteric Ligand	a2a_off
13.04	Consensus	a2a_off	Orthosteric Ligand	8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 5UIG-A_2A-J3.651.884G 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-PubChem 168451710 5K2D-A_2A-ZM241385
13.04	Consensus	cck_off	Orthosteric Ligand	ccka_off
13.04	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
13.04	Consensus	ffa1_on	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
13.04	Consensus	m4_on_allo	Orthosteric Ligand	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
13.04	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
12.90	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.90	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.90	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
12.90	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.90	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
12.90	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
12.90	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
12.90	Consensus	nmur_on	Orthosteric Ligand	nmur1_on nmur2_on
12.90	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.82	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
12.82	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
12.50	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
12.50	Single	5N2R	PubChem 92460631; psb36	5N2R-A_2A-PubChem 92460631; psb36-Na
12.50	Single	5N2S	PSB36	5N2S-A₁-PSB36
12.50	Single	5TVN	LSD	5TVN-5-HT_2B-LSD
12.50	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
12.50	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/&β;1/&γ;2
12.50	Single	6LPL	ZM241385	6LPL-A_2A-ZM241385-Na
12.50	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
12.50	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
12.50	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
12.50	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
12.50	Single	6S0Q	ZM241385	6S0Q-A_2A-ZM241385
12.50	Single	6WQA	ZM241385	6WQA-A_2A-ZM241385-Na
12.50	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
12.50	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.50	Single	7RM5	ZM241385	7RM5-A_2A-ZM241385-Na
12.50	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
12.50	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
12.50	Single	7TRK	Iperoxo	7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2
12.50	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
12.50	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
12.50	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
12.50	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
12.50	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
12.50	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
12.50	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50	Single	7Y27	Somatostatin-14	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
12.50	Single	8FYN	ZM241385	8FYN-A_2A-ZM241385-Na
12.50	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
12.50	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
12.50	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
12.50	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
12.50	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
12.50	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50	Consensus	gs_neuromedin	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50	Consensus	gs_sst	Orthosteric Ligand	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.12	Single	6FJ3	PTH	6FJ3-PTH1-PTH
12.12	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.12	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
12.12	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
12.12	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.00	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/&β;1/&γ;2
12.00	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
12.00	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
12.00	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
12.00	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
12.00	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/&β;1/&γ;2
12.00	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
12.00	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
12.00	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
12.00	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2
12.00	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
12.00	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
12.00	Single	7P2L	4YI	7P2L-mGlu₅-4YI
12.00	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
12.00	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2
12.00	Single	7W41	PD176252	7W41-BB₂-PD176252
12.00	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
12.00	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
12.00	Single	7XOX	Cholecystokinin-8	7XOX-CCK_B-Cholecystokinin-8-Gq/&β;1/&γ;2
12.00	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2
12.00	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
12.00	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
12.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
12.00	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
12.00	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
12.00	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
12.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
12.00	Consensus	alpha1b_off	Orthosteric Ligand	7B6W-α_1b-Cyclazosin
12.00	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
12.00	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
12.00	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
12.00	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
12.00	Consensus	cyslt1_off_ortoallo	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
12.00	Consensus	gi_muscarinic	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
12.00	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
12.00	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
12.00	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
12.00	Consensus	m3_off	Orthosteric Ligand	4U15-M₃-Tiotropium 4U16-M₃-N-Methyl Scopolamine 5ZHP-M₃-PubChem 134828589
12.00	Consensus	mglu2_on	Other Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
11.76	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
11.76	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
11.76	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
11.76	Single	8WCB	Cyclohexylammonium ion	8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
11.76	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
11.76	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
11.76	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
11.54	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
11.54	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
11.54	Single	6OS2	TRV026	6OS2-AT₁-TRV026
11.54	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
11.54	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2
11.54	Single	8I95	EP54	8I95-C3a_B-EP54-Go/&β;1/&γ;2
11.54	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
11.54	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
11.54	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
11.54	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
11.43	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
11.43	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
11.43	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
11.43	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
11.43	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
11.43	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
