Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1Lig 14.93143510
2NT 118.3611115
31x42 4.9455415
41x43 7.3785415
51x57 3.583408
6I1x51 4.3156508
72x38 2.367402
82x39 5.368507
92x46 5.6792509
102x54 4.239408
112x57 6.86829718
122x64 6.2055417
13E1 10.328915
143x46 5.3608519
153x47 6.4652517
163x48 3.54045145
173x49 6.18371719
183x50 4.118419
193x51 5.951408
203x53 6.6785409
213x56 5.08967648
22I2 10.75041147
234x44 7.3585446
244x48 4.6755445
254x491 3.8155405
264x50 3.6194153
274x57 4.40367619
284x60 3.74554149
294x64 3.84416
30E2 9.544711415
315x50 4.618407
32I3 7.769671247
336x53 4.8195416
34E3 6.700771317
357x30 6.6225414
367x42 4.7745416
377x50 6.1612519
387x51 3.6485407
397x54 6.953405
40G.HN.30 3.1554164
41G.HN.36 7.987434
42G.S1.02 6.2405406
43G.H1.01 4.24965179
44G.S3.03 5.72967648
45G.S3.04 11.1515427
46G.S3.06 12.027427
47G.H2.01 6.868429
48G.H2.06 5.575629
49G.H2.07 6.336509
50G.h2s4.01 10.0655409
51G.H3.08 5.023408
52G.H3.09 5.768336119
53G.H3.13 9.694676116
54G.H3.17 11.1908525
55G.S5.05 4.475189
56G.S5.07 3.3416509
57G.hgh4.04 2.76354196
58G.hgh4.05 9.1895406
59G.hgh4.08 6.5975406
60G.hgh4.20 6.034403
61G.hgh4.21 4.6065404
62G.H4.03 3.7765404
63G.H4.07 7.902475
64G.H4.08 5.18714773
65G.H4.10 8.66765197
66G.H4.12 5.9856574
67G.H4.14 7.1754195
68G.H4.15 8.387408
69G.h4s6.12 5.3055402
70G.h4s6.20 4.3415404
71G.S6.02 8.594408
72G.S6.05 7.9796575
73G.H5.03 4.19285189
74G.H5.05 5.5505445
75G.H5.08 6.25567648
76G.H5.17 9.558445
77G.H5.19 5.2344548
78G.H5.20 4.9448
79b.1x4 2.4925408
80b.h2x1 4.2605405
81b.h2x5 3.959405
82b.lhb1x6 4.1285483
83b.l1x3 9.5852539
84b.l1x6 11.11529
85b.b2x1 8.7444528
86b.b2x5 6.46633637
87b.b3x3 4.30954128
88b.l3x1 9.8065429
89b.b4x5 4.60054127
90b.b4x6 9.57771739
91b.b4x7 9.5775438
92b.l4x3 6.686436
93b.b5x3 6.036639
94b.b5x7 5.8815407
95b.l5x1 4.3285138
96b.l5x5 8.655629
97b.b6x1 5.2275429
98b.b6x5 4.652297126
99b.b7x1 6.0705404
100b.b8x4 4.609676136
101b.l9x3 7.35833629
102b.l9x6 5.71629728
103b.b10x5 4.98933609
104b.l10x1 5.052403
105b.b11x4 5.7245429
106b.l11x2 8.1995429
107b.b12x6 9.57067628
108b.b13x3 7.315424
109b.b13x7 8.0912567
110b.l13x3 8.52533669
111b.l13x6 6.478429
112b.l13x7 4.9335469
113b.b15x1 7.3312569
114b.b15x2 6.5405456
115b.l15x2 6.733469
116b.b16x4 11.284466
117b.b16x5 4.9105405
118b.b16x6 8.51371768
119b.b17x5 7.3457
120b.b17x7 8.5505458
121b.l17x3 8.10675859
122b.l17x6 7.5392529
123b.b18x3 4.7825458
124b.l18x1 7.2416106
125b.l18x2 6.6594107
126b.l18x3 8.4254105
127b.b19x2 7.06733656
128b.b19x4 6.3505458
129b.l19x1 6.426429
130b.l19x2 9.1135459
131b.b20x2 7.257456
132b.b20x4 10.7873658
133b.b20x6 7.15267656
134b.b21x1 7.6684557
135b.b21x3 8.319456
136b.b21x5 6.1945404
137b.b21x7 6.30833605
138b.b22x5 6.3344107
139b.l22x5 6.55689
140b.b23x6 7.15571727
141b.l23x1 6.1615426
142b.b24x4 8.524426
143b.b24x6 6.2465428
144b.l24x3 4.2728505
145b.l25x3 8.5876599
146b.l25x6 12.3696528
147b.l27x5 5.1435435
148b.l28x1 10.02729
149b.l28x2 7.819499
150b.b28x3 4.3824537
151b.b28x4 7.05496
152b.b28x6 8.9568599
153b.b28x7 7.3955439
154g.h1x5 2.7325406
155g.h1x8 2.8465407
156g.l1x2 4.6715452
157g.l1x4 5.744458
158g.h2x11 9.6384106
159g.ctx3 7.1475409
160g.ctx6 3.7256586
161g.ctx14 5.214539
162g.ctx15 6.634439
163g.ctx16 5.7685838
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
12x39 G.H5.22 69.29073.738YesNo074
2G.H5.19 G.H5.22 69.08452.72YesNo084
33x53 G.H5.19 32.4313.086YesYes098
43x53 6x50 19.02349.276YesNo099
56x50 6x51 18.12264.092NoNo099
66x51 6x53 17.90583.424NoYes096
76x53 Lig 18.52673.646YesYes160
82x39 8x64 70.10839.134YesNo074
9b.b28x6 b.l25x2 70.4122.81YesNo095
108x67 b.l25x2 70.3113.286NoNo075
118x64 8x67 70.20973.072NoNo047
12G.H5.19 I2 35.247913.148YesYes487
13G.H5.13 I3 19.480211.676NoYes487
14b.b4x7 b.l2x5 33.044416.2YesNo085
15b.l2x5 b.l4x2 63.551723.46NoNo054
16b.l4x2 g.ctx15 62.811213.632NoYes349
17b.l27x5 g.ctx15 63.50943.354YesYes359
18b.l27x5 g.ctx4 71.95296.374YesNo057
19g.ctx3 g.ctx4 72.24954.186YesNo097
20b.l22x1 g.ctx3 75.38398.536NoYes099
21b.b23x1 b.l22x1 75.29094.504NoNo059
22b.b23x1 b.b24x5 75.01115.066NoNo055
23b.b23x3 b.b24x5 74.63543.576NoNo075
24b.b23x3 b.b27x1 74.54114.47NoNo076
25b.b27x1 g.ctx5 74.1623.874NoNo069
26b.lhb1x11 g.ctx5 74.06674.522NoNo049
27b.b25x7 b.lhb1x11 73.97134.24NoNo074
28b.b25x7 b.b28x6 72.591818.678NoYes079
29b.l3x1 b.l5x5 14.72315.258YesYes299
30G.H3.17 b.l28x1 42.96777.308YesYes259
31G.H3.17 b.l23x1 43.47916.478YesYes256
32b.l21x7 b.l23x1 87.65644.668NoYes256
33b.b23x6 b.l21x7 87.6494.03YesNo275
34b.b23x6 b.b24x6 88.38495.788YesYes278
35b.b21x7 b.b24x6 89.89329.452YesYes058
36b.b21x5 b.b21x7 96.355710.778YesYes045
37b.b21x5 b.h2x1 97.06227.07YesYes045
38b.h2x1 b.h2x5 98.04393.538YesYes055
39b.h2x5 b.lhb1x3 49.37094.864YesNo052
40b.l22x5 b.lhb1x3 49.64484.008YesNo092
41b.l22x5 g.ctx6 99.19014.372YesYes896
42g.ctx3 g.ctx6 1007.33YesYes096
43b.b2x1 b.l28x1 75.25637.33YesYes289
44b.l25x6 b.l28x1 43.006717.992YesYes289
45b.l23x1 b.l25x6 43.871910.482YesYes268
46b.h2x5 b.l24x2 49.09234.422YesNo056
47b.l22x5 b.l24x2 49.09238.99YesNo896
48G.H5.10 G.S6.02 18.880113.332NoYes078
49G.H5.13 G.S6.02 19.333611.03NoYes088
50G.H5.10 G.S6.04 10.240811.852NoNo079
51b.b6x1 b.l9x6 66.10665.744YesYes298
52b.b2x1 b.b6x1 66.83046.464YesYes289
53G.H2.07 b.l9x6 40.54144.822YesYes098
54G.H2.04 G.H2.07 38.703510.4NoYes099
55G.H2.04 G.H3.08 38.31659.962NoYes098
56G.H3.08 G.S4.04 37.17036.09YesNo089
57G.H3.09 G.S4.04 36.78284.502YesNo099
58G.H3.09 G.H4.15 29.77918.572YesYes098
59G.H3.06 G.H4.15 12.738510.716NoYes068
60G.H3.06 G.H4.14 10.35465.568NoYes065
61G.H4.15 G.S5.04 15.91419.016YesNo089
62G.S5.04 G.S5.06 11.14574.982NoNo098
63b.l2x3 b.l2x5 30.41524.046NoNo085
64b.b3x1 b.l2x3 30.28757.328NoNo058
65b.b3x1 b.b6x5 61.22795.158NoYes056
66b.b2x4 b.b6x5 52.52573.706NoYes066
67b.b10x4 b.b2x4 52.238419.41NoNo066
68b.b10x2 b.b10x4 51.95123.62NoNo066
69b.b10x2 b.b14x3 51.66394.444NoNo065
70b.b11x3 b.b14x3 45.95673.278NoNo055
71b.b11x3 b.b15x1 43.91426.028NoYes059
72b.b15x1 b.l16x1 38.19273.144YesNo094
73b.l16x1 b.l16x2 37.89762.614NoNo049
74b.l16x2 b.l16x3 37.01163.024NoNo093
75b.b16x7 b.l16x3 36.123914.03NoNo093
76b.b16x7 b.l14x6 35.52114.072NoNo2093
77b.b16x5 b.l14x6 35.23475.26YesNo053
78b.b16x5 b.b17x5 19.61856.122YesYes057
79b.b17x5 b.b21x1 12.869111.226YesYes577
80b.1x19 b.b21x1 11.759310.242NoYes067
81b.1x15 b.1x19 10.52935.764NoNo076
82b.1x15 g.h1x15 10.22133.25NoNo078
83b.b3x1 b.b4x7 31.22953.256NoYes058
84b.l11x1 b.l9x6 17.94997.242NoYes298
85b.b11x6 b.l11x1 17.58183.71NoNo299
86b.b11x6 b.l9x3 15.187613.668NoYes299
87b.b11x4 b.l9x3 11.21046.028YesYes299
88b.b11x4 b.b8x1 10.82923.042YesNo098
89b.b10x3 b.b8x1 10.44383.276NoNo088
90I2 I3 20.88314.072YesYes477
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
5x421Lig11.1620NoYes6010
5x47Lig3.4941NoYes6010
5x51Lig21.611NoYes6010
5x43Lig7.2021NoYes3010
7x29Lig12.470NoYes4010
7x30Lig6.6661YesYes4010
5x48Lig5.7481NoYes7010
5x55Lig5.6720NoYes4010
E3Lig8.2781YesYes7010
3x47Lig5.7421YesYes7010
5x54Lig3.1721NoYes7010
7x46Lig6.991NoYes7010
2x64Lig3.2421YesYes7010
3x43Lig4.091NoYes6010
7x50Lig5.1381YesYes9010
1x42Lig3.61YesYes5010
E1Lig22.6641YesYes5010
1x36Lig6.4561NoYes2010
1x39Lig4.1880NoYes4010
1x40Lig13.2961NoYes2010
1x43Lig9.8981YesYes5010
LigNT104.7421YesYes0501
3x25Lig4.4641NoYes3010
5x41Lig5.4441NoYes6010
1x35Lig6.9861NoYes3010
1x29Lig7.8081NoYes3010
1x25Lig6.1541NoYes5010
NTNT549.6481YesYes5511
E2NT3.9441YesYes5511
1x25NT45.6561NoYes5511
1x28NT14.2381NoYes9521
1x29NT10.2721NoYes3511
1x35NT6.5921NoYes3511
7x34NT3.3840NoYes3521
1x24NT11.0741NoYes8521
1x251x283.1141NoNo5912
1x321x333.151NoNo2312
1x361x407.5461NoNo2211
1x427x413.2561YesNo5512
1x427x4610.031YesNo5711
1x431x446.9521YesNo5412
1x431x474.1081YesNo5712
1x43E18.5561YesYes5511
1x467x505.8560NoYes7921
1x47E13.2961NoYes7521
1x502x6411.9320NoYes7721
1x507x508.990NoYes7921
2x602x645.9340NoYes8721
2x643x393.7141YesNo7612
E1E120.1061YesYes5511
3x35E15.5020NoYes6521
5x41E13.681NoYes6511
3x24E16.0881NoYes1521
3x33E25.0381NoYes7521
3x335x4016.711NoNo7922
3x433x474.7881NoYes6711
3x435x513.1521NoNo6611
3x473x503.3521YesYes7912
3x475x548.3341YesNo7711
3x47E310.111YesYes7711
3x507x525.441YesNo9922
4x67E211.1661NoYes7521
4x675x473.8561NoNo7621
5x46E27.5961NoYes4521
E2E218.9181YesYes5511
5x40E219.7961NoYes9521
5x44E216.591NoYes4511
5x47E23.41NoYes6511
5x42E214.0981NoYes4521
5x425x435.461NoNo4321
5x445x463.8321NoNo4412
5x455x484.3540NoNo2721
5x58E33.8140NoYes7721
5x62E35.241NoYes6721
5x656x535.140NoYes9621
6x486x537.0680NoYes8621
6x516x533.4240NoYes9621
6x52E36.3520NoYes9721
E3E39.4141YesYes7711
7x48E34.791NoYes5721
7x52E311.191NoYes9721
7x49E37.2841NoYes6721
7x27E36.2941NoYes6721
7x307x374.5021YesNo4412
7x307x405.5561YesNo4712
7x307x419.7661YesNo4512
7x467x507.641NoYes7911
7x497x503.1821NoYes6921
4x64E23.4281YesYes6521
E2Lig5.3481YesYes5010
5x44Lig4.5281NoYes4010
6x53Lig3.6461YesYes6010
7x33E33.3281NoYes4721
1x31Lig3.3381NoYes1010
4x68E22.9540NoYes6521
3x23E12.9541NoYes3521
1x427x422.8961YesYes5612
1x27NT2.7720NoYes5521
1x32Lig2.7041NoYes2010
1x301x312.4960NoNo2121
5x49E22.4321NoYes8521
1x51Lig2.2640NoYes7010
5x59E31.6021NoYes4721
3x25E2x501.4561NoNo3312

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
70.59Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
65.71Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
62.86Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
62.50Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
62.16Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
61.90Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
61.11Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
60.98Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
60.53Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
59.46Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
56.76Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
53.85Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
53.66Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
53.49Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
52.50Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
48.72Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
46.15Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
33.33Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
32.56Single6LMLGlucagon6LML-Glucagon-Glucagon
32.50Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
31.58Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
31.37Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
31.25Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
31.11Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
30.95Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
30.95Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
30.43Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
30.23Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
30.00Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
29.79Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
29.55Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
29.55Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
29.55Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
28.89Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
28.57Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
28.57Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
28.26Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
28.26Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
28.26Consensusglp_onOrthosteric Ligandglp1_on glp2_on
28.21Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
28.00Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
27.91Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
27.91Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
27.91Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
27.91Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
27.08Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
27.08Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
26.67Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
26.53Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
26.53Consensuspth_onOrthosteric Ligandpth1_on pth2_on
26.19Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
26.19Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
26.19Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
25.58Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
25.58Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
25.53Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
25.49Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
25.00Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
25.00Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
25.00Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
25.00Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
25.00Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
25.00Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
25.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
24.44Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
24.44Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
24.44Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
24.44Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
24.44Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
24.39Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
24.00Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
24.00Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
23.91Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
23.91Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
23.91Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
23.26Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
