Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1R2.NT 20.02461315.17857
2R2.1x30 6.9225407
3R2.1x39 5.32414
4R2.1x42 5.16407
5R2.1x43 10.7175416
6R2.1x46 5.02375819
7R2.1x53 4.56417
8R2.1x54 3.82415
9R2.I1 6.64556916.2
10R2.2x49 2.8425404
11R2.2x50 4.286517
12R2.2x57 13.13516
13R2.2x58 7.35405
14R2.2x60 10.5075416
15R2.E1x46 7.258515
16R2.E1x50 9.415417
17R2.E1x51 6.28415
18R2.3x29 7.048518
19R2.3x32 5.725416
20R2.3x36 5.03416
21R2.3x39 4.344518
22R2.3x44 5.528508
23R2.3x51 5.70754158
24R2.3x55 6.4275409
25R2.I2 5.873336104.6
26R2.4x53 10.1625417
27R2.E2 8.85501.6
28R2.5x57 4.5025158
29R2.5x65 4.045409
30R2.5x72 8.1885129
31R2.I3 5.956676128
32R2.6x30 4.612867129
33R2.6x37 2.3125408
34R2.6x48 6.41417
35R2.E3 19.742513.28571
36R2.7x39 6.9875415
37R2.7x41 4.1325415
38R2.7x42 5.5925417
39R2.7x46 5.0525418
40R2.7x50 4.22418
41R2.7x52 6.904519
42R2.7x64 8.1975416
43R1.NT 19.89731515
44R1.1x30 8.725407
45R1.1x39 6.515424
46R1.1x43 8.41667626
47R1.1x46 7.13714729
48R1.1x52 3.7415
49R1.1x54 4.426515
50R1.1x56 3.358517
51R1.1x57 4.7425418
52R1.1x58 7.5125414
53R1.1x59 8.2025407
54R1.1x60 3.6775417
55R1.I1 8.11625816
56R1.2x37 3.52418
57R1.2x39 4.72417
58R1.2x40 7.648519
59R1.2x43 7.02419
60R1.2x49 3.2404
61R1.2x50 5.54427
62R1.2x53 5.212528
63R1.2x57 10.94526
64R1.E1x49 2.9375405
65R1.E1x50 5.3725417
66R1.E1x56 11.3725417
67R1.3x25 5.8575426
68R1.3x29 6.636528
69R1.3x32 5.085426
70R1.3x36 6.245426
71R1.3x39 3.7425428
72R1.3x43 3.3725428
73R1.3x44 6.27408
74R1.3x51 6.81754168
75R1.3x54 4.6575408
76R1.3x55 6.332509
77R1.I2 5.503758135
78R1.4x53 11.3625427
79R1.E2 5.47722
80R1.5x42 5525
81R1.5x47 5.395426
82R1.5x56 4.705406
83R1.5x57 5.3445168
84R1.5x65 2.8475409
85R1.5x72 8.42569
86R1.I3 5.14286768
87R1.6x30 4.712569
88R1.6x36 3.0275409
89R1.6x41 5.644179
90R1.6x52 7.355426
91R1.E3 14.054523
92R1.7x39 6.165425
93R1.7x41 4.4425425
94R1.7x49 3.8775428
95R1.7x52 7.188519
96R1.7x58 8.79569
97R1.7x64 7.42416
98R2.Lig 12.75362210
99R1.Lig 12.61282520
100b.h1x2 4.54111
101b.lhb1x8 6.0965193
102b.lhb1x13 4.0625476
103b.lhb1x20 9.424536
104b.lhb1x22 6.44333639
105b.b1x3 6.72437
106b.b1x4 8.2125435
107b.b1x5 7.06857739
108b.l1x4 6.1725436
109b.l1x6 6.72406
110b.b2x2 5.11488
111b.b2x3 3.775439
112b.l2x4 7.384538
113b.l2x5 4.5688
114b.b3x1 5.982538
115b.b3x2 5.4954226
116b.b3x3 10.4975439
117b.l3x7 6.47167639
118b.b4x4 3.22408
119b.l4x1 5.1489
120b.l4x5 7.256676239
121b.l5x1 5.224217
122b.b6x1 3.8425403
123b.b7x1 4.5175449
124b.b7x3 4.6546
125b.b7x4 7.7925488
126b.l7x9 7.774144
127b.b8x3 3.538587
128b.b8x4 10.592548
129b.l8x3 9.144549
130b.l8x5 4.2448
131b.l8x6 6.186549
132b.l8x7 4.8625448
133b.b9x3 4.348508
134b.l9x1 6.0365219
135b.b10x1 6.175408
136b.b10x3 5.105449
137b.l10x2 9.065449
138b.l10x4 5.822548
139b.b11x2 4.0775498
140b.b11x3 12.088509
141b.insx8 5.16598
142b.insx14 6.088549
143b.insx21 7.2875404
144b.insx27 8.272599
145b.insx30 3.775608
146b.insx37 12.3525497
147b.insx39 7.705699
148b.b19x2 3.03407
149b.b19x4 9.2675406
150b.l19x1 7.455187
151b.b21x3 5.39754118
152b.b21x6 15.52407
153b.l21x5 3.5875407
154b.l21x10 5.4845117
155b.l21x14 3.818336118
156b.b22x3 3.5085115
157b.l22x1 6.5275408
158b.b23x1 6.7475478
159b.b23x2 4.8825117
160b.b23x3 7.87678
161b.b24x4 5.894508
162b.l24x4 11.74254198
163b.l25x7 8.31579
164b.b26x3 4.1625408
165b.b26x4 8.695434
166b.l26x1 6.5925439
167b.b27x2 5.5175438
168b.l28x1 6.9875479
169b.l28x2 20.0954209
170b.l28x3 8.615479
171b.b28x3 5.795437
172b.b28x4 7.04578
173b.b28x6 7.61667678
174b.ctx4 9.848575
175G.HN.25 3.9825401
176G.HN.44 3.9525439
177G.HN.50 6.3325435
178G.S1.05 7.2325449
179G.S1.06 4.91409
180G.S2.06 4.1885138
181G.S3.03 5.4025136
182G.S3.04 5.105437
183G.H2.07 8.17549
184G.H2.08 3.855449
185G.H2.09 7.37254209
186G.h2s4.01 5.6475449
187G.h2s4.04 5.7575449
188G.S4.03 6.9825407
189G.S4.04 5.765459
190G.S4.06 3.9175456
191G.s4h3.01 6.19557
192G.H3.09 7.21459
193G.H3.13 4.45655
194G.H3.18 5.1375409
195G.S5.02 7.96458
196G.S5.03 4.6925469
197G.S5.05 4.1975469
198G.S5.06 5.42458
199G.S5.07 6.275409
200G.s5hg.01 8.714259
201G.HG.07 6.57754269
202G.hgh4.01 7.398556
203G.hgh4.02 3.09409
204G.H4.08 5.342554
205G.H4.11 7.566558
206G.S6.02 6.316569
207G.S6.05 10.515457
208G.H5.11 4.2475408
209G.H5.13 8.4725469
210G.H5.17 8.18468
211G.H5.20 4.3125409
212G.H5.23 6.8725418
213G.H5.25 3.98416
214G2.H5.23 6.625410
215G2.H5.25 3.754510
216G2.H5.26 3.7775400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R2.7x42 R2.Lig 15.90626.24YesYes170
2R2.1x46 R2.7x42 18.04426.47YesYes197
3R2.1x46 R2.7x46 33.90037.29YesYes198
4R2.1x49 R2.7x46 24.47333.15NoYes088
5R1.1x52 R2.1x49 24.60253.15YesNo058
6R1.1x52 R2.7x50 24.59862.77YesYes158
7R2.7x46 R2.7x50 25.186.92YesYes188
8R1.1x49 R2.1x52 16.94023.15NoNo085
9R1.1x49 R1.7x46 16.89893.15NoNo088
10R1.1x46 R1.7x46 35.86946.07YesNo098
11R1.1x43 R1.1x46 15.92346.41YesYes269
12R1.1x43 R1.Lig 14.27583.09YesYes260
13R1.E1x46 R1.Lig 14.44635.79NoYes250
14R1.3x25 R1.E1x46 14.02363.45YesNo265
15R1.3x25 R1.E1x45 13.26496.73YesNo263
16R1.E1x45 R1.E1x59 13.037818.12NoNo033
17R1.E1x50 R1.E1x59 12.79847.78YesNo073
18R1.7x50 R2.1x52 17.80782.77NoNo085
19R1.7x46 R1.7x50 19.12748.3NoNo088
20R1.1x46 R1.2x53 15.96175.64YesYes298
21R1.2x53 R1.Lig 14.26324.36YesYes280
22R2.1x52 R2.1x55 34.72054.28NoNo055
23R2.1x55 R2.1x59 34.13932.92NoNo657
24R1.1x52 R1.1x56 49.77142.98YesYes157
25R1.7x58 R2.1x59 34.229913.96YesNo697
26R2.7x64 R2.I1 10.59677.23YesYes166.2
27R1.I1 R2.7x64 11.454114.46YesYes166
28R1.1x60 R1.I1 54.00135.17YesYes176
29R1.1x56 R1.1x60 53.34993.17YesYes177
30R2.3x39 R2.3x43 11.77334.28YesNo088
31R2.3x43 R2.3x47 16.70392.85NoNo089
32R2.3x47 R2.5x57 10.71072.83NoYes098
33R1.1x57 R1.I1 64.02614.6YesYes186
34R1.1x57 R1.2x43 63.95475.61YesYes189
35R1.2x39 R1.2x43 31.53672.83YesYes179
36R1.2x43 R1.7x52 34.22668.24YesYes199
37G.H5.23 R1.2x39 30.83778.83YesYes187
38G.H5.20 R1.3x53 31.00272.98YesNo098
39G.H5.23 R1.3x53 30.9859.22YesNo088
40R1.6x36 R1.7x55 31.35283.07YesNo099
41R1.7x52 R1.7x55 31.48464.5YesNo099
42G.S4.03 G.S5.03 97.87795.71YesYes079
43G.S5.03 G.S6.02 99.11526.04YesYes699
44G.H5.13 G.S6.02 10010.34YesYes699
45G.H5.13 R1.5x72 65.05619.53YesYes699
46R1.5x72 R1.I3 65.22898.5YesYes698
47R1.7x58 R1.I3 65.13273.01YesYes698
48G.H5.16 R1.6x30 35.0163.77NoYes069
49G.H5.16 G.H5.20 34.9792.85NoYes069
50G.S1.06 G.S4.03 95.796811.07YesYes097
51G.H1.01 G.S1.06 96.56452.82NoYes099
52G.H1.01 G.S4.05 96.53686.07NoNo098
53G.S4.05 G.S5.07 96.50964.43NoYes089
54G.S5.07 G.s5hg.01 97.206911.19YesYes099
55G.S4.07 G.s5hg.01 96.901213.83NoYes099
56G.S4.07 G.s4h3.03 96.872211.98NoNo099
57G.H3.01 G.s4h3.03 97.15493.57NoNo099
58G.H3.01 G.s1h1.02 97.09582.77NoNo098
59G.s1h1.02 G.s3h2.03 97.03644.55NoNo089
60G.H2.04 G.s3h2.03 96.886210.51NoNo099
61G.H2.04 G.H2.07 94.713910NoYes099
62G.H2.07 b.l6x2 75.674413.67YesNo099
63G.S2.01 b.l6x2 75.51284.28NoNo099
64G.S2.01 b.l4x5 75.37733.52NoYes2399
65b.l2x1 b.l4x5 76.27974.38NoYes099
66b.l2x1 b.lhb1x24 76.74025.28NoNo098
67b.b2x5 b.lhb1x24 74.73842.98NoNo098
68b.b2x5 b.lhb1x22 74.69528.37NoYes099
69b.lhb1x20 b.lhb1x22 37.768610.48YesYes369
70b.b28x3 b.lhb1x20 39.680811.52YesYes376
71b.b1x3 b.b28x3 76.40793.73YesYes377
72b.b1x3 b.b26x2 79.76663.01YesNo075
73b.b22x2 b.b26x2 79.5723.71NoNo095
74b.b22x2 b.b23x5 79.37733.44NoNo098
75b.b23x5 b.b26x3 75.84713.42NoYes088
76b.b23x3 b.b26x3 70.54275.05YesYes088
77b.b23x3 b.ctx4 68.735413.53YesYes785
78b.ctx4 b.lhb1x11 68.0896.86YesNo053
79b.l25x1 b.lhb1x11 67.88873.07NoNo083
80b.l25x1 b.lhb1x8 67.68837.59NoYes083
81b.lhb1x5 b.lhb1x8 33.2226.12NoYes013
82b.l24x1 b.lhb1x5 33.01432.94NoNo091
83b.l24x1 b.l24x3 65.62632.71NoNo097
84b.l22x6 b.l24x3 63.93654.86NoNo097
85b.l22x6 g.ctx9 60.55287.76NoNo097
86b.l22x5 g.ctx9 60.12953.64NoNo097
87b.l19x1 b.l22x5 59.70613.01YesNo079
88b.b2x3 b.lhb1x22 37.76862.79YesYes399
89b.b28x3 b.b2x3 39.65493.07YesYes379
90b.l24x4 b.lhb1x8 33.65068.62YesYes1983
91b.l24x1 b.l24x4 33.03444.15NoYes098
92b.l19x1 b.l22x1 31.13710.72YesYes078
93b.b23x2 b.l22x1 23.35766.22YesYes078
94G.H2.07 b.l8x6 14.91369.65YesYes499
95b.l8x5 b.l8x6 14.53294.03YesYes489
96b.l10x2 b.l8x5 15.92934.67YesYes498
97b.l10x2 b.l8x3 15.000512.61YesYes499
98b.l8x3 b.l8x7 11.20976.63YesYes498
99b.b5x2 b.b9x3 12.62497.74NoYes088
100b.l19x1 b.l19x3 20.808213.14YesNo075
101b.l19x3 b.l19x5 19.51362.77NoNo054
102b.l19x5 b.l21x1 17.78622.83NoNo046
103b.insx38 b.l21x1 17.35412.85NoNo056
104b.insx38 b.insx47 13.01833.07NoNo056
105b.insx30 b.insx47 12.58554.38YesNo086
106b.b22x3 b.l21x14 10.38354.47YesYes1158
107R1.6x36 R1.7x58 31.05853.49YesYes099
108G.H5.13 R1.6x30 34.90953.58YesYes699
109R2.2x50 R2.7x46 15.5172.85YesYes178
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
R2.1x35R2.1x394.331NoYes5421
R2.1x35R2.E33.711NoYes53.2857121
R2.1x39R2.2x574.511YesYes4611
R2.1x39R2.7x398.61YesYes4511
R2.1x39R2.Lig3.841YesYes4010
R2.1x42R2.7x396.090YesYes7521
R2.1x43R2.1x464.281YesYes6922
R2.1x43R2.2x5728.881YesYes6621
R2.1x43R2.7x426.491YesYes6721
R2.1x46R2.2x535.641YesNo9822
R2.1x46R2.7x426.471YesYes9721
R2.2x53R2.3x325.480NoYes8621
R2.2x56R2.3x328.841NoYes7621
R2.2x57R2.2x6010.921YesYes6611
R2.2x57R2.2x617.031YesNo6712
R2.2x57R2.Lig14.311YesYes6010
R2.2x60R2.2x613.521YesNo6712
R2.2x60R2.Lig26.321YesYes6010
R2.E1x46R2.E1x515.961YesYes5511
R2.E1x46R2.E1x6016.921YesNo5712
R2.3x25R2.E1x463.450NoYes6521
R2.E1x46R2.Lig8.691YesYes5010
R2.E1x51R2.E1x552.91YesNo5212
R2.E1x51R2.E1x6012.091YesNo5712
R2.E1x51R2.Lig4.171YesYes5010
R2.3x29R2.3x302.91YesNo8612
R2.3x29R2.3x3312.791YesNo8711
R2.3x29R2.4x602.91YesNo8812
R2.3x29R2.4x6412.481YesNo8612
R2.3x29R2.Lig4.171YesYes8010
R2.3x32R2.Lig6.991YesYes6010
R2.3x33R2.Lig14.251NoYes7010
R2.4x56R2.Lig7.670NoYes5010
R2.5x40R2.E28.671NoYes21.612
R2.5x40R2.Lig5.321NoYes2010
R2.5x43R2.5x477.781NoNo5612
R2.5x43R2.Lig25.611NoYes5010
R2.5x44R2.6x525.811NoNo6611
R2.5x44R2.Lig13.41NoYes6010
R2.5x47R2.6x483.891NoYes6722
R2.5x47R2.7x413.141NoYes6521
R2.5x48R2.6x526.040NoNo8621
R2.6x48R2.7x416.491YesYes7521
R2.6x52R2.Lig21.441NoYes6010
R2.6x53R2.Lig6.180NoYes4010
R2.6x54R2.E35.751NoYes43.2857121
R2.E3R2.E328.151YesYes3.285713.2857111
R2.E3R2.Lig32.951YesYes3.28571010
R2.7x39R2.7x423.171YesYes5711
R2.7x39R2.Lig10.091YesYes5010
R2.7x41R2.Lig5.221YesYes5010
R2.7x42R2.Lig6.241YesYes7010
R2.6x49R2.Lig2.350NoYes7010
R2.3x37R2.4x571.70NoNo5621
R2.6x51R2.7x411.680NoYes8521
R2.4x57R2.Lig1.611NoYes6010
R2.3x28R2.3x321.590NoYes5621
R2.2x60R2.2x631.271YesNo6612
R2.2x63R2.E1x461.270NoYes6521

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
100.00Consensusclass-d_onOrthosteric Ligandste2_on
100.00Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
72.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
69.23Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
68.00Consensusclass-d_onOrthosteric Ligandste2_on
65.38Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
65.38Consensusgi_class-dOrthosteric Ligandgi_ste
65.38Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
61.54Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
60.87Single7QA8Peptide7QA8-STE2-Peptide
60.87Single7QA8Peptide7QA8-STE2-Peptide
60.87Consensusclass-d_offOrthosteric Ligandste2_off
57.69Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
56.52Consensusclass-d_offOrthosteric Ligandste2_off
33.33Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
33.33Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
33.33Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
33.33Consensusclass-t_onOrthosteric Ligandtaste2_on
33.33Consensusgs_class-tOrthosteric Ligandgs_taste
33.33Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
33.33Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
32.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
32.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
32.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
31.03Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
30.77Single5CXVTiotropium5CXV-M1-Tiotropium
30.77Single7YITNalfurafine7YIT-κ-Nalfurafine
30.77Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
30.77Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
29.63Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
29.63Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.63Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
29.03Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
29.03Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
28.57Single7SK9CCX6627SK9-ACKR3-CCX662
28.57Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
28.57Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
28.12Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
28.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
28.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
28.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
28.00Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
27.59Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
27.27Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
26.92Single4U15Tiotropium4U15-M3-Tiotropium
26.92Single5V54Methiothepin5V54-5-HT1B-Methiothepin
26.92Single5X93K-87945X93-ETB-K-8794
26.92Single6OL9Tiotropium6OL9-M5-Tiotropium
26.92Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
26.92Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
26.92Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
26.92Single8E0GBU728E0G-μ-BU72
26.92Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
26.92Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
26.92Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
26.92Consensus5ht1_offOrthosteric Ligand5ht1b_off
26.92Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
26.92Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
26.92Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
26.47Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
26.09Single6B73PubChem 1319551386B73-κ-PubChem 131955138
26.09Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
26.09Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
25.93Single6HLPNetupitant6HLP-NK1-Netupitant
25.93Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
25.93Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
25.93Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
25.93Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.93Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
25.93Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
25.93Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
25.93Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
25.93Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
25.81Single6PT2KGCHM076PT2-δ-KGCHM07
25.81Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
25.71Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
25.00Single6IQLL7458706IQL-D4-L745870
25.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
25.00Single6TPGEMPA6TPG-OX2-EMPA
25.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
25.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
25.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
25.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
25.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
25.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
25.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
25.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
25.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
25.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
25.00Consensusendothelin_offOrthosteric Ligandetb_off
25.00Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
25.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
25.00Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
24.14Single3NY9PubChem 9131033NY9-β2-PubChem 913103
24.14Single4UG2CGS216804UG2-A2A-CGS21680
24.14Single5ZTYAM102575ZTY-CB2-AM10257
24.14Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
24.00Single2Y01Dobutamine2Y01-β1-Dobutamine
24.00Single2Y04Salbutamol2Y04-β1-Salbutamol
24.00Single4DAJTiotropium4DAJ-M3-Tiotropium
24.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
24.00Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
24.00Single4YAYZD-71554YAY-AT1-ZD-7155
24.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
24.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
24.00Single5DSGTiotropium5DSG-M4-Tiotropium
24.00Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
24.00Single5TGZAM65385TGZ-CB1-AM6538
24.00Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
24.00Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
24.00Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
24.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
24.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
24.00Single6TOTLemborexant6TOT-OX1-Lemborexant
24.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
24.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
24.00Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
24.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
24.00Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
24.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
24.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
24.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
24.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
24.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
24.00Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
24.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
23.33Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
23.33Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
23.33Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
23.33Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
23.33Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
23.33Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
23.33Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
23.08Single2Y00Dobutamine2Y00-β1-Dobutamine
23.08Single2Y03Isoprenaline2Y03-β1-Isoprenaline
23.08Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
23.08Single5C1MBU725C1M-μ-BU72
23.08Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
23.08Single5WIUNemonapride5WIU-D4-Nemonapride
23.08Single5WIVNemonapride5WIV-D4-Nemonapride-Na
23.08Single5WQCEMPA5WQC-OX2-EMPA
23.08Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
23.08Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
23.08Single6GPXMK08126GPX-CCR2-MK0812
23.08Single6TP6Filorexant6TP6-OX1-Filorexant
23.08Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
23.08Single7WC6LSD7WC6-5-HT2A-LSD
23.08Single7YXAONO-54306087YXA-S1P5-ONO-5430608
23.08Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
23.08Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
23.08Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
23.08Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
23.08Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
23.08Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
23.08Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
23.08Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
23.08Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
23.08Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
23.08Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
23.08Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
23.08Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.08Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.86Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
22.86Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
22.86Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
22.86Consensusgo_class-b1Orthosteric Ligandgo_crf
22.86Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
22.73Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
22.58Single3QAKUK-4320973QAK-A2A-UK-432097
22.58Single6HLOAprepitant6HLO-NK1-Aprepitant
22.58Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
22.58Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
22.58Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
22.50Consensuspth_onOrthosteric Ligandpth1_on pth2_on
22.22Single2YDVNECA2YDV-A2A-NECA
22.22Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
22.22Single4DJHJDTic4DJH-κ-JDTic
22.22Single4RWADIPP-NH24RWA-δ-DIPP-NH2
22.22Single4UHRCGS216804UHR-A2A-CGS21680
22.22Single5G53NECA5G53-A2A-NECA-Gs
22.22Single5XRAAM115425XRA-CB1-AM11542
22.22Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
22.22Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
22.22Single6H7JIsoprenaline6H7J-β1-Isoprenaline
22.22Single6J21Aprepitant6J21-NK1-Aprepitant
22.22Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
22.22Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
22.22Single6TQ7SB-3348676TQ7-OX1-SB-334867
22.22Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
22.22Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
22.22Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
22.22Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
22.22Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
22.22Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
22.22Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
22.22Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
22.22Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
22.22Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
22.22Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
22.22Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
22.22Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
22.22Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
22.22Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
22.22Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
22.22Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
22.22Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
22.22Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
22.22Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
22.22Consensushistamine_offOrthosteric Ligandh1_off
22.22Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
22.22Consensusrelaxin_onOrthosteric Ligandrxfp4_on
22.22Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
21.88Single6W25SHU91196W25-MC4-SHU9119-Ca
21.88Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
21.88Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
21.88Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
21.74Single3PBLEticlopride3PBL-D3-Eticlopride
21.74Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
21.74Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
21.74Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
21.74Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
21.74Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
21.74Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
21.62Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
21.62Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
21.43Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
21.43Single4LDEBI1671074LDE-β2-BI167107
21.43Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
21.43Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
21.43Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
21.43Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
21.43Single6ZG4HTL00099366ZG4-M1-HTL0009936
21.43Single7DFPSpiperone7DFP-D2-Spiperone
21.43Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
21.43Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
21.43Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
21.43Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
21.43Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
21.43Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single8WU1KCA8WU1-CB1-KCA-Arrestin1
21.43Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
21.43Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
21.43Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
21.43Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
21.43Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
21.43Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
21.43Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
21.43Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
21.43Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
21.21Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
21.21Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
21.05Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
20.83Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
