Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.52 2.195403
2G.hns1.01 9.54375404
3G.S1.06 5.80125478
4G.S1.07 5.32375428
5G.s1h1.04 6.025836179
6G.H1.08 4.2825409
7G.S2.08 5.422586
8G.S3.03 7.05357788
9G.S3.05 5.39408
10G.S3.06 7.567507
11G.s3h2.03 5.80125429
12G.H2.01 8.031529
13G.H2.04 7.32529
14G.H2.06 7.23583629
15G.H2.07 7.64629
16G.h2s4.01 9.851529
17G.S4.02 4.06528
18G.S4.03 4.539577
19G.S4.04 4.56083629
20G.S4.06 4.0975427
21G.S4.07 9.11254178
22G.s4h3.04 6.264508
23G.H3.06 6.10625406
24G.H3.09 4.90333629
25G.H3.12 4.46875428
26G.H3.13 8.70928726
27G.H3.17 10.0192625
28G.H3.18 5.072529
29G.h3s5.03 3.50625427
30G.S5.03 5.63479
31G.S5.04 5.43375429
32G.S5.05 4.59143779
33G.S5.06 6.45375428
34G.HG.03 5.95406
35G.hgh4.02 4.275508
36G.hgh4.05 13.9075406
37G.hgh4.16 3.65401
38G.hgh4.20 7.85403
39G.H4.03 3.3925404
40G.H4.07 11.345425
41G.H4.08 5.215403
42G.H4.10 9.497507
43G.H4.15 7.671528
44G.S6.01 3.73125425
45G.S6.02 7.720836108
46G.S6.05 10.225425
47G.s6h5.01 6.24625479
48G.H5.03 5.33125479
49G.H5.05 5.51875485
50G.H5.06 5.53583674
51G.H5.08 6.52143788
52G.H5.17 3.418754105
53G.H5.20 4.5575408
54G.H5.23 8.365514
55G.H5.25 5.293508
56G.H5.26 5.07754198
57b.1x3 5.16254201
58b.1x12 3.18875406
59b.1x15 4.311507
60b.h2x1 5.7675405
61b.lhb1x6 3.8625653
62b.l1x3 10.5515149
63b.l1x6 6.186529
64b.b2x1 5.7625428
65b.b2x5 8.294507
66b.b3x3 4.69448
67b.l3x1 7.355429
68b.l3x2 7.90125409
69b.b4x3 5.55583647
70b.b4x5 5.1025447
71b.b4x6 11.9635149
72b.l4x2 12.3254124
73b.b5x2 7.2075407
74b.b5x3 7.242509
75b.b5x5 6.65375445
76b.b5x7 6.65375447
77b.l5x1 5.683548
78b.l5x5 11.868529
79b.b6x1 5.29875429
80b.b6x5 5.492506
81b.l6x5 6.713754184
82b.b7x1 5.5455184
83b.b7x2 4.39875448
84b.b7x4 4.165548
85b.l7x2 4.54875429
86b.l7x4 4.7975429
87b.b8x4 5.15929746
88b.l8x1 4.5175405
89b.l8x8 5.965444
90b.b9x3 4.94375446
91b.l9x3 8.607529
92b.l9x6 6.54357728
93b.b10x3 4.25428
94b.b10x5 6.566509
95b.l10x1 4.202563
96b.b11x3 4.7825465
97b.b11x4 5.82875429
98b.b11x6 7.58625429
99b.l11x2 10.795429
100b.b12x3 4.335468
101b.b12x6 9.56167628
102b.b13x7 9.353567
103b.l13x3 9.557569
104b.l13x6 8.06125429
105b.b14x3 6.18625465
106b.b15x1 9.086569
107b.b15x2 8.69875436
108b.l15x2 7.1475469
109b.b16x4 9.074566
110b.b16x5 5.571535
111b.b16x6 10.333568
112b.b16x7 8.38409
113b.b17x5 7.711537
114b.b17x7 8.795538
115b.l17x3 10.022539
116b.l17x6 6.215629
117b.b18x3 4.881538
118b.b18x5 6.095405
119b.l18x1 8.7235156
120b.l18x2 6.214157
121b.b19x2 8.569536
122b.b19x4 6.04125438
123b.l19x2 3.0475439
124b.b20x2 3.438536
125b.b20x4 10.089538
126b.b20x6 7.5525636
127b.b20x7 6.349509
128b.l20x2 12.5325409
129b.b21x1 9.31375437
130b.b21x5 6.99404
131b.b21x7 6.40333605
132b.b22x5 6.2785157
133b.l22x1 4.90375459
134b.l22x5 6.46917659
135b.b23x6 7.13256167
136b.l23x1 6.63125426
137b.b24x2 4.6475405
138b.b24x4 8.2054166
139b.b24x6 6.136254168
140b.l24x2 4.9775456
141b.l24x3 6.7825405
142b.b25x6 3.86254163
143b.l25x3 7.8465139
144b.l25x6 12.069528
145b.l27x1 7.1975458
146b.l27x5 5.635455
147b.b27x1 3.9975406
148b.b27x3 6.1408
149b.l28x1 12.2525629
150b.l28x2 8.54754139
151b.b28x4 7.374136
152b.b28x5 3.568754125
153b.b28x6 9.304176139
154Lig 14.79172310
1551x31 4.3125413
1561x50 5.42519
1571x53 4.653754118
1581x56 4.4935118
1591x57 6.0615117
1602x40 10.7025407
1612x42 5.61667617
1622x46 3.896519
1632x50 6.059519
1642x60 8.48125416
165E1 6.9925414
166E1x50 10.1162418
167E1x52 8.901507
1683x35 5.3525408
1693x38 5.97375407
1703x41 4.08417615
1713x42 4.726518
1723x46 3.9225419
1733x49 9.75625418
1743x50 7.183519
1753x51 6.733598
1763x54 4.08125408
1773x56 4.5596
1784x39 5.50875403
1794x50 5.6419
1804x65 10.19514
181E2 14.69541413
182E2x50 7.1775419
183E2x52 8.08875414
1845x36 7.3075414
1855x44 5.3925415
1865x47 6.99125408
1875x50 3.53125419
1885x51 4.3775406
1895x57 5.26375497
1905x68 4.8354105
1915x69 4.62404
1926x44 4.89419
1936x48 6.78214719
1946x51 7.4475416
1956x52 7.61875408
1966x55 4.02125415
1976x59 6.6475405
1987x32 2.80625402
1997x35 4.94375414
2007x39 6.60857715
2017x42 10.58417
2027x46 4.4925418
2037x49 7.38125419
2047x53 6.3175619
2058x50 5.805628118
2068x57 3.28125405
207g.h1x3 7.76254216
208g.h1x6 3.043754217
209g.h1x10 3.273754216
210g.l1x4 6.068508
211g.h2x11 10.8254156
212g.ctx3 5.75917659
213g.ctx4 5.23125457
214g.ctx6 3.603556
215g.ctx9 6.24125456
216g.ctx14 6.005409
217g.ctx16 4.432147128
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.l2x3 b.l2x5 39.22455.36NoNo085
2b.b3x1 b.l2x3 25.28689.5NoNo058
3b.b3x1 b.b4x5 11.53883.565NoYes057
4G.hns1.01 b.l3x2 12.30745.175YesYes049
5G.hns1.01 b.l3x1 12.27134.51YesYes049
6G.S4.04 G.S4.06 19.30423.275YesYes297
7G.S4.06 G.S5.06 16.2652.98YesYes278
8G.S5.06 G.S6.05 32.8949.745YesYes285
9G.HG.01 G.S6.05 25.66625.855NoYes265
10G.HG.01 G.HG.04 26.67865.99NoNo068
11G.HG.04 G.s4h3.04 26.31613.52NoYes088
12G.HG.07 G.s4h3.04 27.71449.555NoYes098
13G.HG.07 G.s4h3.02 27.54385.355NoNo099
14G.S4.07 G.s4h3.02 26.15326.625YesNo089
15G.S4.07 G.s1h1.04 25.49147.405YesYes1789
16G.s1h1.04 G.s1h1.05 24.71112.98YesNo099
17G.S4.05 G.s1h1.05 24.37616.465NoNo079
18G.H1.01 G.S4.05 24.04193.795NoNo097
19G.H1.01 G.S1.06 22.75825.64NoYes798
20G.S4.04 G.S5.04 19.46493.65YesYes299
21G.S5.04 G.S5.06 16.49187.61YesYes298
22G.S1.06 G.S4.03 16.78554.28YesYes787
23G.H2.04 G.H3.12 12.41476.89YesYes298
24G.H2.04 G.H2.07 24.171511.5YesYes299
25G.H2.06 b.l17x6 45.641911.06YesYes299
26G.H2.06 b.l9x6 34.54283.58YesYes298
27G.H2.04 G.H3.08 12.385612.505YesNo098
28G.H3.17 b.l28x1 15.97166.56YesYes259
29b.l1x6 b.l28x1 10.427111.02YesYes299
30G.H2.09 b.l25x6 43.62496.425NoYes288
31b.l25x6 b.l28x1 15.513724.49YesYes289
32b.b26x1 b.l28x1 24.51034.325NoYes099
33b.b26x1 b.b26x2 24.24523.44NoNo097
34b.b26x2 b.b2x3 23.98898.915NoNo076
35b.b28x3 b.b2x3 23.73974.24NoNo076
36b.b1x6 b.b28x3 22.62046.23NoNo097
37G.H3.15 G.H3.18 25.58188.24NoYes089
38G.H3.15 G.H3.17 25.71455.65NoYes085
39G.S4.03 G.S5.03 10.59433.68YesYes779
40G.H5.10 G.S5.03 10.751911.195NoYes079
41G.H5.10 G.S6.02 11.947712.065NoYes078
42G.H5.13 G.S6.02 11.625611.49NoYes1088
43G.H5.17 G.H5.20 11.8453.325YesYes058
44G.H5.20 G.H5.25 14.99314.15YesYes088
453x50 G.H5.25 21.82018.505YesYes098
463x50 7x53 25.40034.63YesYes199
473x43 7x53 18.10276.175NoYes189
482x46 3x43 18.29665.005YesNo198
492x46 2x50 52.25254.75YesYes199
501x50 2x50 51.01196.73YesYes199
511x50 2x47 92.26864.69YesNo098
521x53 2x47 92.46253.39YesNo088
531x53 1x57 91.66373.93YesYes1187
541x57 2x40 98.068215.16YesYes077
552x40 8x53 99.33868.775YesNo075
561x60 8x53 99.55656.075NoNo055
571x60 I1x49 99.77724.185NoNo055
58I1x49 b.l1x1 1003.2NoNo057
59b.b1x5 b.l1x1 72.87159.055NoNo037
60b.b1x5 b.b28x4 73.01429.01NoYes036
61b.b28x4 b.b28x6 45.9764.64YesYes1369
62b.b25x7 b.b28x6 19.126126.76NoYes079
63b.b25x7 b.lhb1x11 19.15534.945NoNo074
64b.b27x1 b.lhb1x11 13.90873.04YesNo064
65b.b27x1 g.ctx5 15.0634.47YesNo069
66g.ctx3 g.ctx5 14.7373.395YesNo599
67g.ctx3 g.ctx4 18.4043.22YesYes597
68b.l27x5 g.ctx4 15.62716.71YesYes557
69b.l27x5 g.ctx15 15.31484.195YesNo059
70b.l4x2 g.ctx15 15.462415.995YesNo049
717x49 7x53 21.7327.56YesYes199
722x46 7x49 26.4033.43YesYes199
733x46 7x53 12.31873.68YesYes199
74b.l17x5 b.l17x6 45.12012.945NoYes069
75b.l17x5 b.l19x2 44.80922.945NoYes069
76b.b20x2 b.l19x2 32.80353.615YesYes369
77b.b20x2 b.b20x4 31.91923.235YesYes368
78b.b20x4 b.b20x6 31.14393.21YesYes386
79b.b17x7 b.b20x6 23.46313.395YesYes386
80b.b17x7 b.b21x1 17.93042.985YesYes387
81b.1x19 b.b21x1 10.14212.51NoYes067
82b.1x15 b.1x19 21.91816.26YesNo076
83b.1x12 b.1x15 21.09983.635YesYes067
84b.1x12 g.h1x9 16.52212.82YesNo069
85b.1x11 g.h1x9 14.68965.535NoNo089
86b.1x11 g.h1x10 13.7735.64NoYes086
87b.b20x5 b.b21x7 20.49416.445NoYes075
88b.b20x5 b.b21x4 20.04394.15NoNo075
89b.b20x7 b.b21x4 19.60834.75YesNo095
90b.b20x7 b.l20x3 16.49954.63YesNo097
91b.l20x3 g.h2x1 16.07183.395NoNo078
92b.b21x2 g.h2x1 15.65493.58NoNo068
93b.1x19 b.b21x2 15.13216.425NoNo066
94b.b24x5 b.b25x5 24.93431.84NoNo054
95b.l4x2 g.ctx16 22.15615.675YesYes1248
96b.b1x6 b.b28x5 24.68464.28NoYes095
97b.b28x5 g.ctx16 23.38793.14YesYes1258
98b.b23x3 b.b26x3 27.71794.845NoNo076
99b.b26x3 b.b27x3 82.0462.945NoYes068
100b.b27x3 b.l25x3 54.66627.53YesYes089
101b.l25x3 b.l28x2 27.62343.78YesYes1399
102b.b28x2 b.l28x2 27.495713.14NoYes049
103b.l11x1 b.l9x6 29.30089.415NoYes298
104b.b11x6 b.l11x1 29.29293.71YesNo299
105b.b11x6 b.l9x3 26.184511.855YesYes299
106b.b11x4 b.l9x3 23.5696.85YesYes299
107b.b10x3 b.b11x4 22.93063.38YesYes289
108b.b10x3 b.b6x2 13.08645.07YesNo088
109b.b10x2 b.b6x2 12.75373.38NoNo068
110b.l2x1 b.l2x3 13.75623.355NoNo058
111b.b6x5 b.l2x1 13.56145.79YesNo065
112b.b3x1 b.b6x5 13.56245.275NoYes056
113b.b3x3 b.b6x5 12.15195.05YesYes086
114b.b6x5 b.l8x1 14.17794.105YesYes065
115b.l8x1 b.l8x8 10.93993.725YesYes054
116b.b7x2 b.b8x4 15.20273.155YesYes486
117b.b8x4 b.l8x8 12.16373.155YesYes464
118b.b8x2 b.b8x4 12.78098.905NoYes486
119b.b8x2 b.b9x3 10.95565.03NoYes486
120b.b8x4 b.l8x10 12.78095.05YesNo464
121b.b9x3 b.l8x10 10.95563.565YesNo464
122b.b9x3 b.l7x5 14.60834.785YesNo066
123b.b10x3 b.b11x2 11.53794.91YesNo087
124b.b19x6 b.l19x2 11.40083.68NoYes399
125b.b19x6 b.l17x3 11.12513.945NoYes399
126b.b25x5 b.b25x6 24.67951.84NoYes043
127b.b24x4 b.b25x6 12.69975.91YesYes1663
128b.b24x4 b.b24x6 10.79684.52YesYes1668
129b.b25x3 b.b25x6 11.04193.27NoYes1653
130b.b24x6 b.b25x3 10.88077YesNo1685
131b.b21x7 b.b24x6 25.89796.755YesYes058
132b.b22x1 b.l25x6 60.18058.405NoYes088
133b.b22x1 b.b22x2 60.24855.6NoNo088
134b.b22x2 b.b26x3 60.35474.505NoNo086
1351x50 7x46 40.37782.98YesYes198
1362x53 7x46 36.91643.665NoYes078
1372x53 7x42 32.29278.04NoYes077
1387x42 Lig 25.082314.905YesYes170
1392x46 3x42 12.4923.295YesYes198
1403x38 4x53 10.27234.965YesNo078
1416x48 7x45 11.29212.43YesNo199
1427x45 7x49 11.772413.62NoYes199
143b.l2x5 b.l4x2 36.326124.18NoYes1254
144G.H3.12 G.H3.18 19.133.565YesYes289
145G.H3.12 G.S4.04 30.47693.14YesYes289
146G.H2.06 G.H2.09 48.94554.745YesNo298
147G.H3.08 G.S4.04 12.14628.36NoYes089
148G.H5.13 G.H5.17 10.99853.92NoYes1085
149b.b28x4 b.l25x3 27.17869.825YesYes1369
150b.b28x2 b.l1x1 27.37719.085NoNo047
151b.b27x3 b.b28x6 27.35179.7YesYes089
152b.b23x3 b.b24x5 25.14396.705NoNo075
153G.H2.07 b.l9x6 25.55787.235YesYes298
154G.H3.17 b.l25x6 10.576311.495YesYes258
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
E1Lig13.3951YesYes4010
E2Lig39.941YesYes3010
7x31Lig24.970NoYes3010
E2x51Lig8.851NoYes4010
E2x52Lig6.431YesYes4010
5x36Lig3.0951YesYes4010
6x62Lig4.3951NoYes3010
4x65Lig5.351YesYes4010
6x51Lig13.4951YesYes6010
7x34Lig7.421NoYes5010
7x38Lig31.3951NoYes5010
2x60Lig15.541YesYes6010
7x39Lig7.221YesYes5010
7x42Lig14.9051YesYes7010
3x32Lig4.2050NoYes6010
3x36Lig10.3551NoYes7010
6x55Lig3.2351YesYes5010
6x58Lig11.1151NoYes4010
1x311x357.4751YesNo3522
1x317x323.621YesYes3222
1x317x353.3251YesYes3421
1x322x676.9250NoNo5322
1x32E15.2850NoYes5421
1x357x357.7051NoYes5421
1x357x395.9251NoYes5521
1x392x573.5450NoNo6822
1x397x3916.080NoYes6521
2x577x4212.630NoYes8721
2x602x635.7751YesNo6512
2x603x299.6051YesNo6512
2x647x393.770NoYes5521
2x67E24.5651NoYes3321
E1E24.8951YesYes4311
E1x49E214.4650NoYes5321
3x22E28.5651NoYes3321
3x254x653.4851NoYes9421
3x25E2x507.281NoYes9922
3x294x6524.11NoYes5421
3x29E2x504.721NoYes5922
3x366x483.991NoYes7912
4x64E212.21NoYes4321
4x645x355.921NoNo4222
4x65E2x506.2651YesYes4912
4x65E2x5211.751YesYes4411
E2E240.9451YesYes3311
E2E2x518.21YesNo3411
E2E2x5211.141YesYes3411
5x35E28.471NoYes2321
5x36E25.9351YesYes4311
5x39E23.7251NoYes5321
5x335x364.4950NoYes2421
5x366x6215.7051YesNo4311
5x406x553.0051NoYes5521
5x446x528.41YesYes5822
5x446x555.91YesYes5521
6x486x523.1951YesYes9822
6x516x524.4751YesYes6812
6x516x553.9451YesYes6511
6x517x387.8751YesNo6511
6x547x344.420NoNo5521
6x586x625.9551NoNo4311
6x617x278.551NoNo3312
7x357x393.5151YesYes4511
7x397x426.7451YesYes5711
1x287x323.4151NoYes0212
1x28Lig16.9951NoYes0010
2x537x428.040NoYes7721
2x607x393.0051YesYes6511
2x64E14.3950NoYes5421
5x39E2x523.0351NoYes5421
5x405x444.251NoYes5522
6x587x343.3151NoNo4511
6x61Lig5.5851NoYes3010
7x35Lig5.231YesYes4010
6x617x302.551NoNo3512
3x21E21.7450NoYes8321
1x251x281.350NoNo0021

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
86.96Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
80.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
76.19Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
75.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
75.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
70.83Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
69.23Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
68.00Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
62.50Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
60.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
58.33Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
58.33Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
57.14Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
56.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
56.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
56.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