23.08Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
23.08Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
22.92Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
22.73Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
22.73Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
22.50Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
22.45Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
22.22Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
22.22Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
22.00Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
21.74Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
21.74Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
21.74Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
21.43Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
21.28Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
21.28Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
21.28Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.93Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.93Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
20.83Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
20.83Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
20.59Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
20.45Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
20.45Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
20.45Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
20.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
20.00Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
19.61Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
19.61Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
19.57Single6FJ3PTH6FJ3-PTH1-PTH
19.15Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
19.15Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
19.15Consensusgi_class-dOrthosteric Ligandgi_ste
19.15Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
19.05Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
18.75Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
18.75Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.75Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
18.37Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
18.37Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
17.65Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
17.50Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
17.39Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
17.07Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
17.07Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
17.07Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
17.02Consensusclass-d_onOrthosteric Ligandste2_on
17.02Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.67Single4BWBNeurotensin4BWB-NTS1-Neurotensin
16.33Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
16.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single5T04Neurotensin5T04-NTS1-Neurotensin
15.79Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
15.56Single7XNACYN1548067XNA-SST2-CYN154806
15.56Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
15.22Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
15.09Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
15.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
15.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
15.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
15.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
14.63Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
14.63Single4XEENeurotensin4XEE-NTS1-Neurotensin
14.63Single4XESNeurotensin4XES-NTS1-Neurotensin
14.63Single6IIURamatroban6IIU-TP-Ramatroban
14.63Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
14.63Single6YVRNTS8-136YVR-NTS1-NTS8-13
14.63Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
14.63Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
14.63Consensusnts_onOrthosteric Ligandnts1_on
14.58Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
14.29Single4BUONeurotensin4BUO-NTS1-Neurotensin
14.29Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
14.29Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
14.29Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
14.29Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.29Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
14.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
14.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
14.00Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
13.95Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
13.95Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.95Consensusgs_class-b2Orthosteric Ligandgs_adgr
13.73Single6IGKEndothelin-36IGK-ETB-Endothelin-3
13.73Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
13.64Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
13.64Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
13.56Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
13.51Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
13.46Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
13.33Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
13.33Consensussst_offOrthosteric Ligandsst2_off
13.21Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
13.04Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
12.82Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
12.77Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.77Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
12.50Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
12.50Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
12.50Single8GTGBMK-I1528GTG-CRF1-BMK-I152
12.50Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.50Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
12.50Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
12.24Single4XT3Fractalkine4XT3-US28-Fractalkine
12.24Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
12.24Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
12.24Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.24Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.20Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
12.20Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
12.20Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.20Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.20Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.00Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
12.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
12.00Consensusgo_class-b1Orthosteric Ligandgo_crf
12.00Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
11.90Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
11.90Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
11.90Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
11.90Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
11.90Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.90Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
11.90Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
11.90Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
11.90Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
11.90Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
11.90Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
11.76Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
11.76Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
11.76Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
11.63Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
11.63Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
11.63Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
11.63Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.63Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
11.63Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.63Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Single5GLHEndothelin-15GLH-ETB-Endothelin-1
11.54Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
11.43Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
11.36Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
11.36Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
11.36Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.36Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.36Consensusclass-d_offOrthosteric Ligandste2_off
11.36Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
11.36Consensuslpl_offOrthosteric Ligands1p_off lpa_off
11.36Consensuslpl_onOrthosteric Ligands1p_on lpa_on
11.32Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
11.11Single4XT1Fractalkine4XT1-US28-Fractalkine
11.11Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
11.11Single6LI0GTPL98046LI0-GPR52-GTPL9804
11.11Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
11.11Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
11.11Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
11.11Single7QA8Peptide7QA8-STE2-Peptide
11.11Single7QA8Peptide7QA8-STE2-Peptide
11.11Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
11.11Consensusclass-d_offOrthosteric Ligandste2_off
10.91Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
10.87Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
10.87Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
10.87Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
10.87Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
10.87Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
10.87Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.87Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
10.81Single4O9RCyclopamine4O9R-SMO-Cyclopamine
10.81Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
10.81Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
10.81Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
10.64Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
10.64Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
10.64Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
10.64Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.64Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.64Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
10.53Single4QINSAG1.54QIN-SMO-SAG1.5
10.53Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
10.53Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
10.53Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
10.53Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
10.42Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
10.42Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.42Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
10.42Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
10.42Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
10.42Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
10.42Consensusclass-d_onOrthosteric Ligandste2_on
10.42Consensusgi_class-dOrthosteric Ligandgi_ste
10.42Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.42Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
10.42Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
10.26Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
10.26Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
10.26Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.26Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.26Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
10.26Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
10.26Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.26Consensusgi_class-fOrthosteric Ligandgi_frizzled
10.26Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.26Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
10.26Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.20Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
10.20Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.20Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
10.20Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
10.20Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.20Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
10.20Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
10.00Single4Z9GCP-3763954Z9G-CRF1-CP-376395
10.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
10.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
10.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
10.00Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
10.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
10.00Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
10.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
10.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
10.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
10.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
10.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
10.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
10.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
10.00Single8GTIBMK-C2058GTI-CRF1-BMK-C205
10.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
10.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
10.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
10.00Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
9.80Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
9.80Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
9.80Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
9.76Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
9.76Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
9.76Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
9.76Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
9.76Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
9.76Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
