Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.11 1.82067502
2G.HN.45 1.51063404
3G.S1.01 4.87188436
4G.S1.02 5.28708465
5G.H1.04 3.22958487
6G.H1.07 3.4255589
7G.S2.05 4.38875433
8G.S2.08 7.2675465
9G.S3.03 8.61104467
10G.S3.05 2.96514667
11G.S3.06 7.6085535
12G.S3.07 3.59542469
13G.s3h2.03 4.43817539
14G.H2.02 3.81063438
15G.H2.04 3.3225509
16G.H2.06 4.89694639
17G.H2.07 4.35941739
18G.H2.09 5.130424148
19G.h2s4.01 6.22833439
20G.s4h3.04 5.99639628
21G.s4h3.05 7.64875429
22G.H3.01 5.96188429
23G.H3.09 4.90214729
24G.H3.13 3.60417425
25G.H3.17 7.317505
26G.H3.18 5.873964179
27G.S5.03 2.917588
28G.S5.04 3.33771429
29G.S5.05 3.53429789
30G.S5.07 3.53396489
31G.HG.04 5.092529
32G.HG.07 4.02383529
33G.hgh4.01 4.50542426
34G.hgh4.02 6.04917627
35G.hgh4.05 8.2225427
36G.H4.03 5.13681624
37G.H4.05 3.21567524
38G.H4.10 9.31979426
39G.H4.15 4.19617528
40G.h4s6.02 4.3425428
41G.h4s6.11 3.92438427
42G.S6.02 4.84631797
43G.S6.05 4.05542424
44G.H5.03 4.726588
45G.H5.08 5.57833568
46G.H5.09 3.92458404
47G.H5.13 4.21819698
48G.H5.17 3.715495
49G.H5.20 3.28979409
50G.H5.25 4.69625417
51G.H5.26 3.24271405
52b.1x1 1.59875404
53b.1x11 3.19229408
54b.lhb1x11 3.451254104
55b.b1x4 3.44375447
56b.b1x6 7.20208449
57b.l1x3 7.53792649
58b.b2x1 7.302335148
59b.b2x5 6.19778607
60b.b3x3 3.4054118
61b.l3x2 4.63517549
62b.b4x3 3.339175117
63b.b4x6 8.30952749
64b.l4x2 10.9962444
65b.b5x2 5.10583407
66b.b5x3 6.05208649
67b.b5x5 4.49021405
68b.b5x7 5.441874117
69b.l5x1 3.72055118
70b.l5x5 6.37929739
71b.b6x5 3.96729406
72b.l6x5 5.569584164
73b.b7x1 5.751835164
74b.b7x4 3.025834118
75b.l7x2 3.23167439
76b.b8x4 4.646396116
77b.l8x3 2.978334203
78b.l8x5 3.236874203
79b.l8x8 4.626254114
80b.l9x3 6.60333639
81b.l9x6 4.45509938
82b.b10x5 4.11933509
83b.b11x4 4.81033539
84b.l11x2 6.81633539
85b.b12x5 2.99042476
86b.b12x6 7.97381738
87b.l12x1 2.82687406
88b.b13x7 7.421577
89b.l13x3 7.44679
90b.l13x6 3.95133539
91b.l13x7 4.22271479
92b.b15x2 6.27667456
93b.b15x3 4.38521479
94b.l15x2 4.944579
95b.b16x4 9.79458476
96b.b16x5 4.05633505
97b.b16x6 8.28889678
98b.b17x5 6.27854457
99b.b17x7 6.83146458
100b.l17x3 8.22659
101b.l17x6 5.61133539
102b.b18x3 4.3575458
103b.l18x1 6.359887126
104b.l18x2 6.142294127
105b.b19x2 6.02625656
106b.b19x4 5.40583458
107b.l19x2 6.68167459
108b.b20x4 9.75333558
109b.b20x6 5.9855556
110b.b20x7 3.53688409
111b.l20x2 6.39354409
112b.b21x1 6.93583557
113b.b21x2 3.54833406
114b.b21x5 5.02375404
115b.b21x7 5.58317505
116b.b22x5 4.608756127
117b.l22x5 6.176335189
118b.b23x6 6.280717137
119b.l23x1 7.60646406
120b.b24x4 7.46754136
121b.b24x5 3.14958405
122b.b24x6 5.903544138
123b.l24x3 4.02983505
124b.b25x7 6.877714107
125b.l25x3 8.287835109
126b.b26x3 3.44604406
127b.l28x1 10.47796149
128b.l28x2 7.367714109
129b.b28x3 4.29729447
130b.b28x4 6.844384106
131b.b28x6 7.160836109
132b.b28x7 4.80792409
133g.h1x1 1.66667502
134g.h1x5 2.26033506
135g.h1x15 1.35083408
136g.l1x4 4.53117558
137g.h2x11 8.158124126
138g.ctx3 5.722926229
139g.ctx6 3.48729406
140g.ctx14 4.19042409
141g.ctx15 5.58187449
142g.ctx16 4.53667748
143g.ctx17 2.73354407
144NT 14.47551415
1451x39 3.6995517
1461x50 5.03437409
1471x59 2.64583405
1481x60 3.94938407
149I1x50 8.143334158
1502x39 3.83625408
1512x40 7.726175159
1522x42 5.17183508
1532x46 4.47983519
1542x50 6.12383519
1552x57 6.02274716
1563x25 9.6645519
1573x28 4.64375816
1583x29 9.71083415
1593x33 6.4705515
1603x43 3.9825419
1613x44 4.03667407
1623x46 4.09812419
1633x49 5.87021409
1643x50 5.21083619
1653x51 5.76479408
1664x42 4.49396407
1674x56 2.67415
1684x59 2.89208416
169E2 15.73971814
1705x39 7.18472616
1715x43 3.79896416
1725x58 3.58806619
1735x62 5.19855246
174I3 2.58986695
1756x44 4.89313419
1766x48 6.38726718
1776x52 4.68583506
1786x59 2.7175404
179E3 6.1565512
1807x31 4.75458412
1817x45 6.89958419
1827x49 5.47687419
1837x53 4.10783519
1848x50 5.141464158
185Lig 5.721481810
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b28x5 g.ctx16 11.7724.39667NoYes458
2b.b1x6 b.b28x5 11.44463.0925YesNo495
3b.b1x6 b.b4x6 10.084515.5642YesYes499
4b.b28x7 g.ctx16 24.23624.22833YesYes098
5b.b28x7 b.lhb1x11 30.61623.3875YesYes094
6b.b28x6 b.lhb1x11 38.22032.90667YesYes1094
7b.b27x3 b.b28x6 30.06287.78417NoYes089
8b.b26x3 b.b27x3 78.62183.5625YesNo068
9b.b22x2 b.b26x3 77.64853.87833NoYes086
10b.b22x1 b.b22x2 77.64523.73333NoNo088
11b.b22x1 b.l23x1 77.64243.13417NoYes086
12b.l23x1 b.l25x6 80.433618.0642YesNo068
13b.l25x6 b.l28x1 52.17119.9075NoYes089
14b.b2x1 b.l28x1 51.28825.7075YesYes1489
15b.b2x1 b.l3x1 51.569413.245YesNo089
16b.l3x1 b.l5x5 51.55865.84167NoYes099
17b.b27x3 b.l25x3 83.2027.07583NoYes089
18b.l25x3 b.l28x2 1007.9825YesYes1099
19b.l25x4 b.l28x2 99.82333.76833NoYes059
20I1x49 b.l25x4 99.59632.18917NoNo065
218x49 I1x49 95.68773.375NoNo076
222x40 8x49 94.08384.3025YesNo1597
232x37 2x40 94.04216.79583NoYes079
242x37 2x39 92.88242.71917NoYes078
252x39 3x50 87.32583.3075YesYes089
263x50 G.H5.25 49.47998.19833YesYes197
27G.H5.20 G.H5.25 46.7463.1125YesYes097
28G.H5.20 G.H5.26 42.82092.94333YesYes095
29G.H5.17 G.H5.26 41.3532.99917YesYes055
30G.H5.17 G.h4s6.12 19.32543.9375YesNo054
31G.S6.02 G.h4s6.12 18.555711.5033YesNo074
32G.H5.10 G.S6.02 34.5353.89NoYes067
33G.H5.10 G.S5.03 33.98993.25NoYes068
34G.S4.03 G.S5.03 20.62733.31083NoYes878
35G.S1.04 G.S4.03 20.22333.68583NoNo077
36G.S1.04 G.S3.05 19.66792.59167NoYes077
37G.S2.06 G.S3.05 10.17893.11083NoYes697
38b.b28x4 b.b28x6 17.8926.47667YesYes1069
39b.b28x4 b.l25x3 18.00048.515YesYes1069
40G.H5.13 G.H5.17 21.50893.45667YesYes985
41G.H5.13 G.S6.02 18.60358.04583YesYes987
42G.H3.17 b.l25x6 28.53183.5YesNo058
43G.H3.15 G.H3.17 28.24695.9325NoYes085
44G.H3.15 G.H3.18 28.20114.02833NoYes089
45G.HG.07 G.s4h3.04 12.52194.975YesYes298
46G.H3.09 G.S5.04 10.25733.1475YesYes299
47G.H3.09 G.S5.02 25.12233.4525YesNo096
48G.S4.02 G.S5.02 26.71072.575NoNo086
49G.H3.18 G.S4.02 26.86258.26833YesNo1798
50G.hgh4.01 G.s4h3.04 11.63133.13583YesYes268
51G.hgh4.01 G.hgh4.02 13.45129.29667YesYes267
52G.H3.06 G.hgh4.02 22.92023.99NoYes067
53G.H3.06 G.H4.15 11.69524.975NoYes068
54G.H3.09 G.H4.15 12.54553.92917YesYes298
55G.H3.06 G.h4s6.01 11.67622.94583NoNo064
56G.H3.09 G.h4s6.01 12.32033.34833YesNo094
57G.S5.03 G.S5.05 11.16423.24333YesYes889
58b.l5x5 b.l7x2 49.3784.55667YesYes399
59G.H2.04 G.H2.07 14.55955YesYes099
60b.l7x2 b.l9x6 47.88922.73417YesYes398
61G.H2.04 G.H3.08 13.40592.83417YesNo099
62G.H3.08 G.S4.04 13.22033.55417NoNo099
63G.H3.09 G.S4.04 13.181114.47YesNo099
64b.l11x1 b.l9x6 59.67485.915NoYes398
65b.b11x6 b.l11x1 60.02513.2475NoNo399
66b.b11x6 b.l9x3 58.475314.4117NoYes399
67b.b11x4 b.l9x3 50.6795.25167YesYes399
68b.b10x3 b.b11x4 52.19723.09833NoYes389
69b.b10x3 b.b6x2 52.13764.92917NoNo088
70b.b10x2 b.b6x2 51.97622.81667NoNo068
71b.b10x2 b.b10x4 45.87274.41NoNo066
72b.b10x4 b.b14x5 35.82892.73333NoNo065
73b.b14x5 b.l10x1 33.71644.1525NoNo053
74b.b11x1 b.l10x1 33.31994.21333NoNo053
75b.b11x1 b.b12x5 32.943.215NoYes056
76b.b12x5 b.l16x1 33.13672.48333YesNo064
77b.l16x1 b.l16x2 32.93491.85333NoNo049
78b.l14x5 b.l16x2 32.732710.9283NoNo059
79b.l14x3 b.l14x5 32.53015.5575NoNo055
80b.l14x1 b.l14x3 32.32712.7025NoNo045
81b.b18x5 b.l14x1 31.71573.69833NoNo054
82b.b15x2 b.b18x5 31.30619.3975YesNo065
83b.b15x2 b.b16x5 15.12383.725YesYes065
84b.b16x5 b.b17x5 12.65954.32333YesYes057
85b.b17x5 b.b21x1 11.24069.1375YesYes577
86b.1x19 b.b21x1 20.30938.83417NoYes067
87b.1x15 b.1x19 18.45014.90583NoNo076
88b.1x15 g.h1x15 17.98162.3NoYes078
89b.1x11 g.h1x15 16.57371.315YesYes088
90b.b15x2 b.b19x2 13.70456.99167YesYes566
91b.b17x7 b.b19x2 11.408510.4483YesYes586
92b.b17x7 b.b21x1 11.40293.98083YesYes587
93g.ctx3 g.ctx6 16.02937.23917YesYes096
94b.l22x5 g.ctx6 13.55173.9475YesYes096
95b.b10x4 b.b2x4 13.801110.5325NoNo066
96b.b2x4 b.b6x5 13.5643.08833NoYes066
97b.b3x3 b.b6x5 12.84173.365YesYes086
98b.b3x3 b.b4x3 10.08313.84917YesYes1187
99b.l21x7 b.l23x1 18.14755.31583NoYes056
100b.b23x6 b.l21x7 16.9752.6875YesNo1375
101b.b21x7 b.b24x6 13.74515.86667YesYes058
102b.b23x6 b.b24x6 14.04296.91333YesYes1378
103b.l22x1 g.ctx3 17.42298.0975NoYes2299
1043x50 7x53 42.325.23YesYes199
1053x43 7x53 41.32874.29917YesYes199
1063x43 6x44 41.05693.24917YesYes199
1076x44 6x48 39.6138.10167YesYes198
1086x48 Lig 35.85423.58417YesYes180
1092x46 3x46 10.06822.97167YesYes199
110b.b23x1 b.l22x1 18.6192.75167NoNo059
111G.H2.07 b.l9x6 13.76663.93917YesYes398
112b.b23x1 b.b24x5 12.42044.34583NoYes055
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
NTNT45.2951YesYes5511
3x22NT4.071NoYes3521
E2NT64.72831YesYes4511
E1x50NT5.00251NoYes5521
E1x501NT12.80921NoYes7521
LigNT7.314171YesYes0501
E3NT5.285831YesYes2521
2x573x325.589171YesNo6621
2x577x386.083331YesNo6521
2x603x288.2451NoYes6611
2x60Lig7.054171NoYes6010
2x633x283.649170NoYes4621
2x643x282.855831NoYes5611
2x64Lig4.9151NoYes5010
3x28E1x504.310831YesNo6512
3x28E1x522.933331YesNo6612
3x253x263.959171YesNo9622
3x253x286.666671YesYes9621
3x253x2914.18581YesYes9521
3x25E217.51081YesYes9421
3x26E215.66581NoYes6421
3x283x295.335831YesYes6511
3x28Lig3.153331YesYes6010
3x29E211.151YesYes5411
3x29Lig8.171671YesYes5010
3x32Lig3.698331NoYes6010
3x33E25.366671YesYes5411
3x335x396.921YesYes5612
3x335x432.675831YesYes5611
3x33Lig15.93671YesYes5010
3x366x485.313331NoYes6811
3x36Lig7.960831NoYes6010
3x374x532.918330NoNo5812
3x37Lig4.0450NoYes5010
3x406x484.379170NoYes7821
4x565x392.744171YesYes5622
4x565x432.8551YesYes5621
4x594x603.02751YesNo6522
4x59E24.860831YesYes6421
4x595x392.931YesYes6622
4x60E29.965831NoYes5421
4x605x3914.72081NoYes5622
5x39E210.09581YesYes6421
E2E244.6551YesYes4411
5x40E23.07751NoYes6421
6x58E215.9751NoYes4421
7x31E26.974171YesYes2421
7x34E23.974171NoYes4411
E2Lig7.09751YesYes4010
5x365x388.443331NoNo5422
5x395x435.69751YesYes6621
5x406x553.701671NoNo6621
5x476x4810.76831NoYes7811
5x476x5213.31251NoYes7612
5x47Lig4.456671NoYes7010
6x446x488.101671YesYes9821
6x487x413.241671YesNo8712
6x487x459.32251YesYes8912
6x516x553.543331NoNo6611
6x51Lig3.99251NoYes6010
6x55Lig5.260831NoYes6010
6x587x316.446671NoYes4222
E3E36.276671YesYes2222
7x31E33.174171YesYes2222
7x38Lig8.443330NoYes5010
3x25NT61YesYes9521
2x603x325.1551NoNo6611
3x374x562.630NoYes5512
5x36E29.531671NoYes5421
5x38E26.8051NoYes4421
5x43Lig3.96751YesYes6010
6x447x452.920831YesYes9922
6x48Lig3.584171YesYes8010
7x34Lig2.78751NoYes4010
E1x50E1x5013.486671NoNo5722
7x32NT2.259171NoYes1521
E1x48NT2.070NoYes2521
2x64E1x471.701671NoNo5612
3x303x331.453330NoYes6521
1x32NT1.30251NoYes3521
4x63E21.2250NoYes5421
E1Lig1.14750NoYes0010
1x31NT0.6158330NoYes0521
1x30NT0.6091670NoYes0521

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
83.33Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
78.95Consensuslpl_offOrthosteric Ligands1p_off lpa_off
78.95Consensuslpl_onOrthosteric Ligands1p_on lpa_on
68.42Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
68.42Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
66.67Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
65.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
65.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
65.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
63.16Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
63.16Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
63.16Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
63.16Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
63.16Consensuslpa_offOrthosteric Ligandlpa1_off
63.16Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
63.16Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
61.11Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
60.87Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
60.87Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
60.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
60.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
60.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
59.09Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
57.89Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
57.89Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
57.89Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
57.89Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
57.89Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
57.14Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
57.14Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
57.14Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
56.52Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
56.00Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
55.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
55.00Single8E0GBU728E0G-μ-BU72
55.00Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
55.00Consensuslpa_onOrthosteric Ligandlpa1_on
54.55Single5ZTYAM102575ZTY-CB2-AM10257
54.55Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
54.55Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
54.55Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
52.63Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
52.63Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
52.38Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
52.38Single7YITNalfurafine7YIT-κ-Nalfurafine
52.38Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
52.38Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
52.38Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
52.38Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
52.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
50.00Single5C1MBU725C1M-μ-BU72
50.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
50.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
50.00Single7C4SS1P7C4S-S1P3-S1P
50.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
50.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
50.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
50.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
50.00Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
50.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
50.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
