Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.S1.04 4.365457
2G.S1.05 4.525409
3G.S1.07 3.732519
4G.S2.06 6.59509
5G.S2.08 7.03405
6G.S3.02 11.0825414
7G.S3.03 6.654507
8G.S3.04 5.798516
9G.S3.05 4.674557
10G.S3.06 8.125415
11G.H2.04 4.6275419
12G.H2.06 3.76667619
13G.H2.07 5.62667619
14G.H2.08 4.216518
15G.h2s4.01 5.67419
16G.S4.03 3.914557
17G.S4.04 6.462519
18G.S4.06 4.325417
19G.s4h3.04 5.6256178
20G.H3.09 6.06519
21G.H3.13 3.72515
22G.H3.17 3.84415
23G.H3.18 4.532519
24G.S5.03 3.29458
25G.S5.05 3.69659
26G.S5.06 3.34167618
27G.HG.01 4.16415
28G.HG.04 7.5675409
29G.hgh4.01 3.5625406
30G.hgh4.02 4.558517
31G.hgh4.05 10.185417
32G.H4.03 5.242514
33G.H4.10 6.15416
34G.H4.11 3.675407
35G.H4.15 4.028518
36G.S6.02 4.53833657
37G.S6.05 3.82414
38G.H5.06 6.485453
39G.H5.08 3.6025408
40G.H5.25 3.67527
41G.H5.26 4.3225405
42g.h2x1 2.5475408
43g.h2x11 7.4554126
44g.ctx3 8.022519
45g.ctx14 4.83254149
46g.ctx16 3.94758148
47NT 161.3681626
481x39 4.0175427
491x53 6.7554158
501x57 4.38254159
512x38 7.13469
522x42 5.1568
532x45 7.53468
542x50 3.036509
552x57 6.455627
562x60 5.5125429
572x61 5.298528
58E1 31.56461126
593x29 7.426529
603x33 5.14529
613x34 5.3675408
623x37 4.72428
633x42 9.25714769
643x43 4.83529
653x50 7.56833629
663x54 5.43529
67I2 5.840771327
684x45 6.9469
694x46 6.9525469
704x49 7.745469
714x50 6.918569
724x52 1.85405
73E2 14.87471727
74E2x51 7.482528
755x40 6.1475429
765x54 1.9025408
776x47 3.7375407
786x50 1.77405
796x55 7.24833627
806x59 5.446526
816x65 12.08529
82E3 11.69361125
837x32 5.75425
847x36 9.9825427
857x43 6.0025409
867x52 9.11143729
877x53 5.4654158
88Lig 10.0541020
89Allo1 7.8451420
90b.lhb1x3 3.8854102
91b.lhb1x11 4.976514
92b.b1x6 7.618599
93b.l1x3 6.26699
94b.b2x1 7.49518
95b.b2x5 6.45333607
96b.b3x2 6.4475495
97b.l3x1 5.16519
98b.b4x2 6.4675408
99b.b4x3 4.715407
100b.b4x4 6.12498
101b.b4x5 3.4945117
102b.b4x6 7.14375899
103b.b4x7 6.04754168
104b.l4x2 10.0154144
105b.b5x2 4.8625167
106b.b5x3 5.958599
107b.b5x5 4.32754115
108b.b5x7 8.78407
109b.l5x1 4.0225408
110b.l5x5 6.57833619
111b.b6x5 3.834297116
112b.l6x5 5.1554204
113b.b7x2 3.264118
114b.b7x4 3.9625408
115b.l7x2 3.35419
116b.l7x5 4.64754136
117b.b8x4 6.4725406
118b.b9x3 4.614136
119b.l9x3 5.7849
120b.l9x6 3.6625818
121b.l9x7 4.2975447
122b.b10x3 4.6525448
123b.b10x5 4.03333649
124b.l10x1 3.185403
125b.b11x2 4.7525447
126b.b11x4 5.385649
127b.b11x5 4.005486
128b.b11x6 7.8025449
129b.l11x2 7.4825449
130b.b12x2 4.8375447
131b.b12x3 3.8588
132b.b12x6 9.55667648
133b.b13x7 5.91167687
134b.l13x3 8.75489
135b.l13x6 3.1075419
136b.l13x7 5.256589
137b.b14x1 4.2975418
138b.b14x3 5.2485
139b.b15x1 5.93333689
140b.b15x2 5.9475436
141b.b15x3 4.606589
142b.l15x1 4.486517
143b.b16x5 4.6925435
144b.b16x6 6.83333688
145b.l16x1 3.4525404
146b.b17x4 5.34435
147b.b17x5 5.29537
148b.b17x7 4.994538
149b.l17x3 6.71571739
150b.l17x7 4.498537
151b.b18x3 4.46833638
152b.b18x5 4.155635
153b.l18x1 4.857126
154b.l18x2 4.5854127
155b.b19x2 5.33836
156b.b19x4 5.588538
157b.b20x4 12.0775438
158b.b20x6 6.23636
159b.b20x7 4.4375409
160b.l20x1 3.7775436
161b.b21x1 7.09537
162b.b21x7 4.65571705
163b.l21x2 4.695474
164b.l21x5 3.922574
165b.b22x5 6.134127
166b.l22x5 6.233336109
167b.b23x6 8.668577
168b.b24x3 3.715415
169b.b24x4 7.002576
170b.b24x5 3.8275405
171b.b24x6 5.8478
172b.l24x3 7.0065105
173b.l25x3 6.35667619
174b.l25x5 4.46417
175b.b26x3 3.508516
176b.l27x1 7.19754197
177b.b27x3 4.694518
178b.l28x1 10.9486719
179b.l28x2 4.574519
180b.b28x3 4.662597
181b.b28x6 7.035819
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b3x1 b.b4x7 23.5642.71NoYes058
2b.b3x1 b.b6x5 22.86772.34NoYes056
3b.b6x5 b.b7x2 16.95162.52YesYes1168
4b.b4x7 b.l2x5 27.05713.1YesNo085
5b.l2x5 b.l4x2 27.406824.69NoYes054
6b.l4x2 g.ctx16 18.4213.09YesYes1448
7b.b28x5 g.ctx16 12.6373.77NoYes058
8b.b1x6 b.b28x5 11.00227.14YesNo095
9b.b4x3 b.b7x2 14.84872.98YesYes078
10b.b28x7 g.ctx14 26.74286.81NoYes099
11b.b28x7 b.lhb1x11 43.70324.21NoYes094
12b.b28x6 b.lhb1x11 51.3683.49YesYes194
13b.b28x6 b.l25x3 51.88474.23YesYes199
14b.l25x3 b.l28x2 53.49583.78YesYes199
15b.l25x5 b.l28x2 54.29192.69YesYes179
16b.l25x5 b.l28x1 54.44997.91YesYes179
17G.H2.09 b.l28x1 28.94856.35NoYes189
18G.H2.09 G.H3.17 29.11376.35NoYes185
19G.H2.08 G.H3.17 58.19642.35YesYes185
20G.H2.04 G.H2.08 38.6935.01YesYes198
21G.H2.04 G.S1.07 40.98152.43YesYes199
22G.S1.07 G.S4.04 41.33926.09YesYes199
23G.S4.04 G.S4.06 1002.62YesYes197
24G.H3.05 G.S4.06 94.72376.46NoYes097
25G.H3.05 G.s1h1.02 94.64891.71NoNo097
26G.s1h1.02 G.s1h1.05 94.49921.71NoNo079
27G.S4.05 G.s1h1.05 94.04941.72NoNo079
28G.H1.04 G.S4.05 93.52311.64NoNo077
29G.H1.04 G.H1.08 45.12472.92NoNo078
30G.H1.08 G.S2.06 45.04097.46NoYes089
31G.S2.06 G.S3.03 43.7912.86YesYes097
32G.S1.02 G.S3.03 86.15363.93NoYes057
33G.S1.02 I2 85.81843.17NoYes257
34g.ctx14 g.ctx16 16.90934.83YesYes1498
35b.b1x3 g.ctx16 16.62083.21NoYes078
36b.b1x3 b.b28x7 16.85078.44NoNo079
37G.h2s4.02 b.l28x1 28.95064.36NoYes179
38G.H3.17 G.h2s4.02 29.06353.27YesNo157
39G.H2.04 G.H3.08 40.92656.07YesNo099
40G.H3.08 G.S4.04 40.90816.09NoYes099
41G.H2.08 G.H3.18 19.495.02YesYes189
42G.H3.12 G.H3.18 19.40253.77NoYes189
43G.H3.12 G.S4.04 19.38432.51NoYes189
44G.H1.04 G.S5.05 48.32795.02NoYes079
45G.H5.07 G.S5.05 43.80763.93NoYes589
46G.H5.07 G.S3.03 43.77713.93NoYes087
47G.H2.07 G.s3h2.03 12.68322.19YesNo199
48b.l7x2 b.l9x6 15.29693.52YesYes198
49G.H2.02 G.H2.07 18.16184.94NoYes189
50G.H2.06 b.l9x6 30.34622.39YesYes198
51G.H2.06 b.l17x6 14.9974.15YesNo199
52G.H2.06 b.b18x1 14.99724.2YesNo099
533x54 I2 37.25572.44YesYes297
542x39 I2 44.83183.28NoYes297
553x54 G.H5.25 35.69052.44YesYes297
562x39 3x50 43.74552.7NoYes299
577x52 G.H5.25 35.31552.28YesYes297
583x50 7x52 35.272810.31YesYes299
59b.b16x6 b.b17x3 10.41117.84YesNo085
60b.b17x3 g.h1x10 10.65466.1NoNo059
61g.h1x10 g.h1x14 11.41092.55NoNo099
626x40 7x52 63.250517.04NoYes289
633x43 6x40 61.40356.43YesNo298
643x43 Allo1 59.96172.45YesYes290
65Allo1 E2 17.4597.06YesYes207
66Allo1 Lig 19.33192.81YesYes200
67b.l11x1 b.l9x6 10.12622.9NoYes098
68b.b17x7 b.b20x6 23.10326.43YesYes386
69b.b20x6 b.l17x3 26.39872.26YesYes369
70b.b20x2 b.l17x3 33.09892.74NoYes069
71b.b20x2 b.l19x2 33.60447.23NoNo069
72b.l17x5 b.l19x2 34.13031.47NoNo069
73b.l17x5 b.l19x1 34.40061.47NoNo069
74b.l17x6 b.l19x1 19.79435.32NoNo099
75b.b18x1 b.l19x1 14.87896.73NoNo099
76G.H2.04 G.H2.07 43.21515YesYes199
77G.H2.07 b.l7x2 12.66862.28YesYes199
78G.s3h2.03 b.l9x6 12.6373.38NoYes198
79G.H2.02 b.l9x6 12.63687.63NoYes188
80b.b17x7 b.b21x1 14.5664.78YesYes387
81b.b21x1 g.h1x14 11.66393.9YesNo079
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
NTNT1200.152YesYes6611
6x81NT3.532NoYes4621
6x70NT9.690NoYes5621
6x74NT9.160NoYes4621
6x78NT2.412NoYes5621
E1NT60.722YesYes6611
6x69NT14.222NoYes6611
6x73NT7.572NoYes6621
LigNT16.582YesYes0601
1x29NT7.652NoYes4621
1x32NT5.812NoYes7621
E2NT8.542YesYes7611
E3NT22.722YesYes5611
1x31NT9.332NoYes8621
7x32NT3.652YesYes5621
1x291x3214.772NoNo4722
1x317x322.652NoYes8522
1x32E22.772NoYes7721
2x57E28.342YesYes7721
2x577x429.312YesNo7522
2x57Allo14.572YesYes7021
2x60E24.932YesYes9721
E1E1113.72YesYes6611
3x25E113.532NoYes9621
E1E210.762YesYes6711
E1Lig7.572YesYes6010
3x24E15.840NoYes7621
E1E2x502.792YesNo6912
3x26E113.452NoYes7621
4x61E13.280NoYes8621
3x25E2x507.282NoNo9922
3x28E24.422NoYes7721
3x29E215.732YesYes9721
3x29E2x516.432YesYes9822
3x29E2x525.242YesNo9922
3x367x424.242NoNo5522
3x36Allo12.782NoYes5021
3x43Allo12.452YesYes9021
E2E261.42YesYes7711
5x36E218.872NoYes7721
E2E2x526.652YesNo7912
E2Lig22.782YesYes7010
E2E2x503.922YesNo7912
E2x51E2x523.932YesNo8922
E2E2x518.252YesYes7812
Allo1E2x5114.672YesYes0812
5x40E232YesYes9721
Allo1E27.062YesYes0711
6x66E24.052NoYes5711
5x406x553.392YesYes9722
5x406x5810.722YesNo9821
5x436x5512.452NoYes7722
5x43Allo15.982NoYes7021
5x476x484.612NoNo7722
5x47Allo110.032NoYes7021
6x48Allo12.992NoYes7021
6x516x556.852NoYes8722
6x51Allo12.962NoYes8021
6x557x382.552YesNo7822
6x55Allo110.332YesYes7021
6x586x652.232NoYes8911
6x58Lig11.872NoYes8010
6x616x6525.990NoYes6921
6x626x652.190NoYes6921
6x626x666.370NoNo6521
6x64E37.920NoYes2521
6x65E326.162YesYes9511
6x65Lig3.832YesYes9010
6x66Lig8.922NoYes5010
6x68E39.020NoYes7521
6x696x736.552NoNo6612
6x69Lig13.942NoYes6010
6x726x7623.672NoNo4422
6x72E34.842NoYes4521
6x75E37.280NoYes9521
6x76E313.492NoYes4521
6x786x818.52NoNo5422
E3E316.212YesYes5511
E3Lig3.322YesYes5010
7x327x353.982YesNo5721
7x347x357.130NoNo6721
7x35Lig8.920NoYes7010
7x38Allo15.512NoYes8021
7x42Allo118.452NoYes5021
7x45Allo119.240NoYes7021
Allo1Lig2.812YesYes0010
4x64E11.870NoYes6621
6x79E31.462NoYes5521

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
100.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
81.82Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
72.73Single4QINSAG1.54QIN-SMO-SAG1.5
72.73Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
63.64Single4O9RCyclopamine4O9R-SMO-Cyclopamine
46.15Consensusclass-f_offOrthosteric Ligandsmo_off
45.45Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
41.67Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
35.29Single5V57TC1145V57-SMO-TC114
31.25Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
31.25Single5T04Neurotensin5T04-NTS1-Neurotensin
31.25Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
31.25Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
30.77Single4XNWMRS25004XNW-P2Y1-MRS2500
30.77Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
30.77Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
29.41Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
28.57Single5L7IVismodegib5L7I-SMO-Vismodegib
28.57Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
28.57Consensusgo_proteinOrthosteric Ligandgo_chemokine
28.57Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
27.78Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
27.78Single4BV0Neurotensin4BV0-NTS1-Neurotensin
27.78Single5V56TC1145V56-SMO-TC114
27.78Single6OS1TRV0266OS1-AT1-TRV026
27.78Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
27.78Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
26.67Single4BWBNeurotensin4BWB-NTS1-Neurotensin
26.67Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
26.67Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
26.67Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
26.67Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
26.67Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
26.32Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
26.32Single4XEENeurotensin4XEE-NTS1-Neurotensin
26.32Single4XESNeurotensin4XES-NTS1-Neurotensin
26.32Single6OS2TRV0266OS2-AT1-TRV026
26.32Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
26.32Single6YVRNTS8-136YVR-NTS1-NTS8-13
26.32Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
26.32Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
26.32Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
26.32Consensusnts_onOrthosteric Ligandnts1_on
25.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
25.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
25.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
25.00Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
25.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
23.81Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
23.81Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
23.81Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
23.81Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
23.81Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
23.53Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
23.53Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
23.53Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
22.73Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
22.73Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
22.73Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
22.73Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
22.73Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
22.73Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
22.22Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
22.22Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
22.22Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
22.22Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.22Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.22Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.22Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
22.22Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
21.74Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
21.74Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
21.74Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
21.74Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single6LI0GTPL98046LI0-GPR52-GTPL9804
21.43Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
21.43Single8IY6Endothelin-18IY6-ETB-Endothelin-1
21.43Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
21.05Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
21.05Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
21.05Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.05Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
21.05Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
21.05Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.05Consensuslpa_offOrthosteric Ligandlpa1_off
21.05Consensuslpa_onOrthosteric Ligandlpa1_on
21.05Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
20.83Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
20.83Consensusangiotensin_onOrthosteric Ligandat1_on
20.83Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
20.83Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
20.83Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Single5GLHEndothelin-15GLH-ETB-Endothelin-1
20.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
20.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
20.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
20.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
20.00Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
20.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
20.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
20.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
20.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
20.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
20.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
20.00Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
19.35Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
19.23Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
19.23Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
19.23Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
19.23Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
19.05Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
19.05Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
19.05Single7EZCUKA7EZC-A2A-UKA
19.05Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
19.05Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
18.75Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
18.75Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
18.75Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
18.75Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
18.75Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
18.75Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
18.75Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
18.75Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
18.52Single7SK3CXCL127SK3-ACKR3-CXCL12
18.52Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
18.52Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
18.52Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
18.52Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
18.52Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
18.18Single5WF6UK-4320975WF6-A2A-UK-432097
18.18Single6KNMJN241-96KNM-Apelin-JN241-9
18.18Single8HS2Fab0468HS2-GPR20-Fab046
18.18Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
18.18Consensuslpl_offOrthosteric Ligands1p_off lpa_off
18.18Consensuslpl_onOrthosteric Ligands1p_on lpa_on
17.86Consensusendothelin_onOrthosteric Ligandetb_on eta_on
17.86Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
17.86Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
17.65Single5IU4ZM2413855IU4-A2A-ZM241385-Na
17.65Single5IUBQ274563445IUB-A2A-Q27456344-Na
17.65Single5K2CZM2413855K2C-A2A-ZM241385-Na
17.65Single5NM4ZM2413855NM4-A2A-ZM241385-Na
17.65Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
17.65Single7T32ZM2413857T32-A2A-ZM241385
17.65Single7VV6C48/807VV6-MRGPRX2-C48/80
17.65Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
17.65Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
17.65Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
17.65Consensusgnrh_offOrthosteric Ligandgnrh1_off
17.39Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
17.39Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
17.39Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
17.24Single6IGLIRL16206IGL-ETB-IRL1620
17.24Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
17.24Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
17.24Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.24Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
16.67Single3QAKUK-4320973QAK-A2A-UK-432097
16.67Single4EIYZM2413854EIY-A2A-ZM241385-Na
16.67Single5IU8Q274563475IU8-A2A-Q27456347-Na
16.67Single5OLGZM2413855OLG-A2A-ZM241385-Na
16.67Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
16.67Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
16.67Single6IGKEndothelin-36IGK-ETB-Endothelin-3
16.67Single6LPJZM2413856LPJ-A2A-ZM241385-Na
16.67Single6LPKZM2413856LPK-A2A-ZM241385-Na
16.67Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
16.67Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
16.67Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
16.67Single7PYRPSB-21157PYR-A2A-PSB-2115
16.67Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
16.67Single7SK5CXCL127SK5-ACKR3-CXCL12
16.67Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
16.67Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
16.67Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
16.67Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
16.67Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
16.67Consensusa2_offOrthosteric Liganda2a_off
16.67Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
16.67Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
16.67Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
16.67Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
16.67Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
16.67Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
16.13Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
16.13Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
16.13Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
16.00Single3OE0CVX153OE0-CXCR4-CVX15
16.00Single5WF5UK-4320975WF5-A2A-UK-432097
16.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
16.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
16.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
16.00Single7XNACYN1548067XNA-SST2-CYN154806
16.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
16.00Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
16.00Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
16.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
15.79Single5IUAQ274563485IUA-A2A-Q27456348-Na
15.79Single5N2SPSB365N2S-A1-PSB36
15.79Single5NM2ZM2413855NM2-A2A-ZM241385-Na
15.79Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
15.79Single6LPLZM2413856LPL-A2A-ZM241385-Na
15.79Single6S0QZM2413856S0Q-A2A-ZM241385
15.79Single6WQAZM2413856WQA-A2A-ZM241385-Na
15.79Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
15.79Single7RM5ZM2413857RM5-A2A-ZM241385-Na
15.79Single7YXAONO-54306087YXA-S1P5-ONO-5430608
15.79Single8FYNZM2413858FYN-A2A-ZM241385-Na
15.79Single8GNEKW-63568GNE-A2A-KW-6356-Na
15.79Single8QOTNanobody E8QOT-μ-Nanobody E
15.79Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
15.38Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
15.38Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
15.38Single6JODAngiotensin II6JOD-AT2-Angiotensin II
15.38Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
15.38Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
15.38Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
15.38Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
15.38Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
15.38Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
15.38Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
15.38Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