20.83Single4S0VSuvorexant4S0V-OX2-Suvorexant
20.83Single5DHHSB-6121115DHH-NOP-SB-612111
20.83Single5U09Taranabant5U09-CB1-Taranabant
20.83Single5WS3EMPA5WS3-OX2-EMPA
20.83Single6AKXA4R6AKX-CCR5-A4R
20.83Single6AKYMaraviroc6AKY-CCR5-Maraviroc
20.83Single6KUXRS-799486KUX-α2a-RS-79948
20.83Single6TPJSuvorexant6TPJ-OX2-Suvorexant
20.83Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
20.83Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
20.83Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.83Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
20.83Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
20.83Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
20.83Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
20.83Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
20.83Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.83Single8GGVEpinephrine8GGV-β2-Epinephrine
20.83Single8GGXEpinephrine8GGX-β2-Epinephrine
20.83Single8GH0Epinephrine8GH0-β2-Epinephrine
20.83Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
20.83Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
20.83Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Consensusalpha1_onOrthosteric Ligandalpha1a_on
20.83Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
20.83Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
20.69Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
20.69Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
20.69Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
20.69Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
20.69Single6H7LDobutamine6H7L-β1-Dobutamine
20.69Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
20.69Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
20.69Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
20.69Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
20.69Single7UM4AS26747237UM4-5-HT5A-AS2674723
20.69Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
20.69Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
20.69Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.69Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
20.69Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
20.69Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
20.69Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
20.69Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
20.69Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.69Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.69Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensusorexin_onOrthosteric Ligandox2_on
20.59Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.59Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
20.59Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
20.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
20.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
20.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
20.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
20.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
20.00Single6PS4ICI 118-5516PS4-β2-ICI 118-551
20.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
20.00Single6PT3DPI-2876PT3-δ-DPI-287
20.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
20.00Single6TPNHTL66416TPN-OX2-HTL6641
20.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
20.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
20.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
20.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
20.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
20.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
20.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
20.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
20.00Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
20.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
20.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
20.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
20.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
20.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
20.00Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
20.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
20.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
20.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
20.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
20.00Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
20.00Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GGIEpinephrine8GGI-β2-Epinephrine
20.00Single8GGQEpinephrine8GGQ-β2-Epinephrine
20.00Single8GGTEpinephrine8GGT-β2-Epinephrine
20.00Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
20.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
20.00Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8K2WAMG4878K2W-CXCR3-AMG487
20.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8X5YAstemizole8X5Y-H1-Astemizole
20.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
20.00Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
20.00Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
20.00Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
20.00Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
20.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
20.00Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
20.00Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
20.00Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
20.00Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
20.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
19.44Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
19.35Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
19.35Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
19.35Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.35Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
19.35Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
19.35Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
19.35Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
19.35Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
19.35Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
19.35Consensussst_onOrthosteric Ligandsst2_on sst4_on
19.23Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
19.23Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
19.23Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
19.23Single3NY8ICI 118-5513NY8-β2-ICI 118-551
19.23Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
19.23Single4EJ4Naltrindole4EJ4-δ-Naltrindole
19.23Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
19.23Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
19.23Single4MQSIperoxo4MQS-M2-Iperoxo
19.23Single4U14Tiotropium4U14-M3-Tiotropium
19.23Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
19.23Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
19.23Single6GPSMK08126GPS-CCR2-MK0812
19.23Single6H7MSalbutamol6H7M-β1-Salbutamol
19.23Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
19.23Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
19.23Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
19.23Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
19.23Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
19.23Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
19.23Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
19.23Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
19.23Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
19.23Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
19.23Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
19.23Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
19.23Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
19.23Single7UL4Alvimopan7UL4-μ-Alvimopan
19.23Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
19.23Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
19.23Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
19.23Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
19.23Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.23Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
19.23Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
19.23Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
19.23Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
19.23Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.23Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.23Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.23Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.23Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.23Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.23Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.23Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.23Single8GGJEpinephrine8GGJ-β2-Epinephrine
19.23Single8GGNEpinephrine8GGN-β2-Epinephrine
19.23Single8GGOEpinephrine8GGO-β2-Epinephrine
19.23Single8GGUEpinephrine8GGU-β2-Epinephrine
19.23Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
19.23Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
19.23Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
19.23Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
19.23Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.23Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.23Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
19.23Single8X64Desloratadine8X64-H1-Desloratadine
19.23Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
19.23Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
19.23Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
19.23Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
19.23Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
19.23Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
19.23Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
19.23Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
19.23Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
19.23Consensuscck_offOrthosteric Ligandccka_off
19.23Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
19.23Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
19.23Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
19.23Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
19.23Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
19.23Consensusgi_hcarOrthosteric Ligandgi_hca
19.23Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
19.23Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
19.23Consensushcar_offOrthosteric Ligandsuccinate_off
19.23Consensushistamine_onOrthosteric Ligandh1_on h4_on
19.23Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
19.23Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
19.23Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
19.23Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
19.23Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
19.23Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
19.23Consensustar_onOrthosteric Ligandta1_on
18.92Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
18.92Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.75Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
18.75Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
18.75Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
18.75Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
18.75Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
18.75Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
18.75Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
18.75Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
18.52Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
18.52Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
18.52Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
18.52Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
18.52Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
18.52Single5TVNLSD5TVN-5-HT2B-LSD
18.52Single5XPRBosentan5XPR-ETB-Bosentan
18.52Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
18.52Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
18.52Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
18.52Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
18.52Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
18.52Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
18.52Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
18.52Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
18.52Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
18.52Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
18.52Single6PS6Timolol6PS6-β2-Timolol
18.52Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
18.52Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
18.52Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
18.52Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
18.52Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
18.52Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
18.52Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
18.52Single7SINNPS-21437SIN-CaS-NPS-2143
18.52Single7SINNPS-21437SIN-CaS-NPS-2143
18.52Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
18.52Single7XKAEpinephrine7XKA-β2-Epinephrine
18.52Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Single8EA0Iperoxo8EA0-M3-Iperoxo
18.52Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
18.52Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
18.52Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
18.52Single8QOTNanobody E8QOT-μ-Nanobody E
18.52Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
18.52Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
18.52Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
18.52Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
18.52Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
18.52Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
18.52Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
18.52Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
18.52Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
18.52Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
18.52Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
18.52Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
18.52Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
18.52Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
18.52Consensusep_offOrthosteric Ligandep4_off
18.52Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
18.52Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
18.52Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
18.52Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
18.52Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
18.52Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
18.42Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
18.42Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
18.42Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
18.42Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
18.18Single5WF5UK-4320975WF5-A2A-UK-432097
18.18Single6TQ9SB-4081246TQ9-OX1-SB-408124
18.18Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
18.18Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
18.18Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
18.18Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
18.18Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
17.95Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
17.95Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
17.95Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
17.95Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
17.86Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
17.86Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
17.86Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
17.86Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
17.86Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
17.86Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
17.86Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
17.86Single5XR8AM8415XR8-CB1-AM841
17.86Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
17.86Single6E59L-7607356E59-NK1-L-760735
17.86Single6J20Aprepitant6J20-NK1-Aprepitant
17.86Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
17.86Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
17.86Single6WGTLSD6WGT-5-HT2A-LSD
17.86Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
17.86Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
17.86Single7EPENAM5637EPE-mGlu-NAM563
17.86Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
17.86Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
17.86Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
17.86Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
17.86Single7TUYGSK682753A7TUY-GPR183-GSK682753A
17.86Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
17.86Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
17.86Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
17.86Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
17.86Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
17.86Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
17.86Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
17.86Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
17.86Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
17.86Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
17.86Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
17.86Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
17.86Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
17.86Consensus5ht5_offOrthosteric Ligand5ht5a_off
17.86Consensusa2_onOrthosteric Liganda2a_on a2b_on
17.86Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
17.86Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
17.86Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
17.86Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
17.86Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
17.86Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
17.86Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
17.86Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
17.65Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
17.65Single7C61Ergotamine7C61-5-HT1B-Ergotamine
17.65Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
17.65Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
17.50Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
17.50Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
17.39Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
17.39Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
17.39Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
17.39Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
17.39Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
17.39Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
17.24Single4AMIBucindolol4AMI-β1-Bucindolol
17.24Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.24Single6A93Risperidone6A93-5-HT2A-Risperidone
17.24Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
17.24Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
17.24Single6IIURamatroban6IIU-TP-Ramatroban
17.24Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
17.24Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
17.24Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
17.24Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
17.24Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
17.24Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
17.24Single7K15MKD0467K15-BLT1-MKD046-Na
17.24Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
17.24Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
17.24Single8JJ8Formoterol8JJ8-β2-Formoterol
17.24Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
17.24Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.24Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
17.24Consensusblt_offOrthosteric Ligandblt1_off
17.24Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
17.24Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
17.24Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
17.24Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
17.24Consensusgs_steroidOrthosteric Ligandgs_bileacid
17.24Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
17.24Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
17.24Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
17.24Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
17.14Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
17.14Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
17.14Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
17.14Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
17.14Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
17.14Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.14Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
17.07Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
16.67Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
16.67Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
16.67Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
16.67Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
16.67Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
16.67Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
16.67Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.67Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
16.67Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
16.67Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
16.67Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
16.67Single6HLLCP999946HLL-NK1-CP99994
16.67Single6IBLArformoterol6IBL-β1-Arformoterol
16.67Single6K1QIRL25006K1Q-ETB-IRL2500
16.67Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
16.67Single6TP4ACT-4622066TP4-OX1-ACT-462206
16.67Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
16.67Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
16.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
16.67Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
16.67Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
16.67Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
16.67Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
16.67Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
16.67Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
16.67Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
16.67Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
16.67Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
16.67Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GGSEpinephrine8GGS-β2-Epinephrine
16.67Single8GGYEpinephrine8GGY-β2-Epinephrine
16.67Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
16.67Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
16.67Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
16.67Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
16.67Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
16.67Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
16.67Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
16.67Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
16.67Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
16.67Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
16.67Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
16.67Consensuscyslt_offOrthosteric Ligandcyslt2_off
16.67Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
16.67Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
16.67Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
16.67Consensusgo_class-b2Orthosteric Ligandgo_adhesion
16.67Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
16.67Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
16.67Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
16.67Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
16.67Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
16.67Consensussteroid_onOrthosteric Ligandbileacid_on
16.28Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
16.22Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.22Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
16.22Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
16.22Consensusendothelin_onOrthosteric Ligandetb_on eta_on
16.22Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
16.22Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.22Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.13Single5WF6UK-4320975WF6-A2A-UK-432097
16.13Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
