Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1NT 30.04415
21x40 7.485415
31x43 12.0675416
41x57 3.31407
52x38 6.1125416
62x42 5.08833618
72x44 8.3285126
82x51 3.494127
92x57 12.4717
102x60 3.675416
11E1 10.8878912
123x32 5.102516
133x34 8.01667618
143x37 3.478516
153x39 8.102518
163x40 8.805418
173x41 4.3575415
183x42 7.27571719
193x44 6.145407
203x45 4.7625417
213x46 8.19419
223x49 6.61417
233x50 3.00254118
243x54 4.1345117
25I2 11.68176135
264x46 4.76417
274x52 4.15413
284x53 4.712519
294x60 8.8418
30E2 14.2822914
31E2x51 8.978519
32E2x52 7.525417
335x40 3.99414
345x43 8.36667618
355x44 9.48416
36I3 4.702564
376x29 5.5775465
386x46 3.874516
396x48 6.302519
406x49 4.0175415
41E3 9.784514
427x33 6.74667617
437x43 5.08506
447x47 4.084505
457x54 4.14407
468x67 5.675404
47Lig 14.71362510
48G.HN.43 3.5125439
49G.HN.47 3.1875436
50G.S1.05 7.23489
51G.S1.06 3.645158
52G.S2.08 9.305405
53G.S3.03 6.406676147
54G.S3.04 7.274586
55G.S3.06 9.57586
56G.H2.06 4.088336169
57G.H2.07 7.2475409
58G.h2s4.01 7.572589
59G.S4.02 6.6375407
60G.S4.04 6.17254109
61G.S4.05 3.4925467
62G.s4h3.05 6.67558
63G.s4h3.04 6.5558
64G.H3.01 7.7525459
65G.H3.09 6.6065109
66G.H3.17 4.45404
67G.S5.03 3.618568
68G.S5.05 5.022569
69G.HG.04 5.35408
70G.hgh4.01 4.114554
71G.hgh4.02 4.56558
72G.H4.03 3.2325403
73G.S6.02 6.115468
74G.s6h5.01 5.5975469
75G.H5.08 9.315148
76G.H5.14 4.8025466
77G.H5.26 5.2075465
78b.1x1 3.7325404
79b.1x15 3.3625407
80b.lhb1x6 5.3473
81b.b1x3 4.3725437
82b.b1x6 8.915439
83b.l1x3 7.68333639
84b.l1x6 8.7175409
85b.b2x5 5.85833637
86b.b3x3 4.5685258
87b.l3x1 8.975489
88b.l3x2 5.1075409
89b.b4x2 5.2425438
90b.b4x3 4.1085257
91b.b4x4 5.245638
92b.b4x6 8.25875839
93b.l4x2 8.805404
94b.b5x3 5.82333639
95b.b5x7 5.7075407
96b.l5x1 3.865408
97b.l5x5 10.1986789
98b.b6x5 3.9375406
99b.b7x1 6.225444
100b.b8x3 4.0325446
101b.b8x4 6.435406
102b.b9x4 5.918549
103b.l9x3 6.07429749
104b.l9x6 4.8175408
105b.b10x5 5.2175409
106b.l10x1 3.9175403
107b.b11x4 5.3775449
108b.l11x2 7.738549
109b.b12x6 9.01333648
110b.b13x7 7.77597
111b.l13x3 6.93833699
112b.l15x1 4.463336167
113b.l15x2 5.38499
114b.b16x4 6.5525496
115b.b16x6 8.01429798
116b.b17x5 5.622527
117b.l17x3 7.42428729
118b.b18x3 4.01428
119b.b18x5 3.326505
120b.l18x1 6.6556276
121b.l18x3 10.92254275
122b.b19x2 5.56833626
123b.b19x4 6.925428
124b.l19x2 5.924529
125b.b20x2 7.354526
126b.b20x4 9.07833628
127b.b20x6 7.14667626
128b.l20x2 7.7225409
129b.b21x1 8.69427
130b.b21x3 3.7375426
131b.b21x5 5.925404
132b.b21x7 5.816505
133b.l21x5 4.8854174
134b.b22x5 6.99407
135b.l22x5 7.44667679
136b.b23x6 7.6456177
137b.b24x3 3.845405
138b.b24x4 7.075176
139b.b24x7 7.825479
140b.l24x3 4.6975475
141b.b25x3 11.594175
142b.l25x3 9.1145189
143b.l25x6 10.4354218
144b.b26x3 3.25576
145b.l27x5 4.486535
146b.b27x1 3.7825476
147b.l28x1 10.575219
148b.l28x2 7.88254189
149b.b28x3 4.75437
150b.b28x6 10.11409
151b.b28x7 5.3275439
152g.h1x8 3.73254247
153g.h1x11 4.2525409
154g.l1x4 7.266528
155g.ctx3 6.04679
156g.ctx5 4.345479
157g.ctx6 3.46667676
158g.ctx14 4.815639
159g.ctx16 6.18167638
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
17x43 7x47 13.71413.22YesYes065
21x49 7x47 20.56522.77NoYes065
31x49 7x50 22.27743.42NoNo068
41x50 7x50 11.99086.01NoNo098
51x50 2x51 12.84295.71NoYes1297
61x54 2x51 16.26353.77NoYes1257
71x54 2x44 17.115411.02NoYes1256
82x44 2x45 25.08024.52YesNo068
92x45 3x42 26.111713.56NoYes089
101x53 7x50 12.00143.42NoNo088
111x53 7x54 12.85863.61NoYes087
121x57 7x54 15.4214.19YesYes077
131x57 2x44 22.24994.01YesYes076
143x42 4x50 32.974612.18YesNo199
153x34 4x50 22.31643.86YesNo189
163x34 4x53 20.15664.17YesYes189
173x37 4x53 35.57923.53YesYes169
182x44 2x48 15.99787.28YesNo063
192x48 2x52 16.32632.95NoNo035
202x52 3x35 16.662913.4NoNo056
213x34 3x35 17.00345.16YesNo086
223x38 4x50 11.15644.85NoNo189
233x38 4x53 11.31775.25NoYes189
243x34 4x57 20.12429.67YesNo087
253x37 4x57 20.27933.07YesNo067
26b.b23x6 b.l21x9 11.22569.67YesNo076
27b.b20x3 b.l21x9 12.38613.27NoNo086
28b.b20x3 b.b21x7 12.67564.03NoYes085
29b.b21x7 b.b23x2 15.79344.69YesNo056
30b.b22x5 b.b23x2 16.07916.09YesNo076
31b.b18x4 b.b22x5 16.95448.38NoYes037
32b.b18x4 b.b22x4 17.2343.44NoNo035
33b.b22x4 b.b26x5 17.51384.85NoNo057
34b.b26x5 b.b27x1 17.79413.21NoYes076
358x56 b.l25x4 10.09642.77NoNo065
368x56 b.b24x1 10.26764.96NoNo064
37b.b24x1 b.l25x5 10.43964.83NoNo047
38b.l25x5 b.l28x1 10.56216.78NoYes2179
39G.H2.09 b.l28x1 82.01027.41NoYes089
40G.H2.09 G.H2.10 72.20344.42NoNo086
41G.H2.10 b.l5x5 72.41165.22NoYes069
42G.h2s4.01 b.l5x5 75.974211.02YesYes899
43G.H2.07 G.h2s4.01 76.29944.01YesYes099
44G.H2.07 G.S3.08 85.10618.58YesNo099
45G.S3.08 G.s3h2.01 85.03971.84NoNo099
46G.S3.07 G.s3h2.01 84.97311.68NoNo099
47G.S1.06 G.S3.07 84.62174.07YesNo1589
48G.S1.06 G.S4.03 84.29282.85YesNo087
49G.S1.04 G.S4.03 84.22344.28NoNo077
50G.S1.04 G.S3.03 83.86653.65NoYes1477
51G.S2.06 G.S3.03 83.006612.86NoYes087
52G.H1.08 G.S2.06 82.9339.95NoNo088
53G.H1.04 G.H1.08 82.85922.92NoNo078
54G.H1.04 G.S4.05 81.03614.91NoYes677
55G.S4.05 G.S5.05 80.72924.19YesYes679
56G.S5.03 G.S5.05 81.10245.02YesYes689
57G.S5.03 G.S6.02 80.03913.63YesYes688
58G.H5.13 G.S6.02 79.34274.6NoYes078
595x68 G.H5.13 79.25714.15NoNo077
605x68 G.H5.20 79.08532.82NoNo078
61G.H5.20 G.H5.25 74.59912.77NoNo086
626x40 G.H5.25 74.33115.54NoNo096
635x58 6x40 74.24154.15NoNo079
645x58 6x46 74.15232.85NoYes076
656x46 6x49 75.27674.37YesYes165
665x51 6x49 75.14362.83NoYes175
673x40 5x51 17.14387.31YesNo187
683x40 Lig 14.80383.77YesYes180
69b.b4x7 b.l2x5 99.893414.29NoNo085
70b.l2x5 b.l4x2 1004.12NoYes054
71b.l4x1 b.l4x2 74.03153.82NoYes054
72b.b2x5 b.l4x1 74.00634.94YesNo075
73b.b2x3 b.b2x5 75.72446.98NoYes367
74b.b26x2 b.b2x3 75.80384.86NoNo076
75b.b26x1 b.b26x2 75.77333.44NoNo097
76b.b26x1 b.l28x1 75.76864.94NoYes099
77G.H2.05 G.H2.07 11.38563NoYes079
78G.H2.05 G.H3.08 11.05294.86NoNo079
79G.hgh4.01 G.hgh4.02 12.38846.98YesYes548
80G.H3.03 G.hgh4.02 15.13593.51NoYes048
81G.H3.03 G.H3.06 15.40933.99NoNo047
82G.H3.08 G.S4.04 10.79336.09NoYes1099
83G.H3.06 G.h4s6.01 11.93257.05NoNo074
84G.H3.09 G.h4s6.01 12.12734.96YesNo094
85b.b11x4 b.l9x3 92.65635.48YesYes499
86b.b10x3 b.b11x4 94.51243.38NoYes089
87b.b10x3 b.b6x2 97.14833.38NoNo088
88b.b10x2 b.b6x2 97.21473.38NoNo068
89b.b10x2 b.b10x4 97.28085.57NoNo066
90b.b10x4 b.b2x4 97.34676.77NoNo066
91b.b2x4 b.b6x5 97.41233.27NoYes066
92b.b3x3 b.b6x5 97.60773.79YesYes086
93b.b3x3 b.b4x5 96.36046.14YesNo087
94b.b4x5 b.b5x5 96.62097.95NoNo075
95b.b5x4 b.b5x5 99.51255.54NoNo055
96b.b3x1 b.b5x4 99.56762.98NoNo055
97b.b3x1 b.b4x7 99.62264.07NoNo058
98G.H2.06 b.l9x6 92.93973.58YesYes098
99b.l11x1 b.l9x6 93.65172.9NoYes098
100b.b11x6 b.l11x1 93.73173.71NoNo099
101b.b11x6 b.l9x3 93.127813.95NoYes499
102G.H2.06 b.b18x1 92.35852.8YesNo099
103G.H2.09 G.H3.17 10.30863.39NoYes084
104G.S4.02 G.S5.02 10.2225.89YesNo076
105b.b18x1 b.l19x1 92.277413.46NoNo099
106b.l17x5 b.l19x1 92.19365.89NoNo069
107b.b19x6 b.l17x5 46.37023.26NoNo296
108b.b19x6 b.l17x3 46.2526.97NoYes299
109b.b20x6 b.l17x3 44.53244.53YesYes269
110b.b17x7 b.b20x6 54.01098.57NoYes286
111b.b17x5 b.b17x7 53.81028.2YesNo278
112b.b17x5 b.b21x1 15.00556.53YesYes277
113b.1x15 g.h1x11 17.02981.43YesYes079
114b.1x8 g.h1x11 13.02931.58NoYes059
115b.1x8 g.h1x8 12.02861.7NoYes057
116b.l17x5 b.l19x2 45.73932.94NoYes269
117b.b20x4 b.l19x2 45.02583.57YesYes289
118b.b20x4 b.b20x6 44.53474.28YesYes286
119b.1x15 g.l1x4 12.68443.76YesYes078
120b.l27x5 g.ctx4 31.3585.03YesNo057
121g.ctx3 g.ctx4 31.09534.83YesNo097
122b.b27x1 g.ctx5 15.10254.47YesYes769
123g.ctx3 g.ctx5 17.23624.07YesYes799
124b.l4x2 g.ctx16 15.842617.54YesYes048
125b.l4x2 g.ctx15 14.7029.74YesNo049
126b.b16x5 b.b17x5 32.65296.65NoYes257
127b.b16x5 b.l14x6 63.96696.92NoNo253
128b.b16x7 b.l14x6 31.66655.43NoNo293
129b.b16x7 b.l16x3 31.026312.99NoNo293
130b.b17x2 b.l16x3 60.76595.41NoNo033
131b.b17x2 g.h1x13 59.47887.22NoNo031
132g.h1x10 g.h1x13 58.19142.72NoNo091
133b.b17x3 g.h1x10 54.32034.58NoNo059
134b.b16x6 b.b17x3 41.39157.84YesNo985
135b.b13x7 b.b16x6 20.720717.04YesYes978
136b.b13x5 b.b13x7 15.55693.89NoYes047
137b.b12x5 b.b13x5 14.26192.95NoNo064
138b.b11x1 b.b12x5 11.67119.32NoNo056
139b.b11x1 b.l10x2 10.37533.92NoNo055
140b.b19x2 b.b20x6 34.947910.72YesYes266
141b.b19x2 b.l20x1 32.34993.65YesNo266
142b.b16x5 b.l20x1 31.94744.15NoNo256
143b.b17x4 b.l14x6 31.66658.5NoNo253
144b.b17x4 b.l16x3 31.02635.82NoNo253
145b.b16x4 b.b17x3 11.64064.85YesNo965
146b.b16x4 b.l13x3 10.35056.55YesYes969
147b.b16x6 b.l13x3 10.36657.41YesYes989
148b.l13x3 b.l15x2 10.36223.78YesYes999
1493x37 5x47 57.85953.07YesNo167
1505x47 5x51 57.90252.85NoNo177
151b.l27x5 g.ctx15 13.20036.71YesNo359
152b.l27x5 g.ctx16 13.27643.73YesYes358
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
NTNT46.321YesYes5511
LigNT23.171YesYes0501
1x19NT4.350NoYes1521
1x21Lig7.140NoYes1010
1x22Lig15.620NoYes2010
1x231x268.341NoNo1112
1x23Lig13.871NoYes1010
1x32Lig17.160NoYes4010
1x391x437.651NoYes7622
1x392x579.041NoYes7721
1x402x578.681YesYes5721
1x402x584.131YesNo5622
1x402x6111.271YesNo5621
1x432x5727.511YesYes6721
2x563x284.370NoNo5622
2x563x323.730NoYes5621
2x572x5810.021YesNo7612
2x572x6121.91YesNo7611
2x573x326.011YesYes7611
2x57Lig3.641YesYes7010
2x603x284.281YesNo6612
2x603x292.951YesNo6712
2x603x323.651YesYes6611
2x60Lig3.821YesYes6010
2x61Lig6.651NoYes6010
2x63E13.211NoYes4221
2x633x253.421NoNo4922
E1E120.691YesYes2211
E1Lig14.41YesYes2010
3x22E1101NoYes3221
3x24E14.91NoYes1221
3x25E13.421NoYes9221
E1E216.151YesYes2411
E1E2x524.531YesYes2711
3x223x2414.171NoNo3122
3x25E2x507.281NoNo9922
3x26E27.231NoYes6421
3x26E2x5122.991NoYes6922
3x29E2x525.190NoYes7721
3x323x365.241YesNo6612
3x32Lig6.881YesYes6010
3x334x606.781NoYes8812
3x335x435.811NoYes8811
3x33Lig8.461NoYes8010
3x375x433.791YesYes6821
3x375x473.071YesNo6722
3x405x4713.821YesNo8712
3x405x517.311YesNo8712
3x406x4810.321YesYes8911
3x40Lig3.771YesYes8010
4x605x416.71YesNo8622
4x605x4313.51YesYes8821
4x65E24.121NoYes1421
4x65E2x516.831NoYes1922
4x68E214.291NoYes6421
E2E2x514.521YesYes4912
E2E231.651YesYes4411
E2x50E2x522.790NoYes9721
E2x52Lig17.591YesYes7010
E2Lig15.411YesYes4010
5x42E23.520NoYes6421
5x415x4311.491NoYes6821
5x415x447.831NoYes6621
5x435x4412.41YesYes8611
5x43Lig3.211YesYes8010
5x44Lig16.051YesYes6010
5x475x512.851NoNo7722
5x486x528.790NoNo4521
6x476x483.751NoYes8921
6x477x454.251NoNo8922
6x487x413.381YesNo9811
6x487x457.891YesNo9912
6x48Lig6.171YesYes9010
6x51E39.671NoYes8422
6x517x337.51NoYes8721
6x526x535.241NoNo5512
6x52Lig4.871NoYes5010
E3E38.131YesYes4422
7x33E39.671YesYes7412
7x307x334.681NoYes4721
7x307x342.741NoNo4621
7x337x343.771YesNo7611
7x337x377.251YesNo7811
7x33Lig7.611YesYes7010
7x34Lig5.611NoYes6010
7x37Lig13.061NoYes8010
7x38Lig4.51NoYes6010
7x41Lig6.821NoYes8010
1x357x381.710NoNo7621
5x445x451.641YesNo6512

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusgo_class-b1Orthosteric Ligandgo_crf
92.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
80.77Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
79.17Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
60.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
54.84Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
51.72Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
51.61Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
48.48Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
48.39Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
47.06Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
45.95Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
44.12Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
43.75Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
42.50Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
42.42Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
42.42Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
42.42Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
42.11Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
41.67Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
40.62Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
40.62Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
40.54Consensuspth_onOrthosteric Ligandpth1_on pth2_on
40.00Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
39.39Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
38.71Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
38.71Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
38.24Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
38.24Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
37.50Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
37.50Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
37.14Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
37.14Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
36.84Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
36.36Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
36.36Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
36.36Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
36.00Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
35.29Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
35.29Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
35.29Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
35.29Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
34.62Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
34.62Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
34.48Single3NY9PubChem 9131033NY9-β2-PubChem 913103
34.48Single4UG2CGS216804UG2-A2A-CGS21680
34.48Single5ZTYAM102575ZTY-CB2-AM10257
34.48Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
34.48Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
34.48Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
34.48Consensuslpl_offOrthosteric Ligands1p_off lpa_off
34.38Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
34.38Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.29Single6LMLGlucagon6LML-Glucagon-Glucagon