15.15Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
15.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
15.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
15.00Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
15.00Single7PX4PSB-21137PX4-A2A-PSB-2113
15.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
15.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
15.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
15.00Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
15.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
15.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
15.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
15.00Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
15.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
15.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
15.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
15.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
15.00Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
14.81Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
14.81Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
14.81Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
14.81Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
14.81Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
14.81Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
14.81Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
14.81Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.29Single4XT3Fractalkine4XT3-US28-Fractalkine
14.29Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
14.29Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
14.29Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
14.29Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
14.29Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
14.29Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
14.29Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
14.29Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
14.29Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
14.29Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
14.29Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
14.29Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
14.29Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
14.29Consensuschemokine_offOrthosteric Ligandcxcr_off
14.29Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
14.29Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
14.29Consensuscxcr_offOrthosteric Ligandcxcr4_off
14.29Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
14.29Consensusdp_offOrthosteric Liganddp2_off
14.29Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
14.29Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
14.29Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
14.29Consensusgs_steroidOrthosteric Ligandgs_bileacid
14.29Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
13.79Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
13.79Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
13.79Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
13.79Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
13.79Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
13.79Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.79Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
13.79Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.64Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
13.64Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
13.64Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
13.64Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
13.64Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
13.64Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
13.64Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
13.64Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
13.64Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
13.64Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
13.64Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
13.64Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Consensussteroid_onOrthosteric Ligandbileacid_on
13.33Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
13.33Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
13.33Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
13.33Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
13.33Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
13.33Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
13.33Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
13.04Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
13.04Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
13.04Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
13.04Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
13.04Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
13.04Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
13.04Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
13.04Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
13.04Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
13.04Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
13.04Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
13.04Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
13.04Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
12.90Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
12.82Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
12.50Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
12.50Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
12.50Single7F8XNN90567F8X-CCKA-NN9056
12.50Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
12.50Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
12.50Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
12.50Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
12.50Single7UL2SR486927UL2-NTS1-SR48692-Na
12.50Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
12.50Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
12.50Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
12.50Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
12.50Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
12.50Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
12.50Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
12.50Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
12.50Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
12.50Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
12.50Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
12.50Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
12.50Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
12.50Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Consensusclass-t_onOrthosteric Ligandtaste2_on
12.50Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
12.50Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
12.50Consensusgs_class-tOrthosteric Ligandgs_taste
12.50Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
12.50Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
12.50Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
12.50Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
12.50Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
12.12Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
12.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
12.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
12.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
12.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
12.00Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
12.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
12.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
12.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
12.00Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
12.00Consensussst_offOrthosteric Ligandsst2_off
12.00Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
11.76Single3PWHZM2413853PWH-A2A-ZM241385
11.76Single5K2DZM2413855K2D-A2A-ZM241385
11.76Single5U09Taranabant5U09-CB1-Taranabant
11.76Single6JZHZM2413856JZH-A2A-ZM241385-Na
11.76Single6PS7ZM2413856PS7-A2A-ZM241385-Na
11.76Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.76Single7F8ULintitript7F8U-CCKA-Lintitript
11.76Single7F8YDevazepide7F8Y-CCKA-Devazepide
11.76Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.76Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
11.76Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
11.76Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
11.76Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
11.76Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
11.76Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
11.76Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
11.76Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
11.76Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.76Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.76Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
11.76Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
11.76Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
11.76Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
11.54Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
11.54Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
11.54Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
11.54Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
11.54Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
11.54Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
11.54Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
11.54Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
11.54Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
11.54Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
11.43Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
11.43Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
11.11Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
11.11Single5IU7Q274563465IU7-A2A-Q27456346-Na
11.11Single5JTBZM2413855JTB-A2A-ZM241385
11.11Single5K2BZM2413855K2B-A2A-ZM241385-Na
11.11Single5NLXZM2413855NLX-A2A-ZM241385-Na
11.11Single5UVIZM2413855UVI-A2A-ZM241385
11.11Single6AQFZM2413856AQF-A2A-ZM241385
11.11Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
11.11Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
11.11Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
11.11Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
11.11Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
11.11Single7AROLUF58337ARO-A2A-LUF5833-Na
11.11Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
11.11Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
11.11Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
11.11Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
11.11Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
11.11Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
11.11Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
11.11Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
11.11Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
11.11Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
11.11Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
11.11Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
11.11Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
11.11Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
11.11Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
11.11Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
11.11Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
11.11Single8K5CAcipimox8K5C-HCA2-Acipimox
11.11Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
11.11Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
11.11Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
11.11Consensushca_onOrthosteric Ligandhca2_on hca3_on
11.11Consensushcar_onOrthosteric Ligandhca_on
11.11Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
11.11Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
11.11Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
11.11Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
11.11Consensuss1p_offOrthosteric Ligands1p1_off
11.11Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.71Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
10.71Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
10.71Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
10.71Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.71Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
10.71Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
10.71Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
10.71Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
10.71Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
10.71Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
10.71Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single3EMLZM2413853EML-A2A-ZM241385
10.53Single5K2AZM2413855K2A-A2A-ZM241385-Na
10.53Single5TGZAM65385TGZ-CB1-AM6538
10.53Single5UENDU1725UEN-A1-DU172
10.53Single5VRAZM2413855VRA-A2A-ZM241385-Na
10.53Single6D27CAY104716D27-DP2-CAY10471
10.53Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
10.53Single6S0LZM2413856S0L-A2A-ZM241385
10.53Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
10.53Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
10.53Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
10.53Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
10.53Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
10.53Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
10.53Consensuscck_offOrthosteric Ligandccka_off
10.53Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
10.53Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
10.53Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
10.53Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
10.53Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
10.34Single6FJ3PTH6FJ3-PTH1-PTH
10.34Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.34Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.34Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
10.34Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.34Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
10.34Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
10.34Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.34Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.34Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
10.34Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
10.34Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
10.26Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
10.26Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
10.00Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
10.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
10.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
10.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
10.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
10.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
10.00Single6D35Cholesterol6D35-SMO-Cholesterol
10.00Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
10.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
10.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
10.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
10.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
10.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
10.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
10.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
10.00Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
10.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
10.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
10.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
10.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
10.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
10.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
10.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
10.00Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
10.00Single7DTTCa7DTT-CaS-Ca-Ca
10.00Single7DTTCa7DTT-CaS-Ca-Ca
10.00Single7DTUTryptophan7DTU-CaS-Tryptophan
10.00Single7DTUTryptophan7DTU-CaS-Tryptophan
10.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
10.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
10.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
10.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
10.00Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
10.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
10.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
10.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
10.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
10.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
10.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
10.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
10.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
10.00Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
10.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
10.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
10.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
10.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
10.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
10.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
10.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
10.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single7FIIhCG7FII-LH-hCG-6fuf
10.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
10.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
10.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
10.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
10.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
10.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
10.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
10.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
10.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
10.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
10.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
10.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
10.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
10.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
10.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
10.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
10.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
10.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
10.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
10.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
10.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
10.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
10.00Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
10.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
10.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
10.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
10.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
10.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
10.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
10.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
10.00Single7XW7K1-707XW7-TSH-K1-70
10.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
10.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
10.00Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
10.00Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
10.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
10.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
10.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
10.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
10.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
10.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
10.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
10.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
10.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
10.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
10.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
10.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
10.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
10.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
10.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
10.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
10.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
10.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
10.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
10.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
10.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
10.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
10.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