55.56Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
54.17Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
54.17Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
53.85Consensusangiotensin_onOrthosteric Ligandat1_on
53.85Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
52.17Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
51.85Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
51.85Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
51.85Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
50.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
50.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
50.00Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
50.00Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
50.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
48.39Single5GLHEndothelin-15GLH-ETB-Endothelin-1
48.28Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
48.15Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
48.15Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
48.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
48.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
47.83Consensuschemerin_onOrthosteric Ligandcml1_on
47.83Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
46.43Single6JODAngiotensin II6JOD-AT2-Angiotensin II
46.43Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
46.15Single4IARErgotamine4IAR-5-HT1B-Ergotamine
46.15Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
46.15Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
46.15Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
45.83Single6OS2TRV0266OS2-AT1-TRV026
45.83Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
45.83Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
45.83Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
45.83Consensusdp_offOrthosteric Liganddp2_off
45.16Single6IGLIRL16206IGL-ETB-IRL1620
45.16Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.83Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
44.83Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
44.44Single3QAKUK-4320973QAK-A2A-UK-432097
44.44Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
44.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
44.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
44.00Single7EZCUKA7EZC-A2A-UKA
44.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
44.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
44.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
43.75Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
43.48Single6D26Fevipiprant6D26-DP2-Fevipiprant
43.33Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
43.33Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
42.86Single5WF5UK-4320975WF5-A2A-UK-432097
42.86Single8GNGIstradefylline8GNG-A2A-Istradefylline
42.86Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
42.86Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
42.86Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
42.42Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
42.31Single5WF6UK-4320975WF6-A2A-UK-432097
42.31Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
42.31Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
42.31Single7XN9L-054,5227XN9-SST2-L-054,522
42.31Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
41.94Consensusendothelin_onOrthosteric Ligandetb_on eta_on
41.67Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
41.67Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
41.67Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
41.67Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
41.67Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
41.67Consensuscck_onOrthosteric Ligandccka_on cckb_on
41.38Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
41.38Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
41.38Single7C61Ergotamine7C61-5-HT1B-Ergotamine
41.38Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
41.18Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
40.91Single7AROLUF58337ARO-A2A-LUF5833-Na
40.91Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
40.91Consensushca_onOrthosteric Ligandhca2_on hca3_on
40.91Consensushcar_onOrthosteric Ligandhca_on
40.74Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
40.74Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.74Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
40.74Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
40.74Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
40.74Consensussst_onOrthosteric Ligandsst2_on sst4_on
40.62Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
40.62Single8IY6Endothelin-18IY6-ETB-Endothelin-1
40.62Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
40.62Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
40.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
40.00Single6MXTSalmeterol6MXT-β2-Salmeterol
40.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
40.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
40.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
40.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
40.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
40.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
40.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
40.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
40.00Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
40.00Consensusgs_steroidOrthosteric Ligandgs_bileacid
40.00Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
39.39Single6IGKEndothelin-36IGK-ETB-Endothelin-3
39.29Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
39.29Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
39.29Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
39.29Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
39.29Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
39.13Single6D27CAY104716D27-DP2-CAY10471
39.13Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
39.13Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
39.13Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
39.13Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
39.13Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
39.13Consensusadenosine_onOrthosteric Liganda1_on a2_on
39.13Consensusnucleotide_onOrthosteric Ligandadenosine_on
38.71Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
38.71Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.71Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.71Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
38.71Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
38.46Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
38.46Single6IBLArformoterol6IBL-β1-Arformoterol
38.46Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
38.46Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
38.46Consensussteroid_onOrthosteric Ligandbileacid_on
38.24Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
38.10Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
38.10Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
37.93Single3OE0CVX153OE0-CXCR4-CVX15
37.93Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
37.93Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
37.93Single7XNACYN1548067XNA-SST2-CYN154806
37.93Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
37.93Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
37.93Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.93Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
37.50Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
37.50Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
37.50Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
37.50Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
37.50Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
37.50Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
37.50Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
37.50Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
37.50Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
37.50Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
37.50Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
37.50Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
37.50Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.04Single6KNMJN241-96KNM-Apelin-JN241-9
37.04Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
37.04Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
37.04Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
37.04Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
37.04Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
36.67Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
36.67Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
36.67Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
36.67Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
36.67Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
36.36Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
36.36Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
36.36Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
36.36Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
36.36Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
36.36Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
36.36Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
36.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
36.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
36.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
36.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
36.00Single6OS1TRV0266OS1-AT1-TRV026
36.00Single7PX4PSB-21137PX4-A2A-PSB-2113
36.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
36.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
36.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
36.00Consensusa2_onOrthosteric Liganda2a_on a2b_on
36.00Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
35.71Single7F8XNN90567F8X-CCKA-NN9056
35.71Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
35.71Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
35.71Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
35.71Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
35.71Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
35.71Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
35.48Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
35.48Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
35.48Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.48Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
35.48Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
35.29Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
34.78Single2YDOAdenosine2YDO-A2A-Adenosine
34.78Single6MH8ZM2413856MH8-A2A-ZM241385
34.78Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
34.78Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
34.78Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
34.78Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
34.78Single8K5CAcipimox8K5C-HCA2-Acipimox
34.78Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
34.78Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
34.78Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
34.62Single4N4WSANT-14N4W-SMO-SANT-1
34.62Single6A93Risperidone6A93-5-HT2A-Risperidone
34.62Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
34.62Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
34.62Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
34.62Single7K15MKD0467K15-BLT1-MKD046-Na
34.62Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.62Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
34.62Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
34.62Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
34.62Single8JJ8Formoterol8JJ8-β2-Formoterol
34.62Single8JJLOlodaterol8JJL-β2-Olodaterol
34.62Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
34.62Consensusblt_offOrthosteric Ligandblt1_off
34.62Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
34.48Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
34.48Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
34.48Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
34.48Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
34.48Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.48Consensussst_offOrthosteric Ligandsst2_off
34.48Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
34.38Single4XT3Fractalkine4XT3-US28-Fractalkine
34.38Single7SK3CXCL127SK3-ACKR3-CXCL12
34.38Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
34.38Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.38Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
34.38Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
34.38Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
34.29Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
33.33Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
33.33Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
33.33Single5UENDU1725UEN-A1-DU172
33.33Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