16.13Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
16.13Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
16.13Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
16.13Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
16.13Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
16.13Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
16.13Consensuslpl_offOrthosteric Ligands1p_off lpa_off
16.13Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
16.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
16.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
16.00Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
16.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
16.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
16.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
16.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
16.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
16.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
16.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
16.00Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
16.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
16.00Single6TODEMPA6TOD-OX1-EMPA-Na
16.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
16.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
16.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
16.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
16.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
16.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
16.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
16.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
16.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.00Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
16.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
16.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
16.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
16.00Single7XRRLemborexant7XRR-OX2-Lemborexant
16.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
16.00Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
16.00Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.00Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.00Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.00Single8GGWEpinephrine8GGW-β2-Epinephrine
16.00Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
16.00Single8IHKAcifran8IHK-HCA3-Acifran
16.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
16.00Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single8IWESpermidine8IWE-TAAR9-Spermidine
16.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
16.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
16.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.00Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.00Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.00Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
16.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
16.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
16.00Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
16.00Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
16.00Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
16.00Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
16.00Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
16.00Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
16.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
15.91Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
15.79Single6IGLIRL16206IGL-ETB-IRL1620
15.79Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.79Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
15.79Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
15.79Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
15.79Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
15.79Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
15.62Single4IARErgotamine4IAR-5-HT1B-Ergotamine
15.62Single4XT1Fractalkine4XT1-US28-Fractalkine
15.62Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
15.62Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
15.62Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.62Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
15.62Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
15.62Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
15.62Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
15.62Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
15.62Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
15.62Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
15.38Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
15.38Single3RZECidoxepin3RZE-H1-Cidoxepin
15.38Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
15.38Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
15.38Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
15.38Single5GLHEndothelin-15GLH-ETB-Endothelin-1
15.38Single6A94Zotepine6A94-5-HT2A-Zotepine
15.38Single6IGKEndothelin-36IGK-ETB-Endothelin-3
15.38Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
15.38Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
15.38Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
15.38Single6V9SGTPL114036V9S-OX1-GTPL11403
15.38Single6VI4JDTic6VI4-κ-JDTic
15.38Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
15.38Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
15.38Single6ZG9GSK10347026ZG9-M1-GSK1034702
15.38Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
15.38Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
15.38Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
15.38Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
15.38Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
15.38Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
15.38Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
15.38Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8GGKEpinephrine8GGK-β2-Epinephrine
15.38Single8GGLEpinephrine8GGL-β2-Epinephrine
15.38Single8GGMEpinephrine8GGM-β2-Epinephrine
15.38Single8GGPEpinephrine8GGP-β2-Epinephrine
15.38Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
15.38Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
15.38Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
15.38Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
15.38Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
15.38Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
15.38Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
15.38Single8K5CAcipimox8K5C-HCA2-Acipimox
15.38Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
15.38Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
15.38Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
15.38Consensus5ht5_onOrthosteric Ligand5ht5a_on
15.38Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
15.38Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
15.38Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
15.38Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
15.38Consensusgnrh_offOrthosteric Ligandgnrh1_off
15.38Consensushca_onOrthosteric Ligandhca2_on hca3_on
15.38Consensushcar_onOrthosteric Ligandhca_on
15.38Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
15.38Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
15.38Consensuss1p_offOrthosteric Ligands1p1_off
15.38Consensussensory_offOrthosteric Ligandopsin_off
15.15Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
15.15Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
15.15Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.15Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
15.15Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
15.15Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
15.15Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
15.15Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
15.15Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
15.00Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
14.81Single2Y02Carmoterol2Y02-β1-Carmoterol
14.81Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
14.81Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
14.81Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
14.81Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
14.81Single6DRXLisuride6DRX-5-HT2B-Lisuride
14.81Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
14.81Single6IIVDaltroban6IIV-TP-Daltroban
14.81Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
14.81Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
14.81Single6PS1Timolol6PS1-β2-Timolol
14.81Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
14.81Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
14.81Single7BU7BI1671077BU7-β1-BI167107
14.81Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
14.81Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
14.81Single7F83PF-051904577F83-Ghrelin-PF-05190457
14.81Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
14.81Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
14.81Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
14.81Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
14.81Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
14.81Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
14.81Single7WC7Lisuride7WC7-5-HT2A-Lisuride
14.81Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
14.81Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
14.81Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
14.81Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.81Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
14.81Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
14.81Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
14.81Single8JJOAlprenolol8JJO-β2-Alprenolol
14.81Single8K5DGSK2560738K5D-HCA2-GSK256073
14.81Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
14.81Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
14.81Single8X63Mepyramine8X63-H1-Mepyramine
14.81Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
14.81Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
14.81Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
14.81Consensusblt_onOrthosteric Ligandblt1_on
14.81Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
14.81Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
14.81Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
14.81Consensusleuko_onOrthosteric Ligandblt_on
14.81Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
14.81Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
14.81Consensustachykinin_offOrthosteric Ligandnk1_off
14.81Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
14.71Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
14.71Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
14.71Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
14.71Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
14.71Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
14.71Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
14.71Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
14.71Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
14.71Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
14.71Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
14.71Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.71Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.63Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
14.29Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
14.29Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
14.29Single5NM2ZM2413855NM2-A2A-ZM241385-Na
14.29Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
14.29Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
14.29Single6E67BI1671076E67-β2-BI167107-Gs (fused)
14.29Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
14.29Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
14.29Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
14.29Single7C4SS1P7C4S-S1P3-S1P
14.29Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
14.29Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
14.29Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
14.29Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
14.29Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
14.29Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
14.29Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
14.29Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
14.29Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
14.29Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
14.29Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
14.29Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
14.29Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
14.29Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
14.29Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
14.29Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
14.29Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
14.29Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
14.29Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
14.29Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
14.29Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
14.29Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
14.29Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
14.29Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.29Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
14.29Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
13.89Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
13.89Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
13.89Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
13.89Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
13.89Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
13.89Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
13.89Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.89Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.89Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.89Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
13.89Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.89Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.79Single3P0GBI1671073P0G-β2-BI167107
13.79Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
13.79Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
13.79Single5TZR-5TZR-FFA1 (GPR40)-MK8666
13.79Single5V56TC1145V56-SMO-TC114
13.79Single5V57TC1145V57-SMO-TC114
13.79Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
13.79Single7B6WCyclazosin7B6W-α1b-Cyclazosin
13.79Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
13.79Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
13.79Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
13.79Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
13.79Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
13.79Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
13.79Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
13.79Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
13.79Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
13.79Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
13.79Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
13.79Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
13.79Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
13.79Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
13.79Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
13.79Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
13.79Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensusadenosine_offOrthosteric Liganda1_off a2_off
13.79Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
13.79Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
13.79Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
13.79Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
13.79Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
13.79Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
13.79Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
13.79Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
13.64Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
13.64Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
13.64Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
13.51Single4XT3Fractalkine4XT3-US28-Fractalkine
13.51Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
13.51Single6FJ3PTH6FJ3-PTH1-PTH
13.51Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.51Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.51Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
13.51Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
13.51Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
13.51Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
13.51Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
13.51Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
13.51Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
13.51Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
13.51Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
13.51Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
13.51Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
13.51Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
13.51Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
13.51Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.51Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
13.51Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
13.51Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
13.33Single4PY02MeSATP4PY0-P2Y12-2MeSATP
13.33Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
13.33Single5X33BIIL2605X33-BLT1-BIIL260
13.33Single6CM4Risperidone6CM4-D2-Risperidone
13.33Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
13.33Single6MXTSalmeterol6MXT-β2-Salmeterol
13.33Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
13.33Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
13.33Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
13.33Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
13.33Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
13.33Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
13.33Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
13.33Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
13.33Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.33Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
13.33Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
13.33Single8JJLOlodaterol8JJL-β2-Olodaterol
13.33Single8JWZAB9288JWZ-A2A-AB928-Na
13.33Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
13.33Consensusclass-b2_onOrthosteric Ligandadgrg_on
13.33Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.33Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
13.33Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
13.33Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.33Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
13.16Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
13.16Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
13.16Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
13.16Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.04Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
13.04Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
13.04Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
13.04Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
13.04Consensussensory_onOrthosteric Ligandopsin_on
12.90Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
12.90Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
12.90Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
12.90Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
12.90Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
12.90Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
12.90Single7EZCUKA7EZC-A2A-UKA
12.90Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
12.90Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
12.90Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.90Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
12.90Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.90Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.90Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
12.90Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
12.90Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
12.82Single6LMLGlucagon6LML-Glucagon-Glucagon
12.82Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
12.82Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
12.82Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
12.82Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
12.82Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
12.82Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
12.82Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
12.82Single8IY6Endothelin-18IY6-ETB-Endothelin-1
12.82Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
12.82Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
12.82Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
12.50Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
12.50Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
12.50Single3OE6IT1t3OE6-CXCR4-IT1t
12.50Single3OE8IT1t3OE8-CXCR4-IT1t
12.50Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
12.50Single3UZAGTPL92363UZA-A2A-GTPL9236
12.50Single5EE7MK08935EE7-Glucagon-MK0893
12.50Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
12.50Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
12.50Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
12.50Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
12.50Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
12.50Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single7XN9L-054,5227XN9-SST2-L-054,522
12.50Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
12.50Single8GGREpinephrine8GGR-β2-Epinephrine
12.50Single8GGZEpinephrine8GGZ-β2-Epinephrine
12.50Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
12.50Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
12.50Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
12.50Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
12.50Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
12.50Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
12.50Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
12.50Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
12.50Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
12.50Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
12.50Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
12.50Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
12.50Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.50Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusgs_class-b2Orthosteric Ligandgs_adgr
12.50Consensuslpl_onOrthosteric Ligands1p_on lpa_on
12.50Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
12.20Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
12.20Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
12.20Consensusglp_onOrthosteric Ligandglp1_on glp2_on
12.12Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
12.12Single7F8XNN90567F8X-CCKA-NN9056
12.12Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
12.12Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
12.12Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
12.12Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
12.12Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
12.12Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
12.12Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
12.12Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
12.00Single3OE9IT1t3OE9-CXCR4-IT1t
12.00Single5L7IVismodegib5L7I-SMO-Vismodegib
12.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
12.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
12.00Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
12.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
12.00Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
12.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
12.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single8GH1Epinephrine8GH1-β2-Epinephrine
12.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
12.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
12.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
12.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single8K5BNiacin8K5B-HCA2-Niacin