9.76Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
9.76Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
9.76Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
9.76Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
9.76Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
9.76Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
9.76Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
9.76Consensusep_offOrthosteric Ligandep4_off
9.76Consensusffa3_on_alloOther Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
9.52Single5V56TC1145V56-SMO-TC114
9.52Single5V57TC1145V57-SMO-TC114
9.52Single5XR8AM8415XR8-CB1-AM841
9.52Single5XRAAM115425XRA-CB1-AM11542
9.52Single7EPENAM5637EPE-mGlu-NAM563
9.52Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
9.52Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
9.52Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
9.52Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
9.52Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
9.52Single8J20AR4206268J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
9.52Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.52Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.52Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
9.52Consensuslpa_offOrthosteric Ligandlpa1_off
9.52Consensuslpa_onOrthosteric Ligandlpa1_on
9.52Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
9.52Consensusrelaxin_onOrthosteric Ligandrxfp4_on
9.43Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
9.43Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
9.30Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
9.30Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
9.30Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
9.30Single6OS2TRV0266OS2-AT1-TRV026
9.30Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.30Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
9.30Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
9.30Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
9.30Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.30Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
9.30Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
9.30Single8GTMBMK-C2038GTM-CRF1-BMK-C203
9.30Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.30Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.30Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.30Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
9.30Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
9.30Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
9.30Consensusgi_class-fOther Ligandgi_frizzled
9.30Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.30Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
9.30Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
9.30Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
9.26Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
9.26Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
9.09Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
9.09Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
9.09Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
9.09Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
9.09Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
9.09Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
9.09Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
9.09Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
9.09Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
9.09Single8HS2Fab0468HS2-GPR20-Fab046
9.09Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
9.09Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
9.09Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
9.09Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
9.09Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
9.09Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
9.09Consensussteroid_onOrthosteric Ligandbileacid_on
8.93Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
8.93Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
8.93Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
8.89Single4UG2CGS216804UG2-A2A-CGS21680
8.89Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.89Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
8.89Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
8.89Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
8.89Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
8.89Single7SK9CCX6627SK9-ACKR3-CCX662
8.89Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
8.89Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.89Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.89Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
8.89Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.89Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
8.89Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.89Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
8.70Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
8.70Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
8.70Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
8.70Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
8.70Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
8.70Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
8.70Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
8.70Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
8.57Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
8.51Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
8.51Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
8.51Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
8.51Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
8.51Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.51Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
8.51Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
8.51Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.51Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.51Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
8.33Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
8.33Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
8.33Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
8.33Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
8.33Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
8.33Consensusangiotensin_onOrthosteric Ligandat1_on
8.33Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
8.33Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
8.33Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
8.33Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
8.33Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
8.16Single6JODAngiotensin II6JOD-AT2-Angiotensin II
8.16Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.16Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
8.16Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
8.16Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
8.16Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
8.16Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
8.11Single4XNWMRS25004XNW-P2Y1-MRS2500
8.11Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
8.11Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
8.11Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
8.11Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
8.11Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
8.11Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
8.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
8.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
8.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
8.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
8.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.89Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
7.89Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
7.89Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
7.89Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
7.89Consensusgo_proteinOrthosteric Ligandgo_chemokine
7.89Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
7.84Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
7.84Single7SK3CXCL127SK3-ACKR3-CXCL12
7.84Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
7.84Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
7.84Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
7.84Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
7.84Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
7.84Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
7.84Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
7.84Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
7.69Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
7.69Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
7.69Single4K5YCP-3763954K5Y-CRF1-CP-376395
7.69Single5U09Taranabant5U09-CB1-Taranabant
7.69Single5ZKQABT-4915ZKQ-PAF-ABT-491
7.69Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
7.69Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
7.69Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
7.69Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
7.69Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.69Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
7.69Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
7.69Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
7.69Single8HNNSCH5467388HNN-CXCR3-SCH546738
7.69Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
7.69Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
7.69Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
7.69Consensusclass-f_offOrthosteric Ligandsmo_off
7.69Consensusendothelin_onOrthosteric Ligandetb_on eta_on
7.69Consensusmglu_onOther Ligandmglu2_on mglu4_on
7.69Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
7.55Single6IGLIRL16206IGL-ETB-IRL1620
7.55Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
7.55Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
7.55Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
7.55Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.55Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
7.50Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
7.50Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
7.50Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
7.50Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
7.50Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
7.50Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
7.50Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.50Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
7.50Single7VV6C48/807VV6-MRGPRX2-C48/80
7.50Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
7.50Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
7.50Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
7.50Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
7.50Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
7.50Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
7.50Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
7.50Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
7.50Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.50Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
7.50Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
7.50Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
7.50Consensusgnrh_offOrthosteric Ligandgnrh1_off
7.32Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
7.32Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
7.32Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
7.32Single6IIVDaltroban6IIV-TP-Daltroban
7.32Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
7.32Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
7.32Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.32Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
7.32Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
7.32Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
7.32Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
7.32Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
7.32Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.32Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
7.32Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
7.32Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
7.32Consensushcar_offOrthosteric Ligandsuccinate_off
7.32Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
7.32Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
7.32Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
7.32Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
7.32Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
7.14Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
7.14Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
7.14Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
7.14Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.14Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
7.14Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
7.14Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
7.14Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
7.14Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
7.14Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
7.14Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.14Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
7.14Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
7.14Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
7.14Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
7.14Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
6.98Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
6.98Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