34.29Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
34.29Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
34.29Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
34.29Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
34.21Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
33.33Single2YDVNECA2YDV-A2A-NECA
33.33Single4UHRCGS216804UHR-A2A-CGS21680
33.33Single5G53NECA5G53-A2A-NECA-Gs
33.33Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
33.33Single5XRAAM115425XRA-CB1-AM11542
33.33Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
33.33Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
33.33Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
33.33Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
33.33Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
33.33Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
33.33Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
33.33Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
33.33Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
33.33Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
33.33Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
32.43Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
32.43Consensusglp_onOrthosteric Ligandglp1_on glp2_on
32.35Single6FJ3PTH6FJ3-PTH1-PTH
32.35Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
32.35Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
32.35Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
32.26Single6HLOAprepitant6HLO-NK1-Aprepitant
32.26Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
32.14Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
32.14Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
32.14Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
32.14Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
32.14Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
32.14Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
32.14Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
32.14Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
32.14Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
32.14Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
32.14Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
32.14Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
31.71Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
31.58Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
31.58Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
31.43Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
31.43Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
31.25Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
31.25Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
31.25Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
31.25Consensusangiotensin_onOrthosteric Ligandat1_on
31.25Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
31.25Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
31.03Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
31.03Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
31.03Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
31.03Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
31.03Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
31.03Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
31.03Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
30.77Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
30.77Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
30.77Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
30.77Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
30.77Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
30.56Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
30.56Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
30.56Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
30.30Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
30.30Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
30.30Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
30.30Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
30.00Single7SK9CCX6627SK9-ACKR3-CCX662
29.73Single5GLHEndothelin-15GLH-ETB-Endothelin-1
29.73Single6IGKEndothelin-36IGK-ETB-Endothelin-3
29.63Single5C1MBU725C1M-μ-BU72
29.63Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
29.63Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
29.63Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
29.63Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
29.41Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
29.41Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
29.41Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.03Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
29.03Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
29.03Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
29.03Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
28.57Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
28.57Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
28.57Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
28.57Single5V54Methiothepin5V54-5-HT1B-Methiothepin
28.57Single5XR8AM8415XR8-CB1-AM841
28.57Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
28.57Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
28.57Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
28.57Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
28.57Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
28.57Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
28.57Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
28.57Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
28.57Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
28.57Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
28.57Single8E0GBU728E0G-μ-BU72
28.57Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
28.57Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
28.57Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
28.57Consensus5ht1_offOrthosteric Ligand5ht1b_off
28.57Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
28.57Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
28.57Consensusa2_onOrthosteric Liganda2a_on a2b_on
28.57Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
28.57Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
28.57Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
28.57Consensuslpa_offOrthosteric Ligandlpa1_off
28.57Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
28.57Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
28.57Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
28.21Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
28.21Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
28.12Single3QAKUK-4320973QAK-A2A-UK-432097
28.12Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
28.12Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
28.12Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
28.12Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
28.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
27.78Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
27.78Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
27.78Consensusendothelin_onOrthosteric Ligandetb_on eta_on
27.59Single5CXVTiotropium5CXV-M1-Tiotropium
27.59Single6A93Risperidone6A93-5-HT2A-Risperidone
27.59Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Single7YITNalfurafine7YIT-κ-Nalfurafine
27.59Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Single8WU1KCA8WU1-CB1-KCA-Arrestin1
27.59Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
27.59Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
27.59Consensusdp_offOrthosteric Liganddp2_off
27.59Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
27.59Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
27.59Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
27.59Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
27.27Single5WF5UK-4320975WF5-A2A-UK-432097
27.27Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
27.27Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
27.27Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
27.03Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
27.03Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.03Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
26.92Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
26.92Single7T32ZM2413857T32-A2A-ZM241385
26.92Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
26.92Single8GGTEpinephrine8GGT-β2-Epinephrine
26.92Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
26.92Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
26.92Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
26.67Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
26.67Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
26.67Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
26.67Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
26.67Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
26.67Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
26.67Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
26.67Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
26.67Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
26.67Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
26.67Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
26.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.67Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
26.67Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
26.67Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
26.67Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
26.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
26.67Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
26.67Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
26.67Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
26.47Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
26.47Single6JODAngiotensin II6JOD-AT2-Angiotensin II
26.47Single7C61Ergotamine7C61-5-HT1B-Ergotamine
26.47Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
26.47Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
26.32Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
25.93Single3NY8ICI 118-5513NY8-β2-ICI 118-551
25.93Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
25.93Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
25.93Single4DAJTiotropium4DAJ-M3-Tiotropium
25.93Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
25.93Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
25.93Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
25.93Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
25.93Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
25.93Single5TGZAM65385TGZ-CB1-AM6538
25.93Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
25.93Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
25.93Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
25.93Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
25.93Single7WC7Lisuride7WC7-5-HT2A-Lisuride
25.93Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
25.93Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
25.93Single8CU6LJ-45178CU6-A2A-LJ-4517
25.93Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
25.93Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
25.93Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
25.93Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
25.93Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
25.93Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
25.93Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
25.93Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
25.93Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Consensustar_onOrthosteric Ligandta1_on
25.81Single5WF6UK-4320975WF6-A2A-UK-432097
25.81Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
25.81Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
25.81Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
25.81Single8X5YAstemizole8X5Y-H1-Astemizole
25.81Consensusclass-d_offOrthosteric Ligandste2_off
25.81Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
25.81Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.81Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
25.81Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
25.81Consensuslpl_onOrthosteric Ligands1p_on lpa_on
25.71Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
25.71Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
25.71Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
25.71Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
25.71Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
25.64Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
25.64Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.00Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
25.00Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
25.00Single4XT1Fractalkine4XT1-US28-Fractalkine
25.00Single4XT3Fractalkine4XT3-US28-Fractalkine
25.00Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
25.00Single5NM2ZM2413855NM2-A2A-ZM241385-Na
25.00Single5TVNLSD5TVN-5-HT2B-LSD
25.00Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
25.00Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
25.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
25.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
25.00Single6PS6Timolol6PS6-β2-Timolol
25.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
25.00Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
25.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
25.00Single7QA8Peptide7QA8-STE2-Peptide
25.00Single7QA8Peptide7QA8-STE2-Peptide
25.00Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
25.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
25.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
25.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
25.00Single7XKAEpinephrine7XKA-β2-Epinephrine