10.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
10.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
10.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
10.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
10.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
10.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
10.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
10.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
10.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
10.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
10.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
10.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
10.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
10.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
10.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
10.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
10.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
10.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
10.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
10.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
10.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
10.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
10.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
10.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
10.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
10.00Consensusep_offOrthosteric Ligandep4_off
10.00Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
10.00Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
10.00Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
10.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
10.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
10.00Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
10.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
10.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
10.00Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
10.00Consensusgo_class-b1Orthosteric Ligandgo_crf
10.00Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
10.00Consensusgphr_onOrthosteric Ligandlh_on tsh_on
10.00Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
10.00Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
10.00Consensusgs_proteinOrthosteric Ligandgs_gphr
10.00Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
10.00Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
10.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
10.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
10.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
10.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
10.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
10.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
10.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
10.00Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
10.00Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
10.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
10.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
10.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
10.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
10.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
10.00Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
10.00Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.00Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
10.00Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
9.68Single6LMLGlucagon6LML-Glucagon-Glucagon
9.68Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
9.68Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
9.68Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
9.68Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.68Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
9.68Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
9.68Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
9.68Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
9.68Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
9.68Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
9.68Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
9.68Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
9.68Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.52Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
9.52Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
9.52Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
9.52Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
9.52Single7TUYGSK682753A7TUY-GPR183-GSK682753A
9.52Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
9.52Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
9.52Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
9.52Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
9.52Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
9.52Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
9.52Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
9.52Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
9.52Consensuschemerin_onOrthosteric Ligandcml1_on
9.52Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
9.52Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
9.52Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
9.52Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
9.52Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
9.52Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
9.38Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
9.38Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
9.38Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
9.38Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
9.38Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
9.38Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
9.38Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
9.38Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
9.09Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
9.09Single4N4WSANT-14N4W-SMO-SANT-1
9.09Single4PY02MeSATP4PY0-P2Y12-2MeSATP
9.09Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
9.09Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
9.09Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
9.09Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
9.09Single6MXTSalmeterol6MXT-β2-Salmeterol
9.09Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
9.09Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
9.09Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
9.09Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
9.09Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
9.09Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
9.09Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
9.09Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
9.09Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
9.09Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
9.09Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
9.09Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
9.09Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
9.09Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
9.09Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
9.09Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
9.09Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
9.09Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
9.09Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
9.09Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
9.09Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
9.09Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
9.09Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
9.09Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
9.09Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
9.09Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
9.09Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
9.09Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
9.09Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
9.09Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
9.09Consensusglp_onOrthosteric Ligandglp1_on glp2_on
9.09Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
9.09Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
9.09Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
8.82Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
8.82Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
8.82Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
8.82Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
8.82Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
8.82Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
8.70Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
8.70Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
8.70Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
8.70Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
8.70Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
8.70Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
8.70Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
8.70Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
8.70Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
8.70Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
8.70Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
8.70Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
8.70Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
8.70Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
8.70Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
8.70Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.70Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
8.70Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
8.70Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
8.70Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
8.70Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
8.57Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
8.57Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
8.57Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
8.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
8.57Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
8.57Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
8.33Single4UG2CGS216804UG2-A2A-CGS21680
8.33Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
8.33Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
8.33Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.33Single7SK9CCX6627SK9-ACKR3-CCX662
8.33Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
8.33Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
8.33Single7XN9L-054,5227XN9-SST2-L-054,522
8.33Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
8.33Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
8.33Consensusclass-d_offOrthosteric Ligandste2_off
8.33Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
8.33Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
8.33Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
8.33Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
8.33Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
8.33Consensuspth_onOrthosteric Ligandpth1_on pth2_on
8.33Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
8.11Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
8.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
8.00Single4XT1Fractalkine4XT1-US28-Fractalkine
8.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
8.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
8.00Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.00Single7QA8Peptide7QA8-STE2-Peptide
8.00Single7QA8Peptide7QA8-STE2-Peptide
8.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
8.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
8.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
8.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
8.00Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
8.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
8.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
8.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
8.00Consensusclass-d_offOrthosteric Ligandste2_off
8.00Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
8.00Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
8.00Consensussst_onOrthosteric Ligandsst2_on sst4_on
8.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
7.89Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
7.89Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
7.89Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
7.69Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
7.69Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
7.69Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.69Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
7.69Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
7.69Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
7.69Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
7.69Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
7.69Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
7.69Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
7.69Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
7.69Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.69Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
7.69Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
7.69Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
7.69Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
7.69Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
7.69Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
7.69Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
7.69Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.50Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
7.41Single6PT2KGCHM076PT2-δ-KGCHM07
7.41Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
7.41Single6W25SHU91196W25-MC4-SHU9119-Ca
7.41Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
7.41Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
7.41Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
7.41Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single5L7DCholesterol5L7D-SMO-Cholesterol
7.14Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
7.14Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.14Single7C61Ergotamine7C61-5-HT1B-Ergotamine
7.14Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
7.14Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
7.14Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
7.14Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.14Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
7.14Single8PWNTheophylline8PWN-A2A-Theophylline
7.14Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
7.14Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
7.14Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
6.90Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
6.90Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
6.90Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
6.67Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
6.67Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
6.67Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
6.67Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.67Single8A2OTheophylline8A2O-A2A-Theophylline-Na
6.67Consensusclass-d_onOrthosteric Ligandste2_on
6.67Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
6.45Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
6.45Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
6.45Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
6.45Consensusgi_class-dOrthosteric Ligandgi_ste
6.45Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
6.25Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
6.25Single3OE6IT1t3OE6-CXCR4-IT1t
6.25Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
6.25Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
6.25Single6ME5Agomelatine6ME5-MT1-Agomelatine
6.25Single6ME9Ramelteon6ME9-MT2-Ramelteon
6.25Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
6.25Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
6.25Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
6.25Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
6.25Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
6.25Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
6.25Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
6.25Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
6.25Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
6.25Single7WC5Psilocin7WC5-5-HT2A-Psilocin
6.25Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
6.25Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
6.25Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
6.25Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
6.25Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
6.25Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
6.06Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
6.06Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
6.06Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
5.88Single3OE9IT1t3OE9-CXCR4-IT1t
5.88Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
5.88Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
5.88Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
5.88Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
5.88Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.88Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.88Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
5.88Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
5.88Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
5.88Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
5.88Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single8K5BNiacin8K5B-HCA2-Niacin
5.88Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
5.88Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.88Consensusgo_class-b2Orthosteric Ligandgo_adhesion
5.88Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.88Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
5.71Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.56Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
5.56Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
5.56Single3ODUIT1t3ODU-CXCR4-IT1t
5.56Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
5.56Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
5.56Single5ZKQABT-4915ZKQ-PAF-ABT-491
5.56Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
5.56Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
5.56Single6ME2Ramelteon6ME2-MT1-Ramelteon
5.56Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.56Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.56Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
5.56Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
5.56Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
5.56Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
5.56Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.56Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
5.56Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
5.56Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single8GNGIstradefylline8GNG-A2A-Istradefylline
5.56Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
5.56Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
5.56Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
5.56Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
5.56Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
5.56Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
5.56Consensusgt_class-aOrthosteric Ligandgt_opsin
5.56Consensusgt_opsinOrthosteric Ligandgt_sensory
5.56Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.56Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
5.56Consensusmglu_onOther Ligandmglu2_on mglu4_on
5.56Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.26Single2YDOAdenosine2YDO-A2A-Adenosine
5.26Single3REYPubChem 56973REY-A2A-PubChem 5697
5.26Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
5.26Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
5.26Single6DS0Ly2660976DS0-5-HT2B-Ly266097
5.26Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
5.26Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
5.26Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
5.26Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
5.26Single6MH8ZM2413856MH8-A2A-ZM241385
5.26Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
5.26Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
5.26Single6ZINSR486926ZIN-NTS1-SR48692
5.26Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
5.26Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
5.26Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
5.26Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
5.26Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