11.43	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
11.43	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
11.11	Single	3PXO	All-trans-retinal	3PXO-Rhodopsin-All-trans-retinal
11.11	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
11.11	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
11.11	Single	5DYS	All-trans-retinal	5DYS-Rhodopsin-All-trans-retinal
11.11	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
11.11	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
11.11	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
11.11	Single	7WC4	Serotonin	7WC4-5-HT_2A-Serotonin
11.11	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
11.11	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
11.11	Consensus	adgrg2_on	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
11.11	Consensus	c5a1_off_ortoallo	Orthosteric Ligand	6C1Q-C5a₁-PMX53-NDT9513727 6C1R-C5a₁-PMX53-Avacopan; Na
11.11	Consensus	class-c_on	Other Ligand	gabab_on mglu_on
11.11	Consensus	cyslt2_off	Orthosteric Ligand	6RZ6-CysLT₂-ONO-2570366 6RZ9-CysLT₂-ONO-2770372 6RZ8-CysLT₂-ONO-2080365
11.11	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off
11.11	Consensus	gabab_off	Other Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
11.11	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
11.11	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
11.11	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
10.71	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
10.71	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
10.71	Single	8SAI	1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine	8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
10.71	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
10.71	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
10.71	Consensus	gs_bombesin	Orthosteric Ligand	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
10.53	Single	7MTB	All-trans-retinal	7MTB-Rhodopsin-All-trans-retinal-GRK1
10.53	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
10.53	Single	7XKD	Betahydroxyandrosterone	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
10.53	Consensus	sensory_on	Orthosteric Ligand	opsin_on
10.34	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
10.34	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
10.34	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
10.34	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
10.34	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
10.26	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
10.00	Single	3OE8	IT1t	3OE8-CXCR4-IT1t
10.00	Single	3PQR	All-trans-retinal	3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
10.00	Single	3UZA	GTPL9236	3UZA-A_2A-GTPL9236
10.00	Single	5WKT	Octyl Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
10.00	Single	6OIK	LY2119620	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
10.00	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.00	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
10.00	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
10.00	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
10.00	Single	7MT9	All-trans-retinal	7MT9-Rhodopsin-All-trans-retinal-GRK1
10.00	Single	7MTA	All-trans-retinal	7MTA-Rhodopsin-All-trans-retinal-GRK1
10.00	Single	7S8O	(R)-Zinc-3573	7S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
10.00	Single	8F76	-	8F76-OR51E2-Gs/&β;1/&γ;2
10.00	Single	8J21	Butyric acid	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
10.00	Single	8J24	Acetic acid	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
10.00	Consensus	ffa3_on	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
10.00	Consensus	opsin_on	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
10.00	Consensus	sst_off	Orthosteric Ligand	sst2_off
9.76	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
9.68	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.68	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
9.68	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
9.52	Single	3AYM	All-trans-retinal	3AYM-Rhodopsin-All-trans-retinal
9.52	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
9.52	Single	5OLV	LUAA41063	5OLV-A_2A-LUAA41063-Na
9.52	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
9.52	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
9.52	Single	6TP4	ACT-462206	6TP4-OX₁-ACT-462206
9.52	Single	6U1N	LY2119620	6U1N-M₂-LY2119620-Arrestin2
9.52	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
9.52	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
9.52	Single	7S8N	(R)-Zinc-3573	7S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52	Single	7TRP	LY2033298	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
9.52	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
9.52	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
9.52	Consensus	go_adhesion	Orthosteric Ligand	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
9.52	Consensus	go_class-b2	Orthosteric Ligand	go_adhesion
9.52	Consensus	mt1_on	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
9.52	Consensus	mt2_on	Orthosteric Ligand	7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
9.38	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
9.38	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
9.38	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
9.38	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
9.09	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
9.09	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
9.09	Single	3VG9	ZM241385	3VG9-A_2A-ZM241385-Antibody
9.09	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
9.09	Single	5K2D	ZM241385	5K2D-A_2A-ZM241385
9.09	Single	5OLH	Vipadenant	5OLH-A_2A-Vipadenant-Na
9.09	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
9.09	Single	6JZH	ZM241385	6JZH-A_2A-ZM241385-Na
9.09	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.09	Single	6NWE	Octyl Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
9.09	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
9.09	Single	6PS7	ZM241385	6PS7-A_2A-ZM241385-Na
9.09	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
9.09	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
9.09	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
9.09	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
9.09	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
9.09	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09	Single	7SRS	LSD	7SRS-5-HT_2B-LSD-Arrestin2
9.09	Single	7T6S	PubChem 24776341	7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
9.09	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
9.09	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
9.09	Single	8DWH	Compound-16	8DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09	Single	8GED	Epinephrine	8GED-β₂-Epinephrine-Gs/&β;1/&γ;2
9.09	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
9.09	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09	Single	8J20	Valeric acid	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
9.09	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
9.09	Single	8UNL	Epinephrine	8UNL-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
9.09	Single	8UNT	Epinephrine	8UNT-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
9.09	Single	8UNU	Epinephrine	8UNU-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
9.09	Single	8UO1	Epinephrine	8UO1-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