33.33Single6H7LDobutamine6H7L-β1-Dobutamine
33.33Single6LPJZM2413856LPJ-A2A-ZM241385-Na
33.33Single6LPKZM2413856LPK-A2A-ZM241385-Na
33.33Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
33.33Single6PS1Timolol6PS1-β2-Timolol
33.33Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
33.33Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
33.33Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
33.33Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
33.33Single7UL4Alvimopan7UL4-μ-Alvimopan
33.33Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
33.33Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
33.33Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
33.33Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
33.33Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
33.33Single8K5DGSK2560738K5D-HCA2-GSK256073
33.33Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
33.33Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
33.33Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
33.33Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Consensusgi_hcarOrthosteric Ligandgi_hca
33.33Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
33.33Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
33.33Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
33.33Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
33.33Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
32.43Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
32.43Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
32.43Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
32.43Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
32.35Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
32.35Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
32.26Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
32.26Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
32.26Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.26Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
32.26Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
32.26Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.14Single3NY9PubChem 9131033NY9-β2-PubChem 913103
32.14Single4UG2CGS216804UG2-A2A-CGS21680
32.14Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
32.14Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
32.14Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
32.14Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
32.14Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
32.14Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
32.14Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
32.14Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
32.14Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
32.14Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
32.14Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
32.14Consensuslpl_offOrthosteric Ligands1p_off lpa_off
32.14Consensuslpl_onOrthosteric Ligands1p_on lpa_on
32.14Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.14Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
32.00Single5C1MBU725C1M-μ-BU72
32.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
32.00Single5N2SPSB365N2S-A1-PSB36
32.00Single5WQCEMPA5WQC-OX2-EMPA
32.00Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
32.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
32.00Single6LPLZM2413856LPL-A2A-ZM241385-Na
32.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
32.00Single6S0QZM2413856S0Q-A2A-ZM241385
32.00Single6WQAZM2413856WQA-A2A-ZM241385-Na
32.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
32.00Single7RM5ZM2413857RM5-A2A-ZM241385-Na
32.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
32.00Single7XKAEpinephrine7XKA-β2-Epinephrine
32.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
32.00Single8FYNZM2413858FYN-A2A-ZM241385-Na
32.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
32.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
32.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
32.00Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
32.00Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
32.00Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
32.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
32.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
31.82Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
31.82Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
31.82Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
31.82Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
31.82Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
31.82Single8K5BNiacin8K5B-HCA2-Niacin
31.25Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
31.03Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
31.03Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
31.03Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
31.03Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
31.03Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
31.03Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
31.03Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
31.03Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
30.77Single2YDVNECA2YDV-A2A-NECA
30.77Single3P0GBI1671073P0G-β2-BI167107
30.77Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
30.77Single4UHRCGS216804UHR-A2A-CGS21680
30.77Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
30.77Single5G53NECA5G53-A2A-NECA-Gs
30.77Single6J21Aprepitant6J21-NK1-Aprepitant
30.77Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
30.77Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
30.77Single7F1TMIP-1a7F1T-CCR5-MIP-1a
30.77Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
30.77Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
30.77Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
30.77Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
30.77Single7TUYGSK682753A7TUY-GPR183-GSK682753A
30.77Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.77Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
30.77Single8E0GBU728E0G-μ-BU72
30.77Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
30.77Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
30.77Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
30.77Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
30.77Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Consensusadenosine_offOrthosteric Liganda1_off a2_off
30.77Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
30.77Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
30.77Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
30.77Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
30.77Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
30.77Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
30.43Single3PWHZM2413853PWH-A2A-ZM241385
30.43Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
30.43Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
30.43Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
30.43Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.43Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
30.43Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.43Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
30.43Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
30.43Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.43Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.43Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
30.43Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
30.43Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
30.30Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
30.00Single7SK5CXCL127SK5-ACKR3-CXCL12
30.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
30.00Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
30.00Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
29.73Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
29.63Single4AMIBucindolol4AMI-β1-Bucindolol
29.63Single4LDEBI1671074LDE-β2-BI167107
29.63Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
29.63Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
29.63Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
29.63Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
29.63Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
29.63Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
29.63Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.63Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
29.63Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
29.63Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
29.63Single7YITNalfurafine7YIT-κ-Nalfurafine
29.63Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
29.63Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
29.63Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
29.63Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
29.63Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
29.63Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
29.63Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
29.63Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
29.63Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
29.63Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
29.63Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
29.63Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
29.63Consensusnts_offOrthosteric Ligandnts1_off
29.63Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
29.63Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
29.63Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
29.17Single3REYPubChem 56973REY-A2A-PubChem 5697
29.17Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
29.17Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
29.17Single4MBSMaraviroc4MBS-CCR5-Maraviroc
29.17Single4ZJCSB-6740424ZJC-OX1-SB-674042
29.17Single5IU4ZM2413855IU4-A2A-ZM241385-Na
29.17Single5IUBQ274563445IUB-A2A-Q27456344-Na
29.17Single5K2BZM2413855K2B-A2A-ZM241385-Na
29.17Single5K2CZM2413855K2C-A2A-ZM241385-Na
29.17Single5NLXZM2413855NLX-A2A-ZM241385-Na
29.17Single5NM4ZM2413855NM4-A2A-ZM241385-Na
29.17Single6AQFZM2413856AQF-A2A-ZM241385
29.17Single6DS0Ly2660976DS0-5-HT2B-Ly266097
29.17Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
29.17Single6PS4ICI 118-5516PS4-β2-ICI 118-551
29.17Single6TPGEMPA6TPG-OX2-EMPA
29.17Single6V9SGTPL114036V9S-OX1-GTPL11403
29.17Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
29.17Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
29.17Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
29.17Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
29.17Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
29.17Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
29.17Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.17Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.17Single8GGQEpinephrine8GGQ-β2-Epinephrine
29.17Single8GGTEpinephrine8GGT-β2-Epinephrine
29.17Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.17Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.17Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.17Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
29.17Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
29.17Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
29.03Single6PT2KGCHM076PT2-δ-KGCHM07
29.03Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
29.03Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
29.03Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.03Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
29.03Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
29.03Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
28.57Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
28.57Single4BUONeurotensin4BUO-NTS1-Neurotensin
28.57Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
28.57Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
28.57Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
28.57Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
28.57Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
28.57Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
28.57Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
28.57Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
28.57Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
28.57Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
28.57Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
28.57Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
28.57Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
28.57Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
28.57Single8A2OTheophylline8A2O-A2A-Theophylline-Na
28.57Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
28.57Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
28.57Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
28.57Consensusendothelin_offOrthosteric Ligandetb_off
28.57Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
28.57Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
28.57Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