25.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
25.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
25.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
25.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8EA0Iperoxo8EA0-M3-Iperoxo
25.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
25.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
25.00Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
25.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
25.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
25.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
25.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single8QOTNanobody E8QOT-μ-Nanobody E
25.00Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
25.00Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
25.00Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
25.00Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
25.00Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
25.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
25.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
25.00Consensusclass-d_offOrthosteric Ligandste2_off
25.00Consensusclass-d_onOrthosteric Ligandste2_on
25.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
25.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
25.00Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
25.00Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
25.00Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
25.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
25.00Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
25.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
25.00Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
25.00Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
24.44Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
24.39Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
24.39Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
24.32Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
24.32Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
24.32Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
24.32Consensusgi_class-dOrthosteric Ligandgi_ste
24.32Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
24.32Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
24.24Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
24.24Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
24.24Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
24.24Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
24.24Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
24.24Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
24.24Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
24.24Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
24.24Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
24.14Single3P0GBI1671073P0G-β2-BI167107
24.14Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
24.14Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
24.14Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
24.14Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
24.14Single4U15Tiotropium4U15-M3-Tiotropium
24.14Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
24.14Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
24.14Single5X93K-87945X93-ETB-K-8794
24.14Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
24.14Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
24.14Single6J21Aprepitant6J21-NK1-Aprepitant
24.14Single6OL9Tiotropium6OL9-M5-Tiotropium
24.14Single6WGTLSD6WGT-5-HT2A-LSD
24.14Single7EPENAM5637EPE-mGlu-NAM563
24.14Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
24.14Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
24.14Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
24.14Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
24.14Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
24.14Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
24.14Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
24.14Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
24.14Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
24.14Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
24.14Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
24.14Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
24.14Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
24.14Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
24.14Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.14Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
24.14Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Consensusadenosine_offOrthosteric Liganda1_off a2_off
24.14Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
24.14Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
24.14Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
24.14Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
24.14Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
24.14Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
24.14Consensushistamine_offOrthosteric Ligandh1_off
24.14Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
24.14Consensuslpa_onOrthosteric Ligandlpa1_on
24.14Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
24.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
24.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
24.00Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
24.00Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
24.00Single8GGSEpinephrine8GGS-β2-Epinephrine
24.00Single8GH1Epinephrine8GH1-β2-Epinephrine
24.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
24.00Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
23.68Single6IGLIRL16206IGL-ETB-IRL1620
23.68Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
23.68Single8IY6Endothelin-18IY6-ETB-Endothelin-1
23.68Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
23.68Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
23.53Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
23.53Single6PT2KGCHM076PT2-δ-KGCHM07
23.53Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
23.33Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
23.33Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
23.33Single4AMIBucindolol4AMI-β1-Bucindolol
23.33Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
23.33Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
23.33Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
23.33Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
23.33Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
23.33Single6MXTSalmeterol6MXT-β2-Salmeterol
23.33Single6OS2TRV0266OS2-AT1-TRV026
23.33Single7DFPSpiperone7DFP-D2-Spiperone
23.33Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
23.33Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
23.33Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
23.33Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
23.33Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
23.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
23.33Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
23.33Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
23.33Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.33Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
23.33Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
23.33Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
23.33Single8JJ8Formoterol8JJ8-β2-Formoterol
23.33Single8JJLOlodaterol8JJL-β2-Olodaterol
23.33Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
23.33Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
23.33Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
23.33Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
23.33Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
23.33Consensusgs_steroidOrthosteric Ligandgs_bileacid
23.33Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
23.08Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
23.08Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
23.08Single5U09Taranabant5U09-CB1-Taranabant
23.08Single6KUXRS-799486KUX-α2a-RS-79948
23.08Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
23.08Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
23.08Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
23.08Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
23.08Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
23.08Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
23.08Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
23.08Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
23.08Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
23.08Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.08Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.08Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.08Single8GGVEpinephrine8GGV-β2-Epinephrine
23.08Single8GGXEpinephrine8GGX-β2-Epinephrine
23.08Single8GH0Epinephrine8GH0-β2-Epinephrine
23.08Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.08Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
23.08Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
23.08Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
23.08Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
23.08Consensusalpha1_onOrthosteric Ligandalpha1a_on
23.08Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.08Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
23.08Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
23.08Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
23.08Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
23.08Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
23.08Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
22.86Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.86Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.86Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
22.86Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
22.86Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
22.86Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
22.86Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
22.86Consensusclass-d_onOrthosteric Ligandste2_on
22.86Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
22.86Consensusgi_class-dOrthosteric Ligandgi_ste
22.86Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.58Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
22.58Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
22.58Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
22.58Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
22.58Single7EZCUKA7EZC-A2A-UKA
22.58Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
22.58Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
22.58Single7UM4AS26747237UM4-5-HT5A-AS2674723
22.58Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
22.58Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
22.58Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.58Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
22.58Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
22.58Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
22.58Consensusendothelin_offOrthosteric Ligandetb_off
22.58Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
22.58Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
22.58Consensussteroid_onOrthosteric Ligandbileacid_on
22.50Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
22.50Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
22.22Single2YDOAdenosine2YDO-A2A-Adenosine
22.22Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
22.22Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
22.22Single5IU7Q274563465IU7-A2A-Q27456346-Na
22.22Single5JTBZM2413855JTB-A2A-ZM241385
22.22Single5K2BZM2413855K2B-A2A-ZM241385-Na
22.22Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
22.22Single6A94Zotepine6A94-5-HT2A-Zotepine
22.22Single6AQFZM2413856AQF-A2A-ZM241385
22.22Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
22.22Single6PS4ICI 118-5516PS4-β2-ICI 118-551
22.22Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
22.22Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
22.22Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
22.22Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
22.22Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
22.22Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
22.22Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
22.22Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
22.22Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
22.22Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGIEpinephrine8GGI-β2-Epinephrine
22.22Single8GGKEpinephrine8GGK-β2-Epinephrine
22.22Single8GGLEpinephrine8GGL-β2-Epinephrine
22.22Single8GGMEpinephrine8GGM-β2-Epinephrine
22.22Single8GGPEpinephrine8GGP-β2-Epinephrine
22.22Single8GGQEpinephrine8GGQ-β2-Epinephrine
22.22Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
22.22Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
22.22Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
22.22Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
22.22Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
22.22Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
22.22Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
22.22Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
22.22Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
22.22Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
22.22Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
21.95Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
21.88Single5EE7MK08935EE7-Glucagon-MK0893
21.88Single6PT3DPI-2876PT3-δ-DPI-287
21.88Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
21.88Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
21.88Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
21.88Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
21.88Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