5.26Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
5.26Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
5.26Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
5.26Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
5.26Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
5.26Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
5.26Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
5.26Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
5.26Single8K2WAMG4878K2W-CXCR3-AMG487
5.26Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
5.26Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
5.26Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
5.26Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
5.26Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
5.26Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
5.26Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
5.26Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Consensussensory_offOrthosteric Ligandopsin_off
5.00Single2Y01Dobutamine2Y01-β1-Dobutamine
5.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
5.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.00Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
5.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
5.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
5.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
5.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
5.00Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
5.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
5.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
5.00Single6GPSMK08126GPS-CCR2-MK0812
5.00Single6IIVDaltroban6IIV-TP-Daltroban
5.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
5.00Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
5.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
5.00Single7BU7BI1671077BU7-β1-BI167107
5.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
5.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
5.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
5.00Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
5.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
5.00Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
5.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
5.00Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
5.00Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
5.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
5.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
5.00Single8CU6LJ-45178CU6-A2A-LJ-4517
5.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
5.00Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.00Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
5.00Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
5.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
5.00Single8K5DGSK2560738K5D-HCA2-GSK256073
5.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
5.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
5.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
5.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
5.00Consensusadenosine_onOrthosteric Liganda1_on a2_on
5.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
5.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
5.00Consensusblt_onOrthosteric Ligandblt1_on
5.00Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
5.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
5.00Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
5.00Consensusgi_hcarOrthosteric Ligandgi_hca
5.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
5.00Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
5.00Consensusleuko_onOrthosteric Ligandblt_on
5.00Consensusnucleotide_onOrthosteric Ligandadenosine_on
5.00Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
5.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
5.00Consensustar_onOrthosteric Ligandta1_on
5.00Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
4.76Single2Y00Dobutamine2Y00-β1-Dobutamine
4.76Single4NTJAZD12834NTJ-P2Y12-AZD1283
4.76Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
4.76Single5C1MBU725C1M-μ-BU72
4.76Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
4.76Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
4.76Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
4.76Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
4.76Single6E67BI1671076E67-β2-BI167107-Gs (fused)
4.76Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
4.76Single6GPXMK08126GPX-CCR2-MK0812
4.76Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
4.76Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
4.76Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
4.76Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
4.76Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.76Single6Z4SSR486926Z4S-NTS1-SR48692
4.76Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
4.76Single7C4SS1P7C4S-S1P3-S1P
4.76Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
4.76Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
4.76Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
4.76Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
4.76Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
4.76Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
4.76Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
4.76Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
4.76Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
4.76Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
4.76Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
4.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.76Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
4.76Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
4.76Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
4.76Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
4.76Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
4.76Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
4.76Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
4.76Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
4.76Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
4.76Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single2YDVNECA2YDV-A2A-NECA
4.55Single3P0GBI1671073P0G-β2-BI167107
4.55Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
4.55Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
4.55Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
4.55Single4RWADIPP-NH24RWA-δ-DIPP-NH2
4.55Single4UHRCGS216804UHR-A2A-CGS21680
4.55Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
4.55Single5G53NECA5G53-A2A-NECA-Gs
4.55Single5TZR-5TZR-FFA1 (GPR40)-MK8666
4.55Single5XR8AM8415XR8-CB1-AM841
4.55Single5XRAAM115425XRA-CB1-AM11542
4.55Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
4.55Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
4.55Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
4.55Single6J21Aprepitant6J21-NK1-Aprepitant
4.55Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
4.55Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.55Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.55Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
4.55Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
4.55Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
4.55Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
4.55Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
4.55Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
4.55Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
4.55Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
4.55Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
4.55Single7W41PD1762527W41-BB2-PD176252
4.55Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.55Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
4.55Single8E0GBU728E0G-μ-BU72
4.55Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
4.55Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
4.55Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
4.55Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
4.55Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
4.55Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
4.55Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
4.55Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
4.55Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
4.55Consensusa2_onOrthosteric Liganda2a_on a2b_on
4.55Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
4.55Consensusbombesin_offOrthosteric Ligandbb2_off
4.55Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
4.55Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
4.55Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
4.55Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.55Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
4.55Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
4.55Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
4.35Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
4.35Single4LDEBI1671074LDE-β2-BI167107
4.35Single5X33BIIL2605X33-BLT1-BIIL260
4.35Single6A93Risperidone6A93-5-HT2A-Risperidone
4.35Single6CM4Risperidone6CM4-D2-Risperidone
4.35Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
4.35Single6IIURamatroban6IIU-TP-Ramatroban
4.35Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
4.35Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
4.35Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
4.35Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
4.35Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.35Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
4.35Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
4.35Single7K15MKD0467K15-BLT1-MKD046-Na
4.35Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
4.35Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
4.35Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
4.35Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.35Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
4.35Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
4.35Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
4.35Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
4.35Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single8JJ8Formoterol8JJ8-β2-Formoterol
4.35Single8JJLOlodaterol8JJL-β2-Olodaterol
4.35Single8JWZAB9288JWZ-A2A-AB928-Na
4.35Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
4.35Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.35Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
4.35Single8WU1KCA8WU1-CB1-KCA-Arrestin1
4.35Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
4.35Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
4.35Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
4.35Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
4.35Consensusblt_offOrthosteric Ligandblt1_off
4.35Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
4.35Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
4.35Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
4.35Consensusclass-b2_onOrthosteric Ligandadgrg_on
4.35Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
4.35Consensusgi_class-fOther Ligandgi_frizzled
4.35Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.35Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
4.35Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
4.35Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.35Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
4.35Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
4.35Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
4.35Consensusnts_offOrthosteric Ligandnts1_off
4.35Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
4.35Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
4.35Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.17Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
4.17Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
4.17Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
4.17Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
4.17Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
4.17Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
4.17Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
4.17Single6H7LDobutamine6H7L-β1-Dobutamine
4.17Single6IBLArformoterol6IBL-β1-Arformoterol
4.17Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
4.17Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
4.17Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
4.17Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
4.17Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
4.17Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
4.17Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
4.17Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
4.17Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
4.17Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
4.17Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
4.17Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
4.17Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
4.17Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
4.17Consensuscyslt_offOrthosteric Ligandcyslt2_off
4.17Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.17Consensusorexin_onOrthosteric Ligandox2_on
4.00Single3NY9PubChem 9131033NY9-β2-PubChem 913103
4.00Single5EE7MK08935EE7-Glucagon-MK0893
4.00Single5ZTYAM102575ZTY-CB2-AM10257
4.00Single6PT3DPI-2876PT3-δ-DPI-287
4.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
4.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
4.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
4.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single8X5YAstemizole8X5Y-H1-Astemizole
4.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
4.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
4.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
4.00Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Consensusgs_class-b2Orthosteric Ligandgs_adgr
3.85Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
3.85Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
3.85Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70Single6HLOAprepitant6HLO-NK1-Aprepitant
3.70Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
3.70Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
3.45Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
3.45Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.45Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
3.45Consensusclass-d_onOrthosteric Ligandste2_on
3.45Consensusgi_class-dOrthosteric Ligandgi_ste
3.45Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.33Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
3.33Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
NTNT1200.152YesYes6622
E1NT60.722YesYes6622
6x69NT14.222NoYes6622
LigNT16.582YesYes0612
1x32NT5.812NoYes7622
E2NT8.542YesYes7612
E3NT22.722YesYes5622
1x32E22.772NoYes7721
1x392x577.052YesYes7721
1x392x602.742YesYes7922
2x503x362.440YesNo9521
2x507x452.590YesNo9721
2x573x324.92YesNo7812
2x57E28.342YesYes7711
2x577x394.562YesNo7712
2x577x429.312YesNo7511
2x57Allo14.572YesYes7010
2x60E24.932YesYes9721
E1E1113.72YesYes6622
E1E210.762YesYes6721
E1Lig7.572YesYes6021
E1E2x502.792YesNo6922
3x28E24.422NoYes7721
3x293x337.222YesYes9922
3x29E215.732YesYes9721
3x29E2x516.432YesYes9821
3x29E2x525.242YesNo9922
3x33E2x514.132YesYes9821
3x367x424.242NoNo5511
3x36Allo12.782NoYes5010
3x433x475.192YesNo9712
3x435x502.622YesNo9512
3x436x406.432YesNo9812
3x437x497.462YesNo9812
3x43Allo12.452YesYes9010
E2E261.42YesYes7711
5x36E218.872NoYes7721
E2E2x526.652YesNo7912
E2Lig22.782YesYes7011
E2E2x503.922YesNo7912
E2x51E2x523.932YesNo8912
E2E2x518.252YesYes7811
Allo1E2x5114.672YesYes0801
5x40E232YesYes9721
Allo1E27.062YesYes0701
6x66E24.052NoYes5721
5x406x553.392YesYes9721
5x406x5810.722YesNo9822
5x406x597.482YesYes9622
5x436x5512.452NoYes7711
5x43Allo15.982NoYes7010
5x476x484.612NoNo7711
5x47Allo110.032NoYes7010
5x516x488.940NoNo7721
6x407x494.982NoNo8822
6x477x457.780YesNo7721
6x48Allo12.992NoYes7010
6x516x556.852NoYes8711
6x51Allo12.962NoYes8010
6x547x3811.020NoNo7821
6x556x597.922YesYes7612
6x557x382.552YesNo7811
6x55Allo110.332YesYes7010
6x586x652.232NoYes8922
6x58Lig11.872NoYes8021
6x65E326.162YesYes9522
6x65Lig3.832YesYes9021
6x66Lig8.922NoYes5021
6x69Lig13.942NoYes6021
E3E316.212YesYes5522
E3Lig3.322YesYes5021
7x35Lig8.920NoYes7021
7x38Allo15.512NoYes8010
7x42Allo118.452NoYes5010
7x45Allo119.240NoYes7010
Allo1Lig2.812YesYes0001

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
100.00Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
76.47Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
58.82Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
55.56Single4N4WSANT-14N4W-SMO-SANT-1
47.37Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
47.37Consensusclass-b2_onOrthosteric Ligandadgrg_on
47.06Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
47.06Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
45.45Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
44.44Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
42.86Single5WF6UK-4320975WF6-A2A-UK-432097
42.11Single2YDVNECA2YDV-A2A-NECA
42.11Single4UHRCGS216804UHR-A2A-CGS21680
42.11Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
42.11Single5G53NECA5G53-A2A-NECA-Gs
42.11Consensusa2_onOrthosteric Liganda2a_on a2b_on
42.11Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
42.11Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
42.11Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
41.67Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Single2YDOAdenosine2YDO-A2A-Adenosine
41.18Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
41.18Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
41.18Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
41.18Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
41.18Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
41.18Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single4AMIBucindolol4AMI-β1-Bucindolol
40.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
40.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
40.00Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
40.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
40.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
40.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
40.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
40.00Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
38.89Single3NY8ICI 118-5513NY8-β2-ICI 118-551
38.89Single4EJ4Naltrindole4EJ4-δ-Naltrindole
38.89Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
38.89Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
38.89Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
38.89Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
38.89Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
38.89Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
38.89Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
38.89Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
38.89Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
38.89Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
38.89Consensusadenosine_onOrthosteric Liganda1_on a2_on
38.89Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
38.89Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
38.89Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
38.89Consensusnucleotide_onOrthosteric Ligandadenosine_on
38.89Consensustar_onOrthosteric Ligandta1_on
38.10Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
38.10Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
38.10Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
38.10Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
38.10Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
38.10Single7EZCUKA7EZC-A2A-UKA
38.10Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
38.10Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
38.10Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
38.10Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.10Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
38.10Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
38.10Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
37.50Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
36.84Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
36.84Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
36.84Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
36.84Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
36.84Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
36.84Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
36.84Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
36.84Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
