Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1NT.V39 4.61566
2NT.L50 4.52167665
3NT.P51 3.4775405
4NT.L57 3.765467
5NT.I60 4.415414
6NT.I67 4.155665
7NT.H70 4.625454
8NT.F72 4.62167669
9NT.I78 4.555467
10NT.I81 5.09468
11NT.Y82 10.2375414
12NT.Q91 6.23453
13NT.H95 8.1125455
14NT.F97 5.26833669
15NT.Y98 8.185452
16NT.L100 4.3525468
17NT.H105 9.0425417
18NT.R109 13.54415
19NT.N110 5.58416
20NT.L114 4.68428
21NT.Y116 5.4025453
22NT.D118 6.618555
23NT.F130 6.828516
24NT.F134 7.955615
25NT.T136 5.31833629
26NT.L138 5428
27NT.F141 5.95167627
28NT.K146 6.612554
29NT.F154 5.93626
30NT.L156 4.3725427
31NT.E157 8.12518
32NT.T159 6.25415
33NT.N161 5.705408
34NT.M164 4.88527
35NT.F172 5.99833628
36NT.L175 6.752527
37NT.L180 3.725427
38NT.L182 5.82526
39NT.K183 6.7725416
40NT.Y185 8.035417
41NT.N187 6.512529
42NT.F189 8.474528
43NT.F197 6.695409
44NT.N198 6.07254127
45NT.T200 5.11428
46NT.L202 5.302528
47NT.V205 3.742527
48NT.Y206 4.804516
49NT.N208 6.816515
50NT.K209 5.9825417
51NT.F221 6.8275429
52NT.P228 4.998528
53NT.L230 6.062514
54NT.D232 10.4775419
55NT.V233 3.094137
56NT.S234 4.3475419
57NT.L241 3.7865139
58NT.L246 4.2675427
59NT.I253 6.778514
60NT.R255 4.8425414
61NT.P264 4.47509
62NT.F269 4.5454107
63NT.R274 9.135413
64NT.Y279 7.468599
65NT.F286 4.566676108
66NT.F405 7.7225438
67NT.E409 8.234149
68NT.I411 4.392588
691x32 5.86254164
701x39 4.3175409
711x47 3.15407
721x53 3.954579
731x56 5.835478
741x57 4.0625478
752x38 4.056549
762x40 5.61409
772x41 5.478549
782x46 5.94833649
792x50 6.378549
802x53 5.378539
812x56 6.034539
822x57 3.734539
83E1.Y481 5.53667688
84E1.Y482 5.2925408
85E1.I486 6.62498
86E1x50 6.366589
873x32 4.45509
883x33 3.786539
893x37 6.012538
903x38 5.6725409
913x42 3.725449
923x51 5.17407
934x46 4.834549
944x50 6.484549
95E2.Y563 9.026539
96E2.I568 5.07439
97E2x51 6.074539
98E2.M572 7.37439
995x39 5.35167639
1005x43 5.1025437
1015x51 7.875408
1025x58 6.72667649
1036x44 5.2875408
1046x54 7.9475408
1056x59 2.584536
1067x37 5.1675439
1077x41 5.63167639
1087x42 4.69439
1097x49 7.965449
1107x53 4.97143749
1118x50 5.58667679
1128x54 3.15475
113Lig 62.15292110
114Allo1 6.967141430
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1NT.L100 NT.L125 25.91454.15YesNo088
2NT.L125 NT.V147 41.73762.98NoNo087
3NT.L175 NT.V147 42.14474.47YesNo077
4NT.C176 NT.F154 53.40958.38NoYes266
5NT.C176 NT.E178 53.08453.04NoNo065
6NT.E178 NT.I152 51.03769.56NoNo053
7NT.F153 NT.I152 50.62695.02NoNo053
8Lig NT.F153 50.211437.2YesNo105
9NT.A121 NT.S96 33.75251.71NoNo097
10NT.A121 NT.D118 32.76721.54NoYes095
11NT.D118 NT.Y116 13.94849.2YesYes553
12NT.Q91 NT.Y116 11.98272.25YesYes533
13NT.F97 NT.S96 27.87185.28YesNo097
14NT.F97 NT.L122 15.05128.53YesNo097
15NT.L138 NT.M164 11.00424.24YesYes287
16NT.L156 NT.L175 19.32055.54YesYes277
17NT.L156 NT.L182 44.37264.15YesYes276
18NT.L175 NT.L180 19.86564.15YesYes277
19NT.L180 NT.L182 44.17724.15YesYes276
20Lig NT.T179 11.40054.5YesNo105
21NT.K201 NT.T179 11.01863NoNo045
22NT.K201 NT.Y225 10.11034.78NoNo044
23NT.L182 NT.V205 86.73444.47YesYes267
24NT.F189 NT.N210 10.88224.83YesNo289
25NT.L231 NT.V205 88.30872.98NoYes077
26NT.L213 NT.N210 13.77174.12NoNo099
27NT.L213 NT.T236 13.83414.42NoNo099
28NT.L231 NT.V233 89.65394.47NoYes077
29NT.T236 NT.V238 14.06616.35NoNo097
30NT.L241 NT.V233 89.54232.98YesYes1397
31NT.L241 NT.P264 53.92623.28YesYes099
32NT.L263 NT.P264 51.50753.28NoYes089
33NT.H282 NT.L263 50.51416.43NoNo098
34NT.H282 NT.Y279 1006.53NoYes099
35NT.L241 NT.L252 49.92922.77YesNo099
36NT.L252 NT.L277 49.88132.77NoNo099
37NT.H282 NT.L277 49.67743.86NoNo099
38E1.I486 NT.Y279 98.425913.3YesYes989
39E1.A485 NT.I281 98.19033.25NoNo099
40E1.I486 NT.I281 98.3852.94YesNo089
41E1.A485 E1.Y481 97.99526.67NoYes098
42E1.Y481 E2.S567 20.92115.09YesNo889
437x34 E2.S567 20.77123.06NoNo099
447x34 E2.I568 18.25854.36NoYes099
45E2.I568 E2x51 14.45635.71YesYes399
46Allo1 E2x51 12.980213.32YesYes309
47E1.Y481 NT.I411 73.60957.25YesYes888
482x60 NT.I411 69.65872.94NoYes088
492x56 2x60 69.45388.46YesNo098
502x53 2x56 55.90133.59YesYes399
511x50 2x47 10.49764.69NoNo099
521x50 2x50 11.53876.73NoYes099
532x50 7x46 57.3754.42YesNo099
542x53 7x46 57.92916.13YesNo099
552x46 2x50 28.57245.43YesYes499
562x50 7x49 18.26369.42YesYes499
572x46 7x53 12.97933.52YesYes499
587x49 7x53 12.17294.65YesYes499
592x56 3x32 11.29458.74YesYes099
603x47 5x57 13.39973.38NoNo099
613x47 5x58 14.003712.48NoYes099
625x58 7x53 20.56122.98YesYes499
633x51 5x57 10.06663.92YesNo079
64NT.L241 NT.V238 14.06162.98YesNo1397
65NT.F97 NT.L100 15.03253.65YesYes698
66NT.L122 NT.L125 15.43314.15NoNo078
67NT.F154 NT.L156 24.74533.65YesYes267
68NT.F154 NT.L180 26.94613.65YesYes267
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
NT.E35NT.R384.650NoNo1421
NT.R38NT.T566.471NoNo4512
LigNT.R3810.471YesNo0401
LigNT.K424.781YesNo0201
NT.I60NT.K584.361YesNo4512
NT.I60NT.S843.11YesNo4711
LigNT.I608.831YesYes0401
LigNT.S844.641YesNo0701
NT.I85NT.N1104.251NoYes6611
LigNT.I852.941YesNo0601
NT.E107NT.R10918.611NoYes6521
NT.E107NT.F13471NoYes6522
NT.N110NT.R1097.231YesYes6511
NT.F134NT.R10914.971YesYes5521
LigNT.R10913.351YesYes0501
NT.N110NT.N1355.451YesNo6812
LigNT.N1105.391YesYes0601
NT.F153NT.I1525.021NoNo5312
LigNT.F15337.21YesNo0501
NT.K201NT.T17930NoNo4521
NT.D203NT.T17914.451NoNo6511
LigNT.T1794.51YesNo0501
NT.D203NT.T1814.341NoNo6712
NT.K209NT.N1864.21YesNo7712
LigNT.D20320.741YesNo0601
NT.A204NT.Y2065.341NoYes5612
NT.A204NT.L2303.151NoYes5411
LigNT.A20441YesNo0501
NT.N208NT.Y2063.491YesYes5622
NT.L230NT.Y2065.861YesYes4612
NT.K209NT.N2086.991YesYes7512
LigNT.K20910.031YesYes0701
NT.E251NT.L2305.31NoYes5411
NT.I253NT.L2304.281YesYes4421
LigNT.L23011.721YesYes0401
NT.E251NT.R27412.791NoYes5312
LigNT.E25115.041YesNo0501
NT.I253NT.R2746.261YesYes4322
LigNT.S3837.641YesNo0401
NT.D386NT.Y3854.61NoNo5412
LigNT.D3865.431YesNo0501
LigNT.Y38729.911YesNo0401
NT.K209NT.Q2352.711YesNo7412
LigNT.S2292.541YesNo0501
NT.E61NT.I601.370NoYes5421
LigNT.D3821.361YesNo0401

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
100.00Single6D35Cholesterol6D35-SMO-Cholesterol
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
100.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
100.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
100.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
100.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
100.00Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00Single7FIIhCG7FII-LH-hCG-6fuf
100.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
100.00Single7XW7K1-707XW7-TSH-K1-70
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
100.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
100.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
100.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
100.00Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
100.00Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
100.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
100.00Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusgphr_onOrthosteric Ligandlh_on tsh_on
100.00Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00Consensusgs_proteinOrthosteric Ligandgs_gphr
100.00Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
100.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
100.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
100.00Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
100.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
100.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
100.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
100.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
100.00Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
100.00Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
33.33Single8HS2Fab0468HS2-GPR20-Fab046
25.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
25.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
20.00Single5L7DCholesterol5L7D-SMO-Cholesterol
20.00Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
20.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
20.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29Single4XNWMRS25004XNW-P2Y1-MRS2500
14.29Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
14.29Single6LI0GTPL98046LI0-GPR52-GTPL9804
14.29Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.29Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
14.29Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
12.50Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
12.50Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.50Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50Consensusgo_proteinOrthosteric Ligandgo_chemokine
12.50Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11Single4BWBNeurotensin4BWB-NTS1-Neurotensin
11.11Single4QINSAG1.54QIN-SMO-SAG1.5
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.11Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.11Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
11.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
11.11Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Consensusclass-f_offOrthosteric Ligandsmo_off
11.11Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
10.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
10.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00Single7VV6C48/807VV6-MRGPRX2-C48/80
10.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
10.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
10.00Consensusgi_class-fOrthosteric Ligandgi_frizzled
10.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
10.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
10.00Consensuss1p_offOrthosteric Ligands1p1_off
9.09Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single5TGZAM65385TGZ-CB1-AM6538
9.09Single6D27CAY104716D27-DP2-CAY10471
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.09Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
9.09Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
9.09Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
9.09Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
9.09Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
9.09Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.33Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
8.33Single5C1MBU725C1M-μ-BU72
8.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.33Single7C4SS1P7C4S-S1P3-S1P
8.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
8.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
8.33Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
8.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YXAONO-54306087YXA-S1P5-ONO-5430608
8.33Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.33Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
7.69Single4BV0Neurotensin4BV0-NTS1-Neurotensin
7.69Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
7.69Single5V56TC1145V56-SMO-TC114
7.69Single5V57TC1145V57-SMO-TC114
7.69Single6OS1TRV0266OS1-AT1-TRV026
7.69Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
7.69Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
7.69Single7F1TMIP-1a7F1T-CCR5-MIP-1a
7.69Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
7.69Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
7.69Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
7.69Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
7.69Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
7.69Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7.69Single8E0GBU728E0G-μ-BU72
7.69Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.69Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.69Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
7.69Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.69Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7.69Consensuslpa_offOrthosteric Ligandlpa1_off
7.69Consensuslpa_onOrthosteric Ligandlpa1_on
7.69Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7.69Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
7.14Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
7.14Single4XEENeurotensin4XEE-NTS1-Neurotensin
7.14Single4XESNeurotensin4XES-NTS1-Neurotensin
7.14Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
7.14Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
7.14Single6OS2TRV0266OS2-AT1-TRV026
7.14Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
7.14Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single6YVRNTS8-136YVR-NTS1-NTS8-13
7.14Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
7.14Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7.14Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
7.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.14Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
7.14Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
7.14Consensuschemokine_offOrthosteric Ligandcxcr_off
7.14Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
7.14Consensuscxcr_offOrthosteric Ligandcxcr4_off
7.14Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
7.14Consensusdp_offOrthosteric Liganddp2_off
7.14Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
7.14Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
7.14Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
7.14Consensusnts_onOrthosteric Ligandnts1_on
7.14Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
7.14Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
6.67Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
6.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
6.67Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
6.67Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
6.67Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
6.67Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
6.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.67Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
6.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
6.67Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.67Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.67Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
6.67Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
6.25Single6KNMJN241-96KNM-Apelin-JN241-9
6.25Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
6.25Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
6.25Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.25Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
6.25Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
6.25Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.25Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
6.25Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25Consensuslpl_offOrthosteric Ligands1p_off lpa_off
6.25Consensuslpl_onOrthosteric Ligands1p_on lpa_on
6.25Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
6.25Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
5.88Single4XT1Fractalkine4XT1-US28-Fractalkine