12.00Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
11.90Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
11.90Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
11.76Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
11.76Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
11.76Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
11.76Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
11.76Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
11.63Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
11.63Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.54Single3ODUIT1t3ODU-CXCR4-IT1t
11.54Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
11.54Single5K2DZM2413855K2D-A2A-ZM241385
11.54Single6JZHZM2413856JZH-A2A-ZM241385-Na
11.54Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
11.54Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
11.54Single6PS7ZM2413856PS7-A2A-ZM241385-Na
11.54Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.54Single7F8ULintitript7F8U-CCKA-Lintitript
11.54Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
11.54Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
11.54Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
11.54Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
11.54Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
11.54Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
11.54Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
11.54Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
11.54Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
11.54Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
11.54Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
11.54Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
11.54Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
11.54Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.54Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
11.54Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
11.54Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.54Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.54Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.54Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
11.54Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
11.54Consensusclass-f_offOrthosteric Ligandsmo_off
11.54Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
11.54Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.54Consensusgt_class-aOrthosteric Ligandgt_opsin
11.54Consensusgt_opsinOrthosteric Ligandgt_sensory
11.54Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
11.54Consensusmglu_onOther Ligandmglu2_on mglu4_on
11.43Single3OE0CVX153OE0-CXCR4-CVX15
11.43Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
11.43Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
11.43Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
11.43Consensusangiotensin_onOrthosteric Ligandat1_on
11.43Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
11.43Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
11.43Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single2YDOAdenosine2YDO-A2A-Adenosine
11.11Single5IU4ZM2413855IU4-A2A-ZM241385-Na
11.11Single5IU7Q274563465IU7-A2A-Q27456346-Na
11.11Single5IUBQ274563445IUB-A2A-Q27456344-Na
11.11Single5JTBZM2413855JTB-A2A-ZM241385
11.11Single5K2CZM2413855K2C-A2A-ZM241385-Na
11.11Single5NLXZM2413855NLX-A2A-ZM241385-Na
11.11Single5NM4ZM2413855NM4-A2A-ZM241385-Na
11.11Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
11.11Single5UVIZM2413855UVI-A2A-ZM241385
11.11Single6DS0Ly2660976DS0-5-HT2B-Ly266097
11.11Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
11.11Single6TPKRetosiban6TPK-OT-Retosiban
11.11Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
11.11Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
11.11Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
11.11Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
11.11Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single7T32ZM2413857T32-A2A-ZM241385
11.11Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
11.11Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
11.11Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
11.11Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
11.11Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
11.11Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
11.11Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
11.11Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
11.11Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
11.11Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
11.11Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
11.11Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
11.11Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
11.11Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
11.11Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
11.11Consensusvasopressin-ot_offOrthosteric Ligandot_off
10.81Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.81Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
10.81Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
10.81Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.81Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.81Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
10.81Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.81Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
10.81Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
10.81Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
10.81Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.81Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.81Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Single3EMLZM2413853EML-A2A-ZM241385
10.71Single4EIYZM2413854EIY-A2A-ZM241385-Na
10.71Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
10.71Single5IU8Q274563475IU8-A2A-Q27456347-Na
10.71Single5K2AZM2413855K2A-A2A-ZM241385-Na
10.71Single5OLGZM2413855OLG-A2A-ZM241385-Na
10.71Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
10.71Single5VRAZM2413855VRA-A2A-ZM241385-Na
10.71Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
10.71Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
10.71Single6LPJZM2413856LPJ-A2A-ZM241385-Na
10.71Single6LPKZM2413856LPK-A2A-ZM241385-Na
10.71Single6S0LZM2413856S0L-A2A-ZM241385
10.71Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single7PYRPSB-21157PYR-A2A-PSB-2115
10.71Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
10.71Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
10.71Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
10.71Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
10.71Single8CU6LJ-45178CU6-A2A-LJ-4517
10.71Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
10.71Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
10.71Consensusa2_offOrthosteric Liganda2a_off
10.71Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
10.71Consensusadenosine_onOrthosteric Liganda1_on a2_on
10.71Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
10.71Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
10.71Consensusnucleotide_onOrthosteric Ligandadenosine_on
10.71Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
10.53Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
10.53Single7SK3CXCL127SK3-ACKR3-CXCL12
10.53Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
10.53Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
10.53Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
10.42Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
10.42Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
10.34Single4NTJAZD12834NTJ-P2Y12-AZD1283
10.34Single5CGCHTL142425CGC-mGlu5-HTL14242
10.34Single5IUAQ274563485IUA-A2A-Q27456348-Na
10.34Single5N2SPSB365N2S-A1-PSB36
10.34Single6D26Fevipiprant6D26-DP2-Fevipiprant
10.34Single6LPLZM2413856LPL-A2A-ZM241385-Na
10.34Single6LUQHaloperidol6LUQ-D2-Haloperidol
10.34Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
10.34Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
10.34Single6S0QZM2413856S0Q-A2A-ZM241385
10.34Single6WQAZM2413856WQA-A2A-ZM241385-Na
10.34Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
10.34Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
10.34Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
10.34Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.34Single7RM5ZM2413857RM5-A2A-ZM241385-Na
10.34Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
10.34Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
10.34Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
10.34Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
10.34Single8FYNZM2413858FYN-A2A-ZM241385-Na
10.34Single8GNEKW-63568GNE-A2A-KW-6356-Na
10.34Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
10.26Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
10.26Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.26Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
10.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
10.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
10.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
10.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
10.00Single7P2L4YI7P2L-mGlu5-4YI
10.00Single7PX4PSB-21137PX4-A2A-PSB-2113
10.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
10.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
10.00Single7W41PD1762527W41-BB2-PD176252
10.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
10.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
10.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
10.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
10.00Consensusbombesin_offOrthosteric Ligandbb2_off
10.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
10.00Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
10.00Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.00Consensuslpa_offOrthosteric Ligandlpa1_off
10.00Consensuslpa_onOrthosteric Ligandlpa1_on
10.00Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
10.00Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
10.00Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
10.00Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.76Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.76Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
9.76Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Single4N4WSANT-14N4W-SMO-SANT-1
9.68Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
9.68Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.68Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
9.68Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
9.68Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.68Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
9.68Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
9.68Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.68Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.68Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
9.68Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
9.68Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
9.68Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
9.68Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.68Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
9.68Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
9.68Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
9.68Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
9.68Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.68Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
9.68Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
9.68Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
9.68Consensusdp_offOrthosteric Liganddp2_off
9.68Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
9.68Consensusgi_class-fOther Ligandgi_frizzled
9.68Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.68Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
9.52Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
9.38Single5CGDHTL142425CGD-mGlu5-HTL14242
9.38Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
9.38Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
9.38Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
9.38Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
9.38Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.38Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
9.38Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.30Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
9.30Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
9.09Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
9.09Single6W25Ca6W25-MC4-SHU9119-Ca
9.09Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
9.09Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
9.09Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
9.09Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
9.09Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
9.09Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.82Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.82Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.82Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
8.82Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
8.70Single7WC4Serotonin7WC4-5-HT2A-Serotonin
8.70Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
8.70Consensusclass-c_onOther Ligandgabab_on mglu_on
8.70Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
8.57Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
8.57Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
8.57Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
8.57Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.57Single7SK5CXCL127SK5-ACKR3-CXCL12
8.57Consensussst_offOrthosteric Ligandsst2_off
8.51Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
8.33Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
8.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
8.33Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
8.33Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
8.33Single7XNACYN1548067XNA-SST2-CYN154806
8.33Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
8.33Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
8.33Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
8.33Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
8.11Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
8.11Single6JODAngiotensin II6JOD-AT2-Angiotensin II
8.11Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
8.11Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
8.11Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
8.11Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
8.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
8.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
8.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
8.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
8.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
8.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
8.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
8.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
8.00Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
7.89Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
7.69Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
7.69Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
7.69Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
7.69Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
7.69Single7SRQLSD7SRQ-5-HT2B-LSD
7.69Single7UL2SR486927UL2-NTS1-SR48692-Na
7.69Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
7.69Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
7.69Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
7.69Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
7.69Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
7.69Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
7.69Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
7.69Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
7.50Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
7.50Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
7.50Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
7.50Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
7.50Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
7.41Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
7.41Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
7.41Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
7.41Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
7.41Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
7.41Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
7.41Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.41Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
7.41Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
7.41Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
7.41Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
7.41Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.41Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
7.41Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
7.32Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
7.32Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
7.32Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
7.14Single3REYPubChem 56973REY-A2A-PubChem 5697
7.14Single5K2BZM2413855K2B-A2A-ZM241385-Na
7.14Single6AQFZM2413856AQF-A2A-ZM241385
7.14Single6FFIMMPEP6FFI-mGlu5-MMPEP
7.14Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
7.14Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
7.14Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
7.14Single7AROLUF58337ARO-A2A-LUF5833-Na
7.14Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
7.14Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
7.14Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
7.14Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
7.14Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
7.14Single7VODCariprazine7VOD-5-HT2A-Cariprazine
7.14Single7VV6C48/807VV6-MRGPRX2-C48/80
7.14Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
7.14Single8IYXYL-3658IYX-GPR34-YL-365
7.14Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
7.14Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
6.98Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
6.90Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
6.90Single5T04Neurotensin5T04-NTS1-Neurotensin
6.90Single5UENDU1725UEN-A1-DU172
6.90Single6FFHFenobam6FFH-mGlu5-Fenobam
6.90Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
6.90Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
6.90Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
6.90Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
6.90Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
6.90Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
6.90Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
6.90Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
6.90Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
6.90Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
6.90Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
6.82Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
6.67Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
6.67Single6Z4SSR486926Z4S-NTS1-SR48692
6.67Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
6.67Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
6.67Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
6.67Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
6.67Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
6.67Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
6.67Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
6.52Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
6.45Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
6.45Single4BV0Neurotensin4BV0-NTS1-Neurotensin
6.45Single6OS1TRV0266OS1-AT1-TRV026
6.45Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
6.45Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
6.45Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
6.45Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
6.45Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.45Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.45Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
6.45Consensuschemerin_onOrthosteric Ligandcml1_on
6.45Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
6.38Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
6.25Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
6.25Single4XEENeurotensin4XEE-NTS1-Neurotensin
6.25Single4XESNeurotensin4XES-NTS1-Neurotensin
6.25Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
6.25Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
6.25Single6YVRNTS8-136YVR-NTS1-NTS8-13
6.25Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
6.25Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensuschemokine_offOrthosteric Ligandcxcr_off
6.25Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
6.25Consensuscxcr_offOrthosteric Ligandcxcr4_off
6.25Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
6.25Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
6.25Consensusnts_offOrthosteric Ligandnts1_off
6.25Consensusnts_onOrthosteric Ligandnts1_on
6.06Single4BUONeurotensin4BUO-NTS1-Neurotensin
6.06Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
6.06Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
6.06Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
6.06Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
6.06Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
6.06Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.00Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
5.88Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
5.88Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
5.88Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
5.88Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
5.77Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
5.71Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.71Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.56Single7SHEPI; PE7SHE-GPR158-PI; PE
5.56Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.41Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.26Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single8W8SAA-148W8S-GPR101-AA-14
4.76Single8W8RAA-148W8R-GPR101-AA-14-chim(NtGi1-Gs)/&β;1/&γ;2
4.65Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.65Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.65Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.44Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
4.44Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.35Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
4.17Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
4.00Single3RFMCaffeine3RFM-A2A-Caffeine
3.85Single4XNWMRS25004XNW-P2Y1-MRS2500
3.85Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
3.85Single6LI0GTPL98046LI0-GPR52-GTPL9804
3.85Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
3.85Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
3.85Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
3.85Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
3.85Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
3.85Single8WG8Peptide8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
3.85Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
3.85Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
3.70Single4O9RCyclopamine4O9R-SMO-Cyclopamine
3.70Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
3.70Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
3.70Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
3.70Consensusgo_proteinOrthosteric Ligandgo_chemokine
3.57Single3PWHZM2413853PWH-A2A-ZM241385
3.57Single4BWBNeurotensin4BWB-NTS1-Neurotensin
3.57Single4QINSAG1.54QIN-SMO-SAG1.5
3.57Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
3.57Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
3.57Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
3.57Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
3.57Single7WV9ZCZ0117WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
3.57Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
3.57Single8GNGIstradefylline8GNG-A2A-Istradefylline
3.57Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