50.00Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
48.28Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
48.00Consensusangiotensin_onOrthosteric Ligandat1_on
48.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
48.00Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
47.83Single4UG2CGS216804UG2-A2A-CGS21680
47.83Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
47.83Single7SK9CCX6627SK9-ACKR3-CCX662
47.83Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
47.83Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
47.83Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
47.62Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
47.62Single4DJHJDTic4DJH-κ-JDTic
47.62Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
47.62Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
47.62Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
47.62Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
47.62Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
47.62Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
47.62Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
47.62Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
47.62Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
47.62Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
47.62Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
47.37Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
47.37Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
47.37Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
47.37Consensus5ht5_onOrthosteric Ligand5ht5a_on
47.37Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
47.37Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
47.37Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
47.37Consensuss1p_offOrthosteric Ligands1p1_off
46.15Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
46.15Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
45.83Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
45.83Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
45.83Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
45.83Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
45.83Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
45.83Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
45.45Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
45.45Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
45.45Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
45.45Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
45.45Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
45.45Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
45.45Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
45.45Single8WU1KCA8WU1-CB1-KCA-Arrestin1
45.45Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
45.45Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
45.45Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
45.45Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
45.45Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
45.45Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
45.45Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
45.16Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
45.00Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
45.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
45.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
45.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
45.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
45.00Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
45.00Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
45.00Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
44.83Single6IGLIRL16206IGL-ETB-IRL1620
44.44Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
44.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
44.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
43.48Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
43.48Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
43.48Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
43.48Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
43.48Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
43.48Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
43.48Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
43.48Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
43.48Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
43.48Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
43.48Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
43.48Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
43.48Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
43.48Consensusendothelin_offOrthosteric Ligandetb_off
43.48Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
43.48Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
43.48Consensusorexin_onOrthosteric Ligandox2_on
43.33Single5GLHEndothelin-15GLH-ETB-Endothelin-1
43.33Single6IGKEndothelin-36IGK-ETB-Endothelin-3
42.86Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
42.86Single6TP6Filorexant6TP6-OX1-Filorexant
42.86Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
42.86Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
42.86Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
42.86Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
42.86Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
42.86Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
42.86Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
42.86Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
42.86Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
42.86Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
42.86Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
42.31Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
42.31Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
42.11Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
42.11Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
42.11Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
42.11Single6AKXA4R6AKX-CCR5-A4R
42.11Single6B73PubChem 1319551386B73-κ-PubChem 131955138
42.11Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
42.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
42.11Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
42.11Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.11Consensusorexin_offOrthosteric Ligandox2_off ox1_off
41.67Single3NY9PubChem 9131033NY9-β2-PubChem 913103
41.67Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
41.67Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single8X5YAstemizole8X5Y-H1-Astemizole
41.67Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
41.67Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
41.67Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
41.38Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
40.91Single2YDVNECA2YDV-A2A-NECA
40.91Single3P0GBI1671073P0G-β2-BI167107
40.91Single4RWADIPP-NH24RWA-δ-DIPP-NH2
40.91Single4UHRCGS216804UHR-A2A-CGS21680
40.91Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
40.91Single5G53NECA5G53-A2A-NECA-Gs
40.91Single5X93K-87945X93-ETB-K-8794
40.91Single5XR8AM8415XR8-CB1-AM841
40.91Single5XRAAM115425XRA-CB1-AM11542
40.91Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
40.91Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
40.91Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
40.91Single6H7JIsoprenaline6H7J-β1-Isoprenaline
40.91Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
40.91Single6TQ7SB-3348676TQ7-OX1-SB-334867
40.91Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
40.91Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
40.91Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
40.91Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
40.91Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
40.91Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
40.91Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
40.91Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
40.91Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
40.91Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
40.91Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
40.91Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.91Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
40.91Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
40.91Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
40.91Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
40.91Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
40.91Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
40.91Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
40.91Consensusa2_onOrthosteric Liganda2a_on a2b_on
40.91Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
40.91Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
40.91Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
40.91Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
40.91Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.91Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
40.91Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
40.74Single6JODAngiotensin II6JOD-AT2-Angiotensin II
40.74Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.74Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
40.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
40.00Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
40.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
40.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
40.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
40.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
40.00Single6TPGEMPA6TPG-OX2-EMPA
40.00Single6TPNHTL66416TPN-OX2-HTL6641
40.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
40.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
40.00Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
40.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
40.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
40.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
40.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
40.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
40.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
40.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
40.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
40.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
40.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
40.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
40.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
40.00Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
40.00Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
40.00Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
40.00Consensussensory_offOrthosteric Ligandopsin_off
40.00Consensussst_onOrthosteric Ligandsst2_on sst4_on
39.29Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
39.29Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
39.29Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
39.29Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
39.29Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
39.13Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
39.13Single4AMIBucindolol4AMI-β1-Bucindolol
39.13Single4LDEBI1671074LDE-β2-BI167107
39.13Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
39.13Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
39.13Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
39.13Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
39.13Single6ZG4HTL00099366ZG4-M1-HTL0009936
39.13Single7DFPSpiperone7DFP-D2-Spiperone
39.13Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
39.13Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
39.13Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
39.13Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
39.13Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
39.13Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
39.13Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
39.13Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
39.13Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
39.13Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
39.13Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
39.13Single8JJ8Formoterol8JJ8-β2-Formoterol
39.13Single8JJLOlodaterol8JJL-β2-Olodaterol
39.13Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
39.13Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
39.13Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
39.13Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
39.13Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
38.71Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
38.71Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
38.46Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
38.46Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
38.46Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
38.46Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
38.46Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
38.10Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
38.10Single2Y04Salbutamol2Y04-β1-Salbutamol
38.10Single3NY8ICI 118-5513NY8-β2-ICI 118-551
38.10Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
38.10Single4EJ4Naltrindole4EJ4-δ-Naltrindole
38.10Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
38.10Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
38.10Single6DRXLisuride6DRX-5-HT2B-Lisuride
38.10Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
38.10Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
38.10Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
38.10Single6TOTLemborexant6TOT-OX1-Lemborexant
38.10Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
38.10Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
38.10Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
38.10Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
38.10Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