5.88Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.88Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.88Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
5.88Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
5.88Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
5.88Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.88Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
5.88Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.88Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.88Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.88Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
5.88Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.88Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.88Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
5.88Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
5.56Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
5.56Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.56Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
5.56Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.56Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.56Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
5.56Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.56Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.56Single7SK5CXCL127SK5-ACKR3-CXCL12
5.56Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.56Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.56Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
5.56Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
5.26Single3OE0CVX153OE0-CXCR4-CVX15
5.26Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
5.26Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.26Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
5.26Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
5.26Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.26Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.26Consensusangiotensin_onOrthosteric Ligandat1_on
5.26Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.26Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
5.26Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.26Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.26Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
5.26Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
5.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
5.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
5.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
5.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
5.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
5.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
5.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
5.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
5.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
5.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
5.00Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
5.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
5.00Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
5.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.00Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
5.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.76Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.76Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
4.76Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
4.76Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.76Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.76Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.76Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
4.76Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.76Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.76Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
4.76Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
4.76Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.76Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
4.76Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
4.55Single4XT3Fractalkine4XT3-US28-Fractalkine
4.55Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
4.55Single6FJ3PTH6FJ3-PTH1-PTH
4.55Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.55Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.55Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7SK3CXCL127SK3-ACKR3-CXCL12
4.55Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
4.55Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
4.55Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.55Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
4.55Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
4.55Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.55Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
4.55Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.55Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.35Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
4.35Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.35Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.35Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.35Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
4.35Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.35Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.35Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
4.35Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.35Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.35Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.35Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
4.35Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.35Consensusgo_class-b1Orthosteric Ligandgo_crf
4.35Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.35Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.17Single6LMLGlucagon6LML-Glucagon-Glucagon
4.17Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.17Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.17Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.17Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.17Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.17Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.17Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
4.17Single8IY6Endothelin-18IY6-ETB-Endothelin-1
4.17Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
4.17Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
4.17Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.17Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
4.17Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.17Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.17Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.17Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
4.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
4.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
4.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.00Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.00Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.00Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
4.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
4.00Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.00Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
3.85Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.85Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.85Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.85Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.85Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.85Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.85Consensusglp_onOrthosteric Ligandglp1_on glp2_on
3.85Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
3.70Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.70Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.70Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.70Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.70Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
3.57Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.57Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.57Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.57Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.57Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.57Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
3.57Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.57Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
3.57Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.45Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
3.45Consensuspth_onOrthosteric Ligandpth1_on pth2_on
3.33Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.33Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.23Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.23Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
3.23Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.12Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.12Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.12Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.03Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
3.03Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.94Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.86Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
NT.D403NT.F4058.360NoYes8821
E2.K565NT.F40514.890NoYes7821
E2.M572NT.F4053.733YesYes9811
Allo1NT.F4053.913YesYes0801
3x323x333.170YesYes9922
3x32E2x512.950YesYes9921
3x327x413.750YesYes9922
3x33E2.Y5635.053YesYes9922
3x33E2x523.533YesNo9921
3x335x393.793YesYes9922
3x374x563.983YesNo8722
3x375x438.563YesYes8721
4x565x432.983NoYes7721
E2.Y563E2x528.343YesNo9921
E2.I568E2.V5663.073YesNo9922
E2.M572E2.V5666.093YesNo9912
E2.I568E2x515.713YesYes9921
7x37E2.I5687.143YesYes9922
E2.M572E2x514.243YesYes9911
7x37E2x514.153YesYes9921
Allo1E2x5113.323YesYes0901
Allo1E2x528.433YesNo0901
Allo1E2.M57215.423YesYes0901
5x395x435.053YesYes9721
5x406x592.943NoYes7611
5x40Allo17.333NoYes7010
5x43Allo13.823YesYes7010
5x446x554.733NoNo8911
5x44Allo17.993NoYes8010
6x517x413.630NoYes9912
6x51Allo17.330NoYes9010
6x547x365.860YesNo8821
6x55Allo15.053NoYes9010
6x58Allo16.070NoYes9010
6x59Allo15.493YesYes6010
Allo1E3.P6523.163YesNo0901
7x307x333.230NoNo7921
7x33Allo15.780NoYes9010
7x36Allo14.440NoYes8010
7x377x413.523YesYes9922
5x446x562.773NoNo8712
5x416x591.540NoYes5621
5x40E2.T5741.523NoNo7612
6x59E2.T5741.523YesNo6612
6x596x601.433YesNo6512

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
75.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
60.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
60.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
56.25Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
56.25Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
52.94Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
50.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
44.44Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
43.75Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
42.11Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
42.11Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
40.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
40.00Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
38.89Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
38.89Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
37.50Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
37.50Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
36.84Single5N2SPSB365N2S-A1-PSB36
36.84Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
36.84Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
36.84Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
36.84Single8GNEKW-63568GNE-A2A-KW-6356-Na
36.36Single5WF6UK-4320975WF6-A2A-UK-432097
36.36Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
35.71Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
35.29Single5K2DZM2413855K2D-A2A-ZM241385
35.29Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
35.29Single6JZHZM2413856JZH-A2A-ZM241385-Na
35.29Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
35.29Single6PS7ZM2413856PS7-A2A-ZM241385-Na
35.29Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
35.29Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
35.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
35.00Single7PX4PSB-21137PX4-A2A-PSB-2113
35.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.00Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
35.00Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.78Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
34.78Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
34.78Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
34.78Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
34.62Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
34.62Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
34.62Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
33.33Single3QAKUK-4320973QAK-A2A-UK-432097
33.33Single5IU4ZM2413855IU4-A2A-ZM241385-Na
33.33Single5IU7Q274563465IU7-A2A-Q27456346-Na
33.33Single5IUBQ274563445IUB-A2A-Q27456344-Na
33.33Single5JTBZM2413855JTB-A2A-ZM241385
33.33Single5K2CZM2413855K2C-A2A-ZM241385-Na
33.33Single5NLXZM2413855NLX-A2A-ZM241385-Na
33.33Single5NM4ZM2413855NM4-A2A-ZM241385-Na
33.33Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
33.33Single5UVIZM2413855UVI-A2A-ZM241385
33.33Single6MH8ZM2413856MH8-A2A-ZM241385
33.33Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
33.33Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
33.33Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
33.33Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
33.33Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7VV6C48/807VV6-MRGPRX2-C48/80
33.33Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
33.33Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
33.33Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
33.33Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
33.33Consensusgnrh_offOrthosteric Ligandgnrh1_off
32.14Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
32.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
32.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
32.00Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
32.00Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
31.82Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
31.82Single7EZCUKA7EZC-A2A-UKA
31.82Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
31.82Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
31.82Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
31.82Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
31.82Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
31.82Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
31.58Single3EMLZM2413853EML-A2A-ZM241385
31.58Single4EIYZM2413854EIY-A2A-ZM241385-Na
31.58Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
31.58Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