3.57Consensuscb1_on_alloOther Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
3.57Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
3.57Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
3.57Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
3.45Single6MH8ZM2413856MH8-A2A-ZM241385
3.45Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
3.45Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
3.45Single6ZINSR486926ZIN-NTS1-SR48692
3.45Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
3.45Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
3.45Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
3.45Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
3.45Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
3.45Consensusgi_class-fOrthosteric Ligandgi_frizzled
3.45Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
3.45Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
3.33Single6D27CAY104716D27-DP2-CAY10471
3.33Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
3.33Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
3.33Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
3.23Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
3.23Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.23Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.23Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.12Single7F1TMIP-1a7F1T-CCR5-MIP-1a
3.12Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
3.12Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
3.12Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
3.12Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
3.12Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
3.03Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
3.03Single6OS2TRV0266OS2-AT1-TRV026
3.03Single7SHEPI; PE7SHE-GPR158-PI; PE
3.03Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
3.03Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
2.94Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.94Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
2.86Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
2.86Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
2.78Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
2.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.70Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
R1.1x39R1.2x575.642YesYes4611
R1.1x39R1.2x613.992YesNo4712
R1.1x39R1.7x398.62YesYes4511
R1.1x39R1.Lig7.832YesYes4010
R1.1x42R1.7x394.562NoYes7521
R1.1x43R1.1x466.412YesYes6912
R1.1x43R1.2x534.532YesYes6811
R1.1x43R1.2x5724.762YesYes6611
R1.1x43R1.7x393.932YesYes6511
R1.1x43R1.7x427.782YesNo6712
R1.1x43R1.Lig3.092YesYes6010
R1.1x46R1.2x535.642YesYes9821
R1.1x46R1.7x4214.232YesNo9722
R1.2x53R1.3x324.112YesYes8611
R1.2x53R1.3x367.422YesYes8611
R1.2x53R1.Lig4.362YesYes8010
R1.2x56R1.3x325.90NoYes7621
R1.2x57R1.2x608.942YesNo6611
R1.2x57R1.2x614.692YesNo6712
R1.2x57R1.Lig10.672YesYes6010
R1.2x60R1.E1x475.092NoNo6512
R1.2x60R1.Lig22.82NoYes6010
R1.E1x46R1.E1x6014.512NoNo5712
R1.3x25R1.E1x463.452YesNo6521
R1.E1x46R1.Lig5.792NoYes5010
R1.E1x51R1.E1x6012.092NoNo5722
R1.E1x51R1.E25.062NoYes5221
R1.E1x60R1.E26.142NoYes7221
R1.3x29R1.3x302.92YesNo8612
R1.3x29R1.3x336.982YesNo8711
R1.3x29R1.4x6416.232YesNo8612
R1.3x29R1.Lig5.622YesYes8010
R1.3x30R1.4x613.490NoNo6522
R1.3x32R1.Lig8.742YesYes6010
R1.3x33R1.4x614.212NoNo7512
R1.3x33R1.Lig10.042NoYes7010
R1.3x36R1.3x402.872YesNo6612
R1.3x36R1.4x536.762YesYes6712
R1.3x36R1.Lig7.932YesYes6010
R1.3x40R1.4x5316.42NoYes6722
R1.4x53R1.5x4615.262YesNo7622
R1.4x56R1.5x423.822NoYes5512
R1.4x56R1.5x464.892NoNo5612
R1.4x56R1.Lig4.62NoYes5010
R1.4x59R1.E24.072NoYes3221
R1.4x59R1.5x423.582NoYes3522
R1.4x67R1.E27.570NoYes3221
R1.E2R1.Lig4.732YesYes2010
R1.5x42R1.E29.022YesYes5221
R1.5x40R1.5x444.042NoNo2611
R1.5x40R1.Lig10.62NoYes2010
R1.5x41R1.Lig10.440NoYes3010
R1.5x43R1.5x477.782NoYes5611
R1.5x43R1.Lig38.292NoYes5010
R1.5x44R1.6x523.492NoYes6611
R1.5x44R1.Lig19.052NoYes6010
R1.5x47R1.6x526.242YesYes6611
R1.5x47R1.7x413.142YesYes6511
R1.5x47R1.Lig4.422YesYes6010
R1.5x48R1.6x526.040NoYes8621
R1.6x48R1.7x416.490NoYes7521
R1.6x52R1.Lig13.652YesYes6010
R1.6x54R1.E37.372NoYes4321
R1.E3R1.E315.232YesYes3311
R1.E3R1.Lig30.582YesYes3010
R1.7x39R1.Lig7.572YesYes5010
R1.7x41R1.Lig6.462YesYes5010
R1.6x53R1.Lig2.470NoYes4010
R1.1x35R1.E31.862NoYes5321
R1.3x37R1.4x571.70NoNo5621
R1.4x63R1.E21.70NoYes3221
R1.6x51R1.7x411.680NoYes8521
R1.4x57R1.Lig1.612NoYes6010
R1.3x28R1.3x321.590NoYes5621
R1.3x29R1.4x601.452YesNo8812

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
100.00Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
95.65Consensusclass-d_onOrthosteric Ligandste2_on
70.37Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
69.57Consensusclass-d_offOrthosteric Ligandste2_off
67.86Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
66.67Single7QA8Peptide7QA8-STE2-Peptide
66.67Single7QA8Peptide7QA8-STE2-Peptide
66.67Consensusclass-d_offOrthosteric Ligandste2_off
65.38Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
65.38Consensusclass-d_onOrthosteric Ligandste2_on
65.38Consensusgi_class-dOrthosteric Ligandgi_ste
65.38Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
60.71Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
57.14Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
40.54Consensuspth_onOrthosteric Ligandpth1_on pth2_on
39.02Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
38.46Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
37.84Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
36.67Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
36.36Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
36.11Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
36.11Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
35.14Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
34.48Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
34.29Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
34.21Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
33.33Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
33.33Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
33.33Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
33.33Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
33.33Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
33.33Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
32.43Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
32.35Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
32.35Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
32.26Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
32.14Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
32.14Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
32.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
31.71Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
31.43Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
31.43Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
31.43Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
31.25Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
31.03Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
31.03Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
31.03Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
31.03Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
30.77Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
30.77Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
30.56Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
30.56Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
30.56Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
30.56Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
30.56Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
30.30Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
30.30Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
30.30Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
30.30Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
30.00Single5ZTYAM102575ZTY-CB2-AM10257
30.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
30.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
30.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
29.73Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
29.63Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
29.63Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
29.63Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
29.63Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
29.41Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
29.17Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
29.17Consensusclass-t_onOrthosteric Ligandtaste2_on
29.17Consensusgs_class-tOrthosteric Ligandgs_taste
29.17Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
29.17Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
29.03Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
29.03Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
28.57Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
28.57Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
28.57Single7EPENAM5637EPE-mGlu-NAM563
28.57Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
28.57Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
28.57Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
28.57Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
28.57Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
28.57Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
28.57Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
28.57Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
28.57Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
28.12Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
28.00Single5U09Taranabant5U09-CB1-Taranabant
28.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
27.78Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
27.78Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
27.78Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Single5CXVTiotropium5CXV-M1-Tiotropium
27.59Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
27.59Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
27.59Single7YITNalfurafine7YIT-κ-Nalfurafine
27.59Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
27.59Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
27.59Single8WU1KCA8WU1-CB1-KCA-Arrestin1
27.59Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
27.59Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
27.59Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
27.59Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
27.50Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
27.27Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
27.03Single6LMLGlucagon6LML-Glucagon-Glucagon
27.03Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
27.03Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
27.03Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
26.92Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
26.92Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
26.92Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
26.92Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
26.92Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
26.83Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
26.83Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
26.67Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
26.67Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
26.67Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
26.67Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
26.67Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
26.67Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
26.67Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Consensusendothelin_offOrthosteric Ligandetb_off
26.67Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
26.47Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
26.47Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.47Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Single4DAJTiotropium4DAJ-M3-Tiotropium
25.93Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
25.93Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
25.93Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
25.93Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
25.93Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
25.93Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
25.93Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
25.93Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
25.81Single3NY9PubChem 9131033NY9-β2-PubChem 913103
25.81Single4UG2CGS216804UG2-A2A-CGS21680
25.81Single5EE7MK08935EE7-Glucagon-MK0893
25.81Single7SK9CCX6627SK9-ACKR3-CCX662
25.81Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
25.81Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
25.81Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.81Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
25.81Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
25.81Consensusgs_class-b2Orthosteric Ligandgs_adgr
25.81Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
25.81Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.81Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
25.71Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
25.71Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
25.71Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
25.71Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single6FJ3PTH6FJ3-PTH1-PTH
25.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
25.00Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
25.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
25.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
25.00Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
25.00Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
25.00Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
25.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
25.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
25.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
25.00Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
25.00Single8EA0Iperoxo8EA0-M3-Iperoxo
25.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
25.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
25.00Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
25.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
25.00Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
25.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
25.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
25.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
25.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
25.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
25.00Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
25.00Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
25.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
24.39Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
24.32Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
24.32Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
24.32Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
24.32Consensusgo_class-b1Orthosteric Ligandgo_crf
24.32Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
24.32Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
24.24Single3QAKUK-4320973QAK-A2A-UK-432097
24.24Single6HLOAprepitant6HLO-NK1-Aprepitant
24.24Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
24.24Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
24.24Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
24.24Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
24.24Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
24.14Single2YDVNECA2YDV-A2A-NECA
24.14Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
24.14Single4U15Tiotropium4U15-M3-Tiotropium
24.14Single4UHRCGS216804UHR-A2A-CGS21680
24.14Single5G53NECA5G53-A2A-NECA-Gs
24.14Single5V54Methiothepin5V54-5-HT1B-Methiothepin
24.14Single5X93K-87945X93-ETB-K-8794
24.14Single5XR8AM8415XR8-CB1-AM841
24.14Single5XRAAM115425XRA-CB1-AM11542
24.14Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
24.14Single6J21Aprepitant6J21-NK1-Aprepitant
24.14Single6OL9Tiotropium6OL9-M5-Tiotropium
24.14Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
24.14Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
24.14Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
24.14Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
24.14Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
24.14Single8E0GBU728E0G-μ-BU72
24.14Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
24.14Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
24.14Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
24.14Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
24.14Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
24.14Consensus5ht1_offOrthosteric Ligand5ht1b_off
24.14Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
24.14Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
24.14Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
24.14Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
24.14Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
24.14Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
24.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
24.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
24.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
23.68Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
23.68Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
23.68Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
23.68Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
23.68Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
23.68Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
23.53Single6PT2KGCHM076PT2-δ-KGCHM07
23.53Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
23.53Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
23.53Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
23.33Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
23.33Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
23.33Single7DFPSpiperone7DFP-D2-Spiperone
23.33Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
23.33Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
23.33Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
23.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
23.33Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
23.33Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.33Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
23.33Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
23.33Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
23.33Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
23.33Consensusclass-b2_onOrthosteric Ligandadgrg_on
23.33Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
23.33Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
23.33Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
23.33Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
23.33Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
23.08Single6AKXA4R6AKX-CCR5-A4R
23.08Single6AKYMaraviroc6AKY-CCR5-Maraviroc
23.08Single6B73PubChem 1319551386B73-κ-PubChem 131955138
23.08Single6ME2Ramelteon6ME2-MT1-Ramelteon
23.08Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
23.08Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
23.08Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
23.08Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
23.08Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
23.08Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.08Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
23.08Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
23.08Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.08Consensusmglu_onOther Ligandmglu2_on mglu4_on
22.86Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
22.86Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
22.86Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
22.86Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
22.86Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
22.58Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
22.58Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
22.58Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
22.58Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
22.58Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
22.58Single6K1QIRL25006K1Q-ETB-IRL2500
22.58Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
22.58Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
22.58Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
22.58Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
22.58Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
22.58Single7UM4AS26747237UM4-5-HT5A-AS2674723
22.58Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
22.58Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
22.58Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
22.58Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.58Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
22.58Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
22.58Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
22.58Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
22.58Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
22.58Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.58Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
22.58Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.58Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.58Consensusorexin_onOrthosteric Ligandox2_on
22.58Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
22.58Consensussteroid_onOrthosteric Ligandbileacid_on
22.50Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
22.50Consensusglp_onOrthosteric Ligandglp1_on glp2_on
22.50Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
22.22Single4MBSMaraviroc4MBS-CCR5-Maraviroc
22.22Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
22.22Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
22.22Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
22.22Single6TPGEMPA6TPG-OX2-EMPA
22.22Single6TPNHTL66416TPN-OX2-HTL6641
22.22Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
22.22Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
22.22Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.22Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
22.22Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
22.22Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
22.22Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
22.22Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
22.22Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
22.22Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
22.22Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
22.22Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
22.22Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
21.95Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
21.88Single6PT3DPI-2876PT3-δ-DPI-287
21.88Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
21.88Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
21.88Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
21.62Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
21.62Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
21.43Single2Y04Salbutamol2Y04-β1-Salbutamol
21.43Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
21.43Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
21.43Single4MQSIperoxo4MQS-M2-Iperoxo
21.43Single4U14Tiotropium4U14-M3-Tiotropium
21.43Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
21.43Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
21.43Single5DSGTiotropium5DSG-M4-Tiotropium
21.43Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
21.43Single5TGZAM65385TGZ-CB1-AM6538
21.43Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
21.43Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
21.43Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
21.43Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
21.43Single6TOTLemborexant6TOT-OX1-Lemborexant
21.43Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
21.43Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
21.43Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
21.43Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
21.43Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
