Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x34 1.89405
21x39 6.068517
31x45 2.20875406
41x50 4.56125409
51x55 5.311254184
6I1x50 4.5475407
72x38 3.03125407
82x39 8.30375408
92x42 5.625197
102x46 6.39254179
112x50 5.4365179
122x56 5.01125417
132x64 5.67333614
14E1x50 7.5325408
15E1x52 4.76625407
16I2x51 3.9125105
174x53 3.90375408
184x61 4.703515
19E2 12.02591713
205x34 3.355401
215x39 4.781515
225x43 5.428516
235x47 9.58875418
245x54 4.156254208
255x57 6.8525407
265x58 5.836208
275x65 3.678598
28I3 5.375634
296x22 4.273533
306x26 8.79375493
316x30 4.92929797
326x44 9.3325409
336x47 2.78125408
346x48 11.5087408
356x52 9.1417
366x54 3.5925405
376x55 8.2625415
386x59 4.17375414
39E3 9.521113
407x30 4.64875414
417x31 7.5675414
427x40 3.8375408
437x42 4.77375417
447x56 4.29875407
458x53 3.995406
468x54 6.12875407
478x57 6.513754185
48Lig 10.89721810
49G.HN.43 3.87875409
50G.HN.51 6.643754134
51G.S1.06 5.05625408
52G.S3.03 5.88167608
53G.s3h2.03 7.199549
54G.H2.04 5.37449
55G.H2.06 6.620836149
56G.H2.07 6.955549
57G.h2s4.02 5.36875458
58G.S4.02 5.73448
59G.S4.04 5.849549
60G.S4.06 4.805547
61G.S4.07 7.69625438
62G.s4h3.02 3.56125439
63G.s4h3.03 5.21438
64G.s4h3.04 6.79875408
65G.H3.01 8.78125409
66G.H3.08 5.78625448
67G.H3.09 7.46625409
68G.H3.13 10.5025406
69G.H3.17 9.826555
70G.S5.04 7.73875449
71G.S5.05 5.1625439
72G.S5.06 5.568548
73G.S5.07 4.015539
74G.s5hg.01 6.38125439
75G.hgh4.02 4.24625408
76G.hgh4.08 6.77125436
77G.hgh4.11 2.17875405
78G.H4.10 7.81407
79G.H4.12 4.739534
80G.H4.13 6.02875433
81G.H4.15 10.2175448
82G.S6.02 5.881538
83G.S6.03 4.37125435
84G.H5.03 6.34875439
85G.H5.08 7.621254108
86G.H5.15 3.488336108
87b.1x3 5.17401
88b.1x15 3.4125407
89b.h2x1 4.00625405
90b.h2x4 2.21125403
91b.b1x3 6.91407
92b.l1x3 7.997147119
93b.l1x6 9.1025459
94b.b2x1 8.31458
95b.b2x5 8.6555237
96b.l3x2 6.593754139
97b.b4x3 4.75754157
98b.b4x6 8.969176119
99b.b5x2 4.10625407
100b.b5x3 8.85375409
101b.b5x5 5.784215
102b.b5x7 7.256254157
103b.l5x1 5.99754158
104b.l5x5 9.315509
105b.b6x1 4.611559
106b.b6x5 5.08125406
107b.l7x3 4.695409
108b.b8x4 5.5056156
109b.l8x5 4.685403
110b.b9x4 8.03479
111b.l9x3 7.334579
112b.l9x6 6.57508
113b.b10x4 4.33125406
114b.b10x5 4.966509
115b.b11x4 4.15625479
116b.l11x2 5.922579
117b.b12x6 11.228578
118b.b13x3 7.24125474
119b.b13x7 6.9865167
120b.l13x6 6.33625409
121b.b16x4 8.2745166
122b.b16x6 9.8056168
123b.b17x5 7.149527
124b.b17x7 7.647528
125b.l17x3 6.10643729
126b.l17x6 7.045149
127b.b18x3 4.96375428
128b.b18x5 3.77833625
129b.l18x1 6.229297126
130b.b19x2 6.795626
131b.b19x4 5.6875428
132b.b19x6 5.415429
133b.l19x2 8.19429
134b.b20x4 9.23875428
135b.b20x6 7.22833626
136b.b20x7 6.02375409
137b.b21x7 5.82765
138b.l21x5 3.3464
139b.b22x5 8.28875407
140b.l22x5 5.9985229
141b.b23x6 7.49333667
142b.l23x1 6.654556
143b.l23x2 6.115468
144b.b24x4 8.08875466
145b.b24x6 7.8375468
146b.b25x3 6.05125465
147b.l25x3 7.174589
148b.l25x6 13.856558
149b.l28x1 10.2658659
150b.l28x2 9.99375489
151b.b28x3 4.798754117
152b.b28x6 7.04357789
153g.h2x11 11.00634126
154g.ctx3 5.3925259
155g.ctx6 3.628506
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
16x52 Lig 46.03975.09YesYes170
26x48 6x52 52.77887.935YesYes087
36x44 6x48 57.342318.04YesYes098
45x54 6x44 74.42364.395YesYes089
55x54 5x58 74.77953.025YesYes2088
65x58 6x40 41.76553.61YesNo087
76x36 6x40 42.07915.105NoNo087
86x36 7x56 42.39276.52NoYes087
97x56 8x47 18.26283.755YesNo078
108x47 G.H5.24 18.07254.47NoNo086
112x40 G.H5.24 10.07073.405NoNo086
128x53 I1x50 10.95046.565YesYes067
133x43 6x44 17.77868.195NoYes099
142x46 3x43 11.35345.32YesNo1799
153x50 5x58 39.39826.175NoYes098
163x50 G.H5.25 39.66966.68NoNo098
17G.H5.20 G.H5.25 39.81584.155NoNo088
183x54 G.H5.20 40.28622.85NoNo088
193x54 5x65 40.41592.85NoYes988
205x65 6x30 97.0226.075YesYes987
21G.S5.03 G.S6.02 10.09076.645NoYes398
22G.S5.03 G.S5.05 10.01233.14NoYes399
236x33 7x56 55.99224.845NoYes087
245x65 6x33 56.12793.46YesNo088
256x27 6x30 91.6533.1NoYes047
266x23 6x27 92.27725.3NoNo034
276x23 I3 47.55698.76NoYes334
28G.S6.03 I3 44.92844.775YesYes354
29G.S6.01 G.S6.03 95.97013.765NoYes055
30G.S6.01 G.h4s6.02 95.89996.025NoNo057
31G.H3.09 G.h4s6.02 95.31614.62YesNo097
32G.H3.09 G.S4.04 93.356310.18YesYes099
33G.H3.08 G.S4.04 1007.765YesYes489
34G.H2.04 G.H3.08 99.65948.935YesYes498
35G.H2.04 G.H2.07 98.56824.5YesYes499
36G.H2.07 G.h2s4.01 23.10354.51YesNo099
37G.h2s4.01 b.l5x5 23.50869.02NoYes099
38G.S1.03 b.l5x5 28.0735NoYes099
39G.S1.03 G.hns1.01 27.822814.4NoNo094
40G.hns1.01 b.l1x4 21.26768.79NoNo1346
41G.HN.51 b.l1x4 21.23689.87YesNo1346
426x22 6x23 44.82363.425YesNo333
436x22 G.S6.03 50.39535.34YesYes335
44G.HN.48 G.HN.51 19.95954.07NoYes044
45G.HN.44 G.HN.48 19.18994.46NoNo064
46G.HN.44 b.b5x3 18.93168.775NoYes069
47G.H2.07 G.s3h2.03 37.64129.855YesYes499
48G.s3h2.03 b.l7x4 42.09643.3YesNo499
49G.H2.07 b.l9x6 44.51539.165YesYes098
50b.b6x1 b.l9x6 40.97665.39YesYes098
51b.b2x1 b.b6x1 46.82676.585YesYes589
52b.b2x1 b.l28x1 50.23364.825YesYes589
53b.l25x6 b.l28x1 26.753813.995YesYes589
54b.l3x1 b.l5x5 10.02669.31NoYes099
55b.l23x1 b.l25x6 25.934717.27YesYes568
56b.l7x4 b.l9x5 41.9554.24NoNo098
57b.l11x2 b.l9x5 41.7672.515YesNo098
58b.l11x2 b.l9x3 31.3393.15YesYes799
59b.b11x4 b.l9x3 29.32023.425YesYes799
60b.b10x3 b.b11x4 28.12555.915NoYes089
61b.b10x3 b.b6x2 27.93043.38NoNo088
62b.b10x2 b.b6x2 27.73532.535NoNo068
63b.b10x2 b.b10x4 26.84213.48NoYes066
64b.b10x4 b.b14x4 25.39333.955YesNo068
65b.b14x4 b.b18x5 25.18553.3NoYes085
66b.b18x5 b.b19x2 12.62543.215YesYes256
67b.1x19 b.b21x1 13.881915.485NoNo067
68b.1x15 b.1x19 13.43676.89YesNo076
69b.1x15 g.h1x11 10.31342.14YesNo079
70b.b18x5 b.l20x1 10.63523.045YesNo256
71b.l25x5 b.l28x1 26.13297.91NoYes079
72b.b24x1 b.l25x5 25.92590.605NoNo047
73b.b24x1 b.b24x2 25.7190.605NoNo045
74b.b24x2 b.l23x2 25.31056.73NoYes058
75b.b23x6 b.l23x2 50.36315.75YesYes678
76b.b23x6 b.b24x6 46.35046.75YesYes678
77b.b21x7 b.b24x6 45.569411.09YesYes658
78b.b21x7 b.b23x2 13.45384.69YesNo056
79b.b22x5 b.b23x2 12.071114.615YesNo076
80b.b22x5 b.l18x1 10.686310.185YesYes076
81b.l21x7 b.l23x1 27.53673.115NoYes056
82b.l21x7 b.l23x2 27.31517.78NoYes058
83b.b21x5 b.b21x7 30.32838.385NoYes645
84b.b21x5 b.h2x1 29.88397.07NoYes045
85b.h2x1 b.h2x5 25.80465.16YesNo055
86b.h2x5 b.l24x2 24.44066.635NoNo056
87b.l22x5 b.l24x2 21.67925.465YesNo2296
88b.l22x5 g.ctx6 19.42167.29YesYes096
89b.lhb1x6 g.ctx6 13.91433.725NoYes036
90b.lhb1x6 b.lhb1x9 12.99323.07NoNo033
91b.lhb1x11 b.lhb1x9 12.53222.92NoNo043
92b.b28x6 b.lhb1x11 10.2143.49YesNo894
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x532x563.9650NoYes7721
2x533x363.7250NoNo7721
2x563x326.1051YesNo7612
2x567x423.491YesYes7712
2x56Lig6.4851YesYes7010
2x602x645.751NoYes6421
2x607x3810.1251NoNo6522
2x63E1x5013.4951NoYes5812
2x63Lig11.8351NoYes5010
2x647x314.891YesYes4411
2x647x343.1451YesNo4411
2x647x355.3651YesNo4412
2x647x386.691YesNo4512
2x64Lig8.21YesYes4010
3x22E26.2551NoYes4321
3x25E24.091NoYes9321
3x283x294.2350NoNo5521
3x29Lig13.731NoYes5010
3x334x614.640NoYes4521
3x36Lig5.8751NoYes7010
4x61E2x524.721YesNo5411
4x615x386.1551YesNo5612
4x61Lig4.3051YesYes5010
E2E237.171YesYes3311
5x28E23.8751NoYes5321
E2E2x518.721YesNo3112
5x29E212.391NoYes3321
E2E322.691YesYes3311
E2Lig17.5451YesYes3010
E2E2x528.3451YesNo3411
E2x52Lig21.3551NoYes4010
5x35E27.051NoYes3321
5x38E25.991NoYes6321
5x39E26.7151YesYes5321
6x55E28.941YesYes5311
6x59E23.181YesYes4321
5x29E33.2651NoYes3321
5x396x554.271YesYes5521
5x396x593.261YesYes5422
5x435x475.6751YesYes6822
5x436x523.961YesYes6721
5x476x5219.4151YesYes8721
6x486x527.9350YesYes8721
6x517x416.8151NoNo5812
6x51Lig8.611NoYes5010
6x546x583.660YesNo5422
6x547x343.7250YesNo5421
6x556x596.9951YesYes5412
6x55Lig12.8451YesYes5010
6x576x6112.271NoNo4222
6x57E34.61NoYes4321
6x61E37.7051NoYes2321
E3E315.981YesYes3311
7x30E36.31YesYes4311
E3Lig12.451YesYes3010
7x30Lig6.9551YesYes4010
7x317x356.6751YesNo4412
7x31Lig18.0851YesYes4010
7x34Lig3.031NoYes4010
4x65Lig4.1850NoYes5010
6x52Lig5.091YesYes7010
2x607x423.5851NoYes6722
E1E25.971NoYes4321
4x615x393.6951YesYes5512
5x36E28.3451NoYes3321
5x33E38.240NoYes1321
5x36E34.871NoYes3321
5x395x435.9651YesYes5622
6x587x303.950NoYes4421
5x30E32.640NoYes3321
7x277x301.390NoYes3421
7x287x310.620NoYes3421

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
72.73Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
72.73Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
68.18Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
66.67Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
57.69Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
57.69Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
56.52Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
52.63Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
52.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
50.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
50.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
47.83Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
47.83Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
47.83Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
47.62Single4BUONeurotensin4BUO-NTS1-Neurotensin
47.62Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
47.62Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
47.62Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.62Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
45.45Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
45.45Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
45.45Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
45.45Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
45.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44Single5K2BZM2413855K2B-A2A-ZM241385-Na
44.44Single5NLXZM2413855NLX-A2A-ZM241385-Na
44.44Single5UVIZM2413855UVI-A2A-ZM241385
44.44Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
44.44Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
44.44Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
44.44Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
44.00Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
43.48Single7F8XNN90567F8X-CCKA-NN9056
43.48Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
42.86Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
42.86Single4XEENeurotensin4XEE-NTS1-Neurotensin
42.86Single4XESNeurotensin4XES-NTS1-Neurotensin
42.86Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
42.86Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
42.86Single6YVRNTS8-136YVR-NTS1-NTS8-13
42.86Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
42.86Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.86Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
42.86Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
42.86Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
42.31Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.11Single3EMLZM2413853EML-A2A-ZM241385
42.11Single5K2AZM2413855K2A-A2A-ZM241385-Na
42.11Single5VRAZM2413855VRA-A2A-ZM241385-Na
42.11Single6LPJZM2413856LPJ-A2A-ZM241385-Na
42.11Single6LPKZM2413856LPK-A2A-ZM241385-Na
42.11Single6S0LZM2413856S0L-A2A-ZM241385
40.91Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
40.91Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.74Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
40.74Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
40.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
40.00Single6LPLZM2413856LPL-A2A-ZM241385-Na
40.00Single6S0QZM2413856S0Q-A2A-ZM241385
40.00Single6WQAZM2413856WQA-A2A-ZM241385-Na
40.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
40.00Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
40.00Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
40.00Single7RM5ZM2413857RM5-A2A-ZM241385-Na
40.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
40.00Single8FYNZM2413858FYN-A2A-ZM241385-Na
40.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
40.00Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
40.00Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
40.00Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
39.13Single4UG2CGS216804UG2-A2A-CGS21680
39.13Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