6.98Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
6.98Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
6.98Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
6.98Single6OS1TRV0266OS1-AT1-TRV026
6.98Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
6.98Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
6.98Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
6.98Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
6.98Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
6.98Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
6.98Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
6.98Single7TUYGSK682753A7TUY-GPR183-GSK682753A
6.98Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
6.98Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
6.98Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.98Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
6.98Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
6.98Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
6.98Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
6.98Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.98Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
6.98Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
6.98Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
6.98Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
6.98Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.98Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
6.98Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
6.98Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
6.98Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.98Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
6.98Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
6.98Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
6.98Consensusadenosine_offOrthosteric Liganda1_off a2_off
6.98Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
6.98Consensuscck_onOrthosteric Ligandccka_on cckb_on
6.98Consensuschemerin_onOrthosteric Ligandcml1_on
6.98Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
6.98Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
6.98Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.98Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
6.98Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
6.98Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
6.98Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
6.82Single4N4WSANT-14N4W-SMO-SANT-1
6.82Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
6.82Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
6.82Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
6.82Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
6.82Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
6.82Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
6.82Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
6.82Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
6.82Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.82Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
6.82Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
6.82Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
6.82Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
6.82Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.82Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
6.82Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
6.82Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.82Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
6.82Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.82Single8WU1KCA8WU1-CB1-KCA-Arrestin1
6.82Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
6.82Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
6.82Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
6.82Consensusclass-b2_onOrthosteric Ligandadgrg_on
6.82Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
6.82Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
6.82Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
6.82Consensusgs_steroidOrthosteric Ligandgs_bileacid
6.67Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
6.67Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
6.67Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
6.67Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
6.67Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
6.67Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
6.67Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
6.67Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
6.67Single7UM4AS26747237UM4-5-HT5A-AS2674723
6.67Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
6.67Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
6.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
6.67Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
6.67Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
6.67Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
6.67Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.67Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
6.67Consensuscyslt_offOrthosteric Ligandcyslt2_off
6.67Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.67Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
6.52Single3NY9PubChem 9131033NY9-β2-PubChem 913103
6.52Single5EE7MK08935EE7-Glucagon-MK0893
6.52Single5WF6UK-4320975WF6-A2A-UK-432097
6.52Single5ZTYAM102575ZTY-CB2-AM10257
6.52Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
6.52Single6KNMJN241-96KNM-Apelin-JN241-9
6.52Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
6.52Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
6.52Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.52Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.52Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
6.52Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
6.52Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.52Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
6.52Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
6.52Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
6.52Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
6.52Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
6.52Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
6.52Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.52Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
6.52Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
6.52Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
6.52Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
6.52Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
6.52Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
6.38Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
6.38Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
6.38Single7F8XNN90567F8X-CCKA-NN9056
6.38Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
6.38Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
6.38Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
6.38Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
6.38Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
6.38Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
6.38Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
6.38Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
6.38Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.38Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
6.38Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
6.38Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
6.38Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
6.38Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
6.38Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
6.38Consensussst_onOrthosteric Ligandsst2_on sst4_on
6.25Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
6.25Single6HLOAprepitant6HLO-NK1-Aprepitant
6.25Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
6.25Single7SK5CXCL127SK5-ACKR3-CXCL12
6.25Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
6.25Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
6.25Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
6.12Single6W25SHU91196W25-MC4-SHU9119-Ca
6.12Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
6.12Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
6.12Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.12Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
6.12Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
6.12Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
6.12Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
6.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
6.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
6.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
6.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
6.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
6.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
6.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
6.00Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.00Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
5.88Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
5.88Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
5.88Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
5.88Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
5.88Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
5.88Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.77Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.77Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
5.56Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
5.56Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
5.56Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.56Consensusclass-c_onOther Ligandgabab_on mglu_on
5.41Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
5.41Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
5.41Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
5.26Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
5.26Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.26Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.26Single6ME5Agomelatine6ME5-MT1-Agomelatine
5.26Single6ME9Ramelteon6ME9-MT2-Ramelteon
5.26Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.26Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
5.26Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
5.26Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
5.13Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
5.13Single5L7IVismodegib5L7I-SMO-Vismodegib
5.13Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
5.13Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
5.13Single7UL2SR486927UL2-NTS1-SR48692-Na
5.13Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.13Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
5.13Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
5.13Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
5.13Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
5.13Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
5.13Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
5.13Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
5.13Single8K5BNiacin8K5B-HCA2-Niacin
5.13Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.13Consensusclass-t_onOrthosteric Ligandtaste2_on
5.13Consensusgs_class-tOrthosteric Ligandgs_taste
5.13Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.13Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
5.13Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
5.13Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
5.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
5.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
5.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
5.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
5.00Single3PWHZM2413853PWH-A2A-ZM241385
5.00Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
5.00Single5K2DZM2413855K2D-A2A-ZM241385
5.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
5.00Single6AKXA4R6AKX-CCR5-A4R
5.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
5.00Single6JZHZM2413856JZH-A2A-ZM241385-Na
5.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
5.00Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.00Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.00Single6PS7ZM2413856PS7-A2A-ZM241385-Na
5.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
5.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
5.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
5.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
5.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
5.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
5.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
5.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
5.00Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
5.00Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
5.00Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
5.00Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Consensusgt_class-aOrthosteric Ligandgt_opsin
5.00Consensusgt_opsinOrthosteric Ligandgt_sensory
5.00Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.00Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.00Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
5.00Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
4.88Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
4.88Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
4.88Single4MBSMaraviroc4MBS-CCR5-Maraviroc
4.88Single5IU4ZM2413855IU4-A2A-ZM241385-Na
4.88Single5IU7Q274563465IU7-A2A-Q27456346-Na
4.88Single5IUBQ274563445IUB-A2A-Q27456344-Na
4.88Single5JTBZM2413855JTB-A2A-ZM241385