21.88Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
21.88Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
21.88Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
21.88Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
21.88Consensusgs_class-b2Orthosteric Ligandgs_adgr
21.88Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.88Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
21.62Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
21.62Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
21.62Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
21.62Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
21.62Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
21.62Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
21.43Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
21.43Single2Y01Dobutamine2Y01-β1-Dobutamine
21.43Single2Y02Carmoterol2Y02-β1-Carmoterol
21.43Single2Y04Salbutamol2Y04-β1-Salbutamol
21.43Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
21.43Single3EMLZM2413853EML-A2A-ZM241385
21.43Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
21.43Single4EIYZM2413854EIY-A2A-ZM241385-Na
21.43Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
21.43Single4MQSIperoxo4MQS-M2-Iperoxo
21.43Single4U14Tiotropium4U14-M3-Tiotropium
21.43Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
21.43Single5DSGTiotropium5DSG-M4-Tiotropium
21.43Single5IU8Q274563475IU8-A2A-Q27456347-Na
21.43Single5K2AZM2413855K2A-A2A-ZM241385-Na
21.43Single5OLGZM2413855OLG-A2A-ZM241385-Na
21.43Single5VRAZM2413855VRA-A2A-ZM241385-Na
21.43Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
21.43Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
21.43Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
21.43Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
21.43Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
21.43Single6H7MSalbutamol6H7M-β1-Salbutamol
21.43Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
21.43Single6PS1Timolol6PS1-β2-Timolol
21.43Single6S0LZM2413856S0L-A2A-ZM241385
21.43Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
21.43Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
21.43Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
21.43Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
21.43Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
21.43Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
21.43Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
21.43Single7PYRPSB-21157PYR-A2A-PSB-2115
21.43Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
21.43Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
21.43Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
21.43Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
21.43Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
21.43Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
21.43Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
21.43Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
21.43Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
21.43Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
21.43Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
21.43Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
21.43Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
21.43Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
21.43Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
21.43Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GGJEpinephrine8GGJ-β2-Epinephrine
21.43Single8GGNEpinephrine8GGN-β2-Epinephrine
21.43Single8GGOEpinephrine8GGO-β2-Epinephrine
21.43Single8GGUEpinephrine8GGU-β2-Epinephrine
21.43Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
21.43Single8JJOAlprenolol8JJO-β2-Alprenolol
21.43Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
21.43Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8X63Mepyramine8X63-H1-Mepyramine
21.43Single8X64Desloratadine8X64-H1-Desloratadine
21.43Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
21.43Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
21.43Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
21.43Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
21.43Consensusa2_offOrthosteric Liganda2a_off
21.43Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
21.43Consensusadenosine_onOrthosteric Liganda1_on a2_on
21.43Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
21.43Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
21.43Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
21.43Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
21.43Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
21.43Consensusgi_hcarOrthosteric Ligandgi_hca
21.43Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
21.43Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
21.43Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
21.43Consensushistamine_onOrthosteric Ligandh1_on h4_on
21.43Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
21.43Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
21.43Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
21.43Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
21.43Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
21.43Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
21.43Consensusnucleotide_onOrthosteric Ligandadenosine_on
21.28Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
21.21Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
21.21Single4IARErgotamine4IAR-5-HT1B-Ergotamine
21.21Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
21.21Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
21.21Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
21.21Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
21.21Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
21.21Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
21.05Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
21.05Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
21.05Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
21.05Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
21.05Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
20.69Single2Y00Dobutamine2Y00-β1-Dobutamine
20.69Single2Y03Isoprenaline2Y03-β1-Isoprenaline
20.69Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
20.69Single5IUAQ274563485IUA-A2A-Q27456348-Na
20.69Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
20.69Single5N2SPSB365N2S-A1-PSB36
20.69Single5WIUNemonapride5WIU-D4-Nemonapride
20.69Single5WIVNemonapride5WIV-D4-Nemonapride-Na
20.69Single5XPRBosentan5XPR-ETB-Bosentan
20.69Single6D26Fevipiprant6D26-DP2-Fevipiprant
20.69Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
20.69Single6E67BI1671076E67-β2-BI167107-Gs (fused)
20.69Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
20.69Single6LPLZM2413856LPL-A2A-ZM241385-Na
20.69Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
20.69Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
20.69Single6S0QZM2413856S0Q-A2A-ZM241385
20.69Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
20.69Single6WQAZM2413856WQA-A2A-ZM241385-Na
20.69Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
20.69Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
20.69Single7C4SS1P7C4S-S1P3-S1P
20.69Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
20.69Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
20.69Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
20.69Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
20.69Single7RM5ZM2413857RM5-A2A-ZM241385-Na
20.69Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
20.69Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
20.69Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
20.69Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
20.69Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
20.69Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
20.69Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
20.69Single8FYNZM2413858FYN-A2A-ZM241385-Na
20.69Single8GNEKW-63568GNE-A2A-KW-6356-Na
20.69Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
20.69Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
20.69Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.69Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
20.69Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
20.69Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
20.69Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
20.69Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
20.69Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
20.69Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
20.69Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
20.69Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
20.69Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
20.69Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
20.69Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
20.69Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
20.69Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.69Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
20.69Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.69Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
20.59Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
20.59Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
20.59Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
20.59Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
20.59Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
20.59Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
20.59Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
20.51Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
20.51Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
20.51Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
20.51Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
20.51Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
20.00Single3OE0CVX153OE0-CXCR4-CVX15
20.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
20.00Single4DJHJDTic4DJH-κ-JDTic
20.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
20.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
20.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
20.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
20.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
20.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
20.00Single6OS1TRV0266OS1-AT1-TRV026
20.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
20.00Single6W25SHU91196W25-MC4-SHU9119-Ca
20.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
20.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
20.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
20.00Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
20.00Single7PX4PSB-21137PX4-A2A-PSB-2113
20.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
20.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
20.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
20.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
20.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
20.00Single7W41PD1762527W41-BB2-PD176252
20.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
20.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
20.00Single8GGREpinephrine8GGR-β2-Epinephrine
20.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
20.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
20.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
20.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
20.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
20.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
20.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
20.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
20.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
20.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
20.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
20.00Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
20.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
20.00Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
20.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
20.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
20.00Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
20.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
20.00Consensusbombesin_offOrthosteric Ligandbb2_off
20.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
20.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
20.00Consensuschemerin_onOrthosteric Ligandcml1_on
20.00Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.00Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
20.00Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
20.00Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
20.00Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
20.00Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
20.00Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
20.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
20.00Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
20.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
19.44Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.44Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
19.44Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
19.44Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
19.44Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
19.44Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
19.44Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single4LDEBI1671074LDE-β2-BI167107
19.35Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
19.35Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
19.35Single6CM4Risperidone6CM4-D2-Risperidone
19.35Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
19.35Single6HLPNetupitant6HLP-NK1-Netupitant
19.35Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
19.35Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