39.13Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
39.13Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
39.13Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
38.89Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
38.89Single5K2DZM2413855K2D-A2A-ZM241385
38.89Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
38.89Single6JZHZM2413856JZH-A2A-ZM241385-Na
38.89Single6PS7ZM2413856PS7-A2A-ZM241385-Na
38.46Single7C61Ergotamine7C61-5-HT1B-Ergotamine
38.46Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
38.46Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
38.46Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
38.10Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
38.10Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
38.10Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
38.10Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
38.10Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
38.10Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
38.10Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
38.10Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
38.10Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.10Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.10Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.10Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
38.10Consensuscck_onOrthosteric Ligandccka_on cckb_on
38.10Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
38.10Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.10Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
37.93Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
37.50Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
37.50Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
37.50Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
37.50Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
37.50Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
37.50Consensussst_onOrthosteric Ligandsst2_on sst4_on
37.04Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
37.04Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
37.04Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
37.04Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
36.84Single3REYPubChem 56973REY-A2A-PubChem 5697
36.84Single5IU4ZM2413855IU4-A2A-ZM241385-Na
36.84Single5IU7Q274563465IU7-A2A-Q27456346-Na
36.84Single5IUBQ274563445IUB-A2A-Q27456344-Na
36.84Single5JTBZM2413855JTB-A2A-ZM241385
36.84Single5K2CZM2413855K2C-A2A-ZM241385-Na
36.84Single5NM4ZM2413855NM4-A2A-ZM241385-Na
36.84Single6TPKRetosiban6TPK-OT-Retosiban
36.84Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
36.84Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
36.84Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
36.84Consensusvasopressin-ot_offOrthosteric Ligandot_off
36.67Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
36.36Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.36Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.36Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
36.36Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
36.36Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
36.36Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
36.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
35.71Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
35.71Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
35.00Single4EIYZM2413854EIY-A2A-ZM241385-Na
35.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
35.00Single5OLGZM2413855OLG-A2A-ZM241385-Na
35.00Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
35.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
35.00Single7PYRPSB-21157PYR-A2A-PSB-2115
35.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
35.00Single8CU6LJ-45178CU6-A2A-LJ-4517
35.00Consensusa2_offOrthosteric Liganda2a_off
35.00Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
35.00Consensuscck_offOrthosteric Ligandccka_off
35.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
35.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
35.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
34.78Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
34.78Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
34.78Single7EZCUKA7EZC-A2A-UKA
34.78Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
34.78Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.78Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
34.78Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
34.78Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
34.78Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
34.78Consensusorexin_onOrthosteric Ligandox2_on
34.62Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.62Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
34.62Single7XNACYN1548067XNA-SST2-CYN154806
34.62Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
34.62Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
34.62Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.62Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
34.62Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
33.33Single5N2SPSB365N2S-A1-PSB36
33.33Single5NM2ZM2413855NM2-A2A-ZM241385-Na
33.33Single5WF6UK-4320975WF6-A2A-UK-432097
33.33Single5WQCEMPA5WQC-OX2-EMPA
33.33Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
33.33Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
33.33Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
33.33Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
33.33Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
33.33Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
33.33Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
33.33Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
33.33Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
33.33Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
33.33Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
33.33Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
33.33Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
33.33Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
33.33Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
32.26Single6IGKEndothelin-36IGK-ETB-Endothelin-3
32.14Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.14Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
32.14Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
32.14Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
32.14Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.14Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
32.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
32.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
32.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
32.00Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
32.00Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
32.00Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
32.00Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
32.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
31.82Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
31.82Single4BV0Neurotensin4BV0-NTS1-Neurotensin
31.82Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
31.82Single6J20Aprepitant6J20-NK1-Aprepitant
31.82Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
31.82Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
31.82Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
31.82Single7PX4PSB-21137PX4-A2A-PSB-2113
31.82Single7W41PD1762527W41-BB2-PD176252
31.82Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
31.82Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
31.82Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
31.82Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
31.82Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
31.82Consensusa2_onOrthosteric Liganda2a_on a2b_on
31.82Consensusadenosine_offOrthosteric Liganda1_off a2_off
31.82Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
31.82Consensusbombesin_offOrthosteric Ligandbb2_off
31.82Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
31.82Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
31.82Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
31.82Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
31.58Single3PWHZM2413853PWH-A2A-ZM241385
31.58Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
31.58Single4BWBNeurotensin4BWB-NTS1-Neurotensin
31.58Single6ME2Ramelteon6ME2-MT1-Ramelteon
31.58Single7F8ULintitript7F8U-CCKA-Lintitript
31.58Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
31.58Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
31.58Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
31.58Single8GNGIstradefylline8GNG-A2A-Istradefylline
31.58Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
31.58Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
31.25Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
31.03Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
31.03Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.03Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
30.77Single3QAKUK-4320973QAK-A2A-UK-432097
30.77Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
30.77Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
30.77Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
30.77Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
30.77Consensussst_offOrthosteric Ligandsst2_off
30.43Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.43Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.43Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
30.43Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
30.43Single8JJLOlodaterol8JJL-β2-Olodaterol
30.43Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
30.43Single8JWZAB9288JWZ-A2A-AB928-Na
30.43Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
30.43Consensusdp_offOrthosteric Liganddp2_off
30.43Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.43Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
30.43Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
30.43Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
30.43Consensusnts_offOrthosteric Ligandnts1_off
30.43Consensusnts_onOrthosteric Ligandnts1_on
30.43Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.00Single6AQFZM2413856AQF-A2A-ZM241385
30.00Single6MH8ZM2413856MH8-A2A-ZM241385
30.00Single6TPNHTL66416TPN-OX2-HTL6641
30.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
30.00Single7AROLUF58337ARO-A2A-LUF5833-Na
30.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
30.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
30.00Single7T32ZM2413857T32-A2A-ZM241385
30.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
30.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
29.63Single5WF5UK-4320975WF5-A2A-UK-432097
29.63Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
29.41Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
29.41Single8A2OTheophylline8A2O-A2A-Theophylline-Na
29.41Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
29.41Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
29.41Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
29.17Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
29.17Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
29.17Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
29.17Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
29.17Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
29.17Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
29.17Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
29.17Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
29.17Consensusendothelin_offOrthosteric Ligandetb_off
29.17Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
29.17Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
29.03Single6IGLIRL16206IGL-ETB-IRL1620
28.57Single5T04Neurotensin5T04-NTS1-Neurotensin
28.57Single6D27CAY104716D27-DP2-CAY10471
28.57Single6JODAngiotensin II6JOD-AT2-Angiotensin II
28.57Single6PS1Timolol6PS1-β2-Timolol
28.57Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
28.57Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
28.57Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