4.88Single5K2BZM2413855K2B-A2A-ZM241385-Na
4.88Single5K2CZM2413855K2C-A2A-ZM241385-Na
4.88Single5NLXZM2413855NLX-A2A-ZM241385-Na
4.88Single5NM4ZM2413855NM4-A2A-ZM241385-Na
4.88Single5UVIZM2413855UVI-A2A-ZM241385
4.88Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
4.88Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
4.88Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
4.88Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
4.88Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
4.88Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
4.88Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
4.88Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.88Single7T32ZM2413857T32-A2A-ZM241385
4.88Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
4.88Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
4.88Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
4.88Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
4.88Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
4.88Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.88Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
4.88Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.88Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
4.88Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
4.88Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
4.88Single8K2WAMG4878K2W-CXCR3-AMG487
4.88Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
4.88Single8K5CAcipimox8K5C-HCA2-Acipimox
4.88Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
4.88Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.88Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
4.88Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
4.88Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
4.88Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
4.88Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
4.88Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
4.88Consensuss1p_offOrthosteric Ligands1p1_off
4.88Consensussensory_offOrthosteric Ligandopsin_off
4.76Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
4.76Single3EMLZM2413853EML-A2A-ZM241385
4.76Single4EIYZM2413854EIY-A2A-ZM241385-Na
4.76Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
4.76Single4YAYZD-71554YAY-AT1-ZD-7155
4.76Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
4.76Single5IU8Q274563475IU8-A2A-Q27456347-Na
4.76Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
4.76Single5K2AZM2413855K2A-A2A-ZM241385-Na
4.76Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
4.76Single5OLGZM2413855OLG-A2A-ZM241385-Na
4.76Single5TGZAM65385TGZ-CB1-AM6538
4.76Single5UENDU1725UEN-A1-DU172
4.76Single5VRAZM2413855VRA-A2A-ZM241385-Na
4.76Single6GPSMK08126GPS-CCR2-MK0812
4.76Single6LPJZM2413856LPJ-A2A-ZM241385-Na
4.76Single6LPKZM2413856LPK-A2A-ZM241385-Na
4.76Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
4.76Single6S0LZM2413856S0L-A2A-ZM241385
4.76Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
4.76Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
4.76Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
4.76Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
4.76Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
4.76Single7PYRPSB-21157PYR-A2A-PSB-2115
4.76Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
4.76Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
4.76Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
4.76Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
4.76Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
4.76Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
4.76Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
4.76Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
4.76Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.76Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
4.76Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
4.76Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
4.76Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
4.76Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
4.76Single8K5DGSK2560738K5D-HCA2-GSK256073
4.76Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
4.76Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
4.76Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
4.76Consensusa2_offOrthosteric Liganda2a_off
4.76Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
4.76Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
4.76Consensusblt_onOrthosteric Ligandblt1_on
4.76Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
4.76Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.76Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
4.76Consensusgi_hcarOrthosteric Ligandgi_hca
4.76Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
4.76Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
4.76Consensusleuko_onOrthosteric Ligandblt_on
4.76Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
4.76Consensustar_onOrthosteric Ligandta1_on
4.65Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
4.65Single5C1MBU725C1M-μ-BU72
4.65Single5CGCHTL142425CGC-mGlu5-HTL14242
4.65Single5IUAQ274563485IUA-A2A-Q27456348-Na
4.65Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
4.65Single5N2SPSB365N2S-A1-PSB36
4.65Single5NM2ZM2413855NM2-A2A-ZM241385-Na
4.65Single5TVNLSD5TVN-5-HT2B-LSD
4.65Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
4.65Single6GPXMK08126GPX-CCR2-MK0812
4.65Single6LPLZM2413856LPL-A2A-ZM241385-Na
4.65Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
4.65Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
4.65Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
4.65Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
4.65Single6S0QZM2413856S0Q-A2A-ZM241385
4.65Single6WQAZM2413856WQA-A2A-ZM241385-Na
4.65Single7C4SS1P7C4S-S1P3-S1P
4.65Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
4.65Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
4.65Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
4.65Single7RM5ZM2413857RM5-A2A-ZM241385-Na
4.65Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
4.65Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
4.65Single7YXAONO-54306087YXA-S1P5-ONO-5430608
4.65Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
4.65Single8FYNZM2413858FYN-A2A-ZM241385-Na
4.65Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
4.65Single8GNEKW-63568GNE-A2A-KW-6356-Na
4.65Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
4.65Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
4.65Single8QOTNanobody E8QOT-μ-Nanobody E
4.65Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.65Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.65Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
4.65Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
4.65Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
4.65Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
4.65Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
4.65Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single2YDVNECA2YDV-A2A-NECA
4.55Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
4.55Single4UHRCGS216804UHR-A2A-CGS21680
4.55Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
4.55Single5G53NECA5G53-A2A-NECA-Gs
4.55Single5V54Methiothepin5V54-5-HT1B-Methiothepin
4.55Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
4.55Single6J21Aprepitant6J21-NK1-Aprepitant
4.55Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
4.55Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.55Single6WGTLSD6WGT-5-HT2A-LSD
4.55Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
4.55Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
4.55Single7F1TMIP-1a7F1T-CCR5-MIP-1a
4.55Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
4.55Single7P2L4YI7P2L-mGlu5-4YI
4.55Single7PX4PSB-21137PX4-A2A-PSB-2113
4.55Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
4.55Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
4.55Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
4.55Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
4.55Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
4.55Single8E0GBU728E0G-μ-BU72
4.55Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
4.55Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.55Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
4.55Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
4.55Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
4.55Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
4.55Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
4.55Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
4.55Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
4.55Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.55Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
4.55Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
4.55Consensus5ht1_offOrthosteric Ligand5ht1b_off
4.55Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
4.55Consensus5ht5_offOrthosteric Ligand5ht5a_off
4.55Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
4.55Consensusa2_onOrthosteric Liganda2a_on a2b_on
4.55Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
4.55Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
4.55Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
4.55Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
4.55Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
4.55Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
4.55Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
4.55Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
4.44Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
4.44Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
4.44Single4PY02MeSATP4PY0-P2Y12-2MeSATP
4.44Single5CXVTiotropium5CXV-M1-Tiotropium
4.44Single5X33BIIL2605X33-BLT1-BIIL260
4.44Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
4.44Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
4.44Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
4.44Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
4.44Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
4.44Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
4.44Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
4.44Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
4.44Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
4.44Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
4.44Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
4.44Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
4.44Single8JWZAB9288JWZ-A2A-AB928-Na
4.44Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
4.44Single8TB7PubChem 1685102188TB7-GPR61-PubChem 168510218
4.44Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
4.44Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
4.44Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
4.44Consensuschemokine_offOrthosteric Ligandcxcr_off
4.44Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
4.44Consensuscxcr_offOrthosteric Ligandcxcr4_off
4.44Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
4.44Consensusdp_offOrthosteric Liganddp2_off
4.44Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
4.44Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
4.44Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
4.44Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
4.35Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
4.35Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
4.35Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
4.35Single5CGDHTL142425CGD-mGlu5-HTL14242
4.35Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
4.35Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
4.35Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
4.35Single6K1QIRL25006K1Q-ETB-IRL2500
4.35Single7EZCUKA7EZC-A2A-UKA
4.35Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
4.35Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
4.35Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
4.35Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
4.35Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
4.35Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
4.35Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
4.35Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
4.35Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
4.35Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
4.35Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
4.35Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.35Consensusorexin_onOrthosteric Ligandox2_on
4.26Single6PT3DPI-2876PT3-δ-DPI-287
4.26Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.26Single7XN9L-054,5227XN9-SST2-L-054,522
4.26Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
4.26Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
4.26Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
4.26Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
4.26Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
4.26Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
4.17Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
4.17Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
4.17Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
4.17Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.17Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
4.17Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
4.08Single3QAKUK-4320973QAK-A2A-UK-432097
4.08Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
4.08Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.08Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
4.08Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