36.84Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
36.84Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
36.84Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
36.84Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
36.84Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
36.84Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
36.84Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Single3NY9PubChem 9131033NY9-β2-PubChem 913103
36.36Single4UG2CGS216804UG2-A2A-CGS21680
36.36Single5ZTYAM102575ZTY-CB2-AM10257
36.36Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
36.36Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
36.36Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
36.36Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Consensusgs_class-b2Orthosteric Ligandgs_adgr
36.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
35.29Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
35.29Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
35.29Single6TODEMPA6TOD-OX1-EMPA-Na
35.29Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
35.29Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
35.29Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
35.29Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
35.29Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
35.29Consensusalpha1_onOrthosteric Ligandalpha1a_on
35.29Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
35.29Consensusmglu_onOther Ligandmglu2_on mglu4_on
35.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
35.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
35.00Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
35.00Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
35.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
35.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
35.00Single6J21Aprepitant6J21-NK1-Aprepitant
35.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
35.00Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
35.00Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
35.00Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
35.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
35.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
35.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
35.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
35.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
35.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
35.00Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
35.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
35.00Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
35.00Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
35.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
35.00Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
35.00Consensushistamine_offOrthosteric Ligandh1_off
34.78Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
34.78Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
34.78Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
33.33Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
33.33Single3QAKUK-4320973QAK-A2A-UK-432097
33.33Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
33.33Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
33.33Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
33.33Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
33.33Single4ZJCSB-6740424ZJC-OX1-SB-674042
33.33Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
33.33Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
33.33Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
33.33Single6MH8ZM2413856MH8-A2A-ZM241385
33.33Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
33.33Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
33.33Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
33.33Single6PS4ICI 118-5516PS4-β2-ICI 118-551
33.33Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
33.33Single6TPGEMPA6TPG-OX2-EMPA
33.33Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
33.33Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
33.33Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
33.33Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
33.33Single7DFPSpiperone7DFP-D2-Spiperone
33.33Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
33.33Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
33.33Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
33.33Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
33.33Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
33.33Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
33.33Single7YITNalfurafine7YIT-κ-Nalfurafine
33.33Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GGQEpinephrine8GGQ-β2-Epinephrine
33.33Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
33.33Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
33.33Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
33.33Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
33.33Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
33.33Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
33.33Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
33.33Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
33.33Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
33.33Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
33.33Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
33.33Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
33.33Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
32.00Single5WF5UK-4320975WF5-A2A-UK-432097
32.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
31.82Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
31.82Single6IBLArformoterol6IBL-β1-Arformoterol
31.82Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
31.82Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
31.82Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
31.82Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.82Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
31.82Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
31.82Consensusendothelin_offOrthosteric Ligandetb_off
31.82Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
31.82Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
31.82Consensussteroid_onOrthosteric Ligandbileacid_on
31.58Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
31.58Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
31.58Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
31.58Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
31.58Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
31.58Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
31.58Single5TGZAM65385TGZ-CB1-AM6538
31.58Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
31.58Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
31.58Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
31.58Single6TOTLemborexant6TOT-OX1-Lemborexant
31.58Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
31.58Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
31.58Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
31.58Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
31.58Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
31.58Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
31.58Single7UL4Alvimopan7UL4-μ-Alvimopan
31.58Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
31.58Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
31.58Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
31.58Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
31.58Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
31.58Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
31.58Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
31.58Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
31.58Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
31.58Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8GGJEpinephrine8GGJ-β2-Epinephrine
31.58Single8GGNEpinephrine8GGN-β2-Epinephrine
31.58Single8GGOEpinephrine8GGO-β2-Epinephrine
31.58Single8GGUEpinephrine8GGU-β2-Epinephrine
31.58Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
31.58Single8JJOAlprenolol8JJO-β2-Alprenolol
31.58Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
31.58Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
31.58Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
31.58Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
31.58Single8X64Desloratadine8X64-H1-Desloratadine
31.58Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
31.58Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
31.58Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
31.58Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
31.25Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
31.25Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
31.25Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
31.25Single8GGZEpinephrine8GGZ-β2-Epinephrine
30.77Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
30.43Single6PT3DPI-2876PT3-δ-DPI-287
30.43Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Single7XN9L-054,5227XN9-SST2-L-054,522
30.43Single8X5YAstemizole8X5Y-H1-Astemizole
30.43Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
30.00Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
30.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
30.00Single5C1MBU725C1M-μ-BU72
30.00Single5CGCHTL142425CGC-mGlu5-HTL14242
30.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
30.00Single5WQCEMPA5WQC-OX2-EMPA
30.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
30.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
30.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
30.00Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
30.00Single6PS6Timolol6PS6-β2-Timolol
30.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
30.00Single6TP6Filorexant6TP6-OX1-Filorexant
30.00Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
30.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
30.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
30.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
30.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
30.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
30.00Single7WC6LSD7WC6-5-HT2A-LSD
30.00Single7XKAEpinephrine7XKA-β2-Epinephrine
30.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
30.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
30.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
30.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
30.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
30.00Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
30.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
30.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
30.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
30.00Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
30.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
30.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
30.00Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
30.00Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
30.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
30.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
30.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
30.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
29.63Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
29.63Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
29.63Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
29.41Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
29.41Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
29.41Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
29.41Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
29.41Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
29.41Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
29.41Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
29.41Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
29.41Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
29.41Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
29.41Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8GGYEpinephrine8GGY-β2-Epinephrine
29.41Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
29.41Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
29.41Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
29.41Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
29.17Single4IARErgotamine4IAR-5-HT1B-Ergotamine
29.17Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
29.17Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
29.17Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
29.17Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
29.17Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
29.17Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
29.17Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
29.17Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
29.17Consensussst_onOrthosteric Ligandsst2_on sst4_on
28.57Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
28.57Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
28.57Single4DJHJDTic4DJH-κ-JDTic
28.57Single4U15Tiotropium4U15-M3-Tiotropium
28.57Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
28.57Single5X93K-87945X93-ETB-K-8794
28.57Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
28.57Single6H7JIsoprenaline6H7J-β1-Isoprenaline
28.57Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
28.57Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
28.57Single6OL9Tiotropium6OL9-M5-Tiotropium
28.57Single6TQ7SB-3348676TQ7-OX1-SB-334867
28.57Single6WGTLSD6WGT-5-HT2A-LSD
28.57Single7EPENAM5637EPE-mGlu-NAM563
28.57Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
28.57Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
28.57Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
28.57Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
28.57Single7P2L4YI7P2L-mGlu5-4YI
28.57Single7PX4PSB-21137PX4-A2A-PSB-2113
28.57Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
28.57Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
28.57Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
28.57Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
28.57Single8E0GBU728E0G-μ-BU72
28.57Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
28.57Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
28.57Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
28.57Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
28.57Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
28.57Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
28.57Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
28.57Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
28.57Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
28.57Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
28.57Consensuslpa_offOrthosteric Ligandlpa1_off
28.57Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
28.57Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
28.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
28.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
28.00Single6HLOAprepitant6HLO-NK1-Aprepitant
28.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
28.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
28.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
27.78Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
27.78Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
27.78Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
27.78Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
27.78Single5WS3EMPA5WS3-OX2-EMPA
27.78Single6AKXA4R6AKX-CCR5-A4R
27.78Single6B73PubChem 1319551386B73-κ-PubChem 131955138
27.78Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
27.78Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
27.78Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
27.78Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
27.78Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
27.78Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
27.78Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
27.78Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
27.78Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
27.78Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
27.78Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
27.78Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
27.78Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
27.78Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
27.78Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
27.78Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GGVEpinephrine8GGV-β2-Epinephrine
27.78Single8GGWEpinephrine8GGW-β2-Epinephrine
27.78Single8GGXEpinephrine8GGX-β2-Epinephrine
27.78Single8GH0Epinephrine8GH0-β2-Epinephrine
27.78Single8GNGIstradefylline8GNG-A2A-Istradefylline
27.78Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
27.78Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
27.78Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
27.78Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
27.78Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
27.78Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Consensusgt_class-aOrthosteric Ligandgt_opsin
27.78Consensusgt_opsinOrthosteric Ligandgt_sensory
27.78Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
27.78Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
27.78Consensusorexin_offOrthosteric Ligandox2_off ox1_off
27.78Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
27.27Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
27.27Single4LDEBI1671074LDE-β2-BI167107
27.27Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
27.27Single5CXVTiotropium5CXV-M1-Tiotropium
27.27Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
27.27Single6A93Risperidone6A93-5-HT2A-Risperidone
27.27Single6CM4Risperidone6CM4-D2-Risperidone
27.27Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
27.27Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
27.27Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
27.27Single6MXTSalmeterol6MXT-β2-Salmeterol
27.27Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
27.27Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
27.27Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
27.27Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
27.27Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
27.27Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
27.27Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
27.27Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
27.27Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
27.27Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
27.27Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single8JJ8Formoterol8JJ8-β2-Formoterol
27.27Single8JJLOlodaterol8JJL-β2-Olodaterol
27.27Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
27.27Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
27.27Single8WU1KCA8WU1-CB1-KCA-Arrestin1
27.27Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
27.27Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
27.27Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
27.27Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
27.27Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
27.27Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
27.27Consensusgs_steroidOrthosteric Ligandgs_bileacid
27.27Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
27.27Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
27.27Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
26.92Single6PT2KGCHM076PT2-δ-KGCHM07
26.92Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
26.92Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
26.92Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
26.92Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
26.92Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
26.67Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
26.67Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
26.67Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
26.67Single6IGLIRL16206IGL-ETB-IRL1620
26.67Single8PWNTheophylline8PWN-A2A-Theophylline
26.67Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
26.67Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
26.32Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
26.32Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
26.32Single4MBSMaraviroc4MBS-CCR5-Maraviroc
26.32Single5IU7Q274563465IU7-A2A-Q27456346-Na
26.32Single5JTBZM2413855JTB-A2A-ZM241385
26.32Single5K2BZM2413855K2B-A2A-ZM241385-Na
26.32Single6AQFZM2413856AQF-A2A-ZM241385
26.32Single6DS0Ly2660976DS0-5-HT2B-Ly266097
26.32Single6FFIMMPEP6FFI-mGlu5-MMPEP
26.32Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