28.57Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
28.57Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
28.57Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
28.57Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
28.57Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
28.57Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
28.57Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
28.57Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
28.57Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
28.57Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
28.57Consensusadenosine_onOrthosteric Liganda1_on a2_on
28.57Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
28.57Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensusnucleotide_onOrthosteric Ligandadenosine_on
28.12Single5GLHEndothelin-15GLH-ETB-Endothelin-1
28.00Single3NY9PubChem 9131033NY9-β2-PubChem 913103
28.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
28.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.00Single7XN9L-054,5227XN9-SST2-L-054,522
28.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
28.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
28.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
28.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
28.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
28.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
28.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
28.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
27.78Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
27.59Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
27.59Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
27.59Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
27.59Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
27.59Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.59Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
27.59Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
27.27Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
27.27Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
27.27Single6D26Fevipiprant6D26-DP2-Fevipiprant
27.27Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
27.27Single6LUQHaloperidol6LUQ-D2-Haloperidol
27.27Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
27.27Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
27.27Single6Z4SSR486926Z4S-NTS1-SR48692
27.27Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
27.27Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
27.27Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
27.27Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
27.27Single7XKAEpinephrine7XKA-β2-Epinephrine
27.27Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
27.27Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
27.27Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
27.27Single8QOTNanobody E8QOT-μ-Nanobody E
27.27Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.27Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
27.27Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
27.27Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
26.92Single4IARErgotamine4IAR-5-HT1B-Ergotamine
26.92Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
26.92Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
26.92Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
26.92Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
26.92Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
26.92Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
26.92Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
26.67Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
26.67Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
26.67Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
26.32Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
26.32Single6TP4ACT-4622066TP4-OX1-ACT-462206
26.32Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
26.32Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
26.32Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
26.32Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
26.32Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
26.32Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
26.09Single2YDVNECA2YDV-A2A-NECA
26.09Single3P0GBI1671073P0G-β2-BI167107
26.09Single4RWADIPP-NH24RWA-δ-DIPP-NH2
26.09Single4UHRCGS216804UHR-A2A-CGS21680
26.09Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
26.09Single5G53NECA5G53-A2A-NECA-Gs
26.09Single6E59L-7607356E59-NK1-L-760735
26.09Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
26.09Single6H7JIsoprenaline6H7J-β1-Isoprenaline
26.09Single6J21Aprepitant6J21-NK1-Aprepitant
26.09Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
26.09Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
26.09Single6TQ7SB-3348676TQ7-OX1-SB-334867
26.09Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
26.09Single7B6WCyclazosin7B6W-α1b-Cyclazosin
26.09Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
26.09Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
26.09Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
26.09Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
26.09Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
26.09Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
26.09Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
26.09Single8E0GBU728E0G-μ-BU72
26.09Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
26.09Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
26.09Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
26.09Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
26.09Consensus5ht5_offOrthosteric Ligand5ht5a_off
26.09Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
26.09Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
26.09Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
26.09Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
26.09Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
26.09Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
26.09Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
25.93Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
25.93Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
25.93Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
25.93Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
25.93Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
25.93Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.93Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
25.93Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
25.93Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
25.81Consensusendothelin_onOrthosteric Ligandetb_on eta_on
25.81Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
25.00Single4LDEBI1671074LDE-β2-BI167107
25.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
25.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
25.00Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
25.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
25.00Single6MXTSalmeterol6MXT-β2-Salmeterol
25.00Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
25.00Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
25.00Single6OS2TRV0266OS2-AT1-TRV026
25.00Single6PT2KGCHM076PT2-δ-KGCHM07
25.00Single6TODEMPA6TOD-OX1-EMPA-Na
25.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
25.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
25.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
25.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
25.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
25.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
25.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
25.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
25.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
25.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
25.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
25.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
25.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
25.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
25.00Single7XRRLemborexant7XRR-OX2-Lemborexant
25.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
25.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
25.00Single7YITNalfurafine7YIT-κ-Nalfurafine
25.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
25.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
25.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
25.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8JJ8Formoterol8JJ8-β2-Formoterol
25.00Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
25.00Single8WU1KCA8WU1-CB1-KCA-Arrestin1
25.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
25.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
25.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
25.00Consensusangiotensin_onOrthosteric Ligandat1_on
25.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
25.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
25.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
25.00Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
25.00Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
25.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
25.00Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
25.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
25.00Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
24.14Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
24.14Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
24.14Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
24.14Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
24.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
24.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
24.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
24.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
24.00Single6H7LDobutamine6H7L-β1-Dobutamine
24.00Single6IBLArformoterol6IBL-β1-Arformoterol
24.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
24.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
24.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
24.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
24.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.00Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
24.00Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
24.00Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
24.00Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
23.81Single2YDOAdenosine2YDO-A2A-Adenosine
23.81Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
23.81Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
23.81Single4ZJCSB-6740424ZJC-OX1-SB-674042
23.81Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
23.81Single6IQLL7458706IQL-D4-L745870
23.81Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
23.81Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
23.81Single6PS4ICI 118-5516PS4-β2-ICI 118-551
23.81Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
23.81Single6TPGEMPA6TPG-OX2-EMPA
23.81Single6V9SGTPL114036V9S-OX1-GTPL11403
23.81Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
23.81Single6ZINSR486926ZIN-NTS1-SR48692
23.81Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
23.81Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
23.81Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
23.81Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
23.81Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
23.81Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
23.81Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
23.81Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
23.81Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8GGKEpinephrine8GGK-β2-Epinephrine
23.81Single8GGLEpinephrine8GGL-β2-Epinephrine
23.81Single8GGMEpinephrine8GGM-β2-Epinephrine
23.81Single8GGPEpinephrine8GGP-β2-Epinephrine
23.81Single8GGQEpinephrine8GGQ-β2-Epinephrine
23.81Single8GGTEpinephrine8GGT-β2-Epinephrine
23.81Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
23.81Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
23.81Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
23.81Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