31.58Single5IU8Q274563475IU8-A2A-Q27456347-Na
31.58Single5K2AZM2413855K2A-A2A-ZM241385-Na
31.58Single5OLGZM2413855OLG-A2A-ZM241385-Na
31.58Single5VRAZM2413855VRA-A2A-ZM241385-Na
31.58Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
31.58Single6LPJZM2413856LPJ-A2A-ZM241385-Na
31.58Single6LPKZM2413856LPK-A2A-ZM241385-Na
31.58Single6S0LZM2413856S0L-A2A-ZM241385
31.58Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
31.58Single7PYRPSB-21157PYR-A2A-PSB-2115
31.58Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
31.58Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
31.58Consensusa2_offOrthosteric Liganda2a_off
31.58Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
31.58Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
31.58Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
31.25Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
31.25Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
31.25Single6ME5Agomelatine6ME5-MT1-Agomelatine
31.25Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
31.25Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
31.25Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
31.25Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
31.25Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
31.25Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
31.03Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
31.03Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
30.77Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
30.77Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
30.77Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single3NY9PubChem 9131033NY9-β2-PubChem 913103
30.43Single7XN9L-054,5227XN9-SST2-L-054,522
30.43Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
30.43Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
30.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
30.00Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
30.00Single5NM2ZM2413855NM2-A2A-ZM241385-Na
30.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
30.00Single6LPLZM2413856LPL-A2A-ZM241385-Na
30.00Single6S0QZM2413856S0Q-A2A-ZM241385
30.00Single6WQAZM2413856WQA-A2A-ZM241385-Na
30.00Single7RM5ZM2413857RM5-A2A-ZM241385-Na
30.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single8FYNZM2413858FYN-A2A-ZM241385-Na
30.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
30.00Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
30.00Single8QOTNanobody E8QOT-μ-Nanobody E
30.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
30.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
30.00Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.63Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
29.63Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
29.63Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
29.63Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
29.41Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
29.41Single6HLLCP999946HLL-NK1-CP99994
29.41Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
29.41Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
29.41Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
29.41Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
29.41Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
29.17Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
29.17Single7F8XNN90567F8X-CCKA-NN9056
29.17Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
29.17Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
29.17Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
29.17Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
29.17Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
29.17Consensussst_onOrthosteric Ligandsst2_on sst4_on
28.57Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
28.57Single5V56TC1145V56-SMO-TC114
28.57Single6J21Aprepitant6J21-NK1-Aprepitant
28.57Single6WGTLSD6WGT-5-HT2A-LSD
28.57Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
28.57Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
28.57Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
28.57Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
28.57Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
28.57Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
28.57Consensusa2_onOrthosteric Liganda2a_on a2b_on
28.57Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensusadenosine_offOrthosteric Liganda1_off a2_off
28.57Consensuscck_onOrthosteric Ligandccka_on cckb_on
28.57Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
28.57Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
28.57Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
28.57Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
28.57Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
28.57Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
28.57Consensusrelaxin_onOrthosteric Ligandrxfp4_on
28.57Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
28.12Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
28.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
28.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
28.00Single6HLOAprepitant6HLO-NK1-Aprepitant
28.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
28.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
27.78Single3PWHZM2413853PWH-A2A-ZM241385
27.78Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
27.78Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
27.78Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
27.78Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
27.78Single7BR3Elagolix7BR3-GnRH1-Elagolix
27.78Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
27.78Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
27.78Single8GNGIstradefylline8GNG-A2A-Istradefylline
27.78Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
27.78Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
27.78Consensusclass-f_offOrthosteric Ligandsmo_off
27.78Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
27.78Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
27.27Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
27.27Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
27.27Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
27.27Single4XEENeurotensin4XEE-NTS1-Neurotensin
27.27Single4XESNeurotensin4XES-NTS1-Neurotensin
27.27Single6MXTSalmeterol6MXT-β2-Salmeterol
27.27Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
27.27Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
27.27Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
27.27Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
27.27Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
27.27Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
27.27Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
27.27Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
27.27Consensusgs_steroidOrthosteric Ligandgs_bileacid
27.27Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
27.27Consensusnts_onOrthosteric Ligandnts1_on
26.92Single5WF5UK-4320975WF5-A2A-UK-432097
26.92Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
26.92Consensusangiotensin_onOrthosteric Ligandat1_on
26.92Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
26.92Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
26.92Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
26.67Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
26.67Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
26.67Single8IY6Endothelin-18IY6-ETB-Endothelin-1
26.67Single8PWNTheophylline8PWN-A2A-Theophylline
26.67Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
26.32Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
26.32Single5K2BZM2413855K2B-A2A-ZM241385-Na
26.32Single6AQFZM2413856AQF-A2A-ZM241385
26.32Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
26.32Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
26.32Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
26.32Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
26.32Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
26.32Single7AROLUF58337ARO-A2A-LUF5833-Na
26.32Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
26.32Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
26.32Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
26.09Single4BUONeurotensin4BUO-NTS1-Neurotensin
26.09Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
26.09Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.09Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
26.09Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
26.09Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
26.09Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
26.09Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
26.09Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
26.09Single7UM4AS26747237UM4-5-HT5A-AS2674723
26.09Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.09Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
26.09Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
26.09Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
26.09Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
26.09Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
26.09Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
26.09Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
26.09Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
26.09Consensussteroid_onOrthosteric Ligandbileacid_on
25.93Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.93Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
25.93Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
25.93Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
25.93Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
25.93Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.81Single6IGKEndothelin-36IGK-ETB-Endothelin-3
25.00Single2Y02Carmoterol2Y02-β1-Carmoterol
25.00Single3RFMCaffeine3RFM-A2A-Caffeine
25.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
25.00Single4UG2CGS216804UG2-A2A-CGS21680
25.00Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
25.00Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
25.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
25.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
25.00Single5UENDU1725UEN-A1-DU172
25.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
25.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
25.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
25.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
25.00Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
25.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
25.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
25.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
25.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.00Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
25.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
25.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
25.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
25.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
25.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
25.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
25.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
25.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
25.00Single8CU6LJ-45178CU6-A2A-LJ-4517
25.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
25.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
25.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
25.00Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
25.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
25.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
25.00Consensusadenosine_onOrthosteric Liganda1_on a2_on
25.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
25.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
25.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
25.00Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
25.00Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
25.00Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
25.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
25.00Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
25.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusnucleotide_onOrthosteric Ligandadenosine_on
25.00Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
24.14Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
24.14Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
24.14Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
24.14Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
24.14Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
24.14Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
24.14Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
24.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
24.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
24.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
24.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
24.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
24.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
24.00Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
24.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
24.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
23.81Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
23.81Single4NTJAZD12834NTJ-P2Y12-AZD1283
23.81Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
23.81Single5TVNLSD5TVN-5-HT2B-LSD
23.81Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
23.81Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
23.81Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
23.81Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
23.81Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
23.81Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
23.81Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
23.81Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
23.81Single7SINNPS-21437SIN-CaS-NPS-2143
23.81Single7SINNPS-21437SIN-CaS-NPS-2143
23.81Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
23.81Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
23.81Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
23.81Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
23.81Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
23.81Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
23.81Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
23.81Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
23.81Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
23.81Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
23.53Single3UZAGTPL92363UZA-A2A-GTPL9236
23.53Single4XNWMRS25004XNW-P2Y1-MRS2500
23.53Single6ME9Ramelteon6ME9-MT2-Ramelteon
23.53Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
23.53Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
23.53Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