21.43Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
21.43Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
21.43Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
21.43Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
21.43Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
21.43Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
21.43Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
21.43Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.43Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
21.43Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
21.43Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
21.43Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
21.43Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
21.43Consensusgi_hcarOrthosteric Ligandgi_hca
21.43Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
21.43Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
21.43Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
21.43Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
21.43Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
21.43Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
21.43Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
21.43Consensustar_onOrthosteric Ligandta1_on
21.21Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
21.21Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
21.21Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
21.21Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
21.21Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
21.21Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
21.21Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
21.21Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
21.21Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
21.21Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
21.21Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
21.21Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
21.21Consensussst_onOrthosteric Ligandsst2_on sst4_on
21.05Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
21.05Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
21.05Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.69Single2Y03Isoprenaline2Y03-β1-Isoprenaline
20.69Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
20.69Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
20.69Single5C1MBU725C1M-μ-BU72
20.69Single5TVNLSD5TVN-5-HT2B-LSD
20.69Single5WIUNemonapride5WIU-D4-Nemonapride
20.69Single5WIVNemonapride5WIV-D4-Nemonapride-Na
20.69Single5WQCEMPA5WQC-OX2-EMPA
20.69Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
20.69Single5XPRBosentan5XPR-ETB-Bosentan
20.69Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
20.69Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
20.69Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
20.69Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
20.69Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
20.69Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
20.69Single6TP6Filorexant6TP6-OX1-Filorexant
20.69Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
20.69Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
20.69Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
20.69Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
20.69Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
20.69Single7WC6LSD7WC6-5-HT2A-LSD
20.69Single7YXAONO-54306087YXA-S1P5-ONO-5430608
20.69Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
20.69Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.69Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
20.69Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
20.69Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
20.69Single8QOTNanobody E8QOT-μ-Nanobody E
20.69Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
20.69Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
20.69Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
20.69Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
20.69Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
20.69Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
20.69Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
20.69Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
20.69Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
20.69Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
20.69Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.69Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
20.69Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.69Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
20.59Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
20.59Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
20.59Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.59Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
20.59Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
20.59Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
20.51Single6IGLIRL16206IGL-ETB-IRL1620
20.51Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
20.45Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
20.00Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
20.00Single4DJHJDTic4DJH-κ-JDTic
20.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
20.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
20.00Single5WF5UK-4320975WF5-A2A-UK-432097
20.00Single6E59L-7607356E59-NK1-L-760735
20.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
20.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
20.00Single6J20Aprepitant6J20-NK1-Aprepitant
20.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
20.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
20.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
20.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
20.00Single6W25SHU91196W25-MC4-SHU9119-Ca
20.00Single6WGTLSD6WGT-5-HT2A-LSD
20.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
20.00Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
20.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
20.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
20.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
20.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
20.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
20.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
20.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
20.00Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
20.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
20.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
20.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
20.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
20.00Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
20.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
20.00Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
20.00Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
20.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
20.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
20.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
20.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
20.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
20.00Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
20.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
20.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
20.00Consensusa2_onOrthosteric Liganda2a_on a2b_on
20.00Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
20.00Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
20.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
20.00Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
20.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
20.00Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
20.00Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
20.00Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
20.00Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
20.00Consensushistamine_offOrthosteric Ligandh1_off
20.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
20.00Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
20.00Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
20.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
19.51Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
19.51Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
19.44Single7C61Ergotamine7C61-5-HT1B-Ergotamine
19.44Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
19.44Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
19.44Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
19.44Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
19.44Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
19.44Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
19.44Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
19.44Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
19.35Single4LDEBI1671074LDE-β2-BI167107
19.35Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
19.35Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
19.35Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
19.35Single6HLPNetupitant6HLP-NK1-Netupitant
19.35Single6IIURamatroban6IIU-TP-Ramatroban
19.35Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
19.35Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
19.35Single6ZG4HTL00099366ZG4-M1-HTL0009936
19.35Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
19.35Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
19.35Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
19.35Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.35Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
19.35Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
19.35Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.35Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
19.35Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.35Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
19.35Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
19.35Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
19.35Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
19.35Consensusgs_steroidOrthosteric Ligandgs_bileacid
19.35Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
19.35Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
19.35Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
19.23Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
19.23Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
19.23Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
19.23Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
19.23Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
19.23Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
19.23Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
19.23Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
19.23Single8GGSEpinephrine8GGS-β2-Epinephrine
19.23Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
19.23Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.23Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
19.15Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
19.15Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
19.05Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
18.92Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
18.92Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
18.92Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
18.92Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
18.92Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
18.92Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
18.92Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
18.75Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
18.75Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
18.75Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
18.75Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
18.75Single6H7LDobutamine6H7L-β1-Dobutamine
18.75Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
18.75Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
18.75Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
18.75Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
18.75Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
18.75Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.75Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
18.75Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
18.75Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
18.75Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.75Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
18.75Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
18.75Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
18.75Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
18.75Consensuscyslt_offOrthosteric Ligandcyslt2_off
18.75Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
18.75Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.75Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
18.60Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
18.60Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
18.60Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
18.60Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
18.52Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
18.52Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
18.52Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
18.52Single5DHHSB-6121115DHH-NOP-SB-612111
18.52Single5ZKQABT-4915ZKQ-PAF-ABT-491
18.52Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
18.52Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
18.52Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
18.52Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
18.52Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
18.52Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
18.52Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
18.52Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
18.52Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
18.52Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
18.52Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
18.52Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
18.52Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
18.52Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
18.52Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
18.52Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
18.52Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
18.52Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8GGVEpinephrine8GGV-β2-Epinephrine
18.52Single8GGXEpinephrine8GGX-β2-Epinephrine
18.52Single8GH0Epinephrine8GH0-β2-Epinephrine
18.52Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
18.52Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
18.52Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
18.52Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
18.52Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
18.52Consensusalpha1_onOrthosteric Ligandalpha1a_on
18.52Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
18.52Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
18.52Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
18.52Consensusorexin_offOrthosteric Ligandox2_off ox1_off
18.42Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
18.42Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
18.42Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.42Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.42Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
18.18Single5WF6UK-4320975WF6-A2A-UK-432097
18.18Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
18.18Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
18.18Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
18.18Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
18.18Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8X5YAstemizole8X5Y-H1-Astemizole
18.18Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
18.18Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
18.18Consensuslpl_offOrthosteric Ligands1p_off lpa_off
18.18Consensuslpl_onOrthosteric Ligands1p_on lpa_on
17.95Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
17.95Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
17.95Consensusendothelin_onOrthosteric Ligandetb_on eta_on
17.95Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
17.86Single3RZECidoxepin3RZE-H1-Cidoxepin
17.86Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
17.86Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
17.86Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
17.86Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
17.86Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
17.86Single4ZJCSB-6740424ZJC-OX1-SB-674042
17.86Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
17.86Single6A94Zotepine6A94-5-HT2A-Zotepine
17.86Single6IQLL7458706IQL-D4-L745870
17.86Single6PS4ICI 118-5516PS4-β2-ICI 118-551
17.86Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
17.86Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
17.86Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
17.86Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
17.86Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
17.86Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
17.86Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
17.86Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
17.86Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
17.86Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
17.86Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
17.86Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
17.86Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
17.86Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
17.86Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
17.86Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
17.86Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
17.86Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
17.86Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
17.86Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
17.86Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
17.86Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
17.86Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
17.86Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
17.86Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
17.86Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
17.86Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
17.86Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.86Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.86Single8GGIEpinephrine8GGI-β2-Epinephrine
17.86Single8GGKEpinephrine8GGK-β2-Epinephrine
17.86Single8GGLEpinephrine8GGL-β2-Epinephrine
17.86Single8GGMEpinephrine8GGM-β2-Epinephrine
17.86Single8GGPEpinephrine8GGP-β2-Epinephrine
17.86Single8GGQEpinephrine8GGQ-β2-Epinephrine
17.86Single8GGTEpinephrine8GGT-β2-Epinephrine
17.86Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
17.86Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
17.86Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
17.86Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
17.86Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
17.86Single8K5CAcipimox8K5C-HCA2-Acipimox
17.86Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
17.86Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.86Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.86Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
17.86Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
17.86Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
17.86Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Consensus5ht5_onOrthosteric Ligand5ht5a_on
17.86Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
17.86Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
17.86Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
17.86Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
17.86Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
17.86Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
17.86Consensushca_onOrthosteric Ligandhca2_on hca3_on
17.86Consensushcar_onOrthosteric Ligandhca_on
17.86Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
17.86Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
17.86Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
17.86Consensuss1p_offOrthosteric Ligands1p1_off
17.86Consensussensory_offOrthosteric Ligandopsin_off
17.65Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
17.65Single4XT1Fractalkine4XT1-US28-Fractalkine
17.65Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
17.65Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
17.65Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
17.65Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
17.65Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
17.65Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
17.65Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
17.50Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
17.50Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
17.50Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.50Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
17.24Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
17.24Single2Y01Dobutamine2Y01-β1-Dobutamine
17.24Single3NY8ICI 118-5513NY8-β2-ICI 118-551
17.24Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
17.24Single4EJ4Naltrindole4EJ4-δ-Naltrindole
17.24Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
17.24Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
17.24Single4YAYZD-71554YAY-AT1-ZD-7155
17.24Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
17.24Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
17.24Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
17.24Single6DRXLisuride6DRX-5-HT2B-Lisuride
17.24Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
17.24Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
17.24Single6H7MSalbutamol6H7M-β1-Salbutamol
17.24Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
17.24Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
17.24Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
17.24Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.24Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
17.24Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
17.24Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
17.24Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
17.24Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
17.24Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
17.24Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
17.24Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
17.24Single7UL4Alvimopan7UL4-μ-Alvimopan
17.24Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
17.24Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
17.24Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
17.24Single7WC7Lisuride7WC7-5-HT2A-Lisuride
17.24Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
17.24Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.24Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
17.24Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
17.24Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
17.24Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
17.24Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.24Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.24Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.24Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.24Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.24Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.24Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.24Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.24Single8GGJEpinephrine8GGJ-β2-Epinephrine
17.24Single8GGNEpinephrine8GGN-β2-Epinephrine
17.24Single8GGOEpinephrine8GGO-β2-Epinephrine
17.24Single8GGUEpinephrine8GGU-β2-Epinephrine
17.24Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
17.24Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
17.24Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
17.24Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
17.24Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.24Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.24Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