4.08Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
4.08Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
4.00Single3OE0CVX153OE0-CXCR4-CVX15
4.00Single5WF5UK-4320975WF5-A2A-UK-432097
4.00Single6PT2KGCHM076PT2-δ-KGCHM07
4.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
4.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
4.00Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
3.92Single7C61Ergotamine7C61-5-HT1B-Ergotamine
3.85Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.03Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
3.03Single6D35Cholesterol6D35-SMO-Cholesterol
3.03Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.03Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.03Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
3.03Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
3.03Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
3.03Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.03Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.03Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
3.03Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
3.03Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
3.03Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.03Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.03Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.03Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.03Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
3.03Single7DTTCa7DTT-CaS-Ca-Ca
3.03Single7DTTCa7DTT-CaS-Ca-Ca
3.03Single7DTUTryptophan7DTU-CaS-Tryptophan
3.03Single7DTUTryptophan7DTU-CaS-Tryptophan
3.03Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.03Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.03Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.03Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.03Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.03Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.03Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.03Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.03Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.03Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.03Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
3.03Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
3.03Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
3.03Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.03Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.03Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.03Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.03Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.03Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.03Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
3.03Single7FIIhCG7FII-LH-hCG-6fuf
3.03Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
3.03Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
3.03Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.03Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.03Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.03Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.03Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.03Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.03Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.03Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.03Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.03Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.03Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
3.03Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
3.03Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.03Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.03Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.03Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.03Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.03Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.03Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.03Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.03Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
3.03Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.03Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.03Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.03Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.03Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.03Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.03Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
3.03Single7XW7K1-707XW7-TSH-K1-70
3.03Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.03Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.03Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.03Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.03Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.03Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.03Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.03Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.03Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.03Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.03Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.03Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.03Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
3.03Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.03Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.03Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.03Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.03Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
3.03Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
3.03Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.03Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.03Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.03Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.03Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.03Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.03Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.03Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.03Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.03Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
3.03Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
3.03Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
3.03Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
3.03Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.03Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.03Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.03Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.03Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.03Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.03Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.03Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.03Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.03Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.03Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.03Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.03Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.03Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.03Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.03Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.03Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
3.03Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
3.03Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
3.03Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
3.03Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
3.03Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
3.03Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
3.03Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
3.03Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
3.03Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
3.03Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
3.03Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
3.03Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.03Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.03Consensusgphr_onOrthosteric Ligandlh_on tsh_on
3.03Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
3.03Consensusgs_proteinOrthosteric Ligandgs_gphr
3.03Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
3.03Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
3.03Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
3.03Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
3.03Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.03Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.03Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
3.03Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
3.03Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.03Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.03Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
3.03Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
3.03Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
3.03Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
3.03Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
3.03Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
3.03Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
3.03Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
3.03Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
2.94Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
2.94Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
2.94Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
2.94Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
2.94Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
2.94Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
2.94Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
2.94Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
2.94Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
2.94Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
2.86Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
2.86Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
2.78Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
2.78Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
2.78Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
2.78Single6W25Ca6W25-MC4-SHU9119-Ca
2.78Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
2.78Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
2.78Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
2.78Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
2.78Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
2.78Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.78Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
2.78Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
2.70Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
2.70Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
2.70Single5L7DCholesterol5L7D-SMO-Cholesterol
2.70Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
2.70Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
2.70Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
2.70Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
2.70Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
2.70Single8PWNTheophylline8PWN-A2A-Theophylline
2.70Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
2.70Consensusglp1_on_alloOther Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
2.63Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
2.63Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
2.63Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
2.63Single6TQ9SB-4081246TQ9-OX1-SB-408124
2.63Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
2.63Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
2.63Single8A2OTheophylline8A2O-A2A-Theophylline-Na
2.63Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
2.63Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
2.63Consensussensory_onOrthosteric Ligandopsin_on
2.56Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
2.56Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
2.56Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
2.56Single3OE6IT1t3OE6-CXCR4-IT1t
2.56Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
2.56Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
2.56Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
2.56Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
2.56Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
2.56Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.56Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
2.56Single8GGREpinephrine8GGR-β2-Epinephrine
2.56Single8GGZEpinephrine8GGZ-β2-Epinephrine
2.56Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
2.56Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
2.56Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
2.56Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
2.56Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
2.56Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
2.56Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
2.56Single8WG8Peptide8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/&β;1/&γ;2
2.56Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
2.56Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
2.50Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
2.50Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
2.50Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
2.50Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
2.50Single3OE9IT1t3OE9-CXCR4-IT1t
2.50Single3PBLEticlopride3PBL-D3-Eticlopride
2.50Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
2.50Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
2.50Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