28.57Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
28.57Consensusorexin_onOrthosteric Ligandox2_on
28.12Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
28.12Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
28.12Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
28.12Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
28.00Single2Y01Dobutamine2Y01-β1-Dobutamine
28.00Single3EMLZM2413853EML-A2A-ZM241385
28.00Single3NY8ICI 118-5513NY8-β2-ICI 118-551
28.00Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
28.00Single4EIYZM2413854EIY-A2A-ZM241385-Na
28.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
28.00Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
28.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
28.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
28.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
28.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
28.00Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
28.00Single5K2AZM2413855K2A-A2A-ZM241385-Na
28.00Single5OLGZM2413855OLG-A2A-ZM241385-Na
28.00Single5VRAZM2413855VRA-A2A-ZM241385-Na
28.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
28.00Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
28.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
28.00Single6S0LZM2413856S0L-A2A-ZM241385
28.00Single6TOTLemborexant6TOT-OX1-Lemborexant
28.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
28.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
28.00Single7BU7BI1671077BU7-β1-BI167107
28.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
28.00Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
28.00Single7PYRPSB-21157PYR-A2A-PSB-2115
28.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
28.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
28.00Single8CU6LJ-45178CU6-A2A-LJ-4517
28.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
28.00Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
28.00Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
28.00Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
28.00Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.00Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.00Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.00Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.00Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.00Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.00Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.00Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.00Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.00Single8GGJEpinephrine8GGJ-β2-Epinephrine
28.00Single8GGNEpinephrine8GGN-β2-Epinephrine
28.00Single8GGOEpinephrine8GGO-β2-Epinephrine
28.00Single8GGUEpinephrine8GGU-β2-Epinephrine
28.00Single8JJOAlprenolol8JJO-β2-Alprenolol
28.00Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.00Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
28.00Consensusa2_offOrthosteric Liganda2a_off
28.00Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
28.00Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
28.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
28.00Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
28.00Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
28.00Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
27.59Single6PT3DPI-2876PT3-δ-DPI-287
27.59Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
27.59Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.59Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
27.59Single7SK9CCX6627SK9-ACKR3-CCX662
27.59Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
27.59Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.59Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Single8X5YAstemizole8X5Y-H1-Astemizole
27.59Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
27.59Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
27.59Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.59Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
27.27Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
27.27Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
27.27Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
27.27Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
27.27Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
27.27Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
26.92Single2Y00Dobutamine2Y00-β1-Dobutamine
26.92Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
26.92Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
26.92Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
26.92Single5NM2ZM2413855NM2-A2A-ZM241385-Na
26.92Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
26.92Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
26.92Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
26.92Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
26.92Single6E67BI1671076E67-β2-BI167107-Gs (fused)
26.92Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
26.92Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
26.92Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
26.92Single6PS6Timolol6PS6-β2-Timolol
26.92Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
26.92Single6TP6Filorexant6TP6-OX1-Filorexant
26.92Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
26.92Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
26.92Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
26.92Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
26.92Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
26.92Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.92Single7YXAONO-54306087YXA-S1P5-ONO-5430608
26.92Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
26.92Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
26.92Single8GNEKW-63568GNE-A2A-KW-6356-Na
26.92Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
26.92Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
26.92Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
26.92Single8QOTNanobody E8QOT-μ-Nanobody E
26.92Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
26.92Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
26.92Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
26.92Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
26.92Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
26.92Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
26.92Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
26.92Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
26.92Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
26.92Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
26.92Consensusep_offOrthosteric Ligandep4_off
26.92Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
26.92Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
26.92Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
26.92Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single4XT1Fractalkine4XT1-US28-Fractalkine
26.67Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
26.67Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
26.67Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
26.67Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
26.47Single6FJ3PTH6FJ3-PTH1-PTH
26.47Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
26.47Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
26.32Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
26.09Single3OE9IT1t3OE9-CXCR4-IT1t
26.09Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
26.09Single5L7IVismodegib5L7I-SMO-Vismodegib
26.09Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
26.09Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
26.09Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.09Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.09Single8GH1Epinephrine8GH1-β2-Epinephrine
26.09Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
26.09Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.93Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
25.93Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
25.93Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
25.93Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
25.93Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
25.93Single5V56TC1145V56-SMO-TC114
25.93Single5X93K-87945X93-ETB-K-8794
25.93Single6H7JIsoprenaline6H7J-β1-Isoprenaline
25.93Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
25.93Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
25.93Single6TQ7SB-3348676TQ7-OX1-SB-334867
25.93Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
25.93Single6WGTLSD6WGT-5-HT2A-LSD
25.93Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
25.93Single7B6WCyclazosin7B6W-α1b-Cyclazosin
25.93Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
25.93Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
25.93Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
25.93Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
25.93Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
25.93Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
25.93Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
25.93Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
25.93Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
25.93Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.93Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
25.93Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
25.93Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
25.93Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
25.93Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
25.93Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
25.93Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
25.93Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
25.93Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
25.93Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
25.93Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
25.93Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
25.93Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
25.93Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
25.93Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
25.93Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
25.93Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
25.93Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
25.93Consensuslpa_offOrthosteric Ligandlpa1_off
25.93Consensuslpa_onOrthosteric Ligandlpa1_on
25.93Consensusrelaxin_onOrthosteric Ligandrxfp4_on
25.93Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
25.81Single6HLOAprepitant6HLO-NK1-Aprepitant
25.81Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
25.81Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
25.81Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
25.81Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
25.81Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.81Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
25.71Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
25.71Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
25.00Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
25.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
25.00Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
25.00Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
25.00Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
25.00Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
25.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
25.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
25.00Single4XESNeurotensin4XES-NTS1-Neurotensin
25.00Single5K2DZM2413855K2D-A2A-ZM241385
25.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
25.00Single5WS3EMPA5WS3-OX2-EMPA
25.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
25.00Single6AKXA4R6AKX-CCR5-A4R
25.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
25.00Single6CM4Risperidone6CM4-D2-Risperidone
25.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
25.00Single6JZHZM2413856JZH-A2A-ZM241385-Na
25.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
25.00Single6PS7ZM2413856PS7-A2A-ZM241385-Na
25.00Single6TODEMPA6TOD-OX1-EMPA-Na
25.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
25.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
25.00Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
25.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
25.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
25.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
25.00Single7DFPSpiperone7DFP-D2-Spiperone
25.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
25.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
25.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
25.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
25.00Single7F8ULintitript7F8U-CCKA-Lintitript
25.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
25.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
25.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
25.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
25.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