38.10Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
38.10Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
38.10Single7UL4Alvimopan7UL4-μ-Alvimopan
38.10Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
38.10Single7WC7Lisuride7WC7-5-HT2A-Lisuride
38.10Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
38.10Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
38.10Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
38.10Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
38.10Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
38.10Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
38.10Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
38.10Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
38.10Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
38.10Consensusadenosine_onOrthosteric Liganda1_on a2_on
38.10Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
38.10Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
38.10Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
38.10Consensusblt_onOrthosteric Ligandblt1_on
38.10Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
38.10Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
38.10Consensusgi_hcarOrthosteric Ligandgi_hca
38.10Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
38.10Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
38.10Consensusleuko_onOrthosteric Ligandblt_on
38.10Consensusnucleotide_onOrthosteric Ligandadenosine_on
38.10Consensustar_onOrthosteric Ligandta1_on
37.93Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
37.93Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
37.50Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
37.50Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
37.50Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
37.50Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
37.50Single6K1QIRL25006K1Q-ETB-IRL2500
37.50Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
37.50Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
37.50Single7UM4AS26747237UM4-5-HT5A-AS2674723
37.50Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
37.50Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
37.50Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
37.50Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
37.50Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
37.50Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
37.50Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
37.50Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
37.50Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
37.50Consensussteroid_onOrthosteric Ligandbileacid_on
37.04Single5WF5UK-4320975WF5-A2A-UK-432097
37.04Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
37.04Single6PT2KGCHM076PT2-δ-KGCHM07
37.04Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
37.04Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
37.04Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
36.84Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
36.84Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
36.84Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
36.84Single7SRQLSD7SRQ-5-HT2B-LSD
36.84Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
36.84Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
36.84Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
36.84Single8GH1Epinephrine8GH1-β2-Epinephrine
36.84Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
36.67Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
36.67Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
36.67Consensusendothelin_onOrthosteric Ligandetb_on eta_on
36.36Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
36.36Single2Y03Isoprenaline2Y03-β1-Isoprenaline
36.36Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
36.36Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
36.36Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
36.36Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
36.36Single5TVNLSD5TVN-5-HT2B-LSD
36.36Single5WQCEMPA5WQC-OX2-EMPA
36.36Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
36.36Single5XPRBosentan5XPR-ETB-Bosentan
36.36Single6E67BI1671076E67-β2-BI167107-Gs (fused)
36.36Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
36.36Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
36.36Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
36.36Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
36.36Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
36.36Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
36.36Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
36.36Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
36.36Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
36.36Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
36.36Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
36.36Single7WC6LSD7WC6-5-HT2A-LSD
36.36Single7XKAEpinephrine7XKA-β2-Epinephrine
36.36Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
36.36Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
36.36Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
36.36Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.36Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.36Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.36Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
36.36Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
36.36Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
36.36Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
36.36Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
36.36Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
36.36Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
36.36Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
36.36Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
36.36Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
36.36Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
36.36Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
36.36Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
36.36Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
36.36Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
36.11Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
36.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
36.00Single6PT3DPI-2876PT3-δ-DPI-287
36.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
36.00Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
36.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
36.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
36.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
36.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
36.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
36.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
36.00Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
36.00Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
35.71Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
35.71Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
35.71Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
35.71Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
35.71Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
35.71Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
35.48Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
35.48Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
35.48Single8IY6Endothelin-18IY6-ETB-Endothelin-1
35.48Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
35.48Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
35.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
35.00Single5WS3EMPA5WS3-OX2-EMPA
35.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
35.00Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
35.00Single6TODEMPA6TOD-OX1-EMPA-Na
35.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
35.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
35.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
35.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
35.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
35.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
35.00Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
35.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
35.00Single7XRRLemborexant7XRR-OX2-Lemborexant
35.00Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
35.00Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
35.00Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
35.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
35.00Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.00Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
35.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
35.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
35.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
35.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
35.00Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
35.00Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
35.00Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
35.00Consensusmglu_onOther Ligandmglu2_on mglu4_on
35.00Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
34.78Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
34.78Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
34.78Single4U15Tiotropium4U15-M3-Tiotropium
34.78Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
34.78Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
34.78Single6J21Aprepitant6J21-NK1-Aprepitant
34.78Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
34.78Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
34.78Single6OL9Tiotropium6OL9-M5-Tiotropium
34.78Single6WGTLSD6WGT-5-HT2A-LSD
34.78Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
34.78Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
34.78Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
34.78Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
34.78Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
34.78Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
34.78Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
34.78Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
34.78Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
34.78Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
34.78Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
34.78Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
34.78Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
34.78Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
34.78Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
34.78Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
34.78Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
34.78Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
34.78Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
34.78Consensus5ht5_offOrthosteric Ligand5ht5a_off
34.78Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
34.78Consensuscck_onOrthosteric Ligandccka_on cckb_on
34.78Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
34.78Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
34.78Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
34.78Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
34.78Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
34.78Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
34.78Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
34.78Consensushistamine_offOrthosteric Ligandh1_off
34.78Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
34.78Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
34.78Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
34.78Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
34.62Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
34.62Single4IARErgotamine4IAR-5-HT1B-Ergotamine
34.62Single4XT1Fractalkine4XT1-US28-Fractalkine
34.62Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
34.62Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
34.62Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
34.62Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
34.62Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
34.62Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
34.62Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
34.48Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
34.48Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.48Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
34.48Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
34.48Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
34.48Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
34.48Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
34.38Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
33.33Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
33.33Single2YDOAdenosine2YDO-A2A-Adenosine
33.33Single3QAKUK-4320973QAK-A2A-UK-432097
33.33Single3RZECidoxepin3RZE-H1-Cidoxepin
33.33Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
33.33Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
33.33Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
33.33Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
33.33Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
33.33Single4XT3Fractalkine4XT3-US28-Fractalkine
33.33Single5CXVTiotropium5CXV-M1-Tiotropium
33.33Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
33.33Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
33.33Single6A93Risperidone6A93-5-HT2A-Risperidone
33.33Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
33.33Single6CM4Risperidone6CM4-D2-Risperidone
33.33Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
33.33Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
33.33Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
33.33Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
33.33Single6MXTSalmeterol6MXT-β2-Salmeterol
33.33Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
33.33Single6PS4ICI 118-5516PS4-β2-ICI 118-551