17.24Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
17.24Single8X63Mepyramine8X63-H1-Mepyramine
17.24Single8X64Desloratadine8X64-H1-Desloratadine
17.24Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
17.24Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
17.24Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
17.24Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
17.24Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
17.24Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
17.24Consensuscck_offOrthosteric Ligandccka_off
17.24Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
17.24Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
17.24Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
17.24Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
17.24Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
17.24Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
17.24Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
17.24Consensushistamine_onOrthosteric Ligandh1_on h4_on
17.24Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
17.24Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
17.24Consensustachykinin_offOrthosteric Ligandnk1_off
17.14Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
17.14Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
17.14Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
17.14Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
17.14Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
17.14Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
17.14Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
17.14Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
17.07Single5GLHEndothelin-15GLH-ETB-Endothelin-1
17.07Single6IGKEndothelin-36IGK-ETB-Endothelin-3
16.67Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
16.67Single2Y00Dobutamine2Y00-β1-Dobutamine
16.67Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
16.67Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
16.67Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
16.67Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
16.67Single5NM2ZM2413855NM2-A2A-ZM241385-Na
16.67Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
16.67Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
16.67Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
16.67Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
16.67Single6E67BI1671076E67-β2-BI167107-Gs (fused)
16.67Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
16.67Single6GPXMK08126GPX-CCR2-MK0812
16.67Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
16.67Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
16.67Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
16.67Single6PS6Timolol6PS6-β2-Timolol
16.67Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
16.67Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
16.67Single7C4SS1P7C4S-S1P3-S1P
16.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.67Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
16.67Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
16.67Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
16.67Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
16.67Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
16.67Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
16.67Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
16.67Single7XKAEpinephrine7XKA-β2-Epinephrine
16.67Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
16.67Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
16.67Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
16.67Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
16.67Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
16.67Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
16.67Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
16.67Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
16.67Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
16.67Consensusangiotensin_onOrthosteric Ligandat1_on
16.67Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
16.67Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
16.67Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
16.67Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
16.67Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
16.67Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
16.67Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
16.67Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
16.67Consensusclass-c_onOther Ligandgabab_on mglu_on
16.67Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
16.67Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
16.67Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
16.67Consensusep_offOrthosteric Ligandep4_off
16.67Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
16.67Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
16.67Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
16.67Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
16.28Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
16.22Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
16.22Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
16.22Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
16.13Single3P0GBI1671073P0G-β2-BI167107
16.13Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
16.13Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
16.13Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
16.13Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
16.13Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
16.13Single5TZR-5TZR-FFA1 (GPR40)-MK8666
16.13Single5V56TC1145V56-SMO-TC114
16.13Single5V57TC1145V57-SMO-TC114
16.13Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
16.13Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
16.13Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
16.13Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
16.13Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
16.13Single7B6WCyclazosin7B6W-α1b-Cyclazosin
16.13Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
16.13Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
16.13Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
16.13Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
16.13Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
16.13Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
16.13Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.13Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
16.13Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
16.13Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
16.13Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
16.13Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
16.13Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
16.13Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
16.13Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
16.13Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
16.13Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Consensusadenosine_offOrthosteric Liganda1_off a2_off
16.13Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
16.13Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
16.13Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
16.13Consensuscck_onOrthosteric Ligandccka_on cckb_on
16.13Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
16.13Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
16.13Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
16.13Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
16.13Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
16.13Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
16.13Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
16.13Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
16.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
16.00Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
16.00Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
15.91Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
15.91Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
15.79Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
15.79Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.79Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
15.79Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
15.79Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.62Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
15.62Single4AMIBucindolol4AMI-β1-Bucindolol
15.62Single4N4WSANT-14N4W-SMO-SANT-1
15.62Single4PY02MeSATP4PY0-P2Y12-2MeSATP
15.62Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
15.62Single6A93Risperidone6A93-5-HT2A-Risperidone
15.62Single6CM4Risperidone6CM4-D2-Risperidone
15.62Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
15.62Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
15.62Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
15.62Single6MXTSalmeterol6MXT-β2-Salmeterol
15.62Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
15.62Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
15.62Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
15.62Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
15.62Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
15.62Single7K15MKD0467K15-BLT1-MKD046-Na
15.62Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.62Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
15.62Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
15.62Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
15.62Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
15.62Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
15.62Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
15.62Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
15.62Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
15.62Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
15.62Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
15.62Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.62Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
15.62Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
15.62Single8JJ8Formoterol8JJ8-β2-Formoterol
15.62Single8JJLOlodaterol8JJL-β2-Olodaterol
15.62Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
15.62Single8JWZAB9288JWZ-A2A-AB928-Na
15.62Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
15.62Consensusblt_offOrthosteric Ligandblt1_off
15.62Consensusgi_class-fOther Ligandgi_frizzled
15.62Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
15.62Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
15.62Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
15.62Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
15.62Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
15.62Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
15.56Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
15.38Single3OE6IT1t3OE6-CXCR4-IT1t
15.38Single4XT3Fractalkine4XT3-US28-Fractalkine
15.38Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
15.38Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
15.38Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
15.38Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
15.38Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8GGREpinephrine8GGR-β2-Epinephrine
15.38Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
15.38Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
15.38Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
15.38Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
15.38Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
15.38Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
15.38Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
15.38Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
15.15Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
15.15Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
15.15Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
15.15Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
15.15Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
15.15Single6IBLArformoterol6IBL-β1-Arformoterol
15.15Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
15.15Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
15.15Single7EZCUKA7EZC-A2A-UKA
15.15Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.15Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
15.15Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
15.00Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
14.81Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
14.81Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
14.81Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
14.81Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
14.81Single3OE9IT1t3OE9-CXCR4-IT1t
14.81Single3PBLEticlopride3PBL-D3-Eticlopride
14.81Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
14.81Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
14.81Single6HLLCP999946HLL-NK1-CP99994
14.81Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
14.81Single6TP4ACT-4622066TP4-OX1-ACT-462206
14.81Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
14.81Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
14.81Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
14.81Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
14.81Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
14.81Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
14.81Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single8GGYEpinephrine8GGY-β2-Epinephrine
14.81Single8GH1Epinephrine8GH1-β2-Epinephrine
14.81Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
14.81Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
14.81Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
14.81Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
14.81Single8K5BNiacin8K5B-HCA2-Niacin
14.81Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
14.81Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
14.81Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
14.81Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
14.81Consensusgo_class-b2Orthosteric Ligandgo_adhesion
14.81Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
14.81Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
14.81Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
14.71Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
14.71Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
14.71Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
14.71Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
14.71Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.71Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.71Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
14.71Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.71Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
14.71Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
14.71Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
14.71Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
14.71Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
14.71Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
14.71Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
14.71Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.71Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
14.71Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.63Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
14.63Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
14.63Single8IY6Endothelin-18IY6-ETB-Endothelin-1
14.63Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
14.63Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
14.63Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
14.58Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
14.29Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
14.29Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
14.29Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
14.29Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
14.29Single3ODUIT1t3ODU-CXCR4-IT1t
14.29Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
14.29Single4IARErgotamine4IAR-5-HT1B-Ergotamine
14.29Single4S0VSuvorexant4S0V-OX2-Suvorexant
14.29Single5K2DZM2413855K2D-A2A-ZM241385
14.29Single5WS3EMPA5WS3-OX2-EMPA
14.29Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
14.29Single6JZHZM2413856JZH-A2A-ZM241385-Na
14.29Single6KUXRS-799486KUX-α2a-RS-79948
14.29Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
14.29Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
14.29Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
14.29Single6PS7ZM2413856PS7-A2A-ZM241385-Na
14.29Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
14.29Single6TODEMPA6TOD-OX1-EMPA-Na
14.29Single6TPJSuvorexant6TPJ-OX2-Suvorexant
14.29Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
14.29Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
14.29Single7F8YDevazepide7F8Y-CCKA-Devazepide
14.29Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
14.29Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
14.29Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
14.29Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
14.29Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
14.29Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
14.29Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
14.29Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
14.29Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
14.29Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
14.29Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
14.29Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
14.29Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
14.29Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7XRRLemborexant7XRR-OX2-Lemborexant
14.29Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
14.29Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GGWEpinephrine8GGW-β2-Epinephrine
14.29Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
14.29Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
14.29Single8IHKAcifran8IHK-HCA3-Acifran
14.29Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8IWESpermidine8IWE-TAAR9-Spermidine
14.29Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
14.29Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
14.29Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
14.29Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
14.29Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
14.29Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
14.29Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
14.29Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
14.29Consensusclass-f_offOrthosteric Ligandsmo_off
14.29Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
14.29Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
14.29Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
14.29Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
14.29Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusgt_class-aOrthosteric Ligandgt_opsin
14.29Consensusgt_opsinOrthosteric Ligandgt_sensory
14.29Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
14.29Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
13.95Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
13.89Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
13.89Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
13.89Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
13.89Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
13.79Single2YDOAdenosine2YDO-A2A-Adenosine
13.79Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
13.79Single5IU4ZM2413855IU4-A2A-ZM241385-Na
13.79Single5IU7Q274563465IU7-A2A-Q27456346-Na
13.79Single5IUBQ274563445IUB-A2A-Q27456344-Na
13.79Single5JTBZM2413855JTB-A2A-ZM241385
13.79Single5K2CZM2413855K2C-A2A-ZM241385-Na
13.79Single5NLXZM2413855NLX-A2A-ZM241385-Na
13.79Single5NM4ZM2413855NM4-A2A-ZM241385-Na
13.79Single5UVIZM2413855UVI-A2A-ZM241385
13.79Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
13.79Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
13.79Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
13.79Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
13.79Single6TP3Nemorexant6TP3-OX1-Nemorexant
13.79Single6TPKRetosiban6TPK-OT-Retosiban
13.79Single6VI4JDTic6VI4-κ-JDTic
13.79Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
13.79Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
13.79Single6ZG9GSK10347026ZG9-M1-GSK1034702
13.79Single7T32ZM2413857T32-A2A-ZM241385
13.79Single7VODCariprazine7VOD-5-HT2A-Cariprazine
13.79Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
13.79Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
13.79Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
13.79Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
13.79Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.79Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.79Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.79Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
13.79Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
13.79Single8K2WAMG4878K2W-CXCR3-AMG487
13.79Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
13.79Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.79Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.79Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.79Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.79Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
13.79Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
13.79Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
13.79Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
13.79Consensusgnrh_offOrthosteric Ligandgnrh1_off
13.79Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
13.79Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
13.79Consensusvasopressin-ot_offOrthosteric Ligandot_off
13.64Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
13.64Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.51Single3OE0CVX153OE0-CXCR4-CVX15
13.51Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
13.51Single7XNACYN1548067XNA-SST2-CYN154806
13.51Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
13.51Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
13.51Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
13.51Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.51Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.51Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.51Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
13.33Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
13.33Single2Y02Carmoterol2Y02-β1-Carmoterol
13.33Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
13.33Single3EMLZM2413853EML-A2A-ZM241385
13.33Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
13.33Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
13.33Single4EIYZM2413854EIY-A2A-ZM241385-Na
13.33Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
13.33Single5IU8Q274563475IU8-A2A-Q27456347-Na
13.33Single5K2AZM2413855K2A-A2A-ZM241385-Na
13.33Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
13.33Single5OLGZM2413855OLG-A2A-ZM241385-Na
13.33Single5VRAZM2413855VRA-A2A-ZM241385-Na
13.33Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
13.33Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
13.33Single6GPSMK08126GPS-CCR2-MK0812
13.33Single6IIVDaltroban6IIV-TP-Daltroban
13.33Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
13.33Single6LPJZM2413856LPJ-A2A-ZM241385-Na
13.33Single6LPKZM2413856LPK-A2A-ZM241385-Na
13.33Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
13.33Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
13.33Single6PS1Timolol6PS1-β2-Timolol
13.33Single6S0LZM2413856S0L-A2A-ZM241385
13.33Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
13.33Single7F83PF-051904577F83-Ghrelin-PF-05190457
13.33Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
13.33Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
13.33Single7PYRPSB-21157PYR-A2A-PSB-2115
13.33Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
13.33Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
13.33Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
13.33Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
13.33Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
13.33Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