25.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
25.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
25.00Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
25.00Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GGVEpinephrine8GGV-β2-Epinephrine
25.00Single8GGWEpinephrine8GGW-β2-Epinephrine
25.00Single8GGXEpinephrine8GGX-β2-Epinephrine
25.00Single8GH0Epinephrine8GH0-β2-Epinephrine
25.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8IHKAcifran8IHK-HCA3-Acifran
25.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8IWESpermidine8IWE-TAAR9-Spermidine
25.00Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
25.00Single8JWZAB9288JWZ-A2A-AB928-Na
25.00Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
25.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
25.00Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
25.00Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
25.00Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
25.00Consensuschemokine_offOrthosteric Ligandcxcr_off
25.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
25.00Consensuscxcr_offOrthosteric Ligandcxcr4_off
25.00Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
25.00Consensusgi_class-fOther Ligandgi_frizzled
25.00Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
25.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
25.00Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
25.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
25.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
25.00Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
25.00Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
24.24Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
24.24Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
24.24Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
24.14Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
24.14Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
24.14Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
24.14Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
24.14Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
24.14Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
24.14Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
24.14Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
24.14Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
24.14Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
24.14Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
24.14Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
24.14Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
24.14Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
24.14Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
24.14Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
24.14Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
24.00Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
24.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
24.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
24.00Single5JTBZM2413855JTB-A2A-ZM241385
24.00Single5UVIZM2413855UVI-A2A-ZM241385
24.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
24.00Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
24.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
24.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
24.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
24.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
24.00Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
24.00Single6ZINSR486926ZIN-NTS1-SR48692
24.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
24.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
24.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
24.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
24.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
24.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
24.00Single7T32ZM2413857T32-A2A-ZM241385
24.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
24.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
24.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
24.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.00Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
24.00Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
24.00Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
24.00Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
24.00Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
24.00Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
24.00Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
24.00Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
24.00Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
24.00Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
24.00Single8GGIEpinephrine8GGI-β2-Epinephrine
24.00Single8GGKEpinephrine8GGK-β2-Epinephrine
24.00Single8GGMEpinephrine8GGM-β2-Epinephrine
24.00Single8GGPEpinephrine8GGP-β2-Epinephrine
24.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
24.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
24.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
24.00Single8K2WAMG4878K2W-CXCR3-AMG487
24.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
24.00Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
24.00Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
24.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
24.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
24.00Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
24.00Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
24.00Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
24.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
24.00Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
23.81Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
23.81Single8PWNTheophylline8PWN-A2A-Theophylline
23.68Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
23.68Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
23.53Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
23.53Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
23.53Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Single5EE7MK08935EE7-Glucagon-MK0893
23.33Single5ZTYAM102575ZTY-CB2-AM10257
23.33Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
23.33Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
23.33Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.33Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
23.08Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
23.08Single2Y02Carmoterol2Y02-β1-Carmoterol
23.08Single2Y04Salbutamol2Y04-β1-Salbutamol
23.08Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
23.08Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
23.08Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
23.08Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
23.08Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
23.08Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
23.08Single4YAYZD-71554YAY-AT1-ZD-7155
23.08Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
23.08Single5TGZAM65385TGZ-CB1-AM6538
23.08Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
23.08Single6H7MSalbutamol6H7M-β1-Salbutamol
23.08Single6IIVDaltroban6IIV-TP-Daltroban
23.08Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
23.08Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
23.08Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
23.08Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
23.08Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
23.08Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
23.08Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
23.08Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
23.08Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
23.08Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
23.08Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
23.08Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
23.08Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
23.08Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
23.08Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
23.08Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
23.08Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
23.08Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
23.08Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
23.08Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
23.08Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
23.08Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
23.08Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
23.08Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
23.08Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
23.08Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
23.08Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
23.08Consensuscck_offOrthosteric Ligandccka_off
23.08Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
23.08Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
23.08Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
23.08Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
23.08Consensustar_onOrthosteric Ligandta1_on
23.08Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
22.86Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
22.86Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
22.86Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
22.86Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
22.86Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
22.73Single3RFMCaffeine3RFM-A2A-Caffeine
22.73Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
22.73Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.73Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
22.58Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
22.50Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
22.50Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
22.22Single2Y03Isoprenaline2Y03-β1-Isoprenaline
22.22Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
22.22Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
22.22Single5TVNLSD5TVN-5-HT2B-LSD
22.22Single5WIUNemonapride5WIU-D4-Nemonapride
22.22Single5WIVNemonapride5WIV-D4-Nemonapride-Na
22.22Single6GPXMK08126GPX-CCR2-MK0812
22.22Single6LUQHaloperidol6LUQ-D2-Haloperidol
22.22Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
22.22Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
22.22Single6Z4SSR486926Z4S-NTS1-SR48692
22.22Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
22.22Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
22.22Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
22.22Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
22.22Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
22.22Single7SINNPS-21437SIN-CaS-NPS-2143
22.22Single7SINNPS-21437SIN-CaS-NPS-2143
22.22Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
22.22Single7WC6LSD7WC6-5-HT2A-LSD
22.22Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.22Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.22Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
22.22Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
22.22Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
22.22Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
22.22Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
22.22Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
22.22Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
22.22Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
22.22Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
22.22Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
22.22Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
22.22Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
22.22Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
21.88Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
21.88Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
21.74Single3OE6IT1t3OE6-CXCR4-IT1t
21.74Single3UZAGTPL92363UZA-A2A-GTPL9236
21.74Single4XNWMRS25004XNW-P2Y1-MRS2500
21.74Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
21.74Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
21.74Single7WC5Psilocin7WC5-5-HT2A-Psilocin
21.74Single8GGREpinephrine8GGR-β2-Epinephrine
21.74Single8GGZEpinephrine8GGZ-β2-Epinephrine
21.74Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
21.74Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
21.62Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
21.62Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
21.62Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
21.62Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
21.43Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
21.43Single4DJHJDTic4DJH-κ-JDTic
21.43Single5V57TC1145V57-SMO-TC114
21.43Single6J20Aprepitant6J20-NK1-Aprepitant
21.43Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
21.43Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
21.43Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
21.43Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