23.81Single8K5CAcipimox8K5C-HCA2-Acipimox
23.81Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
23.81Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
23.81Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
23.81Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
23.81Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
23.81Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
23.53Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
23.53Single8PWNTheophylline8PWN-A2A-Theophylline
23.53Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
23.33Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
23.33Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
23.33Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
23.08Single5ZTYAM102575ZTY-CB2-AM10257
23.08Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.08Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
23.08Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
23.08Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
23.08Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
23.08Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
23.08Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
23.08Consensuslpl_offOrthosteric Ligands1p_off lpa_off
23.08Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
23.08Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
22.86Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
22.73Single2Y04Salbutamol2Y04-β1-Salbutamol
22.73Single3NY8ICI 118-5513NY8-β2-ICI 118-551
22.73Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
22.73Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
22.73Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
22.73Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
22.73Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
22.73Single4YAYZD-71554YAY-AT1-ZD-7155
22.73Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
22.73Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
22.73Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
22.73Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
22.73Single5UENDU1725UEN-A1-DU172
22.73Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
22.73Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
22.73Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
22.73Single6TOTLemborexant6TOT-OX1-Lemborexant
22.73Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
22.73Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
22.73Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
22.73Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
22.73Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
22.73Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
22.73Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
22.73Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
22.73Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
22.73Single7UL4Alvimopan7UL4-μ-Alvimopan
22.73Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
22.73Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
22.73Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
22.73Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
22.73Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
22.73Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
22.73Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
22.73Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
22.73Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
22.73Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
22.73Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
22.73Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8GGJEpinephrine8GGJ-β2-Epinephrine
22.73Single8GGNEpinephrine8GGN-β2-Epinephrine
22.73Single8GGOEpinephrine8GGO-β2-Epinephrine
22.73Single8GGUEpinephrine8GGU-β2-Epinephrine
22.73Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
22.73Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
22.73Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
22.73Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
22.73Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
22.73Single8JJOAlprenolol8JJO-β2-Alprenolol
22.73Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
22.73Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
22.73Single8K5DGSK2560738K5D-HCA2-GSK256073
22.73Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.73Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
22.73Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
22.73Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
22.73Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
22.73Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
22.73Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
22.73Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
22.73Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
22.73Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
22.73Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
22.73Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
22.73Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
22.73Consensusgi_hcarOrthosteric Ligandgi_hca
22.73Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
22.73Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
22.73Consensustachykinin_offOrthosteric Ligandnk1_off
22.58Single4XT3Fractalkine4XT3-US28-Fractalkine
22.58Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
22.58Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single7SK3CXCL127SK3-ACKR3-CXCL12
22.58Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
22.58Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single3RFMCaffeine3RFM-A2A-Caffeine
22.22Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
22.22Single4XT1Fractalkine4XT1-US28-Fractalkine
22.22Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
22.22Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
22.22Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
22.22Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
22.22Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
22.22Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
21.88Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
21.88Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
21.88Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
21.88Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
21.74Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
21.74Single2Y03Isoprenaline2Y03-β1-Isoprenaline
21.74Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
21.74Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
21.74Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
21.74Single5C1MBU725C1M-μ-BU72
21.74Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
21.74Single5TVNLSD5TVN-5-HT2B-LSD
21.74Single5WIUNemonapride5WIU-D4-Nemonapride
21.74Single5WIVNemonapride5WIV-D4-Nemonapride-Na
21.74Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
21.74Single5XPRBosentan5XPR-ETB-Bosentan
21.74Single6E67BI1671076E67-β2-BI167107-Gs (fused)
21.74Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
21.74Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
21.74Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
21.74Single6PS6Timolol6PS6-β2-Timolol
21.74Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
21.74Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
21.74Single6TP6Filorexant6TP6-OX1-Filorexant
21.74Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
21.74Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
21.74Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
21.74Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
21.74Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
21.74Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
21.74Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
21.74Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
21.74Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
21.74Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
21.74Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
21.74Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
21.74Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
21.74Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
21.74Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
21.74Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
21.74Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
21.74Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
21.74Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
21.74Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
21.74Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
21.74Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
21.74Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
21.74Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
21.74Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
21.74Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
21.74Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
21.74Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
21.74Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
21.74Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
21.43Single6HLOAprepitant6HLO-NK1-Aprepitant
21.43Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
21.43Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
21.43Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
21.43Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
21.43Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
21.43Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
21.21Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
21.21Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
21.21Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
21.21Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
21.21Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
21.21Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single3UZAGTPL92363UZA-A2A-GTPL9236
21.05Single4XNWMRS25004XNW-P2Y1-MRS2500
21.05Single6ME5Agomelatine6ME5-MT1-Agomelatine
21.05Single6ME9Ramelteon6ME9-MT2-Ramelteon
21.05Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
21.05Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
20.83Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
20.83Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
20.83Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
20.83Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
20.83Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
20.83Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
20.83Single5TZR-5TZR-FFA1 (GPR40)-MK8666
20.83Single5X93K-87945X93-ETB-K-8794
20.83Single5XR8AM8415XR8-CB1-AM841
20.83Single5XRAAM115425XRA-CB1-AM11542
20.83Single6WGTLSD6WGT-5-HT2A-LSD
20.83Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
20.83Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
20.83Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
20.83Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
20.83Single7TUYGSK682753A7TUY-GPR183-GSK682753A
20.83Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
20.83Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
20.83Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
20.83Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
20.83Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
20.83Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
20.83Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
20.83Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
20.83Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
20.83Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
20.83Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
20.83Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
20.83Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
20.83Consensuschemerin_onOrthosteric Ligandcml1_on
20.83Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
20.83Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.83Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
20.83Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
20.83Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
20.83Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