33.33Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
33.33Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
33.33Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
33.33Single6TP3Nemorexant6TP3-OX1-Nemorexant
33.33Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
33.33Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
33.33Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
33.33Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
33.33Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
33.33Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
33.33Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
33.33Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
33.33Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
33.33Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
33.33Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
33.33Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
33.33Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
33.33Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
33.33Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
33.33Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
33.33Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
33.33Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
33.33Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
33.33Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
33.33Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
33.33Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
33.33Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
33.33Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
33.33Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
33.33Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GGKEpinephrine8GGK-β2-Epinephrine
33.33Single8GGMEpinephrine8GGM-β2-Epinephrine
33.33Single8GGPEpinephrine8GGP-β2-Epinephrine
33.33Single8GGQEpinephrine8GGQ-β2-Epinephrine
33.33Single8GGTEpinephrine8GGT-β2-Epinephrine
33.33Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
33.33Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
33.33Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
33.33Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
33.33Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
33.33Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
33.33Single8JWZAB9288JWZ-A2A-AB928-Na
33.33Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8K5CAcipimox8K5C-HCA2-Acipimox
33.33Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
33.33Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
33.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
33.33Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
33.33Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
33.33Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
33.33Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
33.33Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
33.33Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
33.33Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
33.33Consensusdp_offOrthosteric Liganddp2_off
33.33Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
33.33Consensusgi_class-fOther Ligandgi_frizzled
33.33Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
33.33Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
33.33Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
33.33Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
33.33Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
33.33Consensusgs_steroidOrthosteric Ligandgs_bileacid
33.33Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
33.33Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
33.33Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
33.33Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
33.33Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
33.33Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
32.26Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
32.26Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
32.26Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
32.26Consensusgo_class-b1Orthosteric Ligandgo_crf
32.26Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
32.14Single6W25SHU91196W25-MC4-SHU9119-Ca
32.14Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
32.14Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
32.14Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
32.14Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.14Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.14Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
32.14Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
32.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
32.00Single6H7LDobutamine6H7L-β1-Dobutamine
32.00Single6IBLArformoterol6IBL-β1-Arformoterol
32.00Single7EZCUKA7EZC-A2A-UKA
32.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
32.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
32.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
32.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
32.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Single2Y02Carmoterol2Y02-β1-Carmoterol
31.82Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
31.82Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
31.82Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
31.82Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
31.82Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
31.82Single4MQSIperoxo4MQS-M2-Iperoxo
31.82Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
31.82Single4U14Tiotropium4U14-M3-Tiotropium
31.82Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
31.82Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
31.82Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
31.82Single5TGZAM65385TGZ-CB1-AM6538
31.82Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
31.82Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
31.82Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
31.82Single6H7MSalbutamol6H7M-β1-Salbutamol
31.82Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
31.82Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
31.82Single6PS1Timolol6PS1-β2-Timolol
31.82Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
31.82Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
31.82Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
31.82Single7BU7BI1671077BU7-β1-BI167107
31.82Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
31.82Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
31.82Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
31.82Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
31.82Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
31.82Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
31.82Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
31.82Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
31.82Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
31.82Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
31.82Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
31.82Single8CU6LJ-45178CU6-A2A-LJ-4517
31.82Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
31.82Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
31.82Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
31.82Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
31.82Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.82Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.82Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.82Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.82Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.82Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.82Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.82Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.82Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.82Single8GGJEpinephrine8GGJ-β2-Epinephrine
31.82Single8GGNEpinephrine8GGN-β2-Epinephrine
31.82Single8GGOEpinephrine8GGO-β2-Epinephrine
31.82Single8GGUEpinephrine8GGU-β2-Epinephrine
31.82Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
31.82Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
31.82Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
31.82Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
31.82Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
31.82Single8JJOAlprenolol8JJO-β2-Alprenolol
31.82Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
31.82Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
31.82Single8K5DGSK2560738K5D-HCA2-GSK256073
31.82Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.82Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.82Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.82Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
31.82Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
31.82Single8X63Mepyramine8X63-H1-Mepyramine
31.82Single8X64Desloratadine8X64-H1-Desloratadine
31.82Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
31.82Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
31.82Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
31.82Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
31.82Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
31.82Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
31.82Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
31.82Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
31.82Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
31.82Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
31.82Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
31.82Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
31.82Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
31.82Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
31.82Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
31.58Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
31.58Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
31.58Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
31.58Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
31.58Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
31.58Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
31.58Single8GGREpinephrine8GGR-β2-Epinephrine
31.58Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
31.43Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
31.43Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
31.25Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
31.25Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
31.03Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
31.03Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
31.03Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
31.03Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
31.03Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
31.03Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
31.03Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
31.03Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
31.03Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single5WF6UK-4320975WF6-A2A-UK-432097
30.77Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
30.77Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
30.77Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
30.77Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.77Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
30.77Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.77Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
30.77Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
30.77Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
30.77Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.56Consensuspth_onOrthosteric Ligandpth1_on pth2_on
30.43Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
30.43Single5N2SPSB365N2S-A1-PSB36
30.43Single5NM2ZM2413855NM2-A2A-ZM241385-Na
30.43Single5WIUNemonapride5WIU-D4-Nemonapride
30.43Single5WIVNemonapride5WIV-D4-Nemonapride-Na
30.43Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
30.43Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
30.43Single6LUQHaloperidol6LUQ-D2-Haloperidol
30.43Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
30.43Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
30.43Single6PS6Timolol6PS6-β2-Timolol
30.43Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
30.43Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
30.43Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
30.43Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
30.43Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
30.43Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
30.43Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
30.43Single7YXAONO-54306087YXA-S1P5-ONO-5430608
30.43Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.43Single8EA0Iperoxo8EA0-M3-Iperoxo
30.43Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
30.43Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
30.43Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
30.43Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
30.43Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
30.43Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
30.43Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
30.43Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
30.43Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
30.43Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
30.43Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.43Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.30Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
30.30Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
30.30Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
30.30Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
30.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
30.00Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
30.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
30.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
30.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