21.43Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
21.43Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
21.43Single7W41PD1762527W41-BB2-PD176252
21.43Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
21.43Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.43Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
21.43Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
21.43Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
21.43Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
21.43Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
21.43Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
21.43Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
21.43Consensus5ht5_offOrthosteric Ligand5ht5a_off
21.43Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
21.43Consensusbombesin_offOrthosteric Ligandbb2_off
21.43Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
21.43Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
21.43Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
21.43Consensushistamine_offOrthosteric Ligandh1_off
21.43Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
21.43Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
21.43Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
21.43Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
21.21Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
21.21Single6W25SHU91196W25-MC4-SHU9119-Ca
21.21Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
21.21Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
21.21Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
21.05Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
20.93Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
20.83Single3PBLEticlopride3PBL-D3-Eticlopride
20.83Single4O9RCyclopamine4O9R-SMO-Cyclopamine
20.83Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
20.83Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
20.83Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
20.83Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
20.83Single7SRQLSD7SRQ-5-HT2B-LSD
20.83Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
20.83Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
20.83Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
20.83Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
20.83Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
20.83Single8GGSEpinephrine8GGS-β2-Epinephrine
20.83Single8GGYEpinephrine8GGY-β2-Epinephrine
20.83Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
20.83Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.83Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
20.83Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
20.83Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
20.83Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
20.83Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
20.83Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
20.69Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
20.69Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
20.69Single6IIURamatroban6IIU-TP-Ramatroban
20.69Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.69Single6ZG4HTL00099366ZG4-M1-HTL0009936
20.69Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
20.69Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
20.69Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
20.69Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
20.69Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
20.69Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
20.69Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.69Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
20.69Single8WU1KCA8WU1-CB1-KCA-Arrestin1
20.69Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
20.69Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
20.69Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
20.69Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
20.69Consensusclass-b2_onOrthosteric Ligandadgrg_on
20.69Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
20.69Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
20.69Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
20.69Consensusnts_onOrthosteric Ligandnts1_on
20.69Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
20.59Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
20.59Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
20.59Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.51Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
20.51Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
20.51Consensusglp_onOrthosteric Ligandglp1_on glp2_on
20.45Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
20.00Single3ODUIT1t3ODU-CXCR4-IT1t
20.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
20.00Single4QINSAG1.54QIN-SMO-SAG1.5
20.00Single5DHHSB-6121115DHH-NOP-SB-612111
20.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
20.00Single6B73PubChem 1319551386B73-κ-PubChem 131955138
20.00Single6KUXRS-799486KUX-α2a-RS-79948
20.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
20.00Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
20.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
20.00Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
20.00Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
20.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
20.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
20.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
20.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
20.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
20.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
20.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
20.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
20.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
20.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
20.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
20.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
20.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
20.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
20.00Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
20.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
20.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
20.00Single7XRRLemborexant7XRR-OX2-Lemborexant
20.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
20.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
20.00Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
20.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
20.00Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
20.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
20.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
20.00Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
20.00Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
20.00Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
20.00Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
20.00Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
20.00Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgt_class-aOrthosteric Ligandgt_opsin
20.00Consensusgt_opsinOrthosteric Ligandgt_sensory
20.00Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
20.00Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
20.00Consensusmglu_onOther Ligandmglu2_on mglu4_on
20.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
19.57Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
19.57Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
19.51Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
19.51Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
19.44Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
19.44Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
19.44Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
19.44Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
19.44Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
19.35Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.35Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
19.35Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
19.35Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.35Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
19.23Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
19.23Single6IQLL7458706IQL-D4-L745870
19.23Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
19.23Single6TPKRetosiban6TPK-OT-Retosiban
19.23Single6VI4JDTic6VI4-κ-JDTic
19.23Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
19.23Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
19.23Single6ZG9GSK10347026ZG9-M1-GSK1034702
19.23Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
19.23Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
19.23Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
19.23Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
19.23Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
19.23Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
19.23Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
19.23Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
19.23Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
19.23Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
19.23Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
19.23Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
19.23Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
19.23Single8GGLEpinephrine8GGL-β2-Epinephrine
19.23Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
19.23Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
19.23Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
19.23Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Consensus5ht5_onOrthosteric Ligand5ht5a_on
19.23Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
19.23Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
19.23Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
19.23Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
19.23Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
19.23Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
19.23Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
19.23Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
19.23Consensuss1p_offOrthosteric Ligands1p1_off
19.23Consensusvasopressin-ot_offOrthosteric Ligandot_off
19.05Single5MZPCaffeine5MZP-A2A-Caffeine-Na
19.05Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
19.05Consensuspth_onOrthosteric Ligandpth1_on pth2_on
18.92Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
18.92Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
18.92Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
18.92Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
18.92Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
18.92Consensusgo_class-b1Orthosteric Ligandgo_crf
18.92Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.92Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
18.92Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.75Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
18.75Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
18.75Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
18.75Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
18.75Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
18.52Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
18.52Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
18.52Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
18.52Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
18.52Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
18.52Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
18.52Single6DRXLisuride6DRX-5-HT2B-Lisuride
18.52Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
18.52Single6GPSMK08126GPS-CCR2-MK0812
18.52Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
18.52Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
18.52Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
18.52Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
18.52Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
18.52Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
18.52Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
18.52Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
18.52Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
18.52Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
18.52Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
18.52Single7WC7Lisuride7WC7-5-HT2A-Lisuride
18.52Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
18.52Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
18.52Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
18.52Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
18.52Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
18.52Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
18.52Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
18.52Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single8X63Mepyramine8X63-H1-Mepyramine
18.52Single8X64Desloratadine8X64-H1-Desloratadine
18.52Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