20.83Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.83Consensuslpa_offOrthosteric Ligandlpa1_off
20.83Consensuslpa_onOrthosteric Ligandlpa1_on
20.83Consensusrelaxin_onOrthosteric Ligandrxfp4_on
20.83Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
20.69Single3OE0CVX153OE0-CXCR4-CVX15
20.69Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.69Single6W25SHU91196W25-MC4-SHU9119-Ca
20.69Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
20.69Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
20.69Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
20.69Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
20.69Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
20.69Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
20.69Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.59Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
20.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
20.00Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
20.00Single3OE9IT1t3OE9-CXCR4-IT1t
20.00Single3PBLEticlopride3PBL-D3-Eticlopride
20.00Single4AMIBucindolol4AMI-β1-Bucindolol
20.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
20.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
20.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
20.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
20.00Single6HLLCP999946HLL-NK1-CP99994
20.00Single6HLPNetupitant6HLP-NK1-Netupitant
20.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
20.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
20.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
20.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
20.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
20.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
20.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
20.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
20.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
20.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
20.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
20.00Single7K15MKD0467K15-BLT1-MKD046-Na
20.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
20.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
20.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
20.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
20.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
20.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
20.00Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
20.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
20.00Single8GGSEpinephrine8GGS-β2-Epinephrine
20.00Single8GGYEpinephrine8GGY-β2-Epinephrine
20.00Single8GH1Epinephrine8GH1-β2-Epinephrine
20.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
20.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
20.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
20.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
20.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
20.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8K5BNiacin8K5B-HCA2-Niacin
20.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
20.00Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
20.00Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
20.00Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
20.00Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
20.00Consensusblt_offOrthosteric Ligandblt1_off
20.00Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
20.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
20.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
20.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
20.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
20.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
20.00Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
20.00Consensusgo_proteinOrthosteric Ligandgo_chemokine
20.00Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
20.00Consensusgs_steroidOrthosteric Ligandgs_bileacid
20.00Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
20.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
20.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
20.00Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
20.00Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
20.00Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
20.00Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
20.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
19.35Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
19.35Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
19.23Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
19.23Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
19.23Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
19.23Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
19.23Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
19.23Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
19.23Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
19.23Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
19.23Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
19.23Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
19.23Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
19.23Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
19.23Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
19.23Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
19.23Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
19.23Consensussteroid_onOrthosteric Ligandbileacid_on
19.05Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
19.05Single4S0VSuvorexant4S0V-OX2-Suvorexant
19.05Single5DHHSB-6121115DHH-NOP-SB-612111
19.05Single5WS3EMPA5WS3-OX2-EMPA
19.05Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
19.05Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
19.05Single6TPJSuvorexant6TPJ-OX2-Suvorexant
19.05Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
19.05Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
19.05Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
19.05Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
19.05Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
19.05Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
19.05Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
19.05Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
19.05Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
19.05Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
19.05Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
19.05Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
19.05Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
19.05Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
19.05Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
19.05Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
19.05Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
19.05Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
19.05Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GGVEpinephrine8GGV-β2-Epinephrine
19.05Single8GGXEpinephrine8GGX-β2-Epinephrine
19.05Single8GH0Epinephrine8GH0-β2-Epinephrine
19.05Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
19.05Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single8IWESpermidine8IWE-TAAR9-Spermidine
19.05Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
19.05Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
19.05Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
19.05Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
19.05Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
18.92Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
18.92Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
18.92Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
18.75Single6FJ3PTH6FJ3-PTH1-PTH
18.75Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
18.75Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
18.52Single6KNMJN241-96KNM-Apelin-JN241-9
18.52Single6PT3DPI-2876PT3-δ-DPI-287
18.52Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
18.52Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
18.52Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
18.52Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
18.52Single8X5YAstemizole8X5Y-H1-Astemizole
18.52Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
18.42Consensuspth_onOrthosteric Ligandpth1_on pth2_on
18.18Single3RZECidoxepin3RZE-H1-Cidoxepin
18.18Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
18.18Single6A94Zotepine6A94-5-HT2A-Zotepine
18.18Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
18.18Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
18.18Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
18.18Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
18.18Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
18.18Single6TP3Nemorexant6TP3-OX1-Nemorexant
18.18Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
18.18Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
18.18Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
18.18Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
18.18Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
18.18Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
18.18Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
18.18Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
18.18Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
18.18Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
18.18Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.18Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
18.18Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
18.18Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
18.18Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
18.18Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
18.18Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
18.18Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
18.18Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
18.18Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
18.18Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
18.18Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
18.18Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
18.18Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8GGIEpinephrine8GGI-β2-Epinephrine
18.18Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
18.18Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
18.18Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
18.18Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
18.18Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
18.18Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
18.18Consensus5ht5_onOrthosteric Ligand5ht5a_on
18.18Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
18.18Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
18.18Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
18.18Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
18.18Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
18.18Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
18.18Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
18.18Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
18.18Consensusgnrh_offOrthosteric Ligandgnrh1_off
18.18Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
18.18Consensushca_onOrthosteric Ligandhca2_on hca3_on
18.18Consensushcar_onOrthosteric Ligandhca_on
18.18Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
17.86Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
17.86Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
17.86Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
17.86Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
17.86Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
17.86Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
17.86Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
17.65Single5MZPCaffeine5MZP-A2A-Caffeine-Na
17.65Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.50Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
17.50Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
17.39Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
17.39Single2Y02Carmoterol2Y02-β1-Carmoterol