30.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
30.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
30.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
30.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
30.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
30.00Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
30.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
30.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
30.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
30.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
30.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
30.00Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
30.00Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.00Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.00Single8GGSEpinephrine8GGS-β2-Epinephrine
30.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
30.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
30.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
30.00Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
30.00Single8K5BNiacin8K5B-HCA2-Niacin
30.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
30.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
30.00Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
30.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
30.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
30.00Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
30.00Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
29.63Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
29.63Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
29.63Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
29.63Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
29.63Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
29.63Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
29.41Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
29.41Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
29.41Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
29.41Consensusglp_onOrthosteric Ligandglp1_on glp2_on
29.17Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
29.17Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
29.17Single4BV0Neurotensin4BV0-NTS1-Neurotensin
29.17Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
29.17Single5V54Methiothepin5V54-5-HT1B-Methiothepin
29.17Single6E59L-7607356E59-NK1-L-760735
29.17Single6J20Aprepitant6J20-NK1-Aprepitant
29.17Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
29.17Single7B6WCyclazosin7B6W-α1b-Cyclazosin
29.17Single7EPENAM5637EPE-mGlu-NAM563
29.17Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
29.17Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
29.17Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
29.17Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
29.17Single7TUYGSK682753A7TUY-GPR183-GSK682753A
29.17Single7W41PD1762527W41-BB2-PD176252
29.17Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
29.17Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
29.17Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
29.17Consensus5ht1_offOrthosteric Ligand5ht1b_off
29.17Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
29.17Consensusadenosine_offOrthosteric Liganda1_off a2_off
29.17Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
29.17Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
29.17Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
29.17Consensusbombesin_offOrthosteric Ligandbb2_off
29.17Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
29.17Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
29.17Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
29.03Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
29.03Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
29.03Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
29.03Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
29.03Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
29.03Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
29.03Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
29.03Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
29.03Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
29.03Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
28.95Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
28.57Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
28.57Single3PWHZM2413853PWH-A2A-ZM241385
28.57Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
28.57Single4S0VSuvorexant4S0V-OX2-Suvorexant
28.57Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
28.57Single6HLOAprepitant6HLO-NK1-Aprepitant
28.57Single6KUXRS-799486KUX-α2a-RS-79948
28.57Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
28.57Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
28.57Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
28.57Single6TPJSuvorexant6TPJ-OX2-Suvorexant
28.57Single7BR3Elagolix7BR3-GnRH1-Elagolix
28.57Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
28.57Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
28.57Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
28.57Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
28.57Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
28.57Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
28.57Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
28.57Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
28.57Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
28.57Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
28.57Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
28.57Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
28.57Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
28.57Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
28.57Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
28.57Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
28.57Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
28.57Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
28.57Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
28.57Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
28.57Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
28.57Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
28.57Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
28.57Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
28.57Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
28.57Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8GGVEpinephrine8GGV-β2-Epinephrine
28.57Single8GGWEpinephrine8GGW-β2-Epinephrine
28.57Single8GGXEpinephrine8GGX-β2-Epinephrine
28.57Single8GH0Epinephrine8GH0-β2-Epinephrine
28.57Single8GNGIstradefylline8GNG-A2A-Istradefylline
28.57Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
28.57Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8IHKAcifran8IHK-HCA3-Acifran
28.57Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
28.57Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
28.57Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
28.57Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
28.57Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
28.57Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
28.57Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
28.57Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
28.57Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
28.57Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
28.57Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
28.57Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
28.57Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
28.57Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
28.57Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
28.57Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
28.57Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensusgt_class-aOrthosteric Ligandgt_opsin
28.57Consensusgt_opsinOrthosteric Ligandgt_sensory
28.57Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
28.57Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
28.12Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
28.12Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
28.12Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
28.12Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
28.00Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
28.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
28.00Single4XESNeurotensin4XES-NTS1-Neurotensin
28.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
28.00Single6HLPNetupitant6HLP-NK1-Netupitant
28.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
28.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
28.00Single7K15MKD0467K15-BLT1-MKD046-Na
28.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
28.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
28.00Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
28.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
28.00Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
28.00Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
28.00Consensusblt_offOrthosteric Ligandblt1_off
28.00Consensusclass-b2_onOrthosteric Ligandadgrg_on
28.00Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
28.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.78Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
27.78Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
27.78Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
27.78Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
27.78Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
27.78Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
27.78Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
27.59Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
27.59Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
27.59Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
27.59Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
27.59Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
27.27Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
27.27Single5IU7Q274563465IU7-A2A-Q27456346-Na
27.27Single5JTBZM2413855JTB-A2A-ZM241385
27.27Single5K2BZM2413855K2B-A2A-ZM241385-Na
27.27Single6A94Zotepine6A94-5-HT2A-Zotepine
27.27Single6AQFZM2413856AQF-A2A-ZM241385
27.27Single6DS0Ly2660976DS0-5-HT2B-Ly266097
27.27Single6IQLL7458706IQL-D4-L745870
27.27Single6LMLGlucagon6LML-Glucagon-Glucagon
27.27Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
27.27Single6MH8ZM2413856MH8-A2A-ZM241385
27.27Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
27.27Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single6TPKRetosiban6TPK-OT-Retosiban
27.27Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
27.27Single6V9SGTPL114036V9S-OX1-GTPL11403
27.27Single6VI4JDTic6VI4-κ-JDTic
27.27Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
27.27Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
27.27Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
27.27Single6ZG9GSK10347026ZG9-M1-GSK1034702
27.27Single7AROLUF58337ARO-A2A-LUF5833-Na
27.27Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
27.27Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
27.27Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
27.27Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
27.27Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Single7T32ZM2413857T32-A2A-ZM241385
27.27Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
27.27Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
27.27Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
27.27Single7VODCariprazine7VOD-5-HT2A-Cariprazine
27.27Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
27.27Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
27.27Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
27.27Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
27.27Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
27.27Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
27.27Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
27.27Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
27.27Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.27Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.27Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.27Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.27Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.27Single8GGIEpinephrine8GGI-β2-Epinephrine
27.27Single8GGLEpinephrine8GGL-β2-Epinephrine
27.27Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
27.27Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
27.27Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
27.27Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
27.27Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.27Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.27Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.27Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
27.27Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
27.27Consensusgnrh_offOrthosteric Ligandgnrh1_off
27.27Consensushca_onOrthosteric Ligandhca2_on hca3_on
27.27Consensushcar_onOrthosteric Ligandhca_on
27.27Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
27.27Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
27.27Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
27.27Consensusvasopressin-ot_offOrthosteric Ligandot_off
27.03Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
26.92Single4BUONeurotensin4BUO-NTS1-Neurotensin
26.92Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
26.92Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
26.92Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
26.92Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
26.92Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
26.92Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.92Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