9.09	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.09	Consensus	a2a_off_allo	Orthosteric Ligand	6ZDR-A_2A-HMS1413f12-Na 6GT3-A_2A-Imaradenant-Na 8CU7-A_2A-LJ-4517-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PubChem 92460631; psb36-Na 5MZJ-A_2A-Theophylline-Na 5OLO-A_2A-Tozadenant-Na 5OLH-A_2A-Vipadenant-Na 5NM4-A_2A-ZM241385-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5MZP-A_2A-Caffeine-Na 8CIC-A_2A-Etrumadenant-Na
9.09	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09	Consensus	ffa3_on_allo	Orthosteric Ligand	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
9.09	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
9.09	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
9.09	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
9.09	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Consensus	m2_on_allo	Other Ligand	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
8.82	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
8.82	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
8.82	Consensus	ghrh_on	Orthosteric Ligand	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
8.70	Single	3REY	PubChem 5697	3REY-A_2A-PubChem 5697
8.70	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
8.70	Single	5JTB	ZM241385	5JTB-A_2A-ZM241385
8.70	Single	5NLX	ZM241385	5NLX-A_2A-ZM241385-Na
8.70	Single	5TE3	Octyl Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
8.70	Single	5UVI	ZM241385	5UVI-A_2A-ZM241385
8.70	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
8.70	Single	6MH8	ZM241385	6MH8-A_2A-ZM241385
8.70	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
8.70	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.70	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
8.70	Single	6ZDV	PubChem 984073	6ZDV-A_2A-PubChem 984073-Na
8.70	Single	7BB6	Acyclovir triphosphate	7BB6-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.70	Single	7EJ8	Brimonidine	7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2
8.70	Single	7EJA	Dexmedetomidine	7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
8.70	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
8.70	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
8.70	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/&β;1/&γ;2
8.70	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
8.70	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
8.70	Single	7XJJ	Galanin	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
8.70	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
8.70	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
8.70	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
8.70	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
8.70	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
8.70	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
8.70	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.70	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
8.70	Consensus	go_galanin	Orthosteric Ligand	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
8.70	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
8.33	Single	3EML	ZM241385	3EML-A_2A-ZM241385
8.33	Single	5K2A	ZM241385	5K2A-A_2A-ZM241385-Na
8.33	Single	5VRA	ZM241385	5VRA-A_2A-ZM241385-Na
8.33	Single	6D27	CAY10471	6D27-DP₂-CAY10471
8.33	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
8.33	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
8.33	Single	6S0L	ZM241385	6S0L-A_2A-ZM241385
8.33	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
8.33	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
8.33	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
8.33	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
8.33	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
8.33	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
8.33	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
8.33	Single	7WQ3	Galanin	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
8.33	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
8.33	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
8.33	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
8.33	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
8.33	Consensus	gal1_on	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
8.33	Consensus	gi_galanin	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
8.33	Consensus	p2y12_off	Orthosteric Ligand	4NTJ-P2Y₁₂-AZD1283 7PP1-P2Y₁₂-Selatogrel
8.11	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
8.11	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
8.11	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
8.00	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
8.00	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
8.00	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
8.00	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.00	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
8.00	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
7.89	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
7.69	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
7.69	Single	7EPE	NAM563	7EPE-mGlu-NAM563
7.69	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
7.69	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2
7.69	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Consensus	gs_compl-peptide	Orthosteric Ligand	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69	Consensus	nts1_on_allo	Orthosteric Ligand	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.41	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
7.41	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
7.41	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.41	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
7.41	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
7.41	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.41	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.41	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
7.41	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/&β;1/&γ;2
7.41	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
7.41	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.41	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.41	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
7.41	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
7.41	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
7.41	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
7.41	Consensus	gpr119_on	Orthosteric Ligand	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
7.41	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.41	Consensus	nts_on	Orthosteric Ligand	nts1_on
7.41	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
7.14	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
7.14	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
7.14	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Consensus	gs_galanin	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.90	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
6.90	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
6.90	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.82	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
6.82	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
6.67	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
6.67	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
6.67	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
6.67	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
6.67	Single	8W8S	AA-14	8W8S-GPR101-AA-14
6.67	Consensus	class-c_off	Other Ligand	gabab_off mglu_off
6.45	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