17.39Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
17.39Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
17.39Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
17.39Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
17.39Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
17.39Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
17.39Single6DRXLisuride6DRX-5-HT2B-Lisuride
17.39Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
17.39Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
17.39Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
17.39Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
17.39Single6H7MSalbutamol6H7M-β1-Salbutamol
17.39Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
17.39Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
17.39Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
17.39Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
17.39Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
17.39Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
17.39Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
17.39Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
17.39Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
17.39Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
17.39Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
17.39Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
17.39Single7WC7Lisuride7WC7-5-HT2A-Lisuride
17.39Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
17.39Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
17.39Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
17.39Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.39Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
17.39Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
17.39Single8X63Mepyramine8X63-H1-Mepyramine
17.39Single8X64Desloratadine8X64-H1-Desloratadine
17.39Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
17.39Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
17.39Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
17.39Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
17.39Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
17.39Consensustar_onOrthosteric Ligandta1_on
17.24Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
17.24Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
17.24Single7SK5CXCL127SK5-ACKR3-CXCL12
17.24Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
17.24Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
17.24Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
17.24Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
17.07Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
16.67Single2Y00Dobutamine2Y00-β1-Dobutamine
16.67Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
16.67Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
16.67Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
16.67Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
16.67Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
16.67Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
16.67Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
16.67Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
16.67Single7SINNPS-21437SIN-CaS-NPS-2143
16.67Single7SINNPS-21437SIN-CaS-NPS-2143
16.67Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
16.67Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
16.67Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
16.67Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single7WC6LSD7WC6-5-HT2A-LSD
16.67Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
16.67Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.67Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
16.67Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
16.67Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
16.67Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
16.67Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
16.67Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
16.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
16.67Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
16.67Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
16.67Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
16.67Consensusglp_onOrthosteric Ligandglp1_on glp2_on
16.67Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
16.67Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
16.28Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
16.22Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
16.22Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
16.22Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
16.13Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
16.13Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
16.13Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.13Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.13Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
16.13Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
16.13Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
16.13Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.00Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
16.00Single4DJHJDTic4DJH-κ-JDTic
16.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
16.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
16.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
16.00Single6OS1TRV0266OS1-AT1-TRV026
16.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
16.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
16.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
16.00Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
16.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
16.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
16.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
16.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
16.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
16.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
16.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
16.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
16.00Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
16.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
16.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
16.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
16.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
16.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
16.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
16.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
16.00Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
16.00Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
16.00Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
16.00Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
16.00Consensushistamine_offOrthosteric Ligandh1_off
16.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
16.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
15.79Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
15.79Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
15.79Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.79Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
15.62Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
15.62Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
15.62Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
15.62Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.62Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.62Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
15.62Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single4N4WSANT-14N4W-SMO-SANT-1
15.38Single6A93Risperidone6A93-5-HT2A-Risperidone
15.38Single6CM4Risperidone6CM4-D2-Risperidone
15.38Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
15.38Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
15.38Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
15.38Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single6ZG4HTL00099366ZG4-M1-HTL0009936
15.38Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
15.38Single7DFPSpiperone7DFP-D2-Spiperone
15.38Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
15.38Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
15.38Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
15.38Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
15.38Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
15.38Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
15.38Consensuschemokine_offOrthosteric Ligandcxcr_off
15.38Consensusclass-b2_onOrthosteric Ligandadgrg_on
15.38Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
15.38Consensuscxcr_offOrthosteric Ligandcxcr4_off
15.38Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
15.38Consensusgi_class-fOther Ligandgi_frizzled
15.38Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
15.38Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
15.38Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
15.15Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
15.15Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
15.15Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
15.15Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
15.15Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
15.15Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
15.15Consensusclass-d_onOrthosteric Ligandste2_on
15.15Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
15.15Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
15.15Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single3OE6IT1t3OE6-CXCR4-IT1t
15.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
15.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
15.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
15.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
15.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
15.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.00Single8GGREpinephrine8GGR-β2-Epinephrine
15.00Single8GGZEpinephrine8GGZ-β2-Epinephrine
15.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
15.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
15.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
15.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
14.81Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
14.81Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
14.81Single6K1QIRL25006K1Q-ETB-IRL2500
14.81Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
14.81Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
14.81Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
14.81Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
14.81Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
14.81Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
14.81Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
14.81Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
14.81Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
14.81Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
14.71Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
14.71Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.71Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
14.71Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
14.71Consensusgi_class-dOrthosteric Ligandgi_ste
14.71Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.71Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
14.63Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
14.29Single5EE7MK08935EE7-Glucagon-MK0893
14.29Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
14.29Single6LMLGlucagon6LML-Glucagon-Glucagon
14.29Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
14.29Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
14.29Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
14.29Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
14.29Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
14.29Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
14.29Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
14.29Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
14.29Single7SK9CCX6627SK9-ACKR3-CCX662
14.29Single7SRQLSD7SRQ-5-HT2B-LSD
14.29Single7UL2SR486927UL2-NTS1-SR48692-Na
14.29Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