19.35Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
19.35Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
19.35Single7K15MKD0467K15-BLT1-MKD046-Na
19.35Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
19.35Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
19.35Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
19.35Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.35Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
19.35Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
19.35Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
19.35Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
19.35Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
19.35Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
19.35Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.35Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
19.35Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
19.35Single8JWZAB9288JWZ-A2A-AB928-Na
19.35Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.35Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
19.35Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
19.35Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
19.35Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
19.35Consensusblt_offOrthosteric Ligandblt1_off
19.35Consensusclass-b2_onOrthosteric Ligandadgrg_on
19.35Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
19.35Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
19.35Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
19.23Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
19.23Single3OE9IT1t3OE9-CXCR4-IT1t
19.23Single3PBLEticlopride3PBL-D3-Eticlopride
19.23Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
19.23Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
19.23Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
19.23Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
19.23Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
19.23Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
19.23Single8GGYEpinephrine8GGY-β2-Epinephrine
19.23Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
19.23Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
19.23Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
19.23Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single8K5BNiacin8K5B-HCA2-Niacin
19.23Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
19.23Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.23Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
19.23Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
19.23Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
19.23Consensusgo_class-b2Orthosteric Ligandgo_adhesion
19.23Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
19.05Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
18.92Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
18.92Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
18.92Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
18.92Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
18.92Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
18.92Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.92Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.92Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.92Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
18.75Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
18.75Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
18.75Single6H7LDobutamine6H7L-β1-Dobutamine
18.75Single6IBLArformoterol6IBL-β1-Arformoterol
18.75Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.75Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
18.75Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.75Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
18.75Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
18.75Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.75Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
18.75Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
18.75Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.75Consensusorexin_onOrthosteric Ligandox2_on
18.60Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
18.52Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
18.52Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
18.52Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
18.52Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
18.52Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
18.52Single5K2DZM2413855K2D-A2A-ZM241385
18.52Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
18.52Single6AKXA4R6AKX-CCR5-A4R
18.52Single6AKYMaraviroc6AKY-CCR5-Maraviroc
18.52Single6B73PubChem 1319551386B73-κ-PubChem 131955138
18.52Single6JZHZM2413856JZH-A2A-ZM241385-Na
18.52Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
18.52Single6ME2Ramelteon6ME2-MT1-Ramelteon
18.52Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
18.52Single6PS7ZM2413856PS7-A2A-ZM241385-Na
18.52Single7BR3Elagolix7BR3-GnRH1-Elagolix
18.52Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
18.52Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
18.52Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
18.52Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
18.52Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
18.52Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
18.52Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
18.52Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
18.52Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
18.52Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
18.52Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
18.52Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
18.52Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
18.52Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
18.52Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
18.52Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
18.52Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8GGWEpinephrine8GGW-β2-Epinephrine
18.52Single8GNGIstradefylline8GNG-A2A-Istradefylline
18.52Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
18.52Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single8IWESpermidine8IWE-TAAR9-Spermidine
18.52Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
18.52Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
18.52Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
18.52Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
18.52Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
18.52Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
18.52Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
18.52Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
18.52Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensusgt_class-aOrthosteric Ligandgt_opsin
18.52Consensusgt_opsinOrthosteric Ligandgt_sensory
18.52Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
18.52Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
18.52Consensusmglu_onOther Ligandmglu2_on mglu4_on
18.42Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
18.42Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
18.42Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.42Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.42Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.42Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
18.42Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
18.42Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
18.18Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
18.18Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
18.18Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
18.18Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
18.18Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
18.18Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
18.18Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
18.18Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
18.18Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
18.18Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
18.18Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.95Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
17.86Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
17.86Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
17.86Single4MBSMaraviroc4MBS-CCR5-Maraviroc
17.86Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
17.86Single5IU4ZM2413855IU4-A2A-ZM241385-Na
17.86Single5IUBQ274563445IUB-A2A-Q27456344-Na
17.86Single5K2CZM2413855K2C-A2A-ZM241385-Na
17.86Single5NLXZM2413855NLX-A2A-ZM241385-Na
17.86Single5NM4ZM2413855NM4-A2A-ZM241385-Na
17.86Single5UVIZM2413855UVI-A2A-ZM241385
17.86Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
17.86Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
17.86Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
17.86Single6MH8ZM2413856MH8-A2A-ZM241385
17.86Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
17.86Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
17.86Single6TPGEMPA6TPG-OX2-EMPA
17.86Single6TPNHTL66416TPN-OX2-HTL6641
17.86Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
17.86Single7AROLUF58337ARO-A2A-LUF5833-Na
17.86Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
17.86Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
17.86Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
17.86Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
17.86Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
17.86Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
17.86Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
17.86Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.86Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
17.86Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
17.86Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
17.86Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
17.86Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
17.86Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
17.86Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
17.86Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.86Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.86Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
17.86Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
17.86Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
17.86Single8K5CAcipimox8K5C-HCA2-Acipimox
17.86Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.86Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.86Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
17.86Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
17.86Consensus5ht5_onOrthosteric Ligand5ht5a_on
17.86Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
17.86Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
17.86Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
17.86Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
17.86Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
17.86Consensusgnrh_offOrthosteric Ligandgnrh1_off
17.86Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
17.86Consensushca_onOrthosteric Ligandhca2_on hca3_on
17.86Consensushcar_onOrthosteric Ligandhca_on
17.86Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
17.86Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
17.86Consensuss1p_offOrthosteric Ligands1p1_off
17.86Consensussensory_offOrthosteric Ligandopsin_off
17.65Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
17.65Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
17.65Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.65Single7F8XNN90567F8X-CCKA-NN9056
17.65Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
17.65Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
17.65Consensussst_onOrthosteric Ligandsst2_on sst4_on
17.50Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
17.50Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
17.24Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
17.24Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
17.24Single4EJ4Naltrindole4EJ4-δ-Naltrindole
17.24Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
17.24Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
17.24Single4YAYZD-71554YAY-AT1-ZD-7155
17.24Single5UENDU1725UEN-A1-DU172
17.24Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
17.24Single6D27CAY104716D27-DP2-CAY10471
17.24Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
17.24Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
17.24Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
17.24Single6IIVDaltroban6IIV-TP-Daltroban
17.24Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
17.24Single6LPJZM2413856LPJ-A2A-ZM241385-Na
17.24Single6LPKZM2413856LPK-A2A-ZM241385-Na
17.24Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
17.24Single6TOTLemborexant6TOT-OX1-Lemborexant
17.24Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.24Single7BU7BI1671077BU7-β1-BI167107
17.24Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
17.24Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
17.24Single7F83PF-051904577F83-Ghrelin-PF-05190457
17.24Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
17.24Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
17.24Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
17.24Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
17.24Single7UL4Alvimopan7UL4-μ-Alvimopan
17.24Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
17.24Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
17.24Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
17.24Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
17.24Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
17.24Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
17.24Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
17.24Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
17.24Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