26.92Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.92Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
26.92Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
26.67Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
26.67Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
26.67Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
26.67Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
26.67Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
26.32Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
26.32Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
26.32Single8A2OTheophylline8A2O-A2A-Theophylline-Na
26.32Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
26.09Single2Y01Dobutamine2Y01-β1-Dobutamine
26.09Single3EMLZM2413853EML-A2A-ZM241385
26.09Single4DAJTiotropium4DAJ-M3-Tiotropium
26.09Single4EIYZM2413854EIY-A2A-ZM241385-Na
26.09Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
26.09Single4YAYZD-71554YAY-AT1-ZD-7155
26.09Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
26.09Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
26.09Single5IU8Q274563475IU8-A2A-Q27456347-Na
26.09Single5K2AZM2413855K2A-A2A-ZM241385-Na
26.09Single5OLGZM2413855OLG-A2A-ZM241385-Na
26.09Single5UENDU1725UEN-A1-DU172
26.09Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
26.09Single5VRAZM2413855VRA-A2A-ZM241385-Na
26.09Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
26.09Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
26.09Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
26.09Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
26.09Single6IIVDaltroban6IIV-TP-Daltroban
26.09Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
26.09Single6S0LZM2413856S0L-A2A-ZM241385
26.09Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
26.09Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
26.09Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
26.09Single7F83PF-051904577F83-Ghrelin-PF-05190457
26.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
26.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
26.09Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
26.09Single7PYRPSB-21157PYR-A2A-PSB-2115
26.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
26.09Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
26.09Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
26.09Consensusa2_offOrthosteric Liganda2a_off
26.09Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
26.09Consensuscck_offOrthosteric Ligandccka_off
26.09Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
26.09Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
26.09Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
26.09Consensushistamine_onOrthosteric Ligandh1_on h4_on
26.09Consensustachykinin_offOrthosteric Ligandnk1_off
26.09Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
25.93Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
25.93Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
25.93Single7XN9L-054,5227XN9-SST2-L-054,522
25.93Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Consensusclass-d_offOrthosteric Ligandste2_off
25.93Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
25.93Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
25.81Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
25.81Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
25.81Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
25.81Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
25.81Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.81Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.71Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
25.71Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
25.00Single2Y00Dobutamine2Y00-β1-Dobutamine
25.00Single3OE6IT1t3OE6-CXCR4-IT1t
25.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
25.00Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
25.00Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
25.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
25.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
25.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
25.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
25.00Single6FJ3PTH6FJ3-PTH1-PTH
25.00Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
25.00Single6LPLZM2413856LPL-A2A-ZM241385-Na
25.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
25.00Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
25.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
25.00Single6S0QZM2413856S0Q-A2A-ZM241385
25.00Single6WQAZM2413856WQA-A2A-ZM241385-Na
25.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
25.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
25.00Single7F8XNN90567F8X-CCKA-NN9056
25.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
25.00Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
25.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
25.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
25.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
25.00Single7QA8Peptide7QA8-STE2-Peptide
25.00Single7QA8Peptide7QA8-STE2-Peptide
25.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7RM5ZM2413857RM5-A2A-ZM241385-Na
25.00Single7SINNPS-21437SIN-CaS-NPS-2143
25.00Single7SINNPS-21437SIN-CaS-NPS-2143
25.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
25.00Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
25.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
25.00Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single8FYNZM2413858FYN-A2A-ZM241385-Na
25.00Single8GGZEpinephrine8GGZ-β2-Epinephrine
25.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
25.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
25.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
25.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
25.00Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
25.00Single8QOTNanobody E8QOT-μ-Nanobody E
25.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
25.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
25.00Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
25.00Consensusclass-d_offOrthosteric Ligandste2_off
25.00Consensusclass-d_onOrthosteric Ligandste2_on
25.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
25.00Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
25.00Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
25.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
25.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
25.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
25.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
25.00Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
24.32Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
24.24Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
24.24Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
24.24Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
24.24Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
24.24Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
24.24Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.24Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
24.24Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
24.24Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
24.24Consensusgi_class-dOrthosteric Ligandgi_ste
24.24Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
24.14Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
24.14Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
24.14Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
24.00Single5TZR-5TZR-FFA1 (GPR40)-MK8666
24.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
24.00Single6OS1TRV0266OS1-AT1-TRV026
24.00Single7PX4PSB-21137PX4-A2A-PSB-2113
24.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
24.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
24.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
24.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
24.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
24.00Consensuschemerin_onOrthosteric Ligandcml1_on
24.00Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
24.00Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
24.00Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
24.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
23.81Single3OE9IT1t3OE9-CXCR4-IT1t
23.81Single3PBLEticlopride3PBL-D3-Eticlopride
23.81Single6HLLCP999946HLL-NK1-CP99994
23.81Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
23.81Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
23.81Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
23.81Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
23.81Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
23.81Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
23.81Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
23.81Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
23.81Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Single8GGYEpinephrine8GGY-β2-Epinephrine
23.81Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
23.81Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
23.81Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
23.81Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.81Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
23.81Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
23.81Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
23.81Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
23.81Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
23.81Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
23.81Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
23.68Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
23.53Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
23.53Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
23.53Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
23.53Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
23.53Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
23.33Single3OE0CVX153OE0-CXCR4-CVX15
23.33Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
23.33Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
23.33Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
23.33Single7XNACYN1548067XNA-SST2-CYN154806
23.33Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
23.33Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
23.33Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
23.08Single4N4WSANT-14N4W-SMO-SANT-1
23.08Single5X33BIIL2605X33-BLT1-BIIL260
23.08Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
23.08Single6IIURamatroban6IIU-TP-Ramatroban
23.08Single6OS2TRV0266OS2-AT1-TRV026
23.08Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single6YVRNTS8-136YVR-NTS1-NTS8-13
23.08Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.08Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
23.08Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
23.08Consensuschemokine_offOrthosteric Ligandcxcr_off
23.08Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
23.08Consensuscxcr_offOrthosteric Ligandcxcr4_off
23.08Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
23.08Consensusnts_onOrthosteric Ligandnts1_on
22.86Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
22.73Single3ODUIT1t3ODU-CXCR4-IT1t
22.73Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
22.73Single4BWBNeurotensin4BWB-NTS1-Neurotensin
22.73Single5DHHSB-6121115DHH-NOP-SB-612111
22.73Single5K2DZM2413855K2D-A2A-ZM241385
22.73Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
22.73Single5ZKQABT-4915ZKQ-PAF-ABT-491
22.73Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
22.73Single6JZHZM2413856JZH-A2A-ZM241385-Na
22.73Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
22.73Single6ME2Ramelteon6ME2-MT1-Ramelteon
22.73Single6PS7ZM2413856PS7-A2A-ZM241385-Na
22.73Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
22.73Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
22.73Single7F8ULintitript7F8U-CCKA-Lintitript
22.73Single7F8YDevazepide7F8Y-CCKA-Devazepide
22.73Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
22.73Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
22.73Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
22.73Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
22.73Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
22.73Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
22.73Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single8IWESpermidine8IWE-TAAR9-Spermidine
22.73Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
22.73Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
22.73Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.73Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
22.73Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
22.58Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
22.58Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.58Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
22.58Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.50Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
22.22Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
22.22Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
22.22Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
22.22Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
22.22Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
22.22Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
22.22Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
22.22Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
22.22Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
22.22Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
22.22Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
21.88Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
21.88Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
21.88Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
21.88Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
21.74Single3REYPubChem 56973REY-A2A-PubChem 5697
21.74Single5IU4ZM2413855IU4-A2A-ZM241385-Na