14.29Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
14.29Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
14.29Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
14.29Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
14.29Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
14.29Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
14.29Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
14.29Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
14.29Consensusclass-d_offOrthosteric Ligandste2_off
14.29Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
14.29Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
14.29Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
14.29Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
14.29Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
14.29Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
13.89Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
13.89Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
13.89Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
13.89Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
13.79Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
13.79Single7QA8Peptide7QA8-STE2-Peptide
13.79Single7QA8Peptide7QA8-STE2-Peptide
13.79Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
13.79Consensusclass-d_offOrthosteric Ligandste2_off
13.64Single3ODUIT1t3ODU-CXCR4-IT1t
13.64Single6AKXA4R6AKX-CCR5-A4R
13.64Single6B73PubChem 1319551386B73-κ-PubChem 131955138
13.64Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
13.64Single6KUXRS-799486KUX-α2a-RS-79948
13.64Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
13.64Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
13.64Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
13.64Single7BR3Elagolix7BR3-GnRH1-Elagolix
13.64Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
13.64Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
13.64Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
13.64Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
13.64Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
13.64Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
13.64Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
13.64Single8GGWEpinephrine8GGW-β2-Epinephrine
13.64Single8IHKAcifran8IHK-HCA3-Acifran
13.64Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
13.64Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
13.64Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
13.64Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Consensusalpha1_onOrthosteric Ligandalpha1a_on
13.64Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
13.64Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
13.64Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
13.64Consensusgt_class-aOrthosteric Ligandgt_opsin
13.64Consensusgt_opsinOrthosteric Ligandgt_sensory
13.64Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
13.64Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
13.64Consensusmglu_onOther Ligandmglu2_on mglu4_on
13.51Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
13.33Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
13.16Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
13.16Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
13.16Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
13.16Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
13.04Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
13.04Single4MBSMaraviroc4MBS-CCR5-Maraviroc
13.04Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
13.04Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
13.04Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
13.04Single6VI4JDTic6VI4-κ-JDTic
13.04Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
13.04Single6ZG9GSK10347026ZG9-M1-GSK1034702
13.04Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
13.04Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
13.04Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
13.04Single7VODCariprazine7VOD-5-HT2A-Cariprazine
13.04Single7VV6C48/807VV6-MRGPRX2-C48/80
13.04Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
13.04Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
13.04Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
13.04Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
13.04Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
13.04Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
13.04Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
13.04Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
13.04Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
13.04Consensuss1p_offOrthosteric Ligands1p1_off
13.04Consensussensory_offOrthosteric Ligandopsin_off
12.82Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
12.82Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
12.50Single2Y01Dobutamine2Y01-β1-Dobutamine
12.50Single4DAJTiotropium4DAJ-M3-Tiotropium
12.50Single4EJ4Naltrindole4EJ4-δ-Naltrindole
12.50Single4MQSIperoxo4MQS-M2-Iperoxo
12.50Single4U14Tiotropium4U14-M3-Tiotropium
12.50Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
12.50Single5DSGTiotropium5DSG-M4-Tiotropium
12.50Single5TGZAM65385TGZ-CB1-AM6538
12.50Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
12.50Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
12.50Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
12.50Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
12.50Single6IIVDaltroban6IIV-TP-Daltroban
12.50Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
12.50Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
12.50Single7BU7BI1671077BU7-β1-BI167107
12.50Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
12.50Single7F83PF-051904577F83-Ghrelin-PF-05190457
12.50Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
12.50Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
12.50Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
12.50Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
12.50Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
12.50Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
12.50Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
12.50Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
12.50Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
12.50Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
12.50Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
12.50Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
12.50Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
12.50Consensusblt_onOrthosteric Ligandblt1_on
12.50Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
12.50Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
12.50Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
12.50Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
12.50Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
12.50Consensushistamine_onOrthosteric Ligandh1_on h4_on
12.50Consensusleuko_onOrthosteric Ligandblt_on
12.50Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
12.50Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
12.50Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
12.50Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
12.50Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
12.12Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
12.12Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
12.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
12.00Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
12.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
12.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
12.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
12.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
12.00Single7C4SS1P7C4S-S1P3-S1P
12.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
12.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
12.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
12.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Single8EA0Iperoxo8EA0-M3-Iperoxo
12.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
12.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
12.00Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
12.00Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
12.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
11.54Single4U15Tiotropium4U15-M3-Tiotropium
11.54Single5V56TC1145V56-SMO-TC114
11.54Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
11.54Single6OL9Tiotropium6OL9-M5-Tiotropium
11.54Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
11.54Single7EPENAM5637EPE-mGlu-NAM563
11.54Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
11.54Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
11.54Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
11.54Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
11.54Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
11.54Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
11.54Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
11.54Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
11.54Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
11.43Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
11.43Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
11.43Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
11.43Consensusgo_class-b1Orthosteric Ligandgo_crf
11.43Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
11.43Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
11.36Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
11.11Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
11.11Single4PY02MeSATP4PY0-P2Y12-2MeSATP
11.11Single5CXVTiotropium5CXV-M1-Tiotropium
11.11Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
11.11Single6IIURamatroban6IIU-TP-Ramatroban
11.11Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
11.11Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
11.11Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
11.11Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
11.11Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
11.11Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
11.11Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
11.11Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
11.11Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
11.11Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
11.11Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
11.11Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.81Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
10.81Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
10.81Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
10.71Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
10.71Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
10.71Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
10.71Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
10.71Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
10.71Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
10.71Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
10.71Consensuscyslt_offOrthosteric Ligandcyslt2_off
10.71Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
10.71Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
10.71Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
10.53Consensusclass-c_onOther Ligandgabab_on mglu_on
10.53Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
10.34Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Consensusgs_class-b2Orthosteric Ligandgs_adgr
10.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
10.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
10.00Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
10.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.00Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
10.00Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
10.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
10.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
10.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
10.00Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensussensory_onOrthosteric Ligandopsin_on
9.68Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