17.24Single8K5DGSK2560738K5D-HCA2-GSK256073
17.24Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
17.24Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
17.24Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
17.24Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
17.24Consensusblt_onOrthosteric Ligandblt1_on
17.24Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
17.24Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
17.24Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
17.24Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
17.24Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
17.24Consensusleuko_onOrthosteric Ligandblt_on
17.24Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
17.24Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
17.24Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
17.24Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
17.24Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
17.14Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
17.14Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
17.14Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
17.14Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
17.14Single7SK5CXCL127SK5-ACKR3-CXCL12
17.14Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
17.14Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
16.67Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
16.67Single5WQCEMPA5WQC-OX2-EMPA
16.67Single6LUQHaloperidol6LUQ-D2-Haloperidol
16.67Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
16.67Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
16.67Single6TP6Filorexant6TP6-OX1-Filorexant
16.67Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
16.67Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7SINNPS-21437SIN-CaS-NPS-2143
16.67Single7SINNPS-21437SIN-CaS-NPS-2143
16.67Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
16.67Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
16.67Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
16.67Single7WC6LSD7WC6-5-HT2A-LSD
16.67Single7XNACYN1548067XNA-SST2-CYN154806
16.67Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
16.67Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
16.67Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
16.67Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
16.67Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
16.67Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
16.67Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
16.22Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
16.22Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.22Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.22Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
16.22Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
16.22Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
16.22Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Single6J20Aprepitant6J20-NK1-Aprepitant
16.13Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
16.13Single7B6WCyclazosin7B6W-α1b-Cyclazosin
16.13Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
16.13Single7F1TMIP-1a7F1T-CCR5-MIP-1a
16.13Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
16.13Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
16.13Single7P2L4YI7P2L-mGlu5-4YI
16.13Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
16.13Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
16.13Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
16.13Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
16.13Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
16.13Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
16.13Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
16.13Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
16.13Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
16.13Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
16.13Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
16.13Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
16.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
16.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
16.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
16.00Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
16.00Consensussensory_onOrthosteric Ligandopsin_on
15.79Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
15.79Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
15.79Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
15.62Single4XEENeurotensin4XEE-NTS1-Neurotensin
15.62Single4XESNeurotensin4XES-NTS1-Neurotensin
15.62Single6IIURamatroban6IIU-TP-Ramatroban
15.62Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
15.62Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
15.62Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Single6YVRNTS8-136YVR-NTS1-NTS8-13
15.62Single6ZG4HTL00099366ZG4-M1-HTL0009936
15.62Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.62Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
15.62Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
15.62Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
15.62Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
15.62Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
15.62Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
15.62Consensusgi_class-fOther Ligandgi_frizzled
15.62Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
15.62Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
15.38Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
15.38Single3OE6IT1t3OE6-CXCR4-IT1t
15.38Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
15.38Single6LI0GTPL98046LI0-GPR52-GTPL9804
15.38Single6ME5Agomelatine6ME5-MT1-Agomelatine
15.38Single6ME9Ramelteon6ME9-MT2-Ramelteon
15.38Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
15.38Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
15.38Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
15.38Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
15.38Single7SK3CXCL127SK3-ACKR3-CXCL12
15.38Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
15.38Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
15.38Single8GGZEpinephrine8GGZ-β2-Epinephrine
15.38Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
15.38Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
15.38Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
15.38Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
15.38Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
15.38Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
15.22Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
15.15Single4BUONeurotensin4BUO-NTS1-Neurotensin
15.15Single5CGDHTL142425CGD-mGlu5-HTL14242
15.15Single6K1QIRL25006K1Q-ETB-IRL2500
15.15Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
15.15Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
15.15Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.15Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
15.15Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
15.15Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.15Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
15.15Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
15.15Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.15Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.15Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
15.15Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
14.81Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
14.81Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
14.81Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
14.81Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
14.81Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
14.81Single6HLLCP999946HLL-NK1-CP99994
14.81Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
14.81Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
14.81Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
14.81Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
14.81Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
14.81Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
14.81Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
14.81Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
14.81Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
14.81Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
14.81Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
14.81Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
14.81Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
14.81Consensusclass-t_onOrthosteric Ligandtaste2_on
14.81Consensusgs_class-tOrthosteric Ligandgs_taste
14.81Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
14.81Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
14.81Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
14.81Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
14.71Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
14.71Single7XN9L-054,5227XN9-SST2-L-054,522
14.71Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
14.71Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
14.71Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.71Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.71Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
14.71Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
14.71Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
14.29Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
14.29Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
14.29Single3ODUIT1t3ODU-CXCR4-IT1t
14.29Single3PWHZM2413853PWH-A2A-ZM241385
14.29Single4BWBNeurotensin4BWB-NTS1-Neurotensin
14.29Single4S0VSuvorexant4S0V-OX2-Suvorexant
14.29Single5DHHSB-6121115DHH-NOP-SB-612111
14.29Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
14.29Single5WS3EMPA5WS3-OX2-EMPA
14.29Single5ZKQABT-4915ZKQ-PAF-ABT-491
14.29Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
14.29Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
14.29Single6TPJSuvorexant6TPJ-OX2-Suvorexant
14.29Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
14.29Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
14.29Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
14.29Single7F8ULintitript7F8U-CCKA-Lintitript
14.29Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
14.29Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
14.29Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
14.29Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
14.29Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
14.29Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
14.29Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
14.29Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
14.29Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
14.29Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
14.29Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
14.29Single7XRRLemborexant7XRR-OX2-Lemborexant
14.29Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
14.29Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
14.29Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
14.29Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
14.29Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
14.29Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
14.29Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
14.29Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
14.29Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
14.29Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
14.29Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
14.29Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
14.29Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
14.29Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
14.29Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
14.29Consensusorexin_offOrthosteric Ligandox2_off ox1_off
14.29Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
14.29Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
14.29Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
13.89Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
13.89Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
13.89Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.89Consensussst_offOrthosteric Ligandsst2_off
13.89Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
13.79Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
13.79Single3REYPubChem 56973REY-A2A-PubChem 5697
13.79Single3RZECidoxepin3RZE-H1-Cidoxepin
13.79Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
13.79Single4ZJCSB-6740424ZJC-OX1-SB-674042
13.79Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
13.79Single6IQLL7458706IQL-D4-L745870
13.79Single6TP3Nemorexant6TP3-OX1-Nemorexant
13.79Single6V9SGTPL114036V9S-OX1-GTPL11403
13.79Single6VI4JDTic6VI4-κ-JDTic
13.79Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
13.79Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
13.79Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
13.79Single6ZG9GSK10347026ZG9-M1-GSK1034702
13.79Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
13.79Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
13.79Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
13.79Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.79Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.79Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
13.79Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
13.79Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
13.79Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
13.79Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
13.79Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.79Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
13.79Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
13.79Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
13.79Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