13.33Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
13.33Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
13.33Single8CU6LJ-45178CU6-A2A-LJ-4517
13.33Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
13.33Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
13.33Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.33Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
13.33Single8JJOAlprenolol8JJO-β2-Alprenolol
13.33Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
13.33Single8K5DGSK2560738K5D-HCA2-GSK256073
13.33Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.33Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
13.33Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
13.33Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
13.33Consensusa2_offOrthosteric Liganda2a_off
13.33Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
13.33Consensusadenosine_onOrthosteric Liganda1_on a2_on
13.33Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
13.33Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
13.33Consensusblt_onOrthosteric Ligandblt1_on
13.33Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
13.33Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
13.33Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
13.33Consensushcar_offOrthosteric Ligandsuccinate_off
13.33Consensusleuko_onOrthosteric Ligandblt_on
13.33Consensusnucleotide_onOrthosteric Ligandadenosine_on
13.33Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
13.33Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
13.33Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
13.33Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
13.33Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
13.16Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
13.16Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
13.16Single6JODAngiotensin II6JOD-AT2-Angiotensin II
13.16Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.16Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
13.16Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
13.16Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.16Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
12.90Single5CGCHTL142425CGC-mGlu5-HTL14242
12.90Single5IUAQ274563485IUA-A2A-Q27456348-Na
12.90Single5N2SPSB365N2S-A1-PSB36
12.90Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
12.90Single6D26Fevipiprant6D26-DP2-Fevipiprant
12.90Single6LPLZM2413856LPL-A2A-ZM241385-Na
12.90Single6LUQHaloperidol6LUQ-D2-Haloperidol
12.90Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
12.90Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
12.90Single6S0QZM2413856S0Q-A2A-ZM241385
12.90Single6WQAZM2413856WQA-A2A-ZM241385-Na
12.90Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
12.90Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
12.90Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
12.90Single7RM5ZM2413857RM5-A2A-ZM241385-Na
12.90Single7SINNPS-21437SIN-CaS-NPS-2143
12.90Single7SINNPS-21437SIN-CaS-NPS-2143
12.90Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
12.90Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
12.90Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
12.90Single8FYNZM2413858FYN-A2A-ZM241385-Na
12.90Single8GNEKW-63568GNE-A2A-KW-6356-Na
12.90Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
12.90Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
12.90Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
12.82Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
12.82Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.82Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
12.82Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
12.82Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.82Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
12.82Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
12.82Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
12.82Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.82Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
12.50Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
12.50Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
12.50Single7PX4PSB-21137PX4-A2A-PSB-2113
12.50Single7SK3CXCL127SK3-ACKR3-CXCL12
12.50Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
12.50Single7W41PD1762527W41-BB2-PD176252
12.50Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
12.50Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
12.50Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
12.50Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
12.50Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
12.50Consensusbombesin_offOrthosteric Ligandbb2_off
12.50Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
12.50Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
12.50Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
12.50Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
12.50Consensuslpa_offOrthosteric Ligandlpa1_off
12.50Consensuslpa_onOrthosteric Ligandlpa1_on
12.50Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.20Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
12.20Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
12.20Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
12.12Single5X33BIIL2605X33-BLT1-BIIL260
12.12Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
12.12Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
12.12Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
12.12Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.12Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.12Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
12.12Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.12Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
12.12Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.12Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
12.12Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
12.12Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
12.12Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
12.12Consensusdp_offOrthosteric Liganddp2_off
12.12Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
12.12Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
12.12Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
12.00Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
12.00Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
11.90Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
11.90Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
11.76Single5CGDHTL142425CGD-mGlu5-HTL14242
11.76Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
11.76Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
11.76Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
11.76Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
11.76Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
11.76Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
11.76Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
11.63Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
11.63Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
11.63Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
11.54Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
11.54Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
11.43Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.43Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
11.43Single7XN9L-054,5227XN9-SST2-L-054,522
11.43Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
11.43Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
11.43Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
11.43Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.36Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
11.11Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
11.11Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
11.11Single3OE8IT1t3OE8-CXCR4-IT1t
11.11Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
11.11Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
11.11Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
11.11Single6ME5Agomelatine6ME5-MT1-Agomelatine
11.11Single6ME9Ramelteon6ME9-MT2-Ramelteon
11.11Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
11.11Single7F8XNN90567F8X-CCKA-NN9056
11.11Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
11.11Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
11.11Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
11.11Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
11.11Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
11.11Single8GGZEpinephrine8GGZ-β2-Epinephrine
11.11Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
11.11Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
11.11Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
11.11Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
11.11Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
11.11Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.11Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
11.11Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
11.11Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
10.81Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
10.81Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
10.81Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
10.81Single7SHEPI; PE7SHE-GPR158-PI; PE
10.81Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.81Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.81Consensussst_offOrthosteric Ligandsst2_off
10.71Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
10.71Single5L7IVismodegib5L7I-SMO-Vismodegib
10.71Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
10.71Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
10.71Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
10.71Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.71Single7SRQLSD7SRQ-5-HT2B-LSD
10.71Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
10.71Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
10.71Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
10.71Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
10.71Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
10.53Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
10.53Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
10.34Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
10.34Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
10.34Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
10.34Single7BR3Elagolix7BR3-GnRH1-Elagolix
10.34Single7F8ULintitript7F8U-CCKA-Lintitript
10.34Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.34Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
10.34Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
10.34Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
10.34Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
10.34Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
10.34Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
10.34Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
10.34Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.34Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
10.34Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
10.34Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
10.34Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
10.34Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
10.34Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
10.34Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
10.34Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.26Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
10.26Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
10.26Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
10.00Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
10.00Single5K2BZM2413855K2B-A2A-ZM241385-Na
10.00Single6AQFZM2413856AQF-A2A-ZM241385
10.00Single6V9SGTPL114036V9S-OX1-GTPL11403
10.00Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
10.00Single7AROLUF58337ARO-A2A-LUF5833-Na
10.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
10.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00Single7VV6C48/807VV6-MRGPRX2-C48/80
10.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
10.00Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
10.00Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
10.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.00Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.80Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
9.68Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
9.68Single5T04Neurotensin5T04-NTS1-Neurotensin
9.68Single5UENDU1725UEN-A1-DU172
9.68Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
9.68Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.68Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.68Single7BU7BI1671077BU7-β1-BI167107
9.68Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
9.52Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
9.43Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
9.38Single4NTJAZD12834NTJ-P2Y12-AZD1283
9.38Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
9.38Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
9.38Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
9.38Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.38Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.38Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
9.38Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
9.38Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
9.38Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
9.38Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
9.09Single4BV0Neurotensin4BV0-NTS1-Neurotensin
9.09Single6OS1TRV0266OS1-AT1-TRV026
9.09Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
9.09Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
9.09Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
9.09Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
9.09Single7P2L4YI7P2L-mGlu5-4YI
9.09Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
9.09Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
9.09Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
9.09Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
9.09Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
9.09Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.82Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
8.82Single4XEENeurotensin4XEE-NTS1-Neurotensin
8.82Single4XESNeurotensin4XES-NTS1-Neurotensin
8.82Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
8.82Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
8.82Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
8.82Single6YVRNTS8-136YVR-NTS1-NTS8-13
8.82Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
8.82Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
8.82Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.82Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
8.82Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.82Consensuschemokine_offOrthosteric Ligandcxcr_off
8.82Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
8.82Consensuscxcr_offOrthosteric Ligandcxcr4_off
8.82Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
8.82Consensusnts_onOrthosteric Ligandnts1_on
8.70Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
8.57Single4BUONeurotensin4BUO-NTS1-Neurotensin
8.57Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
8.57Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
8.57Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
8.57Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
8.33Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
8.33Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
8.33Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
8.16Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
8.11Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.11Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single6W25Ca6W25-MC4-SHU9119-Ca
7.89Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
7.89Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
7.89Single7SK5CXCL127SK5-ACKR3-CXCL12
7.89Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.89Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
7.69Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
7.69Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single7WC4Serotonin7WC4-5-HT2A-Serotonin
7.50Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
7.50Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
7.41Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
7.41Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
7.41Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.41Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Consensussensory_onOrthosteric Ligandopsin_on
7.14Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
7.14Single3UZAGTPL92363UZA-A2A-GTPL9236
7.14Single4XNWMRS25004XNW-P2Y1-MRS2500
7.14Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
7.14Single6LI0GTPL98046LI0-GPR52-GTPL9804
7.14Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
7.14Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
7.14Single7WC5Psilocin7WC5-5-HT2A-Psilocin
7.14Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
7.14Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
7.14Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
6.90Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
6.90Single4O9RCyclopamine4O9R-SMO-Cyclopamine
6.90Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
6.90Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.90Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
6.90Single7UL2SR486927UL2-NTS1-SR48692-Na
6.90Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
6.90Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
6.90Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
6.90Consensusgo_proteinOrthosteric Ligandgo_chemokine
6.90Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.90Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
6.67Single3PWHZM2413853PWH-A2A-ZM241385
6.67Single4BWBNeurotensin4BWB-NTS1-Neurotensin
6.67Single4QINSAG1.54QIN-SMO-SAG1.5
6.67Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
6.67Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
6.67Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
6.67Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
6.67Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
6.67Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
6.67Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
6.67Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
6.67Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
6.67Single8GNGIstradefylline8GNG-A2A-Istradefylline
6.67Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
6.67Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
6.45Single3REYPubChem 56973REY-A2A-PubChem 5697
6.45Single6DS0Ly2660976DS0-5-HT2B-Ly266097
6.45Single6FFIMMPEP6FFI-mGlu5-MMPEP
6.45Single6MH8ZM2413856MH8-A2A-ZM241385
6.45Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
6.45Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.45Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
6.45Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
6.45Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
6.45Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
6.45Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
6.45Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
6.45Single8IYXYL-3658IYX-GPR34-YL-365
6.45Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
6.45Consensusgi_class-fOrthosteric Ligandgi_frizzled
6.45Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.45Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
6.25Single6FFHFenobam6FFH-mGlu5-Fenobam
6.25Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
6.25Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
6.25Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
6.25Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
6.25Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
6.25Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
6.25Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
6.06Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
6.06Single6Z4SSR486926Z4S-NTS1-SR48692
5.88Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
5.88Single7F1TMIP-1a7F1T-CCR5-MIP-1a
5.88Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
5.88Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
5.88Consensuschemerin_onOrthosteric Ligandcml1_on
5.88Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
5.71Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
5.71Single6OS2TRV0266OS2-AT1-TRV026
5.71Single7SHEPI; PE7SHE-GPR158-PI; PE
5.71Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.71Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
5.71Consensusnts_offOrthosteric Ligandnts1_off
5.56Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
5.41Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
5.26Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
4.35Single8W8SAA-148W8S-GPR101-AA-14
4.35Consensusclass-c_offOther Ligandgabab_off mglu_off
4.17Single8W8RAA-148W8R-GPR101-AA-14-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
3.85Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
3.85Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
3.85Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
3.70Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
3.70Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
3.70Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
3.70Single8PWNTheophylline8PWN-A2A-Theophylline
3.57Single3RFMCaffeine3RFM-A2A-Caffeine
3.57Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
3.57Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
3.57Single8A2OTheophylline8A2O-A2A-Theophylline-Na
3.57Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
3.57Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
3.45Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
3.45Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
3.45Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
3.45Single8WG8Peptide8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/&β;1/&γ;2
3.45Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.45Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
3.33Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
3.33Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
3.33Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
3.33Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
3.33Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
3.23Single4XNVBPTU4XNV-P2Y1-BPTU
3.23Single7WV9ZCZ0117WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
3.23Single8HNNSCH5467388HNN-CXCR3-SCH546738
3.23Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
3.23Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
3.23Consensuscb1_on_alloOther Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
3.23Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
3.12Single6ZINSR486926ZIN-NTS1-SR48692
3.12Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
3.12Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.12Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
3.03Single6D27CAY104716D27-DP2-CAY10471
3.03Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
2.63Single6KNMJN241-96KNM-Apelin-JN241-9
2.56Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2

Consensus Members
Id Members
gi_ste 7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
Net Summary
Imin 2.77
Number of Linked Nodes 1044
Number of Links 1310
Number of Hubs 216
Number of Links mediated by Hubs 800
Number of Communities 26
Number of Nodes involved in Communities 328
Number of Links involved in Communities 475
Path Summary
Number Of Nodes in MetaPath 110
Number Of Links MetaPath 109
Number of Shortest Paths 3338023
Length Of Smallest Path 3
Average Path Length 43.5047
Length of Longest Path 80
Minimum Path Strength 1.23
Average Path Strength 6.15058
Maximum Path Strength 34.435
Minimum Path Correlation 0.7
Average Path Correlation 0.99477
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 48.3064
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.2962
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .




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