21.74Single5IUBQ274563445IUB-A2A-Q27456344-Na
21.74Single5K2CZM2413855K2C-A2A-ZM241385-Na
21.74Single5NLXZM2413855NLX-A2A-ZM241385-Na
21.74Single5NM4ZM2413855NM4-A2A-ZM241385-Na
21.74Single5UVIZM2413855UVI-A2A-ZM241385
21.74Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
21.74Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
21.74Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
21.74Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
21.74Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
21.74Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
21.74Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
21.74Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
21.74Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
21.74Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
21.74Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
21.74Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
21.62Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
21.62Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
21.62Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
21.43Single5EE7MK08935EE7-Glucagon-MK0893
21.43Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
21.43Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
21.43Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
21.43Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
21.43Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Consensusgs_class-b2Orthosteric Ligandgs_adgr
21.43Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
21.21Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
21.21Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
21.21Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
21.21Single7SK3CXCL127SK3-ACKR3-CXCL12
21.21Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
21.05Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
21.05Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
21.05Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
21.05Single7WC4Serotonin7WC4-5-HT2A-Serotonin
21.05Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8PWNTheophylline8PWN-A2A-Theophylline
21.05Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
20.83Single5DSGTiotropium5DSG-M4-Tiotropium
20.83Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
20.83Single5T04Neurotensin5T04-NTS1-Neurotensin
20.83Single6D27CAY104716D27-DP2-CAY10471
20.83Single6GPSMK08126GPS-CCR2-MK0812
20.83Single6LPJZM2413856LPJ-A2A-ZM241385-Na
20.83Single6LPKZM2413856LPK-A2A-ZM241385-Na
20.83Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
20.83Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
20.83Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
20.83Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
20.83Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.83Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
20.83Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
20.83Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
20.83Consensushcar_offOrthosteric Ligandsuccinate_off
20.83Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
20.83Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
20.83Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
20.83Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
20.69Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
20.69Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
20.69Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.69Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.69Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
20.59Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
20.59Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
20.59Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
20.59Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
20.59Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Single3RFMCaffeine3RFM-A2A-Caffeine
20.00Single5CGCHTL142425CGC-mGlu5-HTL14242
20.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
20.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
20.00Single6GPXMK08126GPX-CCR2-MK0812
20.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
20.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
20.00Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
20.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
20.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
20.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
20.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
20.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
20.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
20.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
20.00Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
20.00Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
20.00Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
20.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
20.00Consensusep_offOrthosteric Ligandep4_off
20.00Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
20.00Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
20.00Consensussensory_onOrthosteric Ligandopsin_on
20.00Consensussst_offOrthosteric Ligandsst2_off
19.44Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
19.44Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.35Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
19.23Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
19.23Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
19.23Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
19.23Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
19.23Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
19.23Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
19.23Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
19.05Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
19.05Single3OE8IT1t3OE8-CXCR4-IT1t
19.05Single6LI0GTPL98046LI0-GPR52-GTPL9804
19.05Single6ME5Agomelatine6ME5-MT1-Agomelatine
19.05Single6ME9Ramelteon6ME9-MT2-Ramelteon
19.05Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
19.05Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
19.05Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
19.05Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
19.05Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
18.75Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
18.75Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
18.75Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.52Single4PY02MeSATP4PY0-P2Y12-2MeSATP
18.52Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
18.52Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
18.52Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
18.52Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
18.52Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
18.52Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
18.52Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
18.52Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
18.52Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
18.52Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
18.42Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
18.18Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
18.18Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
18.18Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
18.18Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
18.18Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
18.18Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
18.18Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
18.18Consensusclass-t_onOrthosteric Ligandtaste2_on
18.18Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.18Consensusgs_class-tOrthosteric Ligandgs_taste
18.18Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
18.18Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
18.18Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
17.95Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
17.86Single5CGDHTL142425CGD-mGlu5-HTL14242
17.86Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
17.86Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.86Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
17.86Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
17.86Consensuscyslt_offOrthosteric Ligandcyslt2_off
17.86Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
17.86Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
17.65Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
17.50Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
17.39Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
17.39Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
17.39Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
17.39Single5U09Taranabant5U09-CB1-Taranabant
17.39Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
17.39Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
17.39Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
17.39Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
17.39Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
17.24Single6KNMJN241-96KNM-Apelin-JN241-9
17.24Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
17.14Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
17.07Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
16.67Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
16.67Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
16.67Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
16.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.67Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
16.67Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
16.67Single8K2WAMG4878K2W-CXCR3-AMG487
16.67Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
16.67Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
16.67Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
16.67Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
16.13Single7SK5CXCL127SK5-ACKR3-CXCL12
16.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
16.00Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
16.00Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
16.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
15.91Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
15.79Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
15.79Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
15.79Single5MZPCaffeine5MZP-A2A-Caffeine-Na
15.79Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
15.38Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
15.38Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
15.38Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
15.38Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
15.38Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
15.38Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
15.15Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.15Consensusclass-d_onOrthosteric Ligandste2_on
15.15Consensusgi_class-dOrthosteric Ligandgi_ste
15.15Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.00Consensusclass-c_onOther Ligandgabab_on mglu_on
14.81Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
14.81Single5V56TC1145V56-SMO-TC114
14.81Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
14.81Single7F1TMIP-1a7F1T-CCR5-MIP-1a
14.81Single7P2L4YI7P2L-mGlu5-4YI
14.81Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
14.81Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
14.81Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
14.81Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
14.29Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
14.29Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
14.29Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
14.29Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
14.29Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
14.29Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
14.29Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
13.79Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
13.79Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
13.79Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
13.64Single3UZAGTPL92363UZA-A2A-GTPL9236
13.64Single4XNWMRS25004XNW-P2Y1-MRS2500
13.64Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
13.64Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
13.64Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
13.64Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
13.51Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
13.33Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.33Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
13.16Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
13.16Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
13.04Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
13.04Single4O9RCyclopamine4O9R-SMO-Cyclopamine
13.04Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
13.04Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
13.04Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
13.04Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
13.04Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
13.04Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
13.04Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
13.04Consensusgo_class-b2Orthosteric Ligandgo_adhesion
13.04Consensusgo_proteinOrthosteric Ligandgo_chemokine
13.04Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
12.90Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
12.90Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
12.50Single4QINSAG1.54QIN-SMO-SAG1.5
12.50Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
12.50Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
12.20Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
12.20Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
12.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
12.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
12.00Single6ZINSR486926ZIN-NTS1-SR48692
12.00Single7VV6C48/807VV6-MRGPRX2-C48/80