23.53Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
23.53Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
23.53Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
23.53Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
23.53Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
23.33Consensusendothelin_onOrthosteric Ligandetb_on eta_on
23.33Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
23.33Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
23.08Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
23.08Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
23.08Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
23.08Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
23.08Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
23.08Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
23.08Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
23.08Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
22.86Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
22.73Single2YDVNECA2YDV-A2A-NECA
22.73Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
22.73Single4BV0Neurotensin4BV0-NTS1-Neurotensin
22.73Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
22.73Single4RWADIPP-NH24RWA-δ-DIPP-NH2
22.73Single4UHRCGS216804UHR-A2A-CGS21680
22.73Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
22.73Single5G53NECA5G53-A2A-NECA-Gs
22.73Single5V54Methiothepin5V54-5-HT1B-Methiothepin
22.73Single5V57TC1145V57-SMO-TC114
22.73Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
22.73Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
22.73Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
22.73Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
22.73Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
22.73Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
22.73Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
22.73Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
22.73Single7TUYGSK682753A7TUY-GPR183-GSK682753A
22.73Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.73Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
22.73Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
22.73Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
22.73Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.73Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
22.73Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
22.73Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
22.73Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
22.73Consensus5ht1_offOrthosteric Ligand5ht1b_off
22.73Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
22.73Consensus5ht5_offOrthosteric Ligand5ht5a_off
22.73Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
22.73Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
22.73Consensuschemerin_onOrthosteric Ligandcml1_on
22.73Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
22.73Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
22.73Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
22.73Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
22.73Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
22.73Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.73Consensuslpa_offOrthosteric Ligandlpa1_off
22.73Consensuslpa_onOrthosteric Ligandlpa1_on
22.73Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
22.73Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
22.73Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
22.58Single6IGLIRL16206IGL-ETB-IRL1620
22.58Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
22.58Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single3OE0CVX153OE0-CXCR4-CVX15
22.22Single3PBLEticlopride3PBL-D3-Eticlopride
22.22Single4O9RCyclopamine4O9R-SMO-Cyclopamine
22.22Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
22.22Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
22.22Single6PT2KGCHM076PT2-δ-KGCHM07
22.22Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
22.22Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
22.22Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
22.22Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
22.22Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
22.22Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
22.22Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
22.22Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
22.22Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
22.22Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
22.22Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
22.22Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
22.22Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
22.22Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
22.22Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
21.74Single4AMIBucindolol4AMI-β1-Bucindolol
21.74Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
21.74Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
21.74Single6HLPNetupitant6HLP-NK1-Netupitant
21.74Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
21.74Single6OS2TRV0266OS2-AT1-TRV026
21.74Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
21.74Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
21.74Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
21.74Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.74Single6YVRNTS8-136YVR-NTS1-NTS8-13
21.74Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
21.74Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
21.74Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
21.74Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
21.74Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
21.74Single8JJLOlodaterol8JJL-β2-Olodaterol
21.74Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
21.74Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
21.74Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
21.74Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
21.74Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
21.74Consensusclass-b2_onOrthosteric Ligandadgrg_on
21.74Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
21.74Consensusdp_offOrthosteric Liganddp2_off
21.74Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
21.74Consensusgi_class-fOther Ligandgi_frizzled
21.74Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.74Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
21.74Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
21.74Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
21.74Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
21.43Single6JODAngiotensin II6JOD-AT2-Angiotensin II
21.43Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
21.43Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
21.43Single7C61Ergotamine7C61-5-HT1B-Ergotamine
21.43Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
21.43Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
21.43Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
21.21Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
21.21Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
21.05Single4QINSAG1.54QIN-SMO-SAG1.5
21.05Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
21.05Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
21.05Single6ME2Ramelteon6ME2-MT1-Ramelteon
21.05Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
21.05Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
21.05Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
21.05Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
21.05Single7F8ULintitript7F8U-CCKA-Lintitript
21.05Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
21.05Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
21.05Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
21.05Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
21.05Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
21.05Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
21.05Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
21.05Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
21.05Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
21.05Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
21.05Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
21.05Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
21.05Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusgt_class-aOrthosteric Ligandgt_opsin
21.05Consensusgt_opsinOrthosteric Ligandgt_sensory
21.05Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
21.05Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
21.05Consensusmglu_onOther Ligandmglu2_on mglu4_on
20.83Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
20.83Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
20.83Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
20.83Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
20.83Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
20.83Single6IBLArformoterol6IBL-β1-Arformoterol
20.83Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
20.83Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
20.83Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
20.83Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
20.83Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
20.83Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
20.83Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
20.83Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
20.83Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
20.83Consensuscyslt_offOrthosteric Ligandcyslt2_off
20.83Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.69Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.69Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
20.69Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.69Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
20.69Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
20.69Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
20.59Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
20.00Single2YDOAdenosine2YDO-A2A-Adenosine
20.00Single3REYPubChem 56973REY-A2A-PubChem 5697
20.00Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
20.00Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
20.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
20.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
20.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
20.00Single6FJ3PTH6FJ3-PTH1-PTH
20.00Single6KNMJN241-96KNM-Apelin-JN241-9
20.00Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
20.00Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
20.00Single6PS4ICI 118-5516PS4-β2-ICI 118-551
20.00Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
20.00Single6PT3DPI-2876PT3-δ-DPI-287
20.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
20.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
20.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
20.00Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
20.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
20.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
20.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
20.00Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
20.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
20.00Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single7T32ZM2413857T32-A2A-ZM241385
20.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
20.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
20.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
20.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
20.00Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
20.00Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GGKEpinephrine8GGK-β2-Epinephrine
20.00Single8GGLEpinephrine8GGL-β2-Epinephrine
20.00Single8GGMEpinephrine8GGM-β2-Epinephrine
20.00Single8GGPEpinephrine8GGP-β2-Epinephrine
20.00Single8GGQEpinephrine8GGQ-β2-Epinephrine
20.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
20.00Consensusclass-d_offOrthosteric Ligandste2_off
20.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
20.00Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
20.00Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
20.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
20.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.00Consensusgi_class-fOrthosteric Ligandgi_frizzled
20.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
20.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
20.00Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
20.00Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
20.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
20.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
20.00Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
20.00Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
20.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
19.35Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
19.35Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
19.35Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
19.35Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
19.35Consensusgo_class-b1Orthosteric Ligandgo_crf
19.35Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
19.23Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
19.23Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
19.23Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
19.23Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7QA8Peptide7QA8-STE2-Peptide
19.23Single7QA8Peptide7QA8-STE2-Peptide
19.23Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
19.23Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
19.23Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
19.23Consensusclass-d_offOrthosteric Ligandste2_off
19.23Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
19.23Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
19.05Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
19.05Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
19.05Single3NY8ICI 118-5513NY8-β2-ICI 118-551
19.05Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
19.05Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
19.05Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
19.05Single5T04Neurotensin5T04-NTS1-Neurotensin
19.05Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
19.05Single6D27CAY104716D27-DP2-CAY10471
19.05Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
19.05Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
19.05Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
19.05Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
19.05Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
19.05Single7BU7BI1671077BU7-β1-BI167107
19.05Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
19.05Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
19.05Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
19.05Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