13.79Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
13.79Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
13.79Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
13.79Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
13.79Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
13.51Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
13.51Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.51Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
13.51Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.51Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
13.33Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
13.33Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
13.33Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
13.33Single6DRXLisuride6DRX-5-HT2B-Lisuride
13.33Single6GPSMK08126GPS-CCR2-MK0812
13.33Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
13.33Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
13.33Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
13.33Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
13.33Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
13.33Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
13.33Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
13.33Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
13.33Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
13.33Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
13.33Consensuscck_offOrthosteric Ligandccka_off
13.33Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
13.33Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
13.33Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
13.33Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
13.33Consensustachykinin_offOrthosteric Ligandnk1_off
13.16Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
12.90Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
12.90Single5CGCHTL142425CGC-mGlu5-HTL14242
12.90Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
12.90Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
12.90Single6GPXMK08126GPX-CCR2-MK0812
12.90Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
12.90Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
12.90Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
12.90Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
12.90Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
12.90Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
12.90Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
12.90Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
12.90Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
12.90Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.90Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
12.90Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
12.90Consensusep_offOrthosteric Ligandep4_off
12.82Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
12.82Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
12.50Single4BV0Neurotensin4BV0-NTS1-Neurotensin
12.50Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
12.50Single5V56TC1145V56-SMO-TC114
12.50Single5V57TC1145V57-SMO-TC114
12.50Single6E59L-7607356E59-NK1-L-760735
12.50Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
12.50Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
12.50Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
12.50Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
12.50Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
12.50Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
12.50Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
12.50Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
12.50Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
12.50Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
12.50Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
12.50Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
12.50Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
12.50Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
12.50Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
12.20Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.12Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
12.12Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
12.12Single4N4WSANT-14N4W-SMO-SANT-1
12.12Single4PY02MeSATP4PY0-P2Y12-2MeSATP
12.12Single5X33BIIL2605X33-BLT1-BIIL260
12.12Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
12.12Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
12.12Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.12Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.12Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
12.12Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.12Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
12.12Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
12.12Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
12.12Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
12.12Consensuschemokine_offOrthosteric Ligandcxcr_off
12.12Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
12.12Consensuscxcr_offOrthosteric Ligandcxcr4_off
12.12Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
12.12Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
12.12Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
12.12Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
12.12Consensusnts_onOrthosteric Ligandnts1_on
12.12Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
12.12Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
12.00Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
12.00Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
12.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
12.00Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
12.00Single8PWNTheophylline8PWN-A2A-Theophylline
12.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
12.00Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
11.76Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
11.76Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
11.76Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
11.76Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
11.76Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
11.76Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
11.76Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
11.76Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
11.76Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
11.76Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
11.54Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
11.54Single3RFMCaffeine3RFM-A2A-Caffeine
11.54Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
11.54Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
11.54Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
11.54Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
11.54Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
11.54Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
11.54Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
11.43Single6KNMJN241-96KNM-Apelin-JN241-9
11.43Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
11.43Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.43Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
11.43Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
11.43Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
11.43Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
11.11Single3OE8IT1t3OE8-CXCR4-IT1t
11.11Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
11.11Single3UZAGTPL92363UZA-A2A-GTPL9236
11.11Single4XNWMRS25004XNW-P2Y1-MRS2500
11.11Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
11.11Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
11.11Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
11.11Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
11.11Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
11.11Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
11.11Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
11.11Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
10.81Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.81Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
10.71Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
10.71Single4O9RCyclopamine4O9R-SMO-Cyclopamine
10.71Single5L7IVismodegib5L7I-SMO-Vismodegib
10.71Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
10.71Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
10.71Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
10.71Single6TP4ACT-4622066TP4-OX1-ACT-462206
10.71Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
10.71Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
10.71Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
10.71Single7SRQLSD7SRQ-5-HT2B-LSD
10.71Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
10.71Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
10.71Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
10.71Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
10.71Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.71Consensusgo_proteinOrthosteric Ligandgo_chemokine
10.71Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
10.71Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
10.71Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
10.71Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
10.53Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
10.34Single4QINSAG1.54QIN-SMO-SAG1.5
10.34Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
10.34Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
10.34Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
10.34Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
10.34Single6TODEMPA6TOD-OX1-EMPA-Na
10.34Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
10.34Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.34Single7F8YDevazepide7F8Y-CCKA-Devazepide
10.34Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
10.34Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.34Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
10.34Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
10.34Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
10.34Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
10.34Single8IHKAcifran8IHK-HCA3-Acifran
10.34Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
10.34Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
10.34Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.34Consensusclass-f_offOrthosteric Ligandsmo_off
10.34Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
10.26Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
10.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
10.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
10.00Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
10.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
10.00Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
10.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
10.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
10.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
10.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.00Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
10.00Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
10.00Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
10.00Single8K2WAMG4878K2W-CXCR3-AMG487
10.00Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
10.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensusgi_class-fOrthosteric Ligandgi_frizzled
10.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
9.68Single5T04Neurotensin5T04-NTS1-Neurotensin
9.68Single6FFHFenobam6FFH-mGlu5-Fenobam
9.68Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
9.68Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.68Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
9.68Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.68Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
9.68Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.68Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
9.68Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
9.68Consensushcar_offOrthosteric Ligandsuccinate_off
9.68Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
9.68Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
9.38Single4NTJAZD12834NTJ-P2Y12-AZD1283
9.38Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
9.38Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
9.38Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
9.38Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
9.38Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.38Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
9.38Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.38Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.38Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
9.38Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
9.38Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
9.38Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single5TZR-5TZR-FFA1 (GPR40)-MK8666
9.09Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
9.09Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
9.09Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
9.09Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
9.09Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
9.09Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.09Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.82Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
8.82Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
8.82Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
8.82Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
8.57Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
8.57Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
8.57Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
8.57Consensuscyslt_offOrthosteric Ligandcyslt2_off