12.00Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
12.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
12.00Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
12.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
12.00Consensusgi_class-fOrthosteric Ligandgi_frizzled
12.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
12.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single6FFHFenobam6FFH-mGlu5-Fenobam
11.54Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
11.54Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
11.54Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
11.54Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
11.11Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
11.11Single6Z4SSR486926Z4S-NTS1-SR48692
11.11Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
11.11Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.71Single5V57TC1145V57-SMO-TC114
10.71Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
10.71Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
10.71Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
10.53Single8HS2Fab0468HS2-GPR20-Fab046
10.53Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
10.34Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.34Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
10.34Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
10.34Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
10.34Consensusnts_offOrthosteric Ligandnts1_off
10.00Single6W25Ca6W25-MC4-SHU9119-Ca
10.00Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
10.00Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
9.52Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
9.52Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
9.52Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
9.09Single7SHEPI; PE7SHE-GPR158-PI; PE
9.09Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
9.09Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
9.09Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
9.09Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
9.09Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
8.70Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
8.70Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
8.70Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
8.70Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
8.57Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
8.33Single5L7IVismodegib5L7I-SMO-Vismodegib
8.33Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
8.16Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
8.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
8.00Consensusclass-f_offOrthosteric Ligandsmo_off
7.69Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single8IYXYL-3658IYX-GPR34-YL-365
7.50Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
7.50Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
7.14Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
7.14Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
7.14Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
6.45Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
6.25Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
5.88Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
5.56Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.56Single6D35Cholesterol6D35-SMO-Cholesterol
5.56Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.56Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.56Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
5.56Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
5.56Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.56Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.56Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.56Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
5.56Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
5.56Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
5.56Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
5.56Single7DTTCa7DTT-CaS-Ca-Ca
5.56Single7DTTCa7DTT-CaS-Ca-Ca
5.56Single7DTUTryptophan7DTU-CaS-Tryptophan
5.56Single7DTUTryptophan7DTU-CaS-Tryptophan
5.56Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.56Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.56Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.56Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.56Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.56Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.56Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
5.56Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
5.56Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
5.56Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.56Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.56Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.56Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.56Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.56Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.56Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single7FIIhCG7FII-LH-hCG-6fuf
5.56Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.56Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.56Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.56Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.56Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.56Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.56Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.56Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
5.56Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
5.56Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.56Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.56Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.56Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.56Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
5.56Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.56Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.56Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.56Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.56Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.56Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.56Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
5.56Single7XW7K1-707XW7-TSH-K1-70
5.56Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.56Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.56Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.56Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.56Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.56Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.56Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.56Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.56Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.56Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.56Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.56Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.56Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
5.56Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.56Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.56Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.56Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.56Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
5.56Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
5.56Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.56Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.56Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
5.56Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
5.56Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.56Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.56Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.56Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.56Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.56Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
5.56Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
5.56Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.56Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.56Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.56Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.56Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.56Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.56Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.56Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.56Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.56Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.56Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.56Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.56Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
5.56Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
5.56Consensusclass-c_offOther Ligandgabab_off mglu_off
5.56Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
5.56Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
5.56Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
5.56Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.56Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
5.56Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
5.56Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
5.56Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
5.56Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Consensusgphr_onOrthosteric Ligandlh_on tsh_on
5.56Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
5.56Consensusgs_proteinOrthosteric Ligandgs_gphr
5.56Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
5.56Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
5.56Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
5.56Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.56Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.56Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
5.56Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
5.56Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
5.56Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
5.56Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
5.56Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
5.56Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
5.56Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
5.56Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
5.56Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
5.56Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
5.26Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.26Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.26Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.26Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.26Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.26Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.00Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
5.00Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.88Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.76Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.76Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
4.76Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
4.76Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.76Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.76Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.76Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
4.55Single5L7DCholesterol5L7D-SMO-Cholesterol
4.55Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
4.55Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.35Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
4.17Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
4.17Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
4.17Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single7UL2SR486927UL2-NTS1-SR48692-Na
4.00Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
3.85Single4K5YCP-3763954K5Y-CRF1-CP-376395
3.85Single4XNVBPTU4XNV-P2Y1-BPTU
3.85Single7WV9ZCZ0117WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
3.85Single8HNNSCH5467388HNN-CXCR3-SCH546738
3.85Consensuscb1_on_alloOther Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
3.57Single4Z9GCP-3763954Z9G-CRF1-CP-376395
3.57Single8GTIBMK-C2058GTI-CRF1-BMK-C205
3.45Single8GTGBMK-I1528GTG-CRF1-BMK-I152
3.23Single7SHEPI; PE7SHE-GPR158-PI; PE
3.23Single8GTMBMK-C2038GTM-CRF1-BMK-C203

Consensus Members
Id Members
7EW3 7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
7TD4 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
7VIF 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
7EO4 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
7VIG 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
7EVZ 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
7EW4 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
7EW2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7TD0 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
7YU3 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7EW0 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
7EW7 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
Net Summary
Imin 2.57333
Number of Linked Nodes 889
Number of Links 1106
Number of Hubs 185
Number of Links mediated by Hubs 715
Number of Communities 24
Number of Nodes involved in Communities 266
Number of Links involved in Communities 398
Path Summary
Number Of Nodes in MetaPath 113
Number Of Links MetaPath 112
Number of Shortest Paths 900401
Length Of Smallest Path 3
Average Path Length 28.2842
Length of Longest Path 74
Minimum Path Strength 0.3775
Average Path Strength 5.23232
Maximum Path Strength 40.3517
Minimum Path Correlation 0.7
Average Path Correlation 0.967963
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.42857
Average % Of Corr. Nodes 45.5845
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.9094
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gi_lipidgi_cannabinoid
gi_prostanoid
gi_ffa
gi_lpl
gi_leukotriene



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