19.05Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
19.05Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
19.05Single7UL4Alvimopan7UL4-μ-Alvimopan
19.05Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
19.05Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
19.05Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
19.05Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
19.05Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
19.05Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
19.05Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
19.05Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
19.05Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.05Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.05Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GGJEpinephrine8GGJ-β2-Epinephrine
19.05Single8GGNEpinephrine8GGN-β2-Epinephrine
19.05Single8GGOEpinephrine8GGO-β2-Epinephrine
19.05Single8GGUEpinephrine8GGU-β2-Epinephrine
19.05Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
19.05Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
19.05Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
19.05Consensuscck_offOrthosteric Ligandccka_off
19.05Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
19.05Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
19.05Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
19.05Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
19.05Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
18.75Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
18.75Consensusclass-c_onOther Ligandgabab_on mglu_on
18.75Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
18.52Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
18.52Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
18.52Single7SK5CXCL127SK5-ACKR3-CXCL12
18.52Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
18.52Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
18.52Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
18.52Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
18.42Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
18.18Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
18.18Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
18.18Single5C1MBU725C1M-μ-BU72
18.18Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
18.18Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
18.18Single6D26Fevipiprant6D26-DP2-Fevipiprant
18.18Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
18.18Single6E67BI1671076E67-β2-BI167107-Gs (fused)
18.18Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
18.18Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
18.18Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
18.18Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
18.18Single6PS6Timolol6PS6-β2-Timolol
18.18Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
18.18Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
18.18Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
18.18Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
18.18Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
18.18Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.18Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
18.18Single7WC6LSD7WC6-5-HT2A-LSD
18.18Single7XKAEpinephrine7XKA-β2-Epinephrine
18.18Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.18Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
18.18Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
18.18Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
18.18Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
18.18Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
18.18Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
18.18Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
18.18Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
18.18Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
18.18Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
18.18Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
18.18Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
18.18Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
17.86Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
17.86Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
17.86Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
17.86Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
17.86Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
17.86Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
17.65Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
17.65Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
17.65Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
17.65Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
17.65Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
17.65Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
17.65Consensussensory_onOrthosteric Ligandopsin_on
17.39Single3P0GBI1671073P0G-β2-BI167107
17.39Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
17.39Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
17.39Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
17.39Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
17.39Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
17.39Single5TZR-5TZR-FFA1 (GPR40)-MK8666
17.39Single6H7JIsoprenaline6H7J-β1-Isoprenaline
17.39Single6J20Aprepitant6J20-NK1-Aprepitant
17.39Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
17.39Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
17.39Single6OS1TRV0266OS1-AT1-TRV026
17.39Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
17.39Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
17.39Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
17.39Single7F1TMIP-1a7F1T-CCR5-MIP-1a
17.39Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
17.39Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
17.39Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
17.39Single7W41PD1762527W41-BB2-PD176252
17.39Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
17.39Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
17.39Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
17.39Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
17.39Single8E0GBU728E0G-μ-BU72
17.39Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
17.39Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
17.39Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
17.39Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
17.39Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
17.39Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
17.39Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
17.39Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
17.39Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
17.39Consensusbombesin_offOrthosteric Ligandbb2_off
17.39Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
17.39Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
17.39Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
17.39Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
17.24Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
17.24Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
17.24Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
17.24Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
17.24Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
17.24Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
17.24Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.14Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
17.14Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
17.07Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
16.67Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
16.67Single4LDEBI1671074LDE-β2-BI167107
16.67Single4N4WSANT-14N4W-SMO-SANT-1
16.67Single4PY02MeSATP4PY0-P2Y12-2MeSATP
16.67Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
16.67Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
16.67Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
16.67Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
16.67Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
16.67Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
16.67Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
16.67Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
16.67Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
16.67Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
16.67Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
16.67Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.67Single7WC5Psilocin7WC5-5-HT2A-Psilocin
16.67Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
16.67Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
16.67Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
16.67Single7YITNalfurafine7YIT-κ-Nalfurafine
16.67Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single8GGREpinephrine8GGR-β2-Epinephrine
16.67Single8GGZEpinephrine8GGZ-β2-Epinephrine
16.67Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
16.67Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
16.67Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
16.67Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
16.67Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
16.67Single8JJ8Formoterol8JJ8-β2-Formoterol
16.67Single8JWZAB9288JWZ-A2A-AB928-Na
16.67Single8WU1KCA8WU1-CB1-KCA-Arrestin1
16.67Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
16.67Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
16.67Consensuschemokine_offOrthosteric Ligandcxcr_off
16.67Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
16.67Consensuscxcr_offOrthosteric Ligandcxcr4_off
16.67Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
16.67Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
16.67Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
16.67Consensusnts_offOrthosteric Ligandnts1_off
16.67Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
16.67Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
16.67Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
16.67Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
16.67Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.22Consensuspth_onOrthosteric Ligandpth1_on pth2_on
16.13Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.13Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single7SK3CXCL127SK3-ACKR3-CXCL12
16.13Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
16.13Consensusclass-d_onOrthosteric Ligandste2_on
16.13Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
16.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
16.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
16.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
16.00Single6H7LDobutamine6H7L-β1-Dobutamine
16.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
16.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
16.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
16.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
16.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
16.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
16.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
16.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
16.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
16.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusorexin_onOrthosteric Ligandox2_on
16.00Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
15.79Single3OE9IT1t3OE9-CXCR4-IT1t
15.79Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
15.79Single5L7IVismodegib5L7I-SMO-Vismodegib
15.79Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
15.79Single6TP4ACT-4622066TP4-OX1-ACT-462206
15.79Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
15.79Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
15.79Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
15.79Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
15.79Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
15.79Single7UL2SR486927UL2-NTS1-SR48692-Na
15.79Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.79Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
15.79Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
15.79Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
15.79Single8GGSEpinephrine8GGS-β2-Epinephrine
15.79Single8GGYEpinephrine8GGY-β2-Epinephrine
15.79Single8GH1Epinephrine8GH1-β2-Epinephrine
15.79Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
15.79Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
15.79Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
15.79Consensusclass-t_onOrthosteric Ligandtaste2_on
15.79Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
15.79Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
15.79Consensusgo_class-b2Orthosteric Ligandgo_adhesion
15.79Consensusgo_proteinOrthosteric Ligandgo_chemokine
15.79Consensusgs_class-tOrthosteric Ligandgs_taste
15.79Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.79Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
15.79Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
15.79Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.62Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
15.62Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
15.62Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.62Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.62Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
15.62Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
15.62Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
15.62Consensusgi_class-dOrthosteric Ligandgi_ste
15.62Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.62Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
15.62Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.38Single5ZTYAM102575ZTY-CB2-AM10257
15.38Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
15.38Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
15.38Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
15.38Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
15.38Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
15.38Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Consensusgs_class-b2Orthosteric Ligandgs_adgr
15.38Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
15.15Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
15.15Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
15.15Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
15.15Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
15.15Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
15.15Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
15.15Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
15.15Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
15.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
15.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
15.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
15.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