26.32Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
26.32Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
26.32Single6TPNHTL66416TPN-OX2-HTL6641
26.32Single6VI4JDTic6VI4-κ-JDTic
26.32Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
26.32Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
26.32Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
26.32Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
26.32Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
26.32Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
26.32Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
26.32Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
26.32Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
26.32Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
26.32Single7VODCariprazine7VOD-5-HT2A-Cariprazine
26.32Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
26.32Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
26.32Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
26.32Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GGIEpinephrine8GGI-β2-Epinephrine
26.32Single8GGKEpinephrine8GGK-β2-Epinephrine
26.32Single8GGMEpinephrine8GGM-β2-Epinephrine
26.32Single8GGPEpinephrine8GGP-β2-Epinephrine
26.32Single8GGTEpinephrine8GGT-β2-Epinephrine
26.32Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
26.32Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
26.32Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
26.32Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
26.32Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
26.32Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
26.32Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
26.32Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
26.32Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
26.32Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Consensus5ht5_onOrthosteric Ligand5ht5a_on
26.32Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
26.32Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
26.32Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
26.32Consensushca_onOrthosteric Ligandhca2_on hca3_on
26.32Consensushcar_onOrthosteric Ligandhca_on
26.32Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
26.32Consensussensory_offOrthosteric Ligandopsin_off
26.09Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
26.09Single5CGDHTL142425CGD-mGlu5-HTL14242
26.09Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
26.09Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
26.09Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
26.09Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
26.09Single6H7LDobutamine6H7L-β1-Dobutamine
26.09Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
26.09Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
26.09Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
26.09Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
26.09Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
26.09Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
26.09Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
25.93Single6JODAngiotensin II6JOD-AT2-Angiotensin II
25.93Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.93Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
25.81Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
25.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
25.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
25.00Single2Y02Carmoterol2Y02-β1-Carmoterol
25.00Single2Y04Salbutamol2Y04-β1-Salbutamol
25.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
25.00Single3EMLZM2413853EML-A2A-ZM241385
25.00Single4EIYZM2413854EIY-A2A-ZM241385-Na
25.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
25.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
25.00Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
25.00Single5DSGTiotropium5DSG-M4-Tiotropium
25.00Single5EE7MK08935EE7-Glucagon-MK0893
25.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
25.00Single5K2AZM2413855K2A-A2A-ZM241385-Na
25.00Single5OLGZM2413855OLG-A2A-ZM241385-Na
25.00Single5VRAZM2413855VRA-A2A-ZM241385-Na
25.00Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
25.00Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
25.00Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
25.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
25.00Single6FFHFenobam6FFH-mGlu5-Fenobam
25.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
25.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
25.00Single6H7MSalbutamol6H7M-β1-Salbutamol
25.00Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
25.00Single6PS1Timolol6PS1-β2-Timolol
25.00Single6S0LZM2413856S0L-A2A-ZM241385
25.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7BU7BI1671077BU7-β1-BI167107
25.00Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
25.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
25.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
25.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
25.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
25.00Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
25.00Single7PYRPSB-21157PYR-A2A-PSB-2115
25.00Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
25.00Single7SK9CCX6627SK9-ACKR3-CCX662
25.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
25.00Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
25.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
25.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
25.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
25.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
25.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
25.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
25.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
25.00Single8CU6LJ-45178CU6-A2A-LJ-4517
25.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
25.00Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
25.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
25.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
25.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8X63Mepyramine8X63-H1-Mepyramine
25.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
25.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
25.00Consensusa2_offOrthosteric Liganda2a_off
25.00Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
25.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
25.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
25.00Consensusblt_onOrthosteric Ligandblt1_on
25.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
25.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
25.00Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
25.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Consensusgi_hcarOrthosteric Ligandgi_hca
25.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
25.00Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
25.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
25.00Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
25.00Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
25.00Consensushistamine_onOrthosteric Ligandh1_on h4_on
25.00Consensusleuko_onOrthosteric Ligandblt_on
25.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
25.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
25.00Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
25.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
25.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Consensussensory_onOrthosteric Ligandopsin_on
24.14Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
24.14Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
24.14Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
24.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single7F8XNN90567F8X-CCKA-NN9056
24.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
24.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
24.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
24.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
24.00Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
24.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
23.81Single2Y03Isoprenaline2Y03-β1-Isoprenaline
23.81Single5IUAQ274563485IUA-A2A-Q27456348-Na
23.81Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
23.81Single5N2SPSB365N2S-A1-PSB36
23.81Single5NM2ZM2413855NM2-A2A-ZM241385-Na
23.81Single5TVNLSD5TVN-5-HT2B-LSD
23.81Single5XPRBosentan5XPR-ETB-Bosentan
23.81Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
23.81Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
23.81Single6E67BI1671076E67-β2-BI167107-Gs (fused)
23.81Single6LPLZM2413856LPL-A2A-ZM241385-Na
23.81Single6LUQHaloperidol6LUQ-D2-Haloperidol
23.81Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
23.81Single6S0QZM2413856S0Q-A2A-ZM241385
23.81Single6WQAZM2413856WQA-A2A-ZM241385-Na
23.81Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
23.81Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
23.81Single7RM5ZM2413857RM5-A2A-ZM241385-Na
23.81Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
23.81Single7SINNPS-21437SIN-CaS-NPS-2143
23.81Single7SINNPS-21437SIN-CaS-NPS-2143
23.81Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
23.81Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
23.81Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
23.81Single8EA0Iperoxo8EA0-M3-Iperoxo
23.81Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
23.81Single8FYNZM2413858FYN-A2A-ZM241385-Na
23.81Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
23.81Single8GNEKW-63568GNE-A2A-KW-6356-Na
23.81Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
23.81Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
23.81Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
23.81Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
23.81Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
23.81Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
23.81Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
23.81Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
23.81Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
23.81Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
23.53Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
23.53Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
23.53Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
23.53Single3UZAGTPL92363UZA-A2A-GTPL9236
23.53Single6ME5Agomelatine6ME5-MT1-Agomelatine
23.53Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
23.53Single8GGREpinephrine8GGR-β2-Epinephrine
23.53Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
23.53Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
23.53Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
23.53Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
23.53Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
23.33Consensusendothelin_onOrthosteric Ligandetb_on eta_on
23.08Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
23.08Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
22.86Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
22.73Single3P0GBI1671073P0G-β2-BI167107
22.73Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
22.73Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
22.73Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
22.73Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
22.73Single5V54Methiothepin5V54-5-HT1B-Methiothepin
22.73Single5V56TC1145V56-SMO-TC114
22.73Single5XR8AM8415XR8-CB1-AM841
22.73Single5XRAAM115425XRA-CB1-AM11542
22.73Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
22.73Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
22.73Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
22.73Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
22.73Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
22.73Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
22.73Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
22.73Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
22.73Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
22.73Single7W41PD1762527W41-BB2-PD176252
22.73Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
22.73Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
22.73Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
22.73Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
22.73Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
22.73Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
22.73Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
22.73Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
22.73Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
22.73Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
22.73Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
22.73Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
22.73Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
22.73Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
22.73Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
22.73Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
22.73Consensus5ht1_offOrthosteric Ligand5ht1b_off
22.73Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
22.73Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
22.73Consensus5ht5_offOrthosteric Ligand5ht5a_off
22.73Consensusadenosine_offOrthosteric Liganda1_off a2_off
22.73Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
22.73Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
22.73Consensusbombesin_offOrthosteric Ligandbb2_off
22.73Consensuscck_onOrthosteric Ligandccka_on cckb_on
22.73Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
22.73Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
22.73Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
22.73Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
22.73Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.73Consensuslpa_onOrthosteric Ligandlpa1_on
22.73Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
22.73Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
22.73Consensusrelaxin_onOrthosteric Ligandrxfp4_on
22.73Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
22.73Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
22.58Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
22.58Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.58Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
22.22Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
22.22Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
22.22Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
22.22Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
22.22Single3PBLEticlopride3PBL-D3-Eticlopride
22.22Single5L7IVismodegib5L7I-SMO-Vismodegib
22.22Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
22.22Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
22.22Single7SRQLSD7SRQ-5-HT2B-LSD
22.22Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
22.22Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
22.22Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
22.22Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
22.22Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
22.22Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
22.22Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGSEpinephrine8GGS-β2-Epinephrine
22.22Single8GH1Epinephrine8GH1-β2-Epinephrine
22.22Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
22.22Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
22.22Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
22.22Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
22.22Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8K5BNiacin8K5B-HCA2-Niacin
22.22Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
22.22Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
22.22Consensusangiotensin_onOrthosteric Ligandat1_on
22.22Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
22.22Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
22.22Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
22.22Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
22.22Consensusgo_class-b2Orthosteric Ligandgo_adhesion
22.22Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
22.22Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
21.88Single5GLHEndothelin-15GLH-ETB-Endothelin-1
21.88Single6IGKEndothelin-36IGK-ETB-Endothelin-3
21.88Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
21.88Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
21.74Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
21.74Single6HLPNetupitant6HLP-NK1-Netupitant
21.74Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
21.74Single6ZG4HTL00099366ZG4-M1-HTL0009936
21.74Single7K15MKD0467K15-BLT1-MKD046-Na
21.74Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
21.74Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
21.74Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
21.74Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
21.74Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
21.74Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
21.74Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
21.74Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
21.74Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
21.74Single8JWZAB9288JWZ-A2A-AB928-Na
21.74Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
21.74Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
21.74Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
21.74Consensusblt_offOrthosteric Ligandblt1_off
21.74Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
21.74Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
21.74Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
21.74Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
21.74Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
21.74Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
21.74Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
21.74Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
21.74Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
21.43Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
21.43Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
21.43Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
21.43Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
21.43Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
21.43Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
21.21Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
21.05Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
21.05Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
21.05Single3PWHZM2413853PWH-A2A-ZM241385
21.05Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
21.05Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
21.05Single4S0VSuvorexant4S0V-OX2-Suvorexant
21.05Single5K2DZM2413855K2D-A2A-ZM241385
21.05Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
21.05Single6AKYMaraviroc6AKY-CCR5-Maraviroc
21.05Single6JZHZM2413856JZH-A2A-ZM241385-Na
21.05Single6KUXRS-799486KUX-α2a-RS-79948
21.05Single6ME2Ramelteon6ME2-MT1-Ramelteon
21.05Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
21.05Single6PS7ZM2413856PS7-A2A-ZM241385-Na
21.05Single6TPJSuvorexant6TPJ-OX2-Suvorexant
21.05Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
21.05Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
21.05Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
21.05Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
21.05Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
21.05Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
21.05Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
21.05Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
21.05Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
21.05Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
21.05Single7XRRLemborexant7XRR-OX2-Lemborexant
21.05Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
21.05Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
21.05Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
21.05Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
21.05Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
21.05Single8IHKAcifran8IHK-HCA3-Acifran
21.05Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
21.05Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Single8IWESpermidine8IWE-TAAR9-Spermidine
21.05Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
21.05Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
21.05Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
21.05Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
21.05Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
21.05Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
21.05Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
21.05Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