9.52Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
9.52Single3OE8IT1t3OE8-CXCR4-IT1t
9.52Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
9.52Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
9.52Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
9.52Single7WC5Psilocin7WC5-5-HT2A-Psilocin
9.52Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
9.52Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
9.52Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
9.52Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
9.52Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
9.52Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
9.52Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
9.09Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
9.09Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
9.09Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
9.09Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
9.09Single4O9RCyclopamine4O9R-SMO-Cyclopamine
9.09Single5L7IVismodegib5L7I-SMO-Vismodegib
9.09Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
9.09Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
9.09Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
9.09Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
9.09Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
9.09Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
9.09Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
9.09Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
9.09Consensusclass-d_onOrthosteric Ligandste2_on
9.09Consensusclass-t_onOrthosteric Ligandtaste2_on
9.09Consensusgi_class-dOrthosteric Ligandgi_ste
9.09Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
9.09Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
9.09Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
9.09Consensusgo_class-b2Orthosteric Ligandgo_adhesion
9.09Consensusgs_class-tOrthosteric Ligandgs_taste
9.09Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
9.09Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
9.09Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
9.09Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
8.89Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
8.82Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
8.82Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
8.70Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
8.70Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
8.70Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
8.70Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
8.70Single4QINSAG1.54QIN-SMO-SAG1.5
8.70Single5ZKQABT-4915ZKQ-PAF-ABT-491
8.70Single6AKYMaraviroc6AKY-CCR5-Maraviroc
8.70Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
8.70Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
8.70Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
8.70Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
8.70Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
8.70Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
8.70Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
8.70Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
8.70Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
8.70Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
8.70Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
8.70Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
8.70Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
8.70Consensusclass-f_offOrthosteric Ligandsmo_off
8.70Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
8.70Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
8.70Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
8.70Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
8.70Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.33Single6DS0Ly2660976DS0-5-HT2B-Ly266097
8.33Single6FFIMMPEP6FFI-mGlu5-MMPEP
8.33Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
8.33Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.33Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
8.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.33Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
8.33Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
8.33Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
8.33Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
8.33Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
8.33Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
8.33Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single8K2WAMG4878K2W-CXCR3-AMG487
8.33Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
8.33Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
8.33Consensusgi_class-fOrthosteric Ligandgi_frizzled
8.33Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.11Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
8.11Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
8.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
8.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
8.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
8.00Single6FFHFenobam6FFH-mGlu5-Fenobam
8.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
8.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
8.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
8.00Consensushcar_offOrthosteric Ligandsuccinate_off
8.00Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
8.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
8.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
8.00Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
7.89Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
7.89Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
7.69Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
7.69Single5CGCHTL142425CGC-mGlu5-HTL14242
7.69Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
7.69Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
7.69Single7YXAONO-54306087YXA-S1P5-ONO-5430608
7.69Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
7.69Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
7.69Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
7.69Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
7.69Consensusep_offOrthosteric Ligandep4_off
7.69Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
7.69Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
7.41Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
7.41Single5V57TC1145V57-SMO-TC114
7.41Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
7.41Single7P2L4YI7P2L-mGlu5-4YI
7.41Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
7.41Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
7.41Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
7.41Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.41Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
7.41Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
7.32Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
7.14Single5X33BIIL2605X33-BLT1-BIIL260
7.14Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
7.14Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
6.98Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
6.90Single5CGDHTL142425CGD-mGlu5-HTL14242
6.90Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
6.90Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
6.67Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
6.25Consensusclass-c_offOther Ligandgabab_off mglu_off
5.26Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
5.26Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
5.26Single6W25Ca6W25-MC4-SHU9119-Ca
5.26Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
5.26Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.26Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
5.13Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
5.13Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
5.00Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
5.00Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
5.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
5.00Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.88Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
4.76Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
4.76Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
4.76Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
4.76Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
4.76Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
4.55Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
4.55Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
4.55Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
4.55Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.55Single6LI0GTPL98046LI0-GPR52-GTPL9804
4.55Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
4.55Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
4.55Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
4.55Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
4.35Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
4.35Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
4.35Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
4.35Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
4.35Single7FEEZCZ0117FEE-CB1-PubMed 104895-ZCZ011
4.35Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
4.35Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.26Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
4.17Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
4.17Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
4.17Single4XNVBPTU4XNV-P2Y1-BPTU
4.17Single5U09Taranabant5U09-CB1-Taranabant
4.17Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.17Single7WV9ZCZ0117WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.17Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
4.17Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
4.17Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
4.17Single8G94CD698G94-S1P1-CD69-Gi1/&β;1/&γ;2
4.17Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
4.17Consensuscb1_on_alloOther Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
4.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
4.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
4.00Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
3.85Single6GPSMK08126GPS-CCR2-MK0812
3.85Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
3.85Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
3.70Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
3.70Single6GPXMK08126GPX-CCR2-MK0812
3.70Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
3.57Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.45Single7SHEPI; PE7SHE-GPR158-PI; PE
3.33Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.12Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
3.03Single7SHEPI; PE7SHE-GPR158-PI; PE
3.03Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.50Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.38Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3

Consensus Members
Id Members
8H0Q 8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8H0P 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
Net Summary
Imin 3.025
Number of Linked Nodes 865
Number of Links 1019
Number of Hubs 155
Number of Links mediated by Hubs 599
Number of Communities 25
Number of Nodes involved in Communities 219
Number of Links involved in Communities 311
Path Summary
Number Of Nodes in MetaPath 93
Number Of Links MetaPath 92
Number of Shortest Paths 1287559
Length Of Smallest Path 3
Average Path Length 31.6035
Length of Longest Path 60
Minimum Path Strength 0.605
Average Path Strength 6.04871
Maximum Path Strength 19.72
Minimum Path Correlation 0.7
Average Path Correlation 0.978642
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.08333
Average % Of Corr. Nodes 39.0145
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 54.4019
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gs_peptidegs_cck
gs_motilin
gs_neuromedin
gs_orexin
gs_sst
gs_tachykinin
gs_trh
gs_vasopressin-ot
gs_bombesin
gs_bradykinin
gs_compl-peptide
gs_endothelin
gs_galanin
gs_ghrelin
gs_melanocortin



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gs_bombesin.zip



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