2.50Single6HLLCP999946HLL-NK1-CP99994
2.50Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
2.50Single6TP4ACT-4622066TP4-OX1-ACT-462206
2.50Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
2.50Single7CA3rac-BHFF7CA3-GABAB1, GABAB2-rac-BHFF
2.50Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
2.50Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
2.50Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
2.50Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
2.50Single7LD3PubChem 252636037LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
2.50Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.50Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
2.50Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
2.50Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
2.50Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
2.50Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
2.50Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.50Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
2.50Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
2.50Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.50Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.50Single8GGSEpinephrine8GGS-β2-Epinephrine
2.50Single8GGYEpinephrine8GGY-β2-Epinephrine
2.50Single8GH1Epinephrine8GH1-β2-Epinephrine
2.50Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
2.50Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
2.50Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
2.50Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
2.50Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
2.50Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.50Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.50Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
2.50Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
2.50Consensusa1_on_alloOther Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
2.50Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
2.50Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
2.50Consensusgo_class-b2Orthosteric Ligandgo_adhesion
2.50Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
2.50Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
2.50Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
2.50Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
2.44Single3ODUIT1t3ODU-CXCR4-IT1t
2.44Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
2.44Single4XNVBPTU4XNV-P2Y1-BPTU
2.44Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
2.44Single5WS3EMPA5WS3-OX2-EMPA
2.44Single6B73PubChem 1319551386B73-κ-PubChem 131955138
2.44Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
2.44Single6KUXRS-799486KUX-α2a-RS-79948
2.44Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
2.44Single6TODEMPA6TOD-OX1-EMPA-Na
2.44Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
2.44Single7C7QPubChem 70238487C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
2.44Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
2.44Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
2.44Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
2.44Single7F8ULintitript7F8U-CCKA-Lintitript
2.44Single7F8YDevazepide7F8Y-CCKA-Devazepide
2.44Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
2.44Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
2.44Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
2.44Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
2.44Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
2.44Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
2.44Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
2.44Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
2.44Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
2.44Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
2.44Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
2.44Single7XRRLemborexant7XRR-OX2-Lemborexant
2.44Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
2.44Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
2.44Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
2.44Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
2.44Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
2.44Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
2.44Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.44Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
2.44Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
2.44Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
2.44Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
2.44Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
2.44Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.44Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.44Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.44Single8GGVEpinephrine8GGV-β2-Epinephrine
2.44Single8GGWEpinephrine8GGW-β2-Epinephrine
2.44Single8GGXEpinephrine8GGX-β2-Epinephrine
2.44Single8GH0Epinephrine8GH0-β2-Epinephrine
2.44Single8GNGIstradefylline8GNG-A2A-Istradefylline
2.44Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
2.44Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
2.44Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
2.44Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
2.44Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.44Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.44Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.44Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.44Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.44Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.44Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
2.44Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
2.44Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
2.44Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
2.44Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
2.44Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
2.44Consensusalpha1_onOrthosteric Ligandalpha1a_on
2.44Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.44Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
2.44Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
2.44Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
2.44Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
2.44Consensusnts1_on_alloOther Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
2.44Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
2.44Consensusorexin_offOrthosteric Ligandox2_off ox1_off
2.38Single2YDOAdenosine2YDO-A2A-Adenosine
2.38Single3REYPubChem 56973REY-A2A-PubChem 5697
2.38Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
2.38Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
2.38Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
2.38Single4ZJCSB-6740424ZJC-OX1-SB-674042
2.38Single6A94Zotepine6A94-5-HT2A-Zotepine
2.38Single6AQFZM2413856AQF-A2A-ZM241385
2.38Single6FFIMMPEP6FFI-mGlu5-MMPEP
2.38Single6MH8ZM2413856MH8-A2A-ZM241385
2.38Single6PS4ICI 118-5516PS4-β2-ICI 118-551
2.38Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
2.38Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
2.38Single6TPGEMPA6TPG-OX2-EMPA
2.38Single6TPNHTL66416TPN-OX2-HTL6641
2.38Single6VI4JDTic6VI4-κ-JDTic
2.38Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
2.38Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
2.38Single7AROLUF58337ARO-A2A-LUF5833-Na
2.38Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
2.38Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
2.38Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
2.38Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
2.38Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
2.38Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
2.38Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
2.38Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.38Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
2.38Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
2.38Single7VODCariprazine7VOD-5-HT2A-Cariprazine
2.38Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
2.38Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
2.38Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.38Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
2.38Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
2.38Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
2.38Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
2.38Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
2.38Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
2.38Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
2.38Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
2.38Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.38Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.38Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.38Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.38Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.38Single8GGIEpinephrine8GGI-β2-Epinephrine
2.38Single8GGKEpinephrine8GGK-β2-Epinephrine
2.38Single8GGLEpinephrine8GGL-β2-Epinephrine
2.38Single8GGMEpinephrine8GGM-β2-Epinephrine
2.38Single8GGPEpinephrine8GGP-β2-Epinephrine
2.38Single8GGQEpinephrine8GGQ-β2-Epinephrine
2.38Single8GGTEpinephrine8GGT-β2-Epinephrine
2.38Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
2.38Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
2.38Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
2.38Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
2.38Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.38Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.38Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
2.38Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.38Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.38Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.38Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.38Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.38Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
2.38Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
2.38Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
2.38Consensus5ht5_onOrthosteric Ligand5ht5a_on
2.38Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
2.38Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
2.38Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
2.38Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
2.38Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
2.38Consensushca_onOrthosteric Ligandhca2_on hca3_on
2.38Consensushcar_onOrthosteric Ligandhca_on
2.38Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
2.38Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
2.38Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
2.33Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
2.33Single2Y01Dobutamine2Y01-β1-Dobutamine
2.33Single2Y02Carmoterol2Y02-β1-Carmoterol
2.33Single2Y04Salbutamol2Y04-β1-Salbutamol
2.33Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
2.33Single3NY8ICI 118-5513NY8-β2-ICI 118-551
2.33Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
2.33Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
2.33Single4DAJTiotropium4DAJ-M3-Tiotropium
2.33Single4EJ4Naltrindole4EJ4-δ-Naltrindole
2.33Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
2.33Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
2.33Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
2.33Single5DSGTiotropium5DSG-M4-Tiotropium
2.33Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
2.33Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
2.33Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
2.33Single6D27CAY104716D27-DP2-CAY10471
2.33Single6FFHFenobam6FFH-mGlu5-Fenobam
2.33Single6H7MSalbutamol6H7M-β1-Salbutamol
2.33Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
2.33Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
2.33Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
2.33Single6TOTLemborexant6TOT-OX1-Lemborexant
2.33Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
2.33Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
2.33Single7BU7BI1671077BU7-β1-BI167107
2.33Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
2.33Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
2.33Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
2.33Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
2.33Single7RBTPubChem 1631837747RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
2.33Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
2.33Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
2.33Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
2.33Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
2.33Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
2.33Single7UL4Alvimopan7UL4-μ-Alvimopan
2.33Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
2.33Single7WC7Lisuride7WC7-5-HT2A-Lisuride
2.33Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
2.33Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
2.33Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
2.33Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
2.33Single8CU6LJ-45178CU6-A2A-LJ-4517
2.33Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
2.33Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
2.33Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
2.33Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
2.33Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
2.33Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
2.33Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
2.33Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