21.05Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
21.05Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
21.05Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
20.83Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
20.83Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
20.83Single6K1QIRL25006K1Q-ETB-IRL2500
20.83Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
20.83Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
20.83Single7UM4AS26747237UM4-5-HT5A-AS2674723
20.83Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
20.83Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
20.83Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.83Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
20.83Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
20.83Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
20.83Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
20.83Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
20.83Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
20.83Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.83Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.83Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusorexin_onOrthosteric Ligandox2_on
20.83Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.69Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.69Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.69Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
20.69Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.59Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
20.00Single3RZECidoxepin3RZE-H1-Cidoxepin
20.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
20.00Single5IU4ZM2413855IU4-A2A-ZM241385-Na
20.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
20.00Single5K2CZM2413855K2C-A2A-ZM241385-Na
20.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
20.00Single5NLXZM2413855NLX-A2A-ZM241385-Na
20.00Single5NM4ZM2413855NM4-A2A-ZM241385-Na
20.00Single5UVIZM2413855UVI-A2A-ZM241385
20.00Single6A94Zotepine6A94-5-HT2A-Zotepine
20.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
20.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
20.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
20.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
20.00Single6TPKRetosiban6TPK-OT-Retosiban
20.00Single6V9SGTPL114036V9S-OX1-GTPL11403
20.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
20.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
20.00Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
20.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
20.00Single7AROLUF58337ARO-A2A-LUF5833-Na
20.00Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single7T32ZM2413857T32-A2A-ZM241385
20.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
20.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
20.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
20.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
20.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
20.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
20.00Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GGLEpinephrine8GGL-β2-Epinephrine
20.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
20.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
20.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
20.00Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
20.00Single8K5CAcipimox8K5C-HCA2-Acipimox
20.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
20.00Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
20.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
20.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
20.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
20.00Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
20.00Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
20.00Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
20.00Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
20.00Consensusvasopressin-ot_offOrthosteric Ligandot_off
19.35Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.35Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
19.35Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
19.23Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
19.23Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
19.23Single7QA8Peptide7QA8-STE2-Peptide
19.23Single7QA8Peptide7QA8-STE2-Peptide
19.23Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
19.23Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
19.23Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
19.23Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
19.23Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
19.23Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
19.23Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
19.23Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
19.23Consensusclass-d_offOrthosteric Ligandste2_off
19.23Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
19.05Single2Y01Dobutamine2Y01-β1-Dobutamine
19.05Single4DAJTiotropium4DAJ-M3-Tiotropium
19.05Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
19.05Single4MQSIperoxo4MQS-M2-Iperoxo
19.05Single4U14Tiotropium4U14-M3-Tiotropium
19.05Single5UENDU1725UEN-A1-DU172
19.05Single6DRXLisuride6DRX-5-HT2B-Lisuride
19.05Single6IIVDaltroban6IIV-TP-Daltroban
19.05Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
19.05Single6LPJZM2413856LPJ-A2A-ZM241385-Na
19.05Single6LPKZM2413856LPK-A2A-ZM241385-Na
19.05Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
19.05Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
19.05Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
19.05Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
19.05Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
19.05Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
19.05Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
19.05Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
19.05Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
19.05Single8K5DGSK2560738K5D-HCA2-GSK256073
19.05Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
19.05Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
19.05Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
19.05Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
19.05Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
19.05Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
19.05Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
19.05Consensustachykinin_offOrthosteric Ligandnk1_off
19.05Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
18.75Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
18.75Single8IY6Endothelin-18IY6-ETB-Endothelin-1
18.75Consensusclass-c_onOther Ligandgabab_on mglu_on
18.75Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.75Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
18.75Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
18.52Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
18.52Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
18.52Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
18.52Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
18.52Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
18.52Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
18.52Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
18.18Single2Y00Dobutamine2Y00-β1-Dobutamine
18.18Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
18.18Single5WIUNemonapride5WIU-D4-Nemonapride
18.18Single5WIVNemonapride5WIV-D4-Nemonapride-Na
18.18Single6D26Fevipiprant6D26-DP2-Fevipiprant
18.18Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
18.18Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
18.18Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
18.18Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
18.18Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
18.18Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
18.18Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
18.18Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
18.18Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
18.18Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.18Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.18Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.18Single7YXAONO-54306087YXA-S1P5-ONO-5430608
18.18Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
18.18Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
18.18Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
18.18Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
18.18Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
18.18Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
18.18Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
17.86Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
17.86Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
17.65Single3RFMCaffeine3RFM-A2A-Caffeine
17.65Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
17.65Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
17.39Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
17.39Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
17.39Single5V57TC1145V57-SMO-TC114
17.39Single6E59L-7607356E59-NK1-L-760735
17.39Single6J20Aprepitant6J20-NK1-Aprepitant
17.39Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
17.39Single7B6WCyclazosin7B6W-α1b-Cyclazosin
17.39Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
17.39Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
17.39Single7TUYGSK682753A7TUY-GPR183-GSK682753A
17.39Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
17.39Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
17.39Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
17.39Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
17.39Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
17.39Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
17.39Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
17.39Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
17.39Consensuschemerin_onOrthosteric Ligandcml1_on
17.39Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
17.39Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
17.39Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
17.39Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
17.39Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
17.24Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.24Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.24Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.24Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
17.24Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
17.24Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
17.24Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
17.14Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single3OE6IT1t3OE6-CXCR4-IT1t
16.67Single5X33BIIL2605X33-BLT1-BIIL260
16.67Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
16.67Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
16.67Single6IIURamatroban6IIU-TP-Ramatroban
16.67Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
16.67Single6ME9Ramelteon6ME9-MT2-Ramelteon
16.67Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
16.67Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
16.67Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
16.67Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.67Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
16.67Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
16.67Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
16.67Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
16.67Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
16.67Single7WC5Psilocin7WC5-5-HT2A-Psilocin
16.67Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
16.67Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
16.67Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
16.67Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
16.67Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
16.67Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
16.67Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
16.67Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
16.67Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
16.67Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
16.67Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
16.67Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
16.67Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
16.67Consensusdp_offOrthosteric Liganddp2_off
16.67Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
16.67Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
16.67Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
16.67Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
16.67Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
16.67Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
16.67Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.22Consensuspth_onOrthosteric Ligandpth1_on pth2_on
16.13Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.13Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
16.13Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.13Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
16.13Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Consensusclass-d_onOrthosteric Ligandste2_on
16.13Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
16.13Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
16.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
16.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
16.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
16.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
16.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
16.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
16.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
16.00Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
16.00Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
16.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
15.79Single3OE9IT1t3OE9-CXCR4-IT1t
15.79Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
15.79Single6HLLCP999946HLL-NK1-CP99994
15.79Single6TP4ACT-4622066TP4-OX1-ACT-462206
15.79Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
15.79Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
15.79Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
15.79Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
15.79Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
15.79Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
15.79Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
15.79Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
15.79Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
15.79Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
15.62Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
15.62Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
15.62Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.62Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
15.62Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
15.62Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
15.62Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
15.62Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
15.62Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
15.62Consensusgi_class-dOrthosteric Ligandgi_ste
15.62Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
15.62Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.62Consensusgo_class-b1Orthosteric Ligandgo_crf
15.62Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
15.38Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
15.38Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
15.38Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
15.38Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
15.38Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
15.38Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
15.38Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
15.38Consensusclass-d_offOrthosteric Ligandste2_off
15.38Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
15.38Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.38Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.15Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
15.15Single6LMLGlucagon6LML-Glucagon-Glucagon
15.15Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
15.15Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
15.00Single3ODUIT1t3ODU-CXCR4-IT1t
15.00Single5DHHSB-6121115DHH-NOP-SB-612111
15.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
15.00Single5U09Taranabant5U09-CB1-Taranabant
15.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
15.00Single7F8ULintitript7F8U-CCKA-Lintitript
15.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
15.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
15.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
15.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
15.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
15.00Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
15.00Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.00Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
14.81Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
14.81Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
14.71Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
14.71Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
14.71Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
14.71Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
14.29Single3REYPubChem 56973REY-A2A-PubChem 5697
14.29Single6IQLL7458706IQL-D4-L745870
14.29Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
14.29Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
14.29Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
14.29Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
14.29Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
14.29Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
14.29Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
14.29Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
14.29Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
14.29Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
14.29Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
14.29Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
14.29Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
14.29Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
14.29Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
14.29Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
14.29Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
14.29Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
14.29Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
14.29Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
14.29Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
14.29Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
14.29Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
14.29Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
14.29Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
13.89Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
13.89Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.79Single6W25SHU91196W25-MC4-SHU9119-Ca
13.79Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
13.79Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
13.79Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
13.79Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
13.64Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
13.64Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
13.64Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
13.64Single6D27CAY104716D27-DP2-CAY10471
13.64Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
13.64Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
13.64Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
13.64Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
13.64Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.64Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.64Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
13.64Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
13.64Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
13.64Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
13.64Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
13.64Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
13.51Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
13.51Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
13.51Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
13.33Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
13.33Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
13.33Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