8.57Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.51Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
8.33Single8HS2Fab0468HS2-GPR20-Fab046
8.16Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
8.11Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
8.11Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
8.00Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
8.00Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
8.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
7.69Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
7.69Single7WC4Serotonin7WC4-5-HT2A-Serotonin
7.69Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
7.69Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.41Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
7.41Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
7.14Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
7.14Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
7.14Single7WC5Psilocin7WC5-5-HT2A-Psilocin
6.90Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
6.90Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.90Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
6.82Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
6.67Single4K5YCP-3763954K5Y-CRF1-CP-376395
6.67Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
6.67Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
6.67Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
6.67Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
6.67Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
6.67Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
6.67Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.52Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
6.45Single6TPKRetosiban6TPK-OT-Retosiban
6.45Single7VV6C48/807VV6-MRGPRX2-C48/80
6.45Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.45Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
6.45Consensusvasopressin-ot_offOrthosteric Ligandot_off
6.38Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
6.25Single4Z9GCP-3763954Z9G-CRF1-CP-376395
6.25Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
6.25Single8GTIBMK-C2058GTI-CRF1-BMK-C205
6.25Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
6.25Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.06Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
6.06Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
6.06Single8GTGBMK-I1528GTG-CRF1-BMK-I152
5.88Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
5.71Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
5.71Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.71Single8GTMBMK-C2038GTM-CRF1-BMK-C203
5.71Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.71Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
5.71Consensusnts_offOrthosteric Ligandnts1_off
5.66Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
5.45Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
5.13Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.35Single6D35Cholesterol6D35-SMO-Cholesterol
4.35Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.35Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.35Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
4.35Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
4.35Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.35Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.35Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.35Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
4.35Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
4.35Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
4.35Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.35Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.35Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.35Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.35Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
4.35Single7DTTCa7DTT-CaS-Ca-Ca
4.35Single7DTTCa7DTT-CaS-Ca-Ca
4.35Single7DTUTryptophan7DTU-CaS-Tryptophan
4.35Single7DTUTryptophan7DTU-CaS-Tryptophan
4.35Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.35Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.35Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.35Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.35Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.35Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.35Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
4.35Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
4.35Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
4.35Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.35Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.35Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.35Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.35Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.35Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.35Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single7FIIhCG7FII-LH-hCG-6fuf
4.35Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
4.35Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
4.35Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.35Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.35Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.35Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.35Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.35Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.35Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.35Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.35Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.35Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.35Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
4.35Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
4.35Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.35Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.35Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.35Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.35Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
4.35Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.35Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.35Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.35Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.35Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.35Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.35Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
4.35Single7XW7K1-707XW7-TSH-K1-70
4.35Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.35Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.35Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.35Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.35Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.35Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.35Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.35Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.35Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.35Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.35Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.35Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.35Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
4.35Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.35Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.35Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.35Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.35Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
4.35Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
4.35Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.35Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.35Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.35Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.35Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.35Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.35Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.35Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.35Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.35Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
4.35Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
4.35Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.35Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.35Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.35Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.35Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.35Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.35Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.35Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.35Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.35Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.35Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.35Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.35Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.35Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.35Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
4.35Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
4.35Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
4.35Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
4.35Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.35Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.35Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
4.35Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
4.35Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
4.35Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
4.35Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.35Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.35Consensusgphr_onOrthosteric Ligandlh_on tsh_on
4.35Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
4.35Consensusgs_proteinOrthosteric Ligandgs_gphr
4.35Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
4.35Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
4.35Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
4.35Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.35Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.35Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
4.35Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
4.35Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.35Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.35Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
4.35Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
4.35Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
4.35Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
4.35Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
4.35Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
4.35Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
4.35Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
4.35Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.17Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.17Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.17Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.17Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.17Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.17Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.17Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.17Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.17Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.17Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.00Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.00Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
3.85Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.85Single6W25Ca6W25-MC4-SHU9119-Ca
3.85Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
3.85Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
3.85Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
3.85Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
3.85Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
3.85Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
3.70Single5L7DCholesterol5L7D-SMO-Cholesterol
3.70Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
3.70Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
3.70Consensusclass-c_onOther Ligandgabab_on mglu_on
3.57Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
3.45Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
3.45Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
3.45Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
3.45Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.33Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.33Single7UL2SR486927UL2-NTS1-SR48692-Na
3.33Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
3.23Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
3.12Single6ZINSR486926ZIN-NTS1-SR48692
3.12Single8IYXYL-3658IYX-GPR34-YL-365
3.03Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
2.94Single6Z4SSR486926Z4S-NTS1-SR48692
2.78Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.50Single7SHEPI; PE7SHE-GPR158-PI; PE

Consensus Members
Id Members
7TS0 7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
Net Summary
Imin 2.72
Number of Linked Nodes 807
Number of Links 1006
Number of Hubs 159
Number of Links mediated by Hubs 618
Number of Communities 27
Number of Nodes involved in Communities 273
Number of Links involved in Communities 403
Path Summary
Number Of Nodes in MetaPath 153
Number Of Links MetaPath 152
Number of Shortest Paths 1323628
Length Of Smallest Path 3
Average Path Length 48.8027
Length of Longest Path 98
Minimum Path Strength 1.34
Average Path Strength 5.57398
Maximum Path Strength 24.705
Minimum Path Correlation 0.7
Average Path Correlation 0.984035
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.69492
Average % Of Corr. Nodes 39.858
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 39.0769
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
go_class-b1go_crf



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