15.00Single5WS3EMPA5WS3-OX2-EMPA
15.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.00Single6AKXA4R6AKX-CCR5-A4R
15.00Single6KUXRS-799486KUX-α2a-RS-79948
15.00Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
15.00Single6TODEMPA6TOD-OX1-EMPA-Na
15.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
15.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
15.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
15.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
15.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
15.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
15.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
15.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
15.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
15.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
15.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
15.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
15.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
15.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
15.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
15.00Single7XRRLemborexant7XRR-OX2-Lemborexant
15.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
15.00Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8GGVEpinephrine8GGV-β2-Epinephrine
15.00Single8GGWEpinephrine8GGW-β2-Epinephrine
15.00Single8GGXEpinephrine8GGX-β2-Epinephrine
15.00Single8GH0Epinephrine8GH0-β2-Epinephrine
15.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
15.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
15.00Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
15.00Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
15.00Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
15.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
15.00Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
15.00Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
15.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
15.00Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
15.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
15.00Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
14.81Single4XT1Fractalkine4XT1-US28-Fractalkine
14.81Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
14.81Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
14.81Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
14.81Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
14.81Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
14.81Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
14.81Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
14.71Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
14.71Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
14.71Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
14.63Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
14.29Single4MBSMaraviroc4MBS-CCR5-Maraviroc
14.29Single4ZJCSB-6740424ZJC-OX1-SB-674042
14.29Single6A94Zotepine6A94-5-HT2A-Zotepine
14.29Single6DS0Ly2660976DS0-5-HT2B-Ly266097
14.29Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
14.29Single6TPGEMPA6TPG-OX2-EMPA
14.29Single6TPKRetosiban6TPK-OT-Retosiban
14.29Single6TPNHTL66416TPN-OX2-HTL6641
14.29Single6V9SGTPL114036V9S-OX1-GTPL11403
14.29Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
14.29Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
14.29Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
14.29Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
14.29Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
14.29Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
14.29Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
14.29Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
14.29Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
14.29Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
14.29Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
14.29Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.29Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
14.29Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
14.29Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
14.29Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
14.29Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
14.29Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
14.29Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
14.29Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GGIEpinephrine8GGI-β2-Epinephrine
14.29Single8GGTEpinephrine8GGT-β2-Epinephrine
14.29Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
14.29Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
14.29Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
14.29Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
14.29Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
14.29Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
14.29Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
14.29Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
14.29Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
14.29Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
14.29Consensus5ht5_onOrthosteric Ligand5ht5a_on
14.29Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
14.29Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
14.29Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
14.29Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
14.29Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
14.29Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
14.29Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
14.29Consensushca_onOrthosteric Ligandhca2_on hca3_on
14.29Consensushcar_onOrthosteric Ligandhca_on
14.29Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
14.29Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
14.29Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
14.29Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
14.29Consensusvasopressin-ot_offOrthosteric Ligandot_off
13.79Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.79Single6W25SHU91196W25-MC4-SHU9119-Ca
13.79Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
13.79Single7XNACYN1548067XNA-SST2-CYN154806
13.79Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
13.79Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
13.79Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
13.64Single2Y01Dobutamine2Y01-β1-Dobutamine
13.64Single2Y04Salbutamol2Y04-β1-Salbutamol
13.64Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
13.64Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
13.64Single5TGZAM65385TGZ-CB1-AM6538
13.64Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
13.64Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
13.64Single6H7MSalbutamol6H7M-β1-Salbutamol
13.64Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
13.64Single6PS1Timolol6PS1-β2-Timolol
13.64Single6TOTLemborexant6TOT-OX1-Lemborexant
13.64Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.64Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
13.64Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
13.64Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
13.64Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
13.64Single7WC7Lisuride7WC7-5-HT2A-Lisuride
13.64Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
13.64Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
13.64Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
13.64Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
13.64Single8JJOAlprenolol8JJO-β2-Alprenolol
13.64Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
13.64Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
13.64Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
13.64Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
13.64Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
13.64Single8X64Desloratadine8X64-H1-Desloratadine
13.64Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
13.64Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
13.64Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
13.64Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
13.64Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
13.64Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
13.64Consensusgi_hcarOrthosteric Ligandgi_hca
13.64Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
13.64Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
13.64Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
13.64Consensustachykinin_offOrthosteric Ligandnk1_off
13.64Consensustar_onOrthosteric Ligandta1_on
13.33Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
13.33Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.33Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.33Consensusclass-d_onOrthosteric Ligandste2_on
13.33Consensusgi_class-dOrthosteric Ligandgi_ste
13.33Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.16Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
13.04Single2Y00Dobutamine2Y00-β1-Dobutamine
13.04Single2Y03Isoprenaline2Y03-β1-Isoprenaline
13.04Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
13.04Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
13.04Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
13.04Single5WIUNemonapride5WIU-D4-Nemonapride
13.04Single5WIVNemonapride5WIV-D4-Nemonapride-Na
13.04Single5WQCEMPA5WQC-OX2-EMPA
13.04Single5XPRBosentan5XPR-ETB-Bosentan
13.04Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
13.04Single6TP6Filorexant6TP6-OX1-Filorexant
13.04Single6Z4SSR486926Z4S-NTS1-SR48692
13.04Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
13.04Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
13.04Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
13.04Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.04Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
13.04Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
13.04Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
13.04Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
13.04Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
13.04Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
13.04Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
13.04Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
13.04Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
13.04Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
13.04Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
13.04Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
13.04Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
13.04Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
13.04Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
13.04Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
13.04Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
13.04Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
12.90Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.90Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
12.90Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
12.90Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
12.90Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
12.90Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
12.90Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
12.90Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
12.90Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
12.90Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
12.50Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
12.50Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
12.50Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
12.50Single4XT3Fractalkine4XT3-US28-Fractalkine
12.50Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
12.50Single5X93K-87945X93-ETB-K-8794
12.50Single5XRAAM115425XRA-CB1-AM11542
12.50Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
12.50Single6E59L-7607356E59-NK1-L-760735
12.50Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
12.50Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
12.50Single7B6WCyclazosin7B6W-α1b-Cyclazosin
12.50Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
12.50Single7EPENAM5637EPE-mGlu-NAM563
12.50Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
12.50Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
12.50Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
12.50Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
12.50Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
12.50Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
12.50Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
12.50Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
12.50Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
12.50Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
12.50Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
12.50Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
12.50Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
12.50Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
12.50Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
12.50Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
12.50Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
12.50Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
12.50Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
12.50Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
12.50Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
12.50Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
12.50Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
12.50Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
12.50Consensushistamine_offOrthosteric Ligandh1_off
12.50Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
12.50Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
12.50Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
12.20Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
12.20Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.12Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
12.12Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
12.12Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
12.00Single5CXVTiotropium5CXV-M1-Tiotropium
12.00Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
12.00Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
12.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
12.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
12.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
12.00Single7K15MKD0467K15-BLT1-MKD046-Na
12.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
12.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
12.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
12.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
12.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
12.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
12.00Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
12.00Consensusblt_offOrthosteric Ligandblt1_off
12.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