6.45	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.45	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.38	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
6.25	Single	8W8R	AA-14	8W8R-GPR101-AA-14-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
5.56	Single	4A4M	All-trans-retinal	4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
5.56	Single	5EN0	All-trans-retinal	5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
5.56	Single	6W25	Ca	6W25-MC₄-SHU9119-Ca
5.56	Single	8TLM	Anti-murine CCR8 antibody	8TLM-CCR8-Anti-murine CCR8 antibody
5.56	Consensus	ccr8_off	Orthosteric Ligand	8TLM-CCR8-Anti-murine CCR8 antibody
5.41	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
5.26	Single	5MZJ	Theophylline	5MZJ-A_2A-Theophylline-Na
5.26	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
5.26	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
5.26	Single	8HQM	NPGLY	8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
5.26	Single	8PWN	Theophylline	8PWN-A_2A-Theophylline
5.26	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.00	Single	3RFM	Caffeine	3RFM-A_2A-Caffeine
5.00	Single	6OY9	All-trans-retinal	6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.00	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00	Single	7VDM	Substance P	7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
5.00	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
5.00	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.00	Single	8HVI	NOX-6-7	8HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
5.00	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
4.88	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
4.88	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
4.76	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
4.76	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
4.76	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
4.76	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
4.76	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
4.65	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.55	Single	4MQT	LY2119620	4MQT-M₂-Iperoxo-LY2119620
4.55	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
4.55	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
4.55	Single	7LD3	PubChem 25263603	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
4.55	Single	7UL2	SR48692	7UL2-NTS₁-SR48692-Na
4.55	Single	8A2P	LUAA47070	8A2P-A_2A-LUAA47070-Na
4.55	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
4.55	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
4.55	Single	8X2K	5YM	8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	a1_on_allo	Other Ligand	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
4.55	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.55	Consensus	go_protein	Orthosteric Ligand	go_chemokine
4.55	Consensus	m4_on_allo	Other Ligand	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
4.55	Consensus	nts1_off_allo	Orthosteric Ligand	7UL2-NTS₁-SR48692-Na
4.55	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.35	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
4.35	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
4.35	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.35	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
4.35	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
4.35	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
4.35	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
4.35	Single	8G94	CD69	8G94-S1P₁-CD69-Gi1/&β;1/&γ;2
4.35	Single	8U8F	PML	8U8F-GPR3-PML-Gs/&β;1/&γ;2
4.35	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.35	Consensus	smo_on_allo	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.17	Single	5K2B	ZM241385	5K2B-A_2A-ZM241385-Na
4.17	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
4.17	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
4.17	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
4.17	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
4.17	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
4.17	Single	8HJ5	PubChem 139030531	8HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Single	8IYX	YL-365	8IYX-GPR34-YL-365
4.17	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.17	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
4.00	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
4.00	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
4.00	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
4.00	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.00	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
4.00	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
4.00	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
3.85	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
3.85	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
3.85	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
3.85	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
3.85	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
3.70	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
3.70	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
3.70	Single	6Z4Q	SR142948A	6Z4Q-NTS₁-SR142948A
3.70	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
3.70	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
3.70	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
3.70	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.70	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
3.70	Consensus	cml1_on	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
3.57	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
3.57	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
3.57	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
3.57	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
3.57	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
3.57	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
3.57	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57	Consensus	nts1_off	Orthosteric Ligand	6Z4Q-NTS₁-SR142948A 6Z4S-NTS₁-SR48692
3.57	Consensus	nts_off	Orthosteric Ligand	nts1_off
3.45	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
3.45	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
3.33	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
3.23	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.12	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
3.03	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
2.63	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on

Consensus Members
	Id	Members
	gs_ffa	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2 8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
	gs_prostanoid	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2

Net Summary
I_min	2.92786
Number of Linked Nodes	933
Number of Links	1073
Number of Hubs	154
Number of Links mediated by Hubs	613
Number of Communities	24
Number of Nodes involved in Communities	186
Number of Links involved in Communities	255

Path Summary
Number Of Nodes in MetaPath	96
Number Of Links MetaPath	95
Number of Shortest Paths	4472513
Length Of Smallest Path	3
Average Path Length	43.5624
Length of Longest Path	71
Minimum Path Strength	0.3825
Average Path Strength	5.96268
Maximum Path Strength	17.9864
Minimum Path Correlation	0.700476
Average Path Correlation	0.979891
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	1.44928
Average % Of Corr. Nodes	23.7263
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	52.3492
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
	Id	Components
	gs_class-a	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gs_lipid.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.