2.33Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.33Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.33Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.33Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.33Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.33Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.33Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.33Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.33Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.33Single8GGJEpinephrine8GGJ-β2-Epinephrine
2.33Single8GGNEpinephrine8GGN-β2-Epinephrine
2.33Single8GGOEpinephrine8GGO-β2-Epinephrine
2.33Single8GGUEpinephrine8GGU-β2-Epinephrine
2.33Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
2.33Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
2.33Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
2.33Single8JPFPubChem 1186104278JPF-NTS1-Neurotensin-PubChem 118610427
2.33Single8JR9PCO3718JR9-PTH1-PCO371-chim(NtGi1-Gs)/&β;1/&γ;2
2.33Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
2.33Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
2.33Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.33Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.33Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.33Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
2.33Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
2.33Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
2.33Single8X64Desloratadine8X64-H1-Desloratadine
2.33Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
2.33Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
2.33Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
2.33Consensusadenosine_onOrthosteric Liganda1_on a2_on
2.33Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
2.33Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
2.33Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
2.33Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
2.33Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
2.33Consensuscck_offOrthosteric Ligandccka_off
2.33Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
2.33Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
2.33Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
2.33Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
2.33Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
2.33Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
2.33Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
2.33Consensusnucleotide_onOrthosteric Ligandadenosine_on
2.33Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
2.27Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
2.27Single2Y00Dobutamine2Y00-β1-Dobutamine
2.27Single2Y03Isoprenaline2Y03-β1-Isoprenaline
2.27Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
2.27Single4NTJAZD12834NTJ-P2Y12-AZD1283
2.27Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
2.27Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
2.27Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
2.27Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
2.27Single5WIUNemonapride5WIU-D4-Nemonapride
2.27Single5WIVNemonapride5WIV-D4-Nemonapride-Na
2.27Single5WQCEMPA5WQC-OX2-EMPA
2.27Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
2.27Single5XPRBosentan5XPR-ETB-Bosentan
2.27Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
2.27Single6D26Fevipiprant6D26-DP2-Fevipiprant
2.27Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
2.27Single6E67BI1671076E67-β2-BI167107-Gs (fused)
2.27Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
2.27Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
2.27Single6LUQHaloperidol6LUQ-D2-Haloperidol
2.27Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
2.27Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
2.27Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
2.27Single6PS6Timolol6PS6-β2-Timolol
2.27Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
2.27Single6TP6Filorexant6TP6-OX1-Filorexant
2.27Single6Z4SSR486926Z4S-NTS1-SR48692
2.27Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
2.27Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
2.27Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
2.27Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
2.27Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
2.27Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
2.27Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
2.27Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
2.27Single7SINNPS-21437SIN-CaS-NPS-2143
2.27Single7SINNPS-21437SIN-CaS-NPS-2143
2.27Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
2.27Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
2.27Single7WC6LSD7WC6-5-HT2A-LSD
2.27Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
2.27Single7XKAEpinephrine7XKA-β2-Epinephrine
2.27Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.27Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.27Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
2.27Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
2.27Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.27Single8EA0Iperoxo8EA0-M3-Iperoxo
2.27Single8FN0PubChem 1186104278FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
2.27Single8GW8KHF8GW8-PTH1-KHF-Gs/&β;1/&γ;2
2.27Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
2.27Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
2.27Single8JPCPubChem 118610427; GDP; Mg8JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
2.27Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
2.27Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
2.27Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
2.27Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
2.27Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
2.27Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
2.27Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
2.27Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
2.27Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
2.27Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
2.27Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
2.27Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
2.27Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
2.27Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
2.27Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
2.27Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
2.27Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
2.27Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
2.27Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
2.27Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.27Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
2.27Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
2.22Single3P0GBI1671073P0G-β2-BI167107
2.22Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
2.22Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
2.22Single4DJHJDTic4DJH-κ-JDTic
2.22Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
2.22Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
2.22Single4RWADIPP-NH24RWA-δ-DIPP-NH2
2.22Single4U15Tiotropium4U15-M3-Tiotropium
2.22Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
2.22Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
2.22Single5TZR-5TZR-FFA1 (GPR40)-MK8666
2.22Single5X93K-87945X93-ETB-K-8794
2.22Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
2.22Single6H7JIsoprenaline6H7J-β1-Isoprenaline
2.22Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
2.22Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
2.22Single6OL9Tiotropium6OL9-M5-Tiotropium
2.22Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
2.22Single7B6WCyclazosin7B6W-α1b-Cyclazosin
2.22Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
2.22Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
2.22Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
2.22Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
2.22Single7W41PD1762527W41-BB2-PD176252
2.22Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
2.22Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
2.22Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
2.22Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
2.22Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
2.22Single8JPBPubChem 118610427; GDP; Mg8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
2.22Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
2.22Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
2.22Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
2.22Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
2.22Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
2.22Consensusbombesin_offOrthosteric Ligandbb2_off
2.22Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
2.22Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
2.22Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
2.22Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
2.22Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
2.22Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
2.22Consensushistamine_offOrthosteric Ligandh1_off
2.22Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
2.22Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
2.22Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
2.22Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
2.22Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
2.17Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
2.17Single4AMIBucindolol4AMI-β1-Bucindolol
2.17Single4LDEBI1671074LDE-β2-BI167107
2.17Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
2.17Single6CM4Risperidone6CM4-D2-Risperidone
2.17Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
2.17Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
2.17Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
2.17Single6HLPNetupitant6HLP-NK1-Netupitant
2.17Single6MXTSalmeterol6MXT-β2-Salmeterol
2.17Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
2.17Single7DFPSpiperone7DFP-D2-Spiperone
2.17Single7K15MKD0467K15-BLT1-MKD046-Na
2.17Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.17Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
2.17Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.17Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
2.17Single7YITNalfurafine7YIT-κ-Nalfurafine
2.17Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.17Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
2.17Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
2.17Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
2.17Single8JJ8Formoterol8JJ8-β2-Formoterol
2.17Single8JJLOlodaterol8JJL-β2-Olodaterol
2.17Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
2.17Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
2.17Consensusblt_offOrthosteric Ligandblt1_off
2.17Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
2.17Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
2.17Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
2.17Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
2.17Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
2.17Consensusnts_offOrthosteric Ligandnts1_off
2.13Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
2.13Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
2.13Single6H7LDobutamine6H7L-β1-Dobutamine
2.13Single6IBLArformoterol6IBL-β1-Arformoterol
2.13Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
2.13Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
2.13Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
2.13Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
2.13Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.13Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
2.13Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.13Consensusendothelin_offOrthosteric Ligandetb_off
2.13Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
2.13Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.08Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.08Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.08Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
2.08Single8X5YAstemizole8X5Y-H1-Astemizole
2.08Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
2.04Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
2.04Single4IARErgotamine4IAR-5-HT1B-Ergotamine
2.04Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
2.00Single7SHEPI; PE7SHE-GPR158-PI; PE
2.00Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
1.92Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2

Consensus Members
Id Members
7TYN 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
6NIY 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
8F0J 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
7TYL 7TYL-CT-Amylin-Gs/&β;1/&γ;2
8F0K 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
Net Summary
Imin 3.034
Number of Linked Nodes 867
Number of Links 1072
Number of Hubs 163
Number of Links mediated by Hubs 666
Number of Communities 20
Number of Nodes involved in Communities 250
Number of Links involved in Communities 374
Path Summary
Number Of Nodes in MetaPath 91
Number Of Links MetaPath 90
Number of Shortest Paths 1696900
Length Of Smallest Path 3
Average Path Length 36.6693
Length of Longest Path 69
Minimum Path Strength 0.602
Average Path Strength 6.65009
Maximum Path Strength 57.908
Minimum Path Correlation 0.708
Average Path Correlation 0.973117
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.51515
Average % Of Corr. Nodes 37.6957
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.0612
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gs_calcitonings_ct
gs_cgrp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gs_ct.zip



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