12.00Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
12.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
12.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
11.90Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
11.76Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
11.76Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
11.76Single6LMLGlucagon6LML-Glucagon-Glucagon
11.76Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
11.76Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
11.76Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
11.76Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
11.76Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
11.76Single7WC4Serotonin7WC4-5-HT2A-Serotonin
11.76Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
11.76Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
11.76Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
11.54Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
11.54Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
11.54Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
11.54Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
11.54Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
11.54Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
11.54Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
11.54Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
11.54Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Consensusendothelin_offOrthosteric Ligandetb_off
11.54Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
11.43Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
11.43Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
11.11Single5EE7MK08935EE7-Glucagon-MK0893
11.11Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
11.11Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
11.11Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
11.11Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
11.11Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
11.11Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
11.11Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
11.11Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
11.11Single8X5YAstemizole8X5Y-H1-Astemizole
11.11Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
10.81Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
10.71Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
10.71Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
10.71Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
10.53Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
10.53Single3OE6IT1t3OE6-CXCR4-IT1t
10.53Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
10.53Single6LI0GTPL98046LI0-GPR52-GTPL9804
10.53Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
10.53Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
10.53Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
10.53Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
10.53Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
10.53Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
10.53Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
10.53Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.53Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
10.53Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
10.34Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
10.34Consensussst_offOrthosteric Ligandsst2_off
10.26Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
10.00Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
10.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
10.00Single7SRQLSD7SRQ-5-HT2B-LSD
10.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
10.00Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.00Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
10.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
10.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
10.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single8K5BNiacin8K5B-HCA2-Niacin
10.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
10.00Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
10.00Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.76Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
9.68Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
9.68Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
9.68Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
9.68Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
9.68Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
9.52Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
9.52Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
9.52Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
9.52Single3ODUIT1t3ODU-CXCR4-IT1t
9.52Single4S0VSuvorexant4S0V-OX2-Suvorexant
9.52Single5U09Taranabant5U09-CB1-Taranabant
9.52Single6AKYMaraviroc6AKY-CCR5-Maraviroc
9.52Single6B73PubChem 1319551386B73-κ-PubChem 131955138
9.52Single6TPJSuvorexant6TPJ-OX2-Suvorexant
9.52Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
9.52Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
9.52Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
9.52Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
9.52Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
9.52Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
9.52Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
9.52Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
9.52Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single8IWESpermidine8IWE-TAAR9-Spermidine
9.52Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
9.52Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
9.52Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.52Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
9.52Consensusalpha1_onOrthosteric Ligandalpha1a_on
9.52Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.38Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
9.38Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
9.09Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
9.09Single3RZECidoxepin3RZE-H1-Cidoxepin
9.09Single6IQLL7458706IQL-D4-L745870
9.09Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
9.09Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
9.09Single6TP3Nemorexant6TP3-OX1-Nemorexant
9.09Single6VI4JDTic6VI4-κ-JDTic
9.09Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
9.09Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
9.09Single6ZINSR486926ZIN-NTS1-SR48692
9.09Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
9.09Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
9.09Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
9.09Single7VODCariprazine7VOD-5-HT2A-Cariprazine
9.09Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
9.09Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
9.09Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
9.09Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
9.09Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
9.09Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
9.09Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
9.09Single8K5CAcipimox8K5C-HCA2-Acipimox
9.09Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
9.09Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
9.09Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
9.09Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
9.09Consensussensory_offOrthosteric Ligandopsin_off
8.82Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
8.82Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
8.82Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
8.82Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
8.82Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
8.70Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
8.70Single4DAJTiotropium4DAJ-M3-Tiotropium
8.70Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
8.70Single5DSGTiotropium5DSG-M4-Tiotropium
8.70Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
8.70Single6DRXLisuride6DRX-5-HT2B-Lisuride
8.70Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
8.70Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
8.70Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
8.70Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
8.70Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
8.70Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
8.70Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
8.70Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
8.70Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
8.70Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
8.70Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
8.70Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
8.70Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
8.70Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
8.70Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single8K5DGSK2560738K5D-HCA2-GSK256073
8.70Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single8X63Mepyramine8X63-H1-Mepyramine
8.70Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
8.70Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
8.70Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
8.70Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
8.57Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
8.57Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
8.57Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
8.33Single5CGCHTL142425CGC-mGlu5-HTL14242
8.33Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
8.33Single6LUQHaloperidol6LUQ-D2-Haloperidol
8.33Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
8.33Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
8.33Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
8.33Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
8.33Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
8.33Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
8.33Single7YXAONO-54306087YXA-S1P5-ONO-5430608
8.33Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
8.33Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
8.33Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
8.33Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
8.33Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
8.33Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
8.11Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
8.11Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
8.11Consensusglp_onOrthosteric Ligandglp1_on glp2_on
8.00Single4DJHJDTic4DJH-κ-JDTic
8.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
8.00Single4U15Tiotropium4U15-M3-Tiotropium
8.00Single5XR8AM8415XR8-CB1-AM841
8.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
8.00Single6OL9Tiotropium6OL9-M5-Tiotropium
8.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
8.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
8.00Single7P2L4YI7P2L-mGlu5-4YI
8.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
8.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
8.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
8.00Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
8.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
8.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
8.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
8.00Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
8.00Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
8.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
8.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
8.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7.89Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
7.89Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
7.89Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
7.89Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
7.69Single6A93Risperidone6A93-5-HT2A-Risperidone
7.69Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single7DFPSpiperone7DFP-D2-Spiperone
7.69Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
7.69Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
7.69Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
7.69Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.69Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
7.69Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
7.69Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
7.69Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
7.69Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
7.69Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
7.69Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
7.41Single5CGDHTL142425CGD-mGlu5-HTL14242
7.41Single6K1QIRL25006K1Q-ETB-IRL2500
7.41Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
7.41Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
7.32Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
7.14Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
7.14Single6D35Cholesterol6D35-SMO-Cholesterol
7.14Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
7.14Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
7.14Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
7.14Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
7.14Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.14Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.14Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.14Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
7.14Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
7.14Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
7.14Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
7.14Single7DTTCa7DTT-CaS-Ca-Ca
7.14Single7DTTCa7DTT-CaS-Ca-Ca
7.14Single7DTUTryptophan7DTU-CaS-Tryptophan
7.14Single7DTUTryptophan7DTU-CaS-Tryptophan
7.14Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
7.14Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
7.14Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
7.14Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
7.14Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.14Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.14Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
7.14Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
7.14Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
7.14Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
7.14Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
7.14Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
7.14Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
7.14Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
7.14Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
7.14Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single7FIIhCG7FII-LH-hCG-6fuf
7.14Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
7.14Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
7.14Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.14Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