18.52Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
18.52Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
18.52Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
18.52Consensusblt_onOrthosteric Ligandblt1_on
18.52Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
18.52Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
18.52Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
18.52Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
18.52Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
18.52Consensushistamine_onOrthosteric Ligandh1_on h4_on
18.52Consensusleuko_onOrthosteric Ligandblt_on
18.52Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
18.52Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
18.52Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
18.52Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
18.52Consensustachykinin_offOrthosteric Ligandnk1_off
18.42Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
18.42Single6LMLGlucagon6LML-Glucagon-Glucagon
18.42Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
18.42Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
18.42Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.42Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
18.42Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
18.42Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
18.18Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
18.18Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
18.18Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
18.18Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
18.18Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
18.18Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
18.18Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
17.95Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
17.95Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
17.95Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
17.95Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
17.95Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.86Single5CGCHTL142425CGC-mGlu5-HTL14242
17.86Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
17.86Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
17.86Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
17.86Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
17.86Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
17.86Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
17.86Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
17.86Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
17.86Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
17.86Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
17.86Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
17.86Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
17.86Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
17.86Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
17.86Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
17.50Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
17.39Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
17.39Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
17.39Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
17.39Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
17.39Consensussensory_onOrthosteric Ligandopsin_on
17.24Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
17.24Single4BV0Neurotensin4BV0-NTS1-Neurotensin
17.24Single4U15Tiotropium4U15-M3-Tiotropium
17.24Single5V54Methiothepin5V54-5-HT1B-Methiothepin
17.24Single5XR8AM8415XR8-CB1-AM841
17.24Single5XRAAM115425XRA-CB1-AM11542
17.24Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
17.24Single6E59L-7607356E59-NK1-L-760735
17.24Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
17.24Single6OL9Tiotropium6OL9-M5-Tiotropium
17.24Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
17.24Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
17.24Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
17.24Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
17.24Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
17.24Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
17.24Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.24Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
17.24Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
17.24Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
17.24Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
17.24Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
17.24Consensus5ht1_offOrthosteric Ligand5ht1b_off
17.24Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
17.24Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
17.24Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
17.24Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
17.24Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
17.14Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
17.14Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.14Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
17.14Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
17.14Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
17.07Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
17.07Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
16.67Single3OE8IT1t3OE8-CXCR4-IT1t
16.67Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.67Single4PY02MeSATP4PY0-P2Y12-2MeSATP
16.67Single5CXVTiotropium5CXV-M1-Tiotropium
16.67Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
16.67Single5X33BIIL2605X33-BLT1-BIIL260
16.67Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
16.67Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
16.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
16.67Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
16.67Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
16.67Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
16.67Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
16.67Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.67Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
16.67Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
16.67Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
16.67Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
16.67Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.67Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
16.67Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
16.67Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
16.67Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
16.67Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
16.67Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
16.67Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
16.67Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
16.67Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
16.67Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
16.67Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
16.67Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
16.67Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
16.28Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
16.22Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.22Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
16.22Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.22Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
16.22Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.13Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.13Single5CGDHTL142425CGD-mGlu5-HTL14242
16.13Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
16.13Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
16.13Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
16.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
16.00Single6HLLCP999946HLL-NK1-CP99994
16.00Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
16.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
16.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
16.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
16.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
16.00Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
16.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
16.00Consensusclass-t_onOrthosteric Ligandtaste2_on
16.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
16.00Consensusgs_class-tOrthosteric Ligandgs_taste
16.00Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
16.00Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
16.00Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.79Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
15.79Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
15.62Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
15.62Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Consensusgs_class-b2Orthosteric Ligandgs_adgr
15.62Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
15.38Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
15.38Single4BWBNeurotensin4BWB-NTS1-Neurotensin
15.38Single5U09Taranabant5U09-CB1-Taranabant
15.38Single6ME2Ramelteon6ME2-MT1-Ramelteon
15.38Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
15.38Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
15.38Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
15.38Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
15.38Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
15.38Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
15.38Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
15.38Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
15.38Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
15.38Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
15.38Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
15.38Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
15.38Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Consensusclass-f_offOrthosteric Ligandsmo_off
15.38Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
15.22Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
15.15Single7QA8Peptide7QA8-STE2-Peptide
15.15Single7QA8Peptide7QA8-STE2-Peptide
15.15Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
15.15Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
15.15Consensusclass-d_offOrthosteric Ligandste2_off
15.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
14.89Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
14.81Single3RZECidoxepin3RZE-H1-Cidoxepin
14.81Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
14.81Single6A94Zotepine6A94-5-HT2A-Zotepine
14.81Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
14.81Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
14.81Single6TPNHTL66416TPN-OX2-HTL6641
14.81Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
14.81Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
14.81Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Single7VODCariprazine7VOD-5-HT2A-Cariprazine
14.81Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
14.81Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
14.81Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
14.81Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
14.81Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
14.81Consensusgi_class-fOrthosteric Ligandgi_frizzled
14.81Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
14.81Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
14.81Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
14.81Consensussensory_offOrthosteric Ligandopsin_off
14.71Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
14.71Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.63Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
14.29Single4DAJTiotropium4DAJ-M3-Tiotropium
14.29Single4MQSIperoxo4MQS-M2-Iperoxo
14.29Single4U14Tiotropium4U14-M3-Tiotropium
14.29Single5DSGTiotropium5DSG-M4-Tiotropium
14.29Single5T04Neurotensin5T04-NTS1-Neurotensin
14.29Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
14.29Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
14.29Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
14.29Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
14.29Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
14.29Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
14.29Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
14.29Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
14.29Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
14.29Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
14.29Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensushcar_offOrthosteric Ligandsuccinate_off
14.29Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
14.29Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
14.29Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
14.29Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
13.95Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
13.89Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
13.79Single4NTJAZD12834NTJ-P2Y12-AZD1283
13.79Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