13.33Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
13.33Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
13.33Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
13.33Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.33Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
13.33Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
13.16Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
13.04Single4NTJAZD12834NTJ-P2Y12-AZD1283
13.04Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
13.04Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
13.04Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
13.04Single7C4SS1P7C4S-S1P3-S1P
13.04Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.04Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
13.04Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
13.04Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
13.04Single8QOTNanobody E8QOT-μ-Nanobody E
13.04Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
13.04Consensusep_offOrthosteric Ligandep4_off
12.90Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.90Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
12.90Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
12.90Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
12.90Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
12.90Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
12.90Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.90Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
12.50Single5TZR-5TZR-FFA1 (GPR40)-MK8666
12.50Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
12.50Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
12.50Single6FJ3PTH6FJ3-PTH1-PTH
12.50Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
12.50Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
12.50Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
12.50Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
12.50Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
12.50Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
12.50Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
12.50Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
12.50Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
12.50Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
12.50Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
12.50Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.50Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
12.50Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
12.50Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
12.12Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
12.12Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
12.12Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
12.12Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
12.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
12.00Single6OS2TRV0266OS2-AT1-TRV026
12.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
12.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
12.00Single8GTMBMK-C2038GTM-CRF1-BMK-C203
12.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
12.00Consensuschemokine_offOrthosteric Ligandcxcr_off
12.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
12.00Consensuscxcr_offOrthosteric Ligandcxcr4_off
11.76Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
11.76Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
11.76Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
11.76Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
11.76Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
11.76Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
11.76Single7WC4Serotonin7WC4-5-HT2A-Serotonin
11.76Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
11.76Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
11.76Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
11.76Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
11.76Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
11.63Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
11.54Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
11.54Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
11.54Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
11.54Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
11.54Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
11.54Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
11.54Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.54Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
11.54Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
11.54Consensuscyslt_offOrthosteric Ligandcyslt2_off
11.54Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
11.43Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
11.43Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
11.43Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single6KNMJN241-96KNM-Apelin-JN241-9
11.11Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
11.11Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
11.11Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
11.11Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
11.11Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
11.11Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
11.11Consensusglp_onOrthosteric Ligandglp1_on glp2_on
11.11Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
11.11Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
11.11Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
10.81Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
10.81Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
10.71Single4XT1Fractalkine4XT1-US28-Fractalkine
10.71Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
10.71Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
10.71Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
10.71Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
10.71Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
10.71Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
10.71Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
10.53Single3OE8IT1t3OE8-CXCR4-IT1t
10.53Single6LI0GTPL98046LI0-GPR52-GTPL9804
10.53Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
10.53Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
10.53Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
10.53Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.53Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
10.53Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
10.53Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
10.34Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.34Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
10.34Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
10.34Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
10.34Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.26Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
10.00Single3OE0CVX153OE0-CXCR4-CVX15
10.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
10.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
10.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
10.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
10.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.00Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
10.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
10.00Single7XNACYN1548067XNA-SST2-CYN154806
10.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
10.00Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
10.00Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
10.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
10.00Consensusclass-t_onOrthosteric Ligandtaste2_on
10.00Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.00Consensusgs_class-tOrthosteric Ligandgs_taste
10.00Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.00Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
10.00Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
10.00Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
9.76Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
9.68Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
9.68Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
9.68Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
9.68Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
9.68Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Consensusclass-d_onOrthosteric Ligandste2_on
9.68Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
9.68Consensusgi_class-dOrthosteric Ligandgi_ste
9.68Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
9.52Single4K5YCP-3763954K5Y-CRF1-CP-376395
9.52Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.52Single7BR3Elagolix7BR3-GnRH1-Elagolix
9.52Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
9.52Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
9.52Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
9.52Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
9.52Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
9.52Consensusclass-f_offOrthosteric Ligandsmo_off
9.52Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
9.52Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
9.52Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
9.38Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
9.38Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
9.38Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
9.38Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.38Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
9.38Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.30Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
9.30Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
9.09Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
9.09Single4XT3Fractalkine4XT3-US28-Fractalkine
9.09Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
9.09Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7SK3CXCL127SK3-ACKR3-CXCL12
9.09Single7VV6C48/807VV6-MRGPRX2-C48/80
9.09Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
9.09Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
9.09Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
9.09Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
9.09Single8K2WAMG4878K2W-CXCR3-AMG487
9.09Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
9.09Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
9.09Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
9.09Consensusgnrh_offOrthosteric Ligandgnrh1_off
9.09Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
9.09Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
9.09Consensuss1p_offOrthosteric Ligands1p1_off
8.82Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
8.82Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
8.82Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
8.82Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
8.82Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
8.82Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
8.82Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
8.70Single4YAYZD-71554YAY-AT1-ZD-7155
8.70Single4Z9GCP-3763954Z9G-CRF1-CP-376395
8.70Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
8.70Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
8.70Single6GPSMK08126GPS-CCR2-MK0812
8.70Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
8.70Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
8.70Single7F83PF-051904577F83-Ghrelin-PF-05190457
8.70Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
8.70Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
8.70Single8GTIBMK-C2058GTI-CRF1-BMK-C205
8.70Consensuscck_offOrthosteric Ligandccka_off
8.70Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
8.70Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
8.70Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
8.70Consensushcar_offOrthosteric Ligandsuccinate_off
8.70Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
8.57Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
8.57Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
8.57Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
8.57Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
8.57Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
8.57Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
8.33Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
8.33Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
8.33Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
8.33Single6GPXMK08126GPX-CCR2-MK0812
8.33Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
8.33Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
8.33Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
8.33Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
8.33Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
8.33Single8GTGBMK-I1528GTG-CRF1-BMK-I152
8.33Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.33Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
8.11Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
8.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
8.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
8.00Single6OS1TRV0266OS1-AT1-TRV026
8.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
8.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
8.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
8.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
8.00Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.89Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
7.89Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
7.89Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
7.89Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
7.69Single4PY02MeSATP4PY0-P2Y12-2MeSATP
7.69Single4XEENeurotensin4XEE-NTS1-Neurotensin
7.69Single4XESNeurotensin4XES-NTS1-Neurotensin
7.69Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
7.69Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
7.69Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
7.69Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.69Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.69Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
7.69Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
7.69Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
7.69Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
7.69Consensusnts_onOrthosteric Ligandnts1_on
7.41Single4BUONeurotensin4BUO-NTS1-Neurotensin
7.41Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
7.41Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
7.41Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
7.41Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
7.41Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.41Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
7.41Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
7.14Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
7.14Consensusclass-c_offOther Ligandgabab_off mglu_off
7.14Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.98Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
6.98Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
6.90Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
6.90Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
6.67Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7SHEPI; PE7SHE-GPR158-PI; PE
6.67Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
6.67Single7SK5CXCL127SK5-ACKR3-CXCL12
6.67Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
6.67Consensussst_offOrthosteric Ligandsst2_off
6.52Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
6.45Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
6.25Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
6.06Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
5.88Single6W25Ca6W25-MC4-SHU9119-Ca
5.88Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.88Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
5.56Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
5.56Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
5.56Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
5.56Consensusglp1_on_alloOther Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
5.41Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
5.41Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
5.26Single6TQ9SB-4081246TQ9-OX1-SB-408124
5.26Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.26Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
5.26Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
5.00Single4XNWMRS25004XNW-P2Y1-MRS2500
5.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.00Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.00Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
5.00Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
4.76Single4O9RCyclopamine4O9R-SMO-Cyclopamine
4.76Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
4.76Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.76Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.76Consensusgo_proteinOrthosteric Ligandgo_chemokine
4.55Single4BWBNeurotensin4BWB-NTS1-Neurotensin
4.55Single4QINSAG1.54QIN-SMO-SAG1.5
4.55Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.55Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
4.55Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
4.55Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.55Single7F8YDevazepide7F8Y-CCKA-Devazepide
4.55Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
4.55Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single8HNNSCH5467388HNN-CXCR3-SCH546738
4.55Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
4.55Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.55Consensusnts1_on_alloOther Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.44Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
4.35Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.35Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
4.35Single6ZINSR486926ZIN-NTS1-SR48692
4.35Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.35Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Consensusgi_class-fOrthosteric Ligandgi_frizzled
4.35Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.17Single5T04Neurotensin5T04-NTS1-Neurotensin
4.17Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
4.17Single7RBTPubChem 1631837747RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
4.17Single8JPFPubChem 1186104278JPF-NTS1-Neurotensin-PubChem 118610427
4.17Single8JR9PCO3718JR9-PTH1-PCO371-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
4.17Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Single6Z4SSR486926Z4S-NTS1-SR48692
4.00Single8GW8KHF8GW8-PTH1-KHF-Gs/&β;1/&γ;2
4.00Single8JPCPubChem 118610427; GDP; Mg8JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.00Consensusffa3_on_alloOther Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
3.85Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
3.85Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
3.85Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85Single8J20AR4206268J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
3.85Single8JPBPubChem 118610427; GDP; Mg8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
3.70Single6YVRNTS8-136YVR-NTS1-NTS8-13
3.70Single7SHEPI; PE7SHE-GPR158-PI; PE
3.70Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
3.70Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
3.70Consensusnts_offOrthosteric Ligandnts1_off
3.57Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.45Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
3.23Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
3.12Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
2.63Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.63Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
2.56Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2

Consensus Members
Id Members
gi_frizzled 6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
Net Summary
Imin 2.06
Number of Linked Nodes 782
Number of Links 1033
Number of Hubs 181
Number of Links mediated by Hubs 701
Number of Communities 20
Number of Nodes involved in Communities 282
Number of Links involved in Communities 452
Path Summary
Number Of Nodes in MetaPath 82
Number Of Links MetaPath 81
Number of Shortest Paths 7041013
Length Of Smallest Path 3
Average Path Length 34.5644
Length of Longest Path 51
Minimum Path Strength 1.155
Average Path Strength 4.95774
Maximum Path Strength 41.72
Minimum Path Correlation 0.7
Average Path Correlation 0.996066
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.32558
Average % Of Corr. Nodes 36.4519
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 58.4798
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .




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