7.14Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
7.14Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.14Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.14Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
7.14Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
7.14Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7SK9CCX6627SK9-ACKR3-CCX662
7.14Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
7.14Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
7.14Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
7.14Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
7.14Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
7.14Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
7.14Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
7.14Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
7.14Single7XW7K1-707XW7-TSH-K1-70
7.14Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
7.14Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
7.14Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
7.14Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
7.14Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
7.14Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
7.14Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
7.14Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
7.14Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
7.14Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
7.14Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
7.14Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
7.14Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
7.14Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
7.14Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
7.14Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
7.14Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
7.14Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
7.14Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
7.14Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
7.14Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
7.14Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
7.14Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
7.14Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.14Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.14Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.14Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.14Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.14Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
7.14Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
7.14Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.14Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.14Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.14Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.14Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
7.14Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
7.14Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
7.14Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
7.14Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.14Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.14Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.14Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.14Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
7.14Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
7.14Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
7.14Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
7.14Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
7.14Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
7.14Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.14Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.14Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
7.14Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
7.14Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
7.14Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
7.14Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.14Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.14Consensusgphr_onOrthosteric Ligandlh_on tsh_on
7.14Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
7.14Consensusgs_proteinOrthosteric Ligandgs_gphr
7.14Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
7.14Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
7.14Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
7.14Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.14Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.14Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
7.14Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
7.14Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.14Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.14Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
7.14Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
7.14Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
7.14Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
7.14Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
7.14Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
7.14Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
7.14Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
7.14Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
7.14Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.98Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
6.90Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
6.90Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
6.82Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
6.67Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
6.67Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
6.67Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
6.52Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
6.25Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
6.25Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
6.25Single8HS2Fab0468HS2-GPR20-Fab046
5.88Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
5.88Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
5.88Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
5.88Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
5.88Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
5.88Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
5.88Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.88Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
5.56Single5L7DCholesterol5L7D-SMO-Cholesterol
5.56Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
5.56Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
5.56Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
5.56Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
5.56Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.41Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
5.41Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
5.41Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
5.26Single6TQ9SB-4081246TQ9-OX1-SB-408124
5.26Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.26Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
5.13Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
5.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
5.00Single3OE8IT1t3OE8-CXCR4-IT1t
5.00Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
5.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
5.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
4.76Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
4.76Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
4.76Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
4.76Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
4.76Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
4.76Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
4.76Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
4.76Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
4.76Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
4.76Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
4.76Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
4.76Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
4.76Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
4.76Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
4.76Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
4.55Single5DHHSB-6121115DHH-NOP-SB-612111
4.55Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
4.55Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
4.55Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
4.55Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
4.55Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
4.55Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
4.55Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
4.55Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
4.55Single8IHKAcifran8IHK-HCA3-Acifran
4.55Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
4.55Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
4.55Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
4.55Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
4.55Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
4.55Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
4.35Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
4.35Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
4.35Single6FFIMMPEP6FFI-mGlu5-MMPEP
4.35Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
4.35Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
4.35Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
4.35Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
4.35Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
4.35Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
4.35Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.35Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
4.35Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
4.35Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
4.35Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
4.35Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
4.35Consensuss1p_offOrthosteric Ligands1p1_off
4.17Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
4.17Single4MQSIperoxo4MQS-M2-Iperoxo
4.17Single4U14Tiotropium4U14-M3-Tiotropium
4.17Single4YAYZD-71554YAY-AT1-ZD-7155
4.17Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
4.17Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
4.17Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
4.17Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
4.17Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
4.17Single6FFHFenobam6FFH-mGlu5-Fenobam
4.17Single6GPSMK08126GPS-CCR2-MK0812
4.17Single6IIVDaltroban6IIV-TP-Daltroban
4.17Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
4.17Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
4.17Single7F83PF-051904577F83-Ghrelin-PF-05190457
4.17Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
4.17Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
4.17Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
4.17Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
4.17Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
4.17Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
4.17Consensusblt_onOrthosteric Ligandblt1_on
4.17Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
4.17Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
4.17Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
4.17Consensushistamine_onOrthosteric Ligandh1_on h4_on
4.17Consensusleuko_onOrthosteric Ligandblt_on
4.17Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
4.17Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
4.17Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
4.17Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
4.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
4.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
4.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
4.00Single6GPXMK08126GPX-CCR2-MK0812
4.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
4.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
4.00Single7C4SS1P7C4S-S1P3-S1P
4.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
4.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
4.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Single8EA0Iperoxo8EA0-M3-Iperoxo
4.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
4.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
4.00Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
4.00Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
4.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
4.00Consensusep_offOrthosteric Ligandep4_off
4.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
4.00Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
4.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
3.85Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
3.85Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
3.85Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
3.85Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
3.85Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
3.70Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
3.70Single6CM4Risperidone6CM4-D2-Risperidone
3.70Single6IIURamatroban6IIU-TP-Ramatroban
3.70Single6ZG4HTL00099366ZG4-M1-HTL0009936
3.70Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
3.70Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
3.70Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
3.70Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
3.70Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
3.70Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
3.57Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
3.57Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
3.57Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
3.57Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
3.57Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
3.57Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2

Consensus Members
Id Members
7XW5 7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
Net Summary
Imin 2.94
Number of Linked Nodes 539
Number of Links 686
Number of Hubs 114
Number of Links mediated by Hubs 413
Number of Communities 17
Number of Nodes involved in Communities 181
Number of Links involved in Communities 266
Path Summary
Number Of Nodes in MetaPath 69
Number Of Links MetaPath 68
Number of Shortest Paths 616782
Length Of Smallest Path 3
Average Path Length 26.2761
Length of Longest Path 52
Minimum Path Strength 1.355
Average Path Strength 5.75672
Maximum Path Strength 24.0433
Minimum Path Correlation 0.7
Average Path Correlation 0.97684
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.94118
Average % Of Corr. Nodes 55.5806
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.4139
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
tsh_on_ortoallotsh_on_allotsh_on



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