13.79Single5XPRBosentan5XPR-ETB-Bosentan
13.79Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
13.79Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
13.79Single7C4SS1P7C4S-S1P3-S1P
13.79Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
13.79Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
13.79Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
13.79Single8EA0Iperoxo8EA0-M3-Iperoxo
13.79Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
13.79Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
13.79Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
13.64Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
13.33Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
13.33Single5TZR-5TZR-FFA1 (GPR40)-MK8666
13.33Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
13.33Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
13.33Single7EPENAM5637EPE-mGlu-NAM563
13.33Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
13.33Single7P2L4YI7P2L-mGlu5-4YI
13.33Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
13.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
13.33Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
13.33Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.16Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.16Consensusclass-d_onOrthosteric Ligandste2_on
13.16Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
13.04Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
13.04Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
13.04Single7WC4Serotonin7WC4-5-HT2A-Serotonin
13.04Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
12.90Single6HLPNetupitant6HLP-NK1-Netupitant
12.90Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
12.90Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
12.90Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
12.90Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.90Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.90Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
12.82Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
12.82Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
12.82Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
12.82Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.82Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
12.82Consensusgi_class-dOrthosteric Ligandgi_ste
12.82Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.50Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
12.50Single6K1QIRL25006K1Q-ETB-IRL2500
12.50Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
12.50Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
12.50Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
12.50Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
12.50Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
12.50Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
12.50Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
12.50Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
12.50Consensuscyslt_offOrthosteric Ligandcyslt2_off
12.12Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
12.12Consensusclass-d_offOrthosteric Ligandste2_off
12.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
12.00Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
12.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
12.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
12.00Single6LI0GTPL98046LI0-GPR52-GTPL9804
12.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
12.00Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
12.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
12.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
12.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
11.76Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
11.76Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
11.76Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
11.76Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
11.54Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
11.54Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
11.54Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
11.54Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
11.54Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
11.54Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
11.54Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
11.54Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
11.54Single6TP4ACT-4622066TP4-OX1-ACT-462206
11.54Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.54Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
11.54Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.54Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.54Consensusgo_class-b2Orthosteric Ligandgo_adhesion
11.54Consensusgo_proteinOrthosteric Ligandgo_chemokine
11.54Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
11.43Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
11.43Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
11.11Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
11.11Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
11.11Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
11.11Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
11.11Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
11.11Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
11.11Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
11.11Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.11Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
11.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
11.11Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
11.11Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
11.11Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
11.11Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
11.11Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.11Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
11.11Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
11.11Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.87Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.81Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.81Consensusclass-d_onOrthosteric Ligandste2_on
10.81Consensusgi_class-dOrthosteric Ligandgi_ste
10.81Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.71Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
10.71Single6FFIMMPEP6FFI-mGlu5-MMPEP
10.71Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
10.71Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
10.71Single7VV6C48/807VV6-MRGPRX2-C48/80
10.71Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
10.71Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
10.71Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
10.71Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
10.71Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.34Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
10.34Single6FFHFenobam6FFH-mGlu5-Fenobam
10.34Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
10.34Single7F83PF-051904577F83-Ghrelin-PF-05190457
10.34Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.34Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
10.34Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
10.26Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.00Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
9.76Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
9.68Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
9.68Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
9.68Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.68Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.38Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
9.38Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.70Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
8.70Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
8.33Consensusclass-c_onOther Ligandgabab_on mglu_on
8.11Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
8.00Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
8.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
8.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
8.00Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
8.00Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
7.69Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
7.69Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
7.69Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
7.69Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
7.69Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
7.69Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
7.69Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
7.69Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
7.41Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
7.41Single7UL2SR486927UL2-NTS1-SR48692-Na
7.41Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
7.41Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.41Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
7.14Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.14Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
6.90Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.90Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
6.90Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
6.67Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.45Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.45Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
6.25Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.76Single8W8SAA-148W8S-GPR101-AA-14
4.76Consensusclass-c_offOther Ligandgabab_off mglu_off
4.55Single8W8RAA-148W8R-GPR101-AA-14-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single8HS2Fab0468HS2-GPR20-Fab046
4.17Single6W25Ca6W25-MC4-SHU9119-Ca
4.17Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.17Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
4.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
4.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.85Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
3.85Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.70Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
3.70Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
3.70Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.57Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
3.57Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
3.57Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
3.57Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
3.57Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
3.45Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.45Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
3.45Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
3.33Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
2.94Single7SHEPI; PE7SHE-GPR158-PI; PE
2.86Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.63Single7SHEPI; PE7SHE-GPR158-PI; PE
2.63Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.27Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.22Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.22Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.22Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.22Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.22Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
2.17Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.13Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.13Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.08Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.08Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.00Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
1.92Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
1.89Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
1.82Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

Consensus Members
Id Members
7F2O 7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7EIB 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
Net Summary
Imin 2.945
Number of Linked Nodes 891
Number of Links 1149
Number of Hubs 217
Number of Links mediated by Hubs 786
Number of Communities 22
Number of Nodes involved in Communities 280
Number of Links involved in Communities 427
Path Summary
Number Of Nodes in MetaPath 155
Number Of Links MetaPath 154
Number of Shortest Paths 2003693
Length Of Smallest Path 3
Average Path Length 28.2625
Length of Longest Path 53
Minimum Path Strength 0.755
Average Path Strength 6.50315
Maximum Path Strength 35.6675
Minimum Path Correlation 0.7
Average Path Correlation 0.982483
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 44.791
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 55.951
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gs_peptidegs_cck
gs_motilin
gs_neuromedin
gs_orexin
gs_sst
gs_tachykinin
gs_trh
gs_vasopressin-ot
gs_bombesin
gs_bradykinin
gs_compl-peptide
gs_endothelin
gs_galanin
gs_ghrelin
gs_melanocortin



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gs_